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Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review
Abstract
As the mainstay in the treatment of various cancers, chemotherapy plays a vital role, but still faces many challenges, such as poor tumour selectivity and multidrug resistance (MDR). Targeted drug delivery using nanotechnology has provided a new strategy for addressing the limitations of the conventional chemotherapy. In the last decade, the volume of research published in this area has increased tremendously, especially with functional nano drug delivery systems (nanocarriers). Coupling a specific stimuli-triggered drug release mechanism with these delivery systems is one of the most prevalent approaches for improving therapeutic outcomes. Among the various stimuli, pH triggered delivery is regarded as the most general strategy, targeting the acidic extracellular microenvironment and intracellular organelles of solid tumours. In this review, we discuss recent advances in the development of pH-sensitive nanocarriers for tumour-targeted drug delivery. The review focuses on the chemical design of pH-sensitive biomaterials, which are used to fabricate nanocarriers for extracellular and/or intracellular tumour site-specific drug release. The pH-responsive biomaterials bring forth conformational changes in these nanocarriers through various mechanisms such as protonation, charge reversal or cleavage of a chemical bond, facilitating tumour specific cell uptake or drug release. A greater understanding of these mechanisms will help to design more efficient drug delivery systems to address the challenges encountered in conventional chemotherapy.
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“Acidic pH caused protonation leads to hydrophilic-hydrophobic phase transition for the anionic polymers, and hydrophobic- hydrophilic phase transition for cationic polymers, inducing deformation of amphiphilic structures leading to drug release [136].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [136]
In the citing paper
“Generally, two basic perceptions define the mechanism of the pH-responsive nanoparticles, such as the cleavage of chemical bonds and nanocarrier protonation.138”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [138]
Citations
Cites
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,781
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
(1989) · PubMed · Cited by 3,343
Thermo- and pH-responsive polymers in drug delivery☆
SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023
Danhier, F., Féron, O., & Véronique Préat, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.027 · Cited by 2,891
A review of stimuli-responsive nanocarriers for drug and gene delivery
Ganta, S., Devalapally, H., Shahiwala, A., & Amiji, M. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.017 · Cited by 2,198
Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
WICKI, A. N., Witzigmann, D., Balasubramanian, V., & Huwyler, J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.030 · Cited by 1,962
New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?
Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951
Lipid polymorphism and the functional roles of lipids in biological membranes
Cullis, P. R., & KRUIJFF, B. D. (1979) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(79)90012-1 · Cited by 1,865
Research works printed but not linked: 4
- Immordino, 2006, Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential, Int. J. Nanomedicine, 1, 297
- Liu, 2014, pH-Sensitive nano-systems for drug delivery in cancer therapy, Biotechnol. Adv., 32, 693, 10.1016/j.biotechadv.2013.11.009 · DOI · Paper page
- Sun, 2014, Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds, Biomaterials, 35, 836, 10.1016/j.biomaterials.2013.10.011 · DOI
- Carmali, 2014, Chapter 13-polyacetals, 219
Cited by
Sorted by citations
Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 5,069
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073
“138 Chemical bonds of pH-responsive linkers disassemble at acidic pH and release the drug in the tumor microenvironment.”
BackgroundTumour acidosis: from the passenger to the driver's seat
Corbet, C., & Féron, O. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.77 · Cited by 1,028
Advances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 890
Metal-organic frameworks for stimuli-responsive drug delivery
Wang, Y., Yan, J., Wen, N., Xiong, H., Cai, S., He, Q., Hu, Y., Peng, D., Liu, Z., & Liu, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119619 · Cited by 676
Preparation and application of pH-responsive drug delivery systems
Ding, H., Tan, P., Fu, S., Tian, X., Zhang, H., Ma, X., Gu, Z., & Luo, K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.056 · Cited by 645
Formulation of Poloxamers for Drug Delivery
Bodratti, A. M., & Alexandridis, P. (2018) · Journal of Functional Biomaterials · doi:10.3390/jfb9010011 · Cited by 590
Theranostic Fluorescent Probes
Sharma, A. K., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 512
Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy
Peng, S., Xiao, F., Chen, M., & Gao, H. (2021) · Advanced Science · doi:10.1002/advs.202103836 · Cited by 451
The acidic tumor microenvironment: a target for smart cancer nano-theranostics
Feng, L., Dong, Z., Tao, D., Zhang, Y., & Liu, Z. (2017) · National Science Review · doi:10.1093/nsr/nwx062 · Cited by 430
Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
Zhou, Q., Zhang, L., Yang, T., & Wu, H. Y. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s158696 · Cited by 429
“31 Accordingly, the difference in pH has been widely exploited to achieve tumor site-or organelle-specific activation of pH-responsive PMs and on-demand drug release.”
