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A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration
Open accessAbstract
A multifaceted coating for hard tissue implants, with favorable osteogenesis, angiogenesis, and osteoimmunomodulation abilities, would be of great value since it could improve osseointegration and alleviate prosthesis loosening. However, to date there are few coatings that fully satisfy these criteria. Herein we describe a microporous TiO 2 coating decorated with hydroxyapatite (HA) nanoparticles that is generated by micro-arc oxidation of pure titanium (Ti) and followed annealing. By altering the annealing temperature, it is possible to simultaneously tune the coating's physical (morphology and wettability) and chemical (composites and crystallinity) properties. A coating produced with micro-arc oxidization (MAO) with an annealing temperature of 650 °C (MAO-650) exhibits numerous favorable physicochemical properties, such as hybrid micro-nano morphology, superhydrophilicity, and highly crystalline HA nanoparticles. In vitro experiments reveal that the MAO-650 coating not only supports proliferation and differentiation of both osteoblasts and endothelial cells, but also inhibits the inflammatory response of macrophages and enables a favorable osteoimmunomodulation to facilitate osteo/angio-genesis. In vivo evaluation mirrors these results, and shows that the MAO-650 coating results in ameliorative osseointegration when compared with the pristine MAO coating. These data highlight the profound effect of surface physicochemical properties on the regulation of osteo/angio-genesis and osteoimmunomodulation in the enhancement of osseointegration.
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“It is well-documented that the interaction between the ECM on the surface of endothelial cells and integrins can initiate the intracellular PI3K-AKT-eNOS signaling pathway, leading to the production of NO.”
From Decellularized liver scaffolds for constructing drug-metabolically functional ex vivo human liver models (2025) · cites this paper as [47]
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“This enhancement is likely due to the activation of eNOS following the inoculation of endothelial cells onto the scaffold and their subsequent contact with the ECM, initiating a series of reactions that result in increased NO secretion [47,48].”
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Citations
Cites
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 1×
“Additionally, the conditioned medium fromMFs cultured onMAO450 improves the expression of OPG, which is a decoy receptor for receptor activator of NF-kB ligand (RANKL), exerts a critical role in preventing bone resorption [66].”
BackgroundA role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,498
Molecular mechanisms and clinical applications of angiogenesis
Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467
Anatase TiO2 single crystals with a large percentage of reactive facets
Yang, H. G., Sun, C., Qiao, S., Zou, J., Liu, G., Smith, S. C., Cheng, H., & Lu, G. Q. (2008) · Nature · doi:10.1038/nature06964 · Cited by 4,129
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
Angiogenesis in life, disease and medicine
Carmeliet, P. (2005) · Nature · doi:10.1038/nature04478 · Cited by 3,551
Third-Generation Biomedical Materials
Hench, L. L., & Polak, J. M. (2002) · Science · doi:10.1126/science.1067404 · Cited by 2,794
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
