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MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

Hamzei Taj, Somayyeh, Kho, Widuri, Riou, Adrien, Wiedermann, Dirk, Hoehn, Mathias·2016·Biomaterials
DOI 10.1016/j.biomaterials.2016.03.025
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Abstract

microRNA-124 (miR-124), the most abundant miRNA of the CNS, was recently shown to modulate the polarization of activated microglia and infiltrating macrophages towards the anti-inflammatory M2 phenotype and protect neurons in various ways after brain disease. In ischemic stroke, microglia and macrophages of a detrimental and persistent pro-inflammatory M1 phenotype have been shown to aggravate the secondary injury. Thus, shifting the polarization of microglia/macrophages into the beneficial, anti-inflammatory M2-like phenotype is considered neuroprotective after stroke onset. Here, we have induced 30 min transient occlusion of the right middle cerebral artery (MCAO) in 34 male, C57BL/6 mice. Lesion development was monitored with T2-weighted MRI. Liposomated miR-124 was injected in 11 animals at 48 h and in 5 animals at 10 days after MCAO. Arg-1, a marker for M2 phenotype, was co-stained with Iba-1, NeuN or GFAP. The distribution of astrocytes, neurons and microglia/macrophages and their expression of Arg-1 were quantified. Early miR-124 injection resulted in a significantly increased neuronal survival and a significantly increased number of M2-like polarized microglia/macrophages. Moreover, the lesion core, delineated by reactive astrocytes, was significantly reduced over time upon early miR-124 injection. These neuroprotective and anti-inflammatory effects of the early miR-124 treatment were pronounced during the first week with Arg-1. Number of Arg-1+ microglia/macrophages…

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Research works printed but not linked: 37