Cyclodextrin‐Based Multistimuli‐Responsive Supramolecular Assemblies and Their Biological Functions
Zhang, Y., Liu, Y., & Liu, Y. (2019) · Advanced Materials · doi:10.1002/adma.201806158 · Cited by 402
Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics
Zhao, S., Yu, X., Qian, Y., Chen, W., & Shen, J. (2020) · Theranostics · doi:10.7150/thno.42564 · Cited by 391
“Moreover, the diverse nanostructures and surface modification of nanomaterials should endow themselves with the tumor-targeting ability by EPR effect or other interactions affiliated to the features of tumor tissues [18-21].”
BackgroundOverchuk, M., & Zheng, G. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.024 · Cited by 385
Ramasamy, T., Ruttala, H. B., Gupta, B., Poudel, B. K., Choi, H., Yong, C. S., & Kim, J. O. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.043 · Cited by 374
“cargo, including internalization beyond biological barriers such as the blood brain barrier or interaction with receptors on cellular surfaces [9].”
BackgroundBioinspired Diselenide‐Bridged Mesoporous Silica Nanoparticles for Dual‐Responsive Protein Delivery
Shao, D., Li, M., Wang, Z., Zheng, X., Lao, Y., Chang, Z., Zhang, F., Lu, M., Yue, J., Hu, H., et al. (2018) · Advanced Materials · doi:10.1002/adma.201801198 · Cited by 369
Contact Lens Materials: A Materials Science Perspective
Musgrave, C. S. A., & Fang, F. (2019) · Materials · doi:10.3390/ma12020261 · Cited by 370
“Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery; a review, 152, Copyright 2016, with permission from Elsevier [210].”
BackgroundInfluentialCurrent Multistage Drug Delivery Systems Based on the Tumor Microenvironment
Chen, B., Dai, W., He, B., Zhang, H., Wang, X., Wang, Y., & Zhang, Q. (2017) · Theranostics · doi:10.7150/thno.16684 · Cited by 350
“Among various chemotherapeutics, anthracyclines such as DOX, are the most popular model drugs for hydrazone conjugation, as previously reviewed by Wu et al [135].”
BackgroundpH-Responsive Polymer Nanomaterials for Tumor Therapy
Chu, S., Shi, X., Tian, Y., & Gao, F. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.855019 · Cited by 321
Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting
Liu, J. F., Jang, B., Issadore, D., & Tsourkas, A. (2019) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1571 · Cited by 265
pH ‐sensitive polymers: Classification and some fine potential applications
Ofridam, F., Tarhini, M., Lebaz, N., Gagnière, É., Mangin, D., & Elaissari, A. (2021) · Polymers for Advanced Technologies · doi:10.1002/pat.5230 · Cited by 286
Stealth nanoparticles in oncology: Facing the PEG dilemma
Zalba, S., ten Hagen, T. L. M., Burgui, C., & Garrido, M. J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.002 · Cited by 292
pH-Responsive Nanocarriers in Cancer Therapy
AlSawaftah, N., Awad, N. S., Pitt, W. G., & Husseini, G. A. (2022) · Polymers · doi:10.3390/polym14050936 · Cited by 273
“This will result in vesicular destabilization [38,43].”
BackgroundInfluentialInfection microenvironment-related antibacterial nanotherapeutic strategies
Wang, Z., Liu, X., Duan, Y., & Huang, Y. P. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121249 · Cited by 271
Wang, Z., Deng, X., Ding, J., Zhou, W., Zheng, X., & Tang, G. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.003 · Cited by 271
A review of drug release mechanisms from nanocarrier systems
Ding, C., & Li, Z. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.03.130 · Cited by 269
pH-sensitive biomaterials for drug delivery
Zhuo, S., Zhang, F., Yu, J., Zhang, X., Yang, G., & Liu, X. (2020) · Molecules · doi:10.3390/molecules25235649 · Cited by 247
Wu, W., Luo, L., Wang, Y., Wu, Q., Dai, H.-B., Li, J., Durkan, C., Wang, N., & Wang, G. (2018) · Theranostics · doi:10.7150/thno.23459 · Cited by 255
“The ideal nanocarrier must tightly retain the encapsulated drug without premature release during transport but must show burst release once inside tumor cells to overcome multidrug resistance and subsequently efficiently induce tumor cells apoptosis [70, 105, 196-200].”