Research works printed but not linked: 1
- Boyle, 2003, Osteoclast differentiation and activation, Nature, 423, 337, 10.1038/nature01658 · DOI · Paper page
Cited by
Sorted by citations
Wang, R., Shi, M., Xu, F., Qiu, Y., Zhang, P., Shen, K., Zhao, Q. P., Yu, J., & Zhang, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-18267-1 · Cited by 443
Surface functionalization – The way for advanced applications of smart materials
Wieszczycka, K., Staszak, K., Woźniak-Budych, M., Litowczenko, J., Maciejewska, B. M., & Jurga, S. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.213846 · Cited by 391
Bioinspired surface modification of orthopedic implants for bone tissue engineering
Hu, C. Q., Ashok, D., Nisbet, D. R., & Gautam, V. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119366 · Cited by 330
Liu, W. X., Li, J., Cheng, M., Wang, Q., Yeung, K., Chu, P. K.-H., & Zhang, X. (2018) · Advanced Science · doi:10.1002/advs.201800749 · Cited by 301
Self-citationWang, Y., Wang, J., Gao, R., Liu, X., Feng, Z., Zhang, C., Huang, P., Dong, A., Kong, D., & Wang, W. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121538 · Cited by 270
Li, Y., Liu, X., Li, B., Zheng, Y., Han, Y., Chen, D., Yeung, K., Cui, Z., Liang, Y., Li, Z., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c01486 · Cited by 225
Additively manufactured porous metallic biomaterials
ZADPOOR, A. A. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00420c · Cited by 220
Advances in implant surface modifications to improve osseointegration
Zhu, G. Y., Wang, G., & Li, J. J. (2021) · Materials Advances · doi:10.1039/d1ma00675d · Cited by 228
Bai, L., Chen, P., Zhao, Y., Hang, R., Yao, X., Tang, B. H., Liu, C., Xiao, Y., & Hang, R. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121162 · Cited by 189
Self-citationA review on current research status of the surface modification of Zn-based biodegradable metals
Yuan, W., Xia, D., Wu, S., Zheng, Y., Guan, Z., & Rau, J. V. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.018 · Cited by 187
Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration
Xie, C., Ye, J., Liang, R., Yao, X., Wu, X., Koh, Y. W., Wei, W., Zhang, X., & Ouyang, H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100408 · Cited by 176
Self-citationLiu, Z., Liu, X., & Ramakrishna, S. (2021) · Biotechnology Journal · doi:10.1002/biot.202000116 · Cited by 173
Ding, T., Kang, W., Li, J., Yu, L., & Ge, S. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00992-4 · Cited by 160
Lin, Z., Shen, D., Zhou, W., Zheng, Y., Kong, T., Liu, X., Wu, S., Chu, P. K., Zhao, Y., Wu, J., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.018 · Cited by 155
Self-citationBai, J., Wang, H., Chen, H., Ge, G., Wang, M., Gao, A., Tong, L., Xu, Y., Yang, H., Pan, G., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120197 · Cited by 156
Dual functional approaches for osteogenesis coupled angiogenesis in bone tissue engineering
Rather, H., Jhala, D., & Vasita, R. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109761 · Cited by 144
Yang, C., Zhao, C., Wang, X., Shi, M., Zhu, Y., Jing, L., Wu, C., & Chang, J. (2019) · Nanoscale · doi:10.1039/c9nr05730g · Cited by 145
Wu, Z., Bai, J., Ge, G., Wang, T., Feng, S., Ma, Q., Liang, X., Li, W., Zhang, W., Xu, Y., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200298 · Cited by 136
Bai, L., Liu, Y., Du, Z., Weng, Z., Yao, W., Zhang, X., Huang, X., Yao, X., Crawford, R., Hang, R., et al. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.06.023 · Cited by 129