  1. Jin, 2010, Inflammatory mechanisms in ischemic stroke: role of inflammatory cells, J. Leukoc. Biol., 87, 779, 10.1189/jlb.1109766 · DOI · Paper page
  2. Tobin, 2014, Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here, J. Cereb. Blood Flow Metab. – Off. J. Int. Soc. Cereb. Blood Flow Metab., 34, 1573, 10.1038/jcbfm.2014.130 · DOI · Paper page
  3. Yuan, 2009, Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke, Apoptosis – Int. J. Program. Cell Death, 14, 469, 10.1007/s10495-008-0304-8 · DOI
  4. Benakis, 2014, The role of microglia and myeloid immune cells in acute cerebral ischemia, Front. Cell. Neurosci., 8, 461
  5. Hu, 2015, Microglial and macrophage polarization – new prospects for brain repair, Nat. Rev. Neurol., 11, 56, 10.1038/nrneurol.2014.207 · DOI · Paper page
  6. Chen, 2016, Microglia and neuroprotection, J. Neurochem., 136, 10, 10.1111/jnc.13062 · DOI
  7. Hu, 2012, Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia, Stroke – J. Cereb. Circ., 43, 3063, 10.1161/STROKEAHA.112.659656 · DOI
  8. Chhor, 2013, Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro, Brain Behav. Immun., 32, 70, 10.1016/j.bbi.2013.02.005 · DOI
  9. Franco, 2015, Alternatively activated microglia and macrophages in the central nervous system, Prog. Neurobiol., 131, 65, 10.1016/j.pneurobio.2015.05.003 · DOI
  10. Ponomarev, 2013, MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS, Glia, 61, 91, 10.1002/glia.22363 · DOI · Paper page
  11. Sun, 2013, MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke, CNS Neurosci. Ther., 19, 813, 10.1111/cns.12142 · DOI
  12. Doeppner, 2013, MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation, Acta Neuropathol., 126, 251, 10.1007/s00401-013-1142-5 · DOI
  13. Munder, 2009, Arginase: an emerging key player in the mammalian immune system, Br. J. Pharmacol., 158, 638, 10.1111/j.1476-5381.2009.00291.x · DOI
  14. Quirie, 2013, Effect of stroke on arginase expression and localization in the rat brain, Eur. J. Neurosci., 37, 1193, 10.1111/ejn.12111 · DOI
  15. Estevez, 2006, Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons, J. Neurosci. – Off. J. Soc. Neurosci., 26, 8512, 10.1523/JNEUROSCI.0728-06.2006 · DOI
  16. Bahmani, 2011, Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining, J. Cereb. Blood Flow Metab. – Off. J. Int. Soc. Cereb. Blood Flow Metab., 31, 1311, 10.1038/jcbfm.2010.233 · DOI
  17. Adamczak, 2014, In vivo bioluminescence imaging of vascular remodeling after stroke, Front. Cell. Neurosci., 8, 274, 10.3389/fncel.2014.00274 · DOI
  18. Chen, 2001, Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats, Stroke – J. Cereb. Circ., 32, 2682, 10.1161/hs1101.098367 · DOI
  19. Siddiq, 2015, Looking downstream: the role of cyclic AMP-regulated genes in axonal regeneration, Front. Mol. Neurosci., 8, 26, 10.3389/fnmol.2015.00026 · DOI
  20. Caldwell, 2015, Arginase: an old enzyme with new tricks, Trends Pharmacol. Sci., 36, 395, 10.1016/j.tips.2015.03.006 · DOI
  21. Krol, 2010, Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs, Cell, 141, 618, 10.1016/j.cell.2010.03.039 · DOI · Paper page
  22. Ruegger, 2012, MicroRNA turnover: when, how, and why, Trends Biochem. Sci., 37, 436, 10.1016/j.tibs.2012.07.002 · DOI
  23. Weng, 2011, Plasma miR-124 as a biomarker for cerebral infarction, Biomed. Res., 32, 135, 10.2220/biomedres.32.135 · DOI
  24. Liu, 2013, MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental stroke, Stroke – J. Cereb. Circ., 44, 1973, 10.1161/STROKEAHA.111.000613 · DOI
  25. Jeyaseelan, 2008, MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion, Stroke – J. Cereb. Circ., 39, 959, 10.1161/STROKEAHA.107.500736 · DOI
  26. Zhu, 2014, MicroRNA-124 (miR-124) regulates Ku70 expression and is correlated with neuronal death induced by ischemia/reperfusion, J. Mol. Neurosci. – MN, 52, 148, 10.1007/s12031-013-0155-9 · DOI
  27. Liu, 2015, Downregulation of serum brain specific microRNA is associated with inflammation and infarct volume in acute ischemic stroke, J. Clin. Neurosci. – Off. J. Neurosurg. Soc. Australas., 22, 291
  28. Liu, 2011, MicroRNA profiling in subventricular zone after stroke: MiR-124a regulates proliferation of neural progenitor cells through Notch signaling pathway, PLoS One, 6, e23461, 10.1371/journal.pone.0023461 · DOI
  29. Burda, 2014, Reactive gliosis and the multicellular response to CNS damage and disease, Neuron, 81, 229, 10.1016/j.neuron.2013.12.034 · DOI
  30. Pekny, 2014, The dual role of astrocyte activation and reactive gliosis, Neurosci. Lett., 565, 30, 10.1016/j.neulet.2013.12.071 · DOI
  31. Hol, 2015, Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system, Curr. Opin. Cell Biol., 32, 121, 10.1016/j.ceb.2015.02.004 · DOI · Paper page
  32. Choudhury, 2016, Reactive astrocytes and therapeutic potential in focal ischemic stroke, Neurobiol. Dis., 85, 234, 10.1016/j.nbd.2015.05.003 · DOI
  33. Cheng, 2009, miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche, Nat. Neurosci., 12, 399, 10.1038/nn.2294 · DOI · Paper page
  34. John, 2003, Cytokines: powerful regulators of glial cell activation, Neuroscientist – Rev. J. Bringing Neurobiol. Neurol. Psychiatry, 9, 10
  35. Shechter, 2011, The glial scar-monocyte interplay: a pivotal resolution phase in spinal cord repair, PLoS One, 6, e27969, 10.1371/journal.pone.0027969 · DOI
  36. Raposo, 2014, Glial scar and immune cell involvement in tissue remodeling and repair following acute CNS injuries, Glia, 62, 1895, 10.1002/glia.22676 · DOI
  37. Willemen, 2012, MicroRNA-124 as a novel treatment for persistent hyperalgesia, J. Neuroinflammation, 9, 143, 10.1186/1742-2094-9-143 · DOI · Paper page

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Metadata

Authors
Hamzei Taj, S., Kho, W., Riou, A., Wiedermann, D., & Hoehn, M.
Venue
Biomaterials
Publisher
Elsevier BV
Published
2016-06
Volume
91
Pages
151-165
ISSN
0142-9612
DOI
10.1016/j.biomaterials.2016.03.025
Cited by
175
References
5
Language
en
Licence
Funders
EU-FP7

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