The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration
Open accessAbstract
A multifaceted coating for hard tissue implants, with favorable osteogenesis, angiogenesis, and osteoimmunomodulation abilities, would be of great value since it could improve osseointegration and alleviate prosthesis loosening. However, to date there are few coatings that fully satisfy these criteria. Herein we describe a microporous TiO 2 coating decorated with hydroxyapatite (HA) nanoparticles that is generated by micro-arc oxidation of pure titanium (Ti) and followed annealing. By altering the annealing temperature, it is possible to simultaneously tune the coating's physical (morphology and wettability) and chemical (composites and crystallinity) properties. A coating produced with micro-arc oxidization (MAO) with an annealing temperature of 650 °C (MAO-650) exhibits numerous favorable physicochemical properties, such as hybrid micro-nano morphology, superhydrophilicity, and highly crystalline HA nanoparticles. In vitro experiments reveal that the MAO-650 coating not only supports proliferation and differentiation of both osteoblasts and endothelial cells, but also inhibits the inflammatory response of macrophages and enables a favorable osteoimmunomodulation to facilitate osteo/angio-genesis. In vivo evaluation mirrors these results, and shows that the MAO-650 coating results in ameliorative osseointegration when compared with the pristine MAO coating. These data highlight the profound effect of surface physicochemical properties on the regulation of osteo/angio-genesis and osteoimmunomodulation in the enhancement of osseointegration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It is well-documented that the interaction between the ECM on the surface of endothelial cells and integrins can initiate the intracellular PI3K-AKT-eNOS signaling pathway, leading to the production of NO.”
From Decellularized liver scaffolds for constructing drug-metabolically functional ex vivo human liver models (2025) · cites this paper as [47]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This enhancement is likely due to the activation of eNOS following the inoculation of endothelial cells onto the scaffold and their subsequent contact with the ECM, initiating a series of reactions that result in increased NO secretion [47,48].”
From Decellularized liver scaffolds for constructing drug-metabolically functional ex vivo human liver models (2025) · cites this paper as [47]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 1×
“Additionally, the conditioned medium fromMFs cultured onMAO450 improves the expression of OPG, which is a decoy receptor for receptor activator of NF-kB ligand (RANKL), exerts a critical role in preventing bone