Self-citationOsteoporosis remission via an anti-inflammaging effect by icariin activated autophagy
Bai, L., Liu, Y., Zhang, X., Chen, P., Hang, R., Xiao, Y., Wang, J., & Liu, C. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122125 · Cited by 124
Self-citationZhao, Y., Bai, L., Zhang, Y., Yao, R., Sun, Y., Hang, R., Chen, X., Wang, H., Yao, X., Xiao, Y., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121684 · Cited by 121
Self-citationLu, X., Wu, Z., Xu, K., Wang, X., Wang, S., Qiu, H., Li, X., & Chen, J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.783816 · Cited by 113
Zheng, Y., Gao, A., Bai, J., Liao, Q., Wu, Y., Zhang, W., Guan, M., Tong, L., Geng, D., Zhao, X., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.01.042 · Cited by 113
Wang, Q., Feng, Y., He, M., Zhao, W., Qiu, L., & Zhao, C. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202008906 · Cited by 107
Potential bioactive coating system for high-performance absorbable magnesium bone implants
Sarian, M. N., Iqbal, N., Sotoudehbagha, P., Razavi, M., Ahmed, Q. U., Sukotjo, C., & Hermawan, H. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.10.034 · Cited by 114
Li, S.-J., Zhang, L., Liu, C.-Y., Kim, J., Su, K., Chen, T., Zhao, L., Lu, X., Zhang, H., Cui, Y.-L., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.10.021 · Cited by 119
Shen, X., Fang, K., Yie, K. H. R., Zhou, Z., Shen, Y., Wu, S., Zhu, Y., Deng, Z., Ma, P., Ma, J., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.08.031 · Cited by 102
Bai, L., Zhao, Y., Chen, P., Zhang, X., Huang, X., Du, Z., Crawford, R., Yao, X., Tang, B. H., Hang, R., et al. (2020) · Small · doi:10.1002/smll.202006287 · Cited by 95
Self-citationLiu, W., Zhang, G., Wu, J., Zhang, Y., Liu, J., Luo, H., & Shao, L. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0570-3 · Cited by 91
Xie, L., Wang, G., Wu, Y., Liao, Q., Mo, S., Ren, X., Tong, L., Zhang, W., Guan, M., Pan, H., et al. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100148 · Cited by 89
Zhao, W., Wang, J., Weiyang, J., Qiao, B., Wang, Y., Li, Y., & Jiang, D. (2020) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2020.02.008 · Cited by 87
Zhao, D., Yu, K., Sun, T., Jing, X., Wan, Y., Chen, K., Gao, H., Wang, Y., Chen, L., Guo, X., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202213128 · Cited by 87
He, Y., Mu, C., Shen, X., Zhang, Y., Liu, J., Chen, W., Lin, C., Tao, B., Liu, B., & Cai, K. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.09.036 · Cited by 87
Liu, X., Miao, Y., Liang, H., Diao, J., Hao, L., Shi, Z., Zhao, N., & Wang, Y. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.10.016 · Cited by 82
Graphene oxide coated Titanium Surfaces with Osteoimmunomodulatory Role to Enhance Osteogenesis
Su, J., Du, Z., Xiao, L., Wei, F., Yang, Y., Li, M., Qiu, Y., Liu, J., Chen, J., & Xiao, Y. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110983 · Cited by 79
Self-citationZhao, D., Du, C., Zuo, K., Zhao, Y., Xu, X., Li, Y., Tian, S. T., Yang, H., Lu, Y., Cheng, L., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202202537 · Cited by 74
Self-citationEngineered functional doped hydroxyapatite coating on titanium implants for osseointegration
Li, J., Zhang, T., Liao, Z., Wei, Y., Hang, R., & Huang, D. (2023) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2023.09.239 · Cited by 74
Self-citationYang, C., Zhu, K., Yuan, X., Zhang, X., Qian, Y., & Cheng, T. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14842 · Cited by 72