BackgroundMethodYang, Y., Li, M., Pan, G., Chen, J., & Guo, B. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202214089 · Cited by 243
Wang, Z., Ye, Q., Yu, S., & Akhavan, B. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300105 · Cited by 249
Schubert, J., & Chanana, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180601101859 · Cited by 245
“smart properties like responsiveness [23] (pH, [24-27]”
Internal stimuli-responsive nanocarriers for drug delivery: Design strategies and applications
Liu, M., Du, H., Zhang, W., & Zhai, G. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2016.11.030 · Cited by 235
Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance
Zhou, L., Wang, H., & Li, Y. (2018) · Theranostics · doi:10.7150/thno.22679 · Cited by 232
“These nanomedicines remain stable at physiological pH, but collapse in an acidic microenvironment due to hydrolysis of acid labile bonds or protonation of chemical groups, resulting in release of their cargo into the cytosol, which promotes cytoplasmic drug concentrations to exceed the capacity of the efflux transport…”
BackgroundApplication of polydopamine in tumor targeted drug delivery system and its drug release behavior
Wang, Z., Duan, Y., & Duan, Y. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.10.009 · Cited by 235
Lu, J., Sun, J., Li, F., Wang, J., Liu, J., Kim, D., Fan, C., Hyeon, T., & Ling, D. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b04169 · Cited by 231
Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches
Ashrafizadeh, M., Delfi, M., Zarrabi, A., Bigham, A., Sharifi, E., Rabiee, N., Paiva‐Santos, A. C., Kumar, A. P., Tan, S. C., Hushmandi, K., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.001 · Cited by 235
Chi, Y., Yin, X., Sun, K., Feng, S., Liu, J., Chen, D., Guo, C., & Wu, Z. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.06.027 · Cited by 220
“This acid-triggered HA shedding may facilitate the liposomes for ‘endosome escape’, allowing drug content to be released to cytoplasm [25].”
BackgroundSelf-citationRational Design of Cancer Nanomedicine for Simultaneous Stealth Surface and Enhanced Cellular Uptake
Jin, Q., Deng, Y., Chen, X., & Ji, J. (2019) · ACS Nano · doi:10.1021/acsnano.8b07746 · Cited by 220
Small‐Molecule Prodrug Nanoassemblies: An Emerging Nanoplatform for Anticancer Drug Delivery
Li, G., Sun, B., Li, Y., Luo, C., He, Z., & Sun, J. (2021) · Small · doi:10.1002/smll.202101460 · Cited by 208
Pei, P., Sun, C., Tao, W., Li, J., Yang, X., & Wang, J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.010 · Cited by 206
Gong, C., Yu, X., You, B., Wu, Y. F., Wang, R., Han, L., Wang, Y., Gao, S., & Yuan, Y. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00649-8 · Cited by 205
Zhou, Y., Chen, X., Cao, J., & Gao, H. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00649a · Cited by 213
Gold Complexes in Anticancer Therapy: From New Design Principles to Particle‐Based Delivery Systems
Moreno‐Alcántar, G., Picchetti, P., & Casini, A. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202218000 · Cited by 207
Stimuli-responsive nano-assemblies for remotely controlled drug delivery
Li, F., Qin, Y., Lee, J., Liao, H., Wang, N., Davis, T. P., Qiao, R., & Ling, D. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.03.051 · Cited by 201
Current Advances in Stimuli-Responsive Hydrogels as Smart Drug Delivery Carriers
Zhang, Y., & Wu, B. M. (2023) · Gels · doi:10.3390/gels9100838 · Cited by 202
“Biological fluid pH is a significant chemical property that holds immense potential in the drug delivery field. pH-responsive hydrogel and nanogels have been developed as intelligent drug delivery carriers, capable of exhibiting swelling or shrinking behavior in response to changes in pH [71–74].”
BackgroundZheng, M., Pan, M., Zhang, W., Lin, H., Wu, S., Lu, C. T., Tang, S., Liu, D., & Cai, J. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.12.001 · Cited by 199
“Several pH-responsive chemical bonds such as imine, hydrazone, boronate, oxime, amide, ether, and orthoester bonds have been incorporated into drug delivery systems to facilitate rapid bond breakage and accelerated drug release at tumor pH [191].”
