JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement
Open accessAbstract
Tissue engineered scaffolds have emerged as a promising solution for heart valve replacement because of their potential for regeneration. However, traditional heart valve tissue engineering has relied on resource-intensive, cell-based manufacturing, which increases cost and hinders clinical translation. To overcome these limitations, in situ tissue engineering approaches aim to develop scaffold materials and manufacturing processes that elicit endogenous tissue remodeling and repair. Yet despite recent advances in synthetic materials manufacturing, there remains a lack of cell-free, automated approaches for rapidly producing biomimetic heart valve scaffolds. Here, we designed a jet spinning process for the rapid and automated fabrication of fibrous heart valve scaffolds. The composition, multiscale architecture, and mechanical properties of the scaffolds were tailored to mimic that of the native leaflet fibrosa and assembled into three dimensional, semilunar valve structures. We demonstrated controlled modulation of these scaffold parameters and show initial biocompatibility and functionality in vitro. Valves were minimally-invasively deployed via transapical access to the pulmonary valve position in an ovine model and shown to be functional for 15 h.
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Gelatin fibers produced by rotary jet spinning and truncated by ultrasonication had a length of 85.9 ± 2.53 μm and a diameter of 4.20 ± 0.23 μm.
“Gelatin fibers produced by rotary jet spinning (Supplementary Fig. 1b) 14, 15 were truncated by ultrasonication to a length of 85.9 ± 2.53 μm with a diameter of 4.20 ± 0.23 μm (mean ± SEM), reducing variance in length and enabling passage through the printing nozzle with a diameter of 200 μm (Supplementary Fig. 1c–d).”
From Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles (2023) · cites this paper as [14]
Materials and Methods §2.2 describes rotary jet spinning of P4HB/gelatin blends, supporting the fiber-production method. It does not report ultrasonic truncation or the stated fiber length and diameter; Results §3.1 instead reports diameters for the blended JetValve scaffold fibers. No page numbers were supplied for these passages. (LLM, conf=0.85)
Experimental — accuracy not yet measuredFiber-spinning techniques can reproduce fine spatial features with higher throughputs and have been used to engineer tissue scaffolds such as heart valves and ventricle models.
“Because fiber-spinning techniques can reproduce these fine spatial features with higher throughputs, they offer a potential solution and have been used previously to engineer tissue scaffolds, such as heart valves (23) and ventricle models (24).”
From Recreating the heart's helical structure-function relationship with focused rotary jet spinning (2022) · cites this paper as [23]
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Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles
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Self-citation
- Authors
- Capulli, A. K., Emmert, M. Y., Pasqualini, F. S., Kehl, D., Caliskan, E., Lind, J. U., Sheehy, S. P., Park, S. J., Ahn, S., Weber, B., Goss, J. A., Hoerstrup, S. P., & Parker, K. K.
- Affiliations
- Harvard University (US)
- University of Zurich (CH)
- Corresponding author
- Parker, Kevin Kit
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 133
- Pages
- 229-241
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC5526340
- OpenAlex
- W2606627786
- Cited by
- 112
- References
- 74
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 10 · 2023: 14 · 2022: 9 · 2021: 16 · 2020: 16 · 2019: 16 · 2018: 10 · 2017: 3
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 296 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Biomaterials (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Defense Threat Reduction Agency (#312659)
- Los Alamos National Laboratory (DE-AC52-06NA25396)
- National Institutes of Health (UH3TR000522)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Keywords
- heart valve replacement, cell-free tissue engineering, fibrous scaffolds, semilunar valves, scaffold architecture, scaffold mechanical properties, pulmonary valve, sheep model, biocompatibility
- MeSH terms
- Animals, Biocompatible Materials, Heart Valve Prosthesis, Heart Valves, Sheep, Tissue Engineering, Biomimetics, Tissue Scaffolds, Nanofibers
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