Self-citationHoma, K., Zakrzewski, W., Dobrzyński, W., Piszko, P. J., Piszko, A., Matys, J., Wiglusz, R. J., & Dobrzyński, M. (2024) · Journal of Functional Biomaterials · doi:10.3390/jfb15020045 · Cited by 68
Xue, H., Zhang, Z., Lin, Z., Su, J., Panayi, A. C., Xiong, Y., Hu, L., Hu, Y., Chen, L., Yan, C., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.05.023 · Cited by 65
Micro-Arc Oxidation in Titanium and Its Alloys: Development and Potential of Implants
Ming, X., Wu, Y. J., Zhang, Z., & Li, Y. (2023) · Coatings · doi:10.3390/coatings13122064 · Cited by 66
Qiao, H., Song, G., Huang, Y., Yang, H., Han, S., Zhang, X., Wang, Z., Ma, J., Bu, X., & Fu, L. (2019) · RSC Advances · doi:10.1039/c9ra01168d · Cited by 64
Self-citationLan, W., Zhang, X., Xu, M., Zhao, L., Huang, D., Wei, X., & Chen, W. (2019) · RSC Advances · doi:10.1039/c9ra08569f · Cited by 63
Self-citationFathi, A. M., Ahmed, M., Afifi, M., Menazea, A. A., & Uskoković, V. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01105 · Cited by 62
Metal-phenolic networks as a novel filler to advance multi-functional immunomodulatory biocomposites
Gao, X., Wang, Q., Ren, L., Gong, P., He, M., Tian, W., & Zhao, W. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.131825 · Cited by 61
Zhao, Q. P., Shi, M., Yin, C., Zhao, Z., Zhang, J., Wang, J., Shen, K., Zhang, L., Tang, H., Xiao, Y., et al. (2020) · Nano-Micro Letters · doi:10.1007/s40820-020-00540-z · Cited by 59
Self-citationFazel, M., Salimijazi, H. R., SHAMANIAN, M., Minneboo, M., Modaresifar, K., van Hengel, I. A. J., Fratila-Apachitei, L. E., Apachitei, I., & ZADPOOR, A. A. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111745 · Cited by 55
Geng, Z., Wang, X., Zhao, J., Li, Z., Ma, L., Zhu, S., Liang, Y., Cui, Z., He, H., & Yang, X. (2018) · Biomaterials Science · doi:10.1039/c8bm00716k · Cited by 55
Yang, L., Ullah, I., Yu, K., Zhang, W., Zhou, J., Sun, T., Shi, L., Yao, S., Chen, K., Zhang, X., et al. (2020) · Biofabrication · doi:10.1088/1758-5090/abcf8d · Cited by 53
Self-citationWang, Y., Feng, Z., Liu, X., Yang, C., Gao, R., Liu, W., Ouyang, W., Dong, A., Zhang, C., Huang, P., et al. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac003 · Cited by 53
Fialho, L., Grenho, L., Fernandes, M. H., & Carvalho, S. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111761 · Cited by 53
Tannic acid/Mg 2+ -based versatile coating to manipulate the osteoimmunomodulation of implants
He, M., Gao, X., Fan, Y., Li, X., Yang, M., & Tian, W. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01577f · Cited by 53
Yang, S., Sun, Y., Капилевич, Л. В., Zhang, X., & Huang, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1249418 · Cited by 52
Self-citationShen, X., Yie, K. H. R., Wu, X., Zhou, Z., Sun, A., Al-Bishari, A. M., Fang, K., Al-Baadani, M. A., Deng, Z., Ma, P., et al. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.133094 · Cited by 51
Tao, B., Yi, W., Qin, X., Wu, J., Li, K., Guo, A., Hao, J., & Chen, L. (2022) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2022.11.013 · Cited by 51
Yu, Y., Ran, Q., Shen, X., Zheng, H., & Cai, K. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110592 · Cited by 51
Kopp, A., Fischer, H., Soares, A. P., Schmidt‐Bleek, K., Leber, C., Kreiker, H., Duda, G. N., Kröger, N., van Gaalen, K., Hanken, H., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.11.052 · Cited by 51
Bioactive elements manipulate bone regeneration.
Bai, L., Song, P., & Su, J. (2023) · PubMed Central · doi:10.12336/biomatertransl.2023.04.005 · Cited by 50
Self-citationGuan, S. W., Qi, M., Wang, C., Wang, S., & Wang, W. (2020) · Applied Surface Science · doi:10.1016/j.apsusc.2020.148547 · Cited by 50
Surface Engineering for Dental Implantology: Favoring Tissue Responses Along the Implant
van Oirschot, B. A. J. A., Zhang, Y., Alghamdi, H. S., Cordeiro, J. M., NAGAY, B. E., Barão, V. A. R., de Avila, E. D., & van den Beucken, J. J. J. P. (2022) · Tissue Engineering Part A · doi:10.1089/ten.tea.2021.0230 · Cited by 54
Shao, H., Ma, M., Wang, Q., Yan, T., Zhao, B., Guo, S., & Tong, S. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1000401 · Cited by 49
Zhou, J., Wang, X., & Zhao, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-50496-3 · Cited by 49
Kunrath, M. F., Garaicoa‐Pazmiño, C., Giraldo-Osorno, P. M., Mustafa, A. H., Dahlin, C., Larsson, L., & Asa’ad, F. (2024) · Journal of Periodontal Research · doi:10.1111/jre.13273 · Cited by 48
Yuan, P., Chen, M., Lu, X., Yang, H., Wang, L., Bai, T., Zhou, W., Liu, T., & Yu, S. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01714e · Cited by 48
Pan, X., Li, Y., Abdullah, A. O., Wang, W., Qi, M., & Liu, Y. (2019) · Royal Society Open Science · doi:10.1098/rsos.182031 · Cited by 47
Self-citationWang, M., Chen, F., Tang, Y., Wang, J., Chen, X., Li, X., & Zhang, X. (2021) · Materials & Design · doi:10.1016/j.matdes.2021.110302 · Cited by 46
Self-citationQiao, Y., Yu, L., Yang, P., Chen, M., Sun, H., Wang, L., Wu, B., Oh, C., Yang, H., Bai, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202302874 · Cited by 41
Study on strontium doped bioactive coatings on titanium alloys surfaces by micro-arc oxidation
Zhang, Z., Huang, T., Zhai, D.-J., Wang, H., Feng, K., & Xiang, L. (2022) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2022.129045 · Cited by 41
Exosomes secreted by macrophages upon copper ion stimulation can promote angiogenesis
Wang, Z., Zhao, Y., Zhao, Y., Zhang, Y., Yao, X., & Hang, R. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.111981 · Cited by 41
Self-citationA practical guide for evaluating the osteoimmunomodulatory properties of biomaterials
Mestres, G., Carter, S. D., Hailer, N. P., & Díez-Escudero, A. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.038 · Cited by 42
Immunomodulation of surface biofunctionalized 3D printed porous titanium implants
Razzi, F., Fratila-Apachitei, L. E., Fahy, N., Bastiaansen-Jenniskens, Y. M., Apachitei, I., Farrell, E., & ZADPOOR, A. A. (2020) · Biomedical Materials · doi:10.1088/1748-605x/ab7763 · Cited by 42
Zhou, A., Yu, H., Liu, J., Zheng, J., Jia, Y., Wu, B., & Xiang, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00780 · Cited by 40
Silver-loaded microspheres reinforced chitosan scaffolds for skin tissue engineering
Niu, X., Wei, Y., Liu, Q., Yang, B., Ma, N., Li, Z., Zhao, L., Chen, W., & Huang, D. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.109861 · Cited by 39
Self-citationThe State of the Art and Prospects for Osteoimmunomodulatory Biomaterials
Negrescu, A. M., & Cîmpean, A. (2021) · Materials · doi:10.3390/ma14061357 · Cited by 42
Li, Z., He, Y., Klausen, L. H., Yan, N., Liu, J., Chen, F., Song, W., Dong, M., & Zhang, Y. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.10.026 · Cited by 37
Lyu, Z., Zhao, Y., Huo, S., Wang, F., Meng, X., Yuan, Z., Long, T., & Wang, Y. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.111069 · Cited by 36
Self-citationTitanium Implant Surface Effects on Adherent Macrophage Phenotype: A Systematic Review
Pitchai, M. S., Ipe, D. S., Tadakamadla, S. K., & Hamlet, S. M. (2022) · Materials · doi:10.3390/ma15207314 · Cited by 36
Zhang, W., Liu, L., Zhou, H., He, C., Yang, X., Fu, J., Wang, H., Liu, Y., & Zheng, Y. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.112151 · Cited by 36
Self-citationSheng, N., Xing, F., Zhang, Q., Tan, J., Nie, R., Huang, K., Li, H.-X., Jiang, Y., Tan, B., Xiang, Z., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.147985 · Cited by 35
Yi, J., Li, M., Zhu, J., Wang, Z. C., & Li, X. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01081g · Cited by 37
Li, X., Zou, Q., Man, Y., & Li, W. (2019) · Small · doi:10.1002/smll.201901617 · Cited by 36
Sun, H., Yang, Y., Yu, L., Liu, K., Fei, Y., Guo, C., Zhou, Y., Hu, J., Shi, L., & Ji, H. (2022) · ACS Omega · doi:10.1021/acsomega.2c00579 · Cited by 37
Xu, H., Chai, Q., Xu, X., Li, Z., Bao, W., Man, Z., & Li, W. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c11102 · Cited by 38
Harnessing electromagnetic fields to assist bone tissue engineering
Zhao, H., Liu, C., Liu, Y., Ding, Q., Wang, T., Li, H., Wu, H. K., & Ma, T. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03217-z · Cited by 36
Self-citationHe, W., Yao, P., Chu, D., Sun, H. Q., Lai, Q., Wang, Q., Wang, P., Qu, S., & Huang, C. (2022) · Optics & Laser Technology · doi:10.1016/j.optlastec.2022.108082 · Cited by 35
Chen, S., Liu, F., He, X., Wen, D., Zhang, Y., Li, B., & Han, Y. N. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202311965 · Cited by 36
Research Progress on Surface Modification of Titanium Implants
Wu, Y., Wan, K., Lu, J., Yuan, C., Cui, Y., Duan, R., & Yu, J. (2025) · Coatings · doi:10.3390/coatings15020229 · Cited by 37
Bai, L., Yang, Y., Mendhi, J., Du, Z., Hao, R., Hang, R., Yao, X., Huang, N., Tang, B., & Xiao, Y. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01675e · Cited by 35
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Self-citationZhang, Y., Wang, X., Li, Y., Liang, J., Jiang, P., Huang, Q., Yang, Y., Duan, H., Dong, X., Rui, G., et al. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac046 · Cited by 32
Metadata
- Authors
- Bai, L., Du, Z., Du, J., Yao, W., Zhang, J., Weng, Z., Liu, S., Zhao, Y., Liu, Y., Zhang, X., Huang, X., Yao, X., Crawford, R., Hang, R., Huang, D., Tang, B., & Xiao, Y.
- Affiliations
- Queensland University of Technology (AU)
- Taiyuan University of Technology (CN)
- Shanxi Medical University (CN)
- Corresponding author
- Huang, Xiaobo
- Hang, Ruiqiang
- Huang, Di
- Xiao, Yin
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 162
- Pages
- 154-169
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2790044190
- Semantic Scholar
- 12df7ea7aecb42eda735391d73c614df26127aad
- Cited by
- 265
- References
- 84
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 30 · 2023: 33 · 2022: 51 · 2021: 54 · 2020: 34 · 2019: 25 · 2018: 9
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.qut.edu.au
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by-nc-nd)
- Griffith Research Online (submittedVersion, other-oa)
- Funders
- National Natural Science Foundation of China (31400815, 11502158, 31771025, 51671140, 11632013, 31700834)
- Prince Charles Hospital Research Foundation
- Australia-China Centre for Tissue Engineering and Regenerative Medicine at QUT
- China Scholarship Council (201606930017)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
- Keywords
- titanium implants, osseointegration, plasma electrolytic oxidation, TiO2 coating, hydroxyapatite nanoparticles, annealing temperature, osteoimmunomodulation, bone formation, angiogenesis, superhydrophilicity, macrophage inflammation, osteogenic differentiation, endothelial cell proliferation, implant loosening, hard tissue implants
- MeSH terms
- RAW 264.7 Cells, Animals, Cell Line, Cells, Cultured, Humans, Macrophages, Osteoblasts, Surface Properties, Titanium, Osseointegration, Durapatite, Neovascularization, Physiologic, Coated Materials, Biocompatible, Endothelial Cells, Mice
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