BackgroundZhang, L., Wu, S., Qin, Y., Fan, F., Zhang, Z., Huang, C., Ji, W., Lu, L., Wang, C., Sun, H., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00030 · Cited by 189
pH-Sensitive nanoscale materials as robust drug delivery systems for cancer therapy
Shi, Z., Li, Q., & Mei, L. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.03.001 · Cited by 193
pH-Sensitive nanogels for drug delivery in cancer therapy
Li, Z., Huang, J. C., & Wu, J. (2020) · Biomaterials Science · doi:10.1039/d0bm01729a · Cited by 186
Functional biomaterials towards flexible electronics and sensors
Sun, Q., Qian, B., Uto, K., Chen, J., Liu, X., & Minari, T. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.08.018 · Cited by 178
A Hyaluronidase-Responsive Nanoparticle-Based Drug Delivery System for Targeting Colon Cancer Cells
Zhang, M., Xu, C., Wen, L., Han, M. K., Xiao, B., Zhou, J., Zhang, Y., Zhang, Z., Viennois, É., & Merlin, D. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1681 · Cited by 172
“The reported DDS have involved polymeric nanoparticles (3), liposomes (4), dendrimers (5), inorganic nanoparticles (6), and protein nanoparticles (7).”
BackgroundSeverely polarized extracellular acidity around tumour cells
Feng, Q., Bennett, Z. T., Grichuk, A., Pantoja, R., Huang, T., Faubert, B., Huang, G., Chen, M., DeBerardinis, R. J., Sumer, B. D., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01178-7 · Cited by 176
“For tumour-targeted therapy that exploits acidic pH for therapeutic development 50,51 or drug delivery 54 , a lower pH threshold (for example, pH <5.5) should be considered.”
InfluentialZhang, W., Yu, Z., Wu, M. Y., Ren, J., Xia, H.-F., Sa, G., Zhu, J., Pang, D., Zhao, Y., & Chen, G. (2016) · ACS Nano · doi:10.1021/acsnano.6b05630 · Cited by 171
Alsehli, M. (2020) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2020.01.004 · Cited by 174
“amines) are widely used for fabricating pH-responsive nanocarriers to induce the disruption of polymeric micelles in acidic media at the interior and/or exterior of tumor cells (Kanamala et al., 2016; Wang et al., 2018).”
BackgroundSmart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review
Kenchegowda, M., Rahamathulla, M., Hani, U., Begum, M. Y., Guruswamy, S., Osmani, R. A. M., Gowrav, M. P., Alshehri, S., Ghoneim, M. M., Alshlowi, A., et al. (2021) · Molecules · doi:10.3390/molecules27010146 · Cited by 181
Leveraging Physiology for Precision Drug Delivery
Sun, W., Hu, Q., Ji, W., Wright, G., & Gu, Z. (2017) · Physiological Reviews · doi:10.1152/physrev.00015.2016 · Cited by 169
“To control the timing of drug release or activation, DDSs incorporating stimuli-responsive moieties were designed (247) for different types of physiological factors, such as glucose levels (281, 436, 496), pH gradients (189, 236, 317, 401), redox gradients (121, 171, 266, 335), overexpressed enzymes (23, 161), and ATP…”
BackgroundGold Nanoparticles in Cancer Theranostics
Gao, Q., Zhang, J., Gao, J., Zhang, Z., Zhu, H., & Wang, D. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.647905 · Cited by 172
Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy
Chang, D., Ma, Y., Xu, X., Xie, J., & Ju, S. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.707319 · Cited by 171
Programming Stimuli-Responsive Behavior into Biomaterials
Badeau, B. A., & DeForest, C. A. (2019) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-060418-052324 · Cited by 169
“As such, pH-responsive therapeutic carriers have been employed to achieve tumor- or intracellular-specific delivery (18).”
BackgroundKong, X., Qi, Y., Wang, X., Jiang, R., Wang, J., Fang, Y., Gao, J., & Hwang, K. C. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101070 · Cited by 169
“On the basis of the significant decrease of pH values in tumor tissues and cells, the design of pH responsive nano drug delivery systems has become a hot research topic in tumor therapy [176-178].”
BackgroundNanogels for intracellular delivery of biotherapeutics
Li, D., van Nostrum, C. F., Mastrobattista, E., Vermonden, T., & Hennink, W. E. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.12.020 · Cited by 161
Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156
“Acidic pH caused protonation leads to hydrophilic-hydrophobic phase transition for the anionic polymers, and hydrophobichydrophilic phase transition for cationic polymers, inducing deformation of amphiphilic structures leading to drug release [136].”
BackgroundHan, X., Alu, A., Liu, H., Shi, Y., Wei, X., Cai, L., & Wei, Y. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.01.011 · Cited by 165
“These ligands include specific antibodies, aptamers, peptides, and other ligands [30,36].”
BackgroundXie, S., Zhao, L., Song, X., Tang, M., Mo, C., & Li, X. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.10.041 · Cited by 153
Targeted contrast agents and activatable probes for photoacoustic imaging of cancer
Zhao, Z., Swartchick, C. B., & Chan, J. (2022) · Chemical Society Reviews · doi:10.1039/d0cs00771d · Cited by 155
Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy
Moosavian, S. A., Bianconi, V., Pirro, M., & Sahebkar, A. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.025 · Cited by 149
Stimuli-responsive nanoscale drug delivery systems for cancer therapy
Li, L., Yang, W., & Xu, D. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1519029 · Cited by 143
Chen, X., Gao, H., Deng, Y., Jin, Q., Ji, J., & Ding, D. (2020) · ACS Nano · doi:10.1021/acsnano.0c02197 · Cited by 142
Li, R., Peng, F., Cai, J., Yang, D., & Zhang, P. (2019) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2019.06.003 · Cited by 142
Lalu, L., Tambe, V., Pradhan, D., Nayak, K., Bagchi, S., Maheshwari, R., Kalia, K., & Tekade, R. K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.07.035 · Cited by 137
“As evinced from several investigations, they usually elicit zero order kinetic of drug release pattern with characteristic rapid release accompanied by sustained release [37].”
Polymer-based drug delivery systems for cancer treatment
Guo, X., Wang, L., Xiao, W., & Zhou, S. (2016) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.28252 · Cited by 139
Jia, Q., Li, Z., Guo, C., Huang, X., Song, Y., Zhou, N., Wang, M., Zhang, Z., He, L., & Du, M. (2019) · Nanoscale · doi:10.1039/c9nr06195a · Cited by 134
Kong, C., Li, Y., Liu, Z., Ye, J., Wang, Z., Zhang, L., Kong, W., Liu, H., Liu, C., Pang, H., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b08246 · Cited by 127
Prodrug strategy for cancer cell-specific targeting: A recent overview
Zhang, X., Li, X., You, Q., & Zhang, X. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.08.010 · Cited by 131
Fontes, M. D. L., Meneguin, A. B., Tercjak, A., Gutierrez, J., Cury, B. S. F., dos Santos, A. M., Ribeiro, S. J. L., & Barud, H. D. S. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.09.061 · Cited by 130
Stimuli-responsive nanocarriers for delivery of bone therapeutics – Barriers and progresses
Lavrador, P., Gaspar, V. M., & Mano, J. F. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.021 · Cited by 129
“The first one involves the design of nanocarriers with a pH-sensitive release profile resulting from existence of carboxylic acids or amines (including tertiary amines) within the nanocarrier backbone/structure [14,106].”
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Chen, K., Cai, H., Zhang, H., Zhu, H., Gu, Z., Gong, Q., & Luo, K. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.050 · Cited by 128
Li, R., & Xie, Y. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.020 · Cited by 128
Nanogels: Synthesis, properties, and recent biomedical applications
Duan, Q., Zhu, Y., Jia, H., Wang, S., & Wu, F. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101167 · Cited by 124
Advances in pH-responsive drug delivery systems
Mu, Y., Gong, L., Peng, T., Yao, J., & Lin, Z. (2021) · OpenNano · doi:10.1016/j.onano.2021.100031 · Cited by 127
Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery
Askari, E., Seyfoori, A., Amereh, M., Gharaie, S. S., Ghazali, H. S., Ghazali, Z. S., Khunjush, B., & Akbari, M. (2020) · Gels · doi:10.3390/gels6020014 · Cited by 128
Mills, J. A., Liu, F., Jarrett, T. R., Fletcher, N. L., & Thurecht, K. J. (2022) · Biomaterials Science · doi:10.1039/d2bm00181k · Cited by 128
Wang, X., Yang, Y., Zhuang, Y., Gao, P., Yang, F., Shen, H. Y., Guo, H., & Wu, D. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00744 · Cited by 121
Responsive crosslinked polymer nanogels for imaging and therapeutics delivery
Ekkelenkamp, A. E., Elzes, M. R., Engbersen, J. F. J., & Paulusse, J. M. J. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb02239e · Cited by 121
Dimeric prodrug-based nanomedicines for cancer therapy
Li, S., Shan, X., Wang, Y., Chen, Q., Sun, J., He, Z., Sun, B., & Luo, C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.036 · Cited by 115
Stimuli-Responsive Functional Micro-/Nanorobots: A Review
Zhou, Y., Ye, M., Hu, C., Qian, H., Nelson, B. J., & Wang, X. (2023) · ACS Nano · doi:10.1021/acsnano.3c01942 · Cited by 118
Yang, W. J., Zhou, P., Liang, L., Cao, Y., Qiao, J., Li, X., Teng, Z., & Wang, L. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b04394 · Cited by 115
Safe approaches for camptothecin delivery: Structural analogues and nanomedicines
Botella, P., & Rivero-Buceta, E. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.12.023 · Cited by 113
“This factor, together with the lower pH values inside endosomes, suggests that enhancing endosomal escape is the most realistic objective for pH-sensitive nanocarriers in the short term [166].”
BackgroundJia, D., Ma, X., Lu, Y., Li, X., Hou, S., Gao, Y., Xue, P., Kang, Y., & Xu, Z. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.11.052 · Cited by 112
Song, Z., Chen, X., You, X., Huang, K., Dhinakar, A., Gu, Z., & Wu, J. (2017) · Biomaterials Science · doi:10.1039/c7bm00730b · Cited by 113
Li, Q., Sun, L., Hou, M., Chen, Q., Yang, R., Zhang, L., Xu, Z., Kang, Y., & Xue, P. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b19667 · Cited by 110
Yang, Y., Wang, Z., Peng, Y., Ding, J., & Zhou, W. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00010 · Cited by 109
Cao, Z., Li, W., Liu, R., Li, X., Li, H., Liu, L., Chen, Y., Lv, C., & Liu, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109340 · Cited by 109
pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review
Yan, Y., & Ding, H. (2020) · Nanomaterials · doi:10.3390/nano10081613 · Cited by 113
Devnarain, N., Osman, N., Fasiku, V. O., Makhathini, S. S., Salih, M., Ibrahim, U. H., & Govender, T. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1664 · Cited by 110
Photosensitive drug delivery systems for cancer therapy: Mechanisms and applications
Pan, P., Svirskis, D. M., Rees, S. W. P., Barker, D. L. A., Waterhouse, G. I. N., & Wu, Z. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.053 · Cited by 107
Self-citationGe, Y., Zhang, T., Zhou, L., Ding, W., Liang, H., Hu, Z., Chen, Q. K., Dong, J., Xue, F., Yin, X., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121407 · Cited by 109
Chemotherapeutic drug delivery by tumoral extracellular matrix targeting
Raavé, R., van Kuppevelt, T. H., & Daamen, W. F. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.029 · Cited by 106
Tang, S., Meng, Q., Sun, H., Su, J., Yin, Q., Zhang, Z., Yu, H., Chen, L., Gu, W., & Li, Y. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.005 · Cited by 104
Song, Q., Jia, J., Niu, X., Zheng, C., Zhao, H., Sun, L., Zhang, H., Wang, L., Zhang, Z., & Zhang, Y. (2019) · Nanoscale · doi:10.1039/c9nr03802g · Cited by 103
Metadata
- Authors
- Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z.
- Affiliations
- University of Auckland (NZ)
- Corresponding author
- Wu, Zimei
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 85
- Pages
- 152-167
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2288119981
- Cited by
- 1,004
- References
- 213
- Citations by year
- 2026: 65 · 2025: 96 · 2024: 78 · 2023: 85 · 2022: 99 · 2021: 117 · 2020: 129 · 2019: 113 · 2018: 108 · 2017: 77 · 2016: 37
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- Royal Society of New Zealand (UOA1201)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- pH-responsive nanocarriers, tumour-targeted drug delivery, stimuli-responsive drug release, intracellular drug release, protonation, charge reversal, bond cleavage, tumor selectivity, multidrug resistance, chemotherapy
- MeSH terms
- Animals, Biocompatible Materials, Clinical Trials as Topic, Disease Models, Animal, Humans, Hydrogen-Ion Concentration, Neoplasms, Drug Delivery Systems, Nanotechnology, Nanostructures, Drug Liberation
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