Cited by 1,004Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers

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Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

Kanamala, Manju, Wilson, William R., Yang, Mimi, Palmer, Brian D., Wu, Zimei·2016·Biomaterials

DOI 10.1016/j.biomaterials.2016.01.061

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Abstract

As the mainstay in the treatment of various cancers, chemotherapy plays a vital role, but still faces many challenges, such as poor tumour selectivity and multidrug resistance (MDR). Targeted drug delivery using nanotechnology has provided a new strategy for addressing the limitations of the conventional chemotherapy. In the last decade, the volume of research published in this area has increased tremendously, especially with functional nano drug delivery systems (nanocarriers). Coupling a specific stimuli-triggered drug release mechanism with these delivery systems is one of the most prevalent approaches for improving therapeutic outcomes. Among the various stimuli, pH triggered delivery is regarded as the most general strategy, targeting the acidic extracellular microenvironment and intracellular organelles of solid tumours. In this review, we discuss recent advances in the development of pH-sensitive nanocarriers for tumour-targeted drug delivery. The review focuses on the chemical design of pH-sensitive biomaterials, which are used to fabricate nanocarriers for extracellular and/or intracellular tumour site-specific drug release. The pH-responsive biomaterials bring forth conformational changes in these nanocarriers through various mechanisms such as protonation, charge reversal or cleavage of a chemical bond, facilitating tumour specific cell uptake or drug release. A greater understanding of these mechanisms will help to design more efficient drug delivery systems to address the challenges encountered in conventional chemotherapy.

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Authors: Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z.
Affiliations: University of Auckland (NZ)
Corresponding author: Wu, Zimei
ORCID: Wilson, William R.
Yang, Mimi
Wu, Zimei
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2016-04
Volume: 85
Pages: 152-167
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2016.01.061
OpenAlex: W2288119981
Cited by: 1,004
References: 213
Citations by year: 2026: 65 · 2025: 96 · 2024: 78 · 2023: 85 · 2022: 99 · 2021: 117 · 2020: 129 · 2019: 113 · 2018: 108 · 2017: 77 · 2016: 37
FWCI: 5.98
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
ResearchSpace (University of Auckland) (submittedVersion)
Funders: Royal Society of New Zealand (UOA1201)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords: pH-responsive nanocarriers, tumour-targeted drug delivery, stimuli-responsive drug release, intracellular drug release, protonation, charge reversal, bond cleavage, tumor selectivity, multidrug resistance, chemotherapy
MeSH terms: Animals, Biocompatible Materials, Clinical Trials as Topic, Disease Models, Animal, Humans, Hydrogen-Ion Concentration, Neoplasms, Drug Delivery Systems, Nanotechnology, Nanostructures, Drug Liberation

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Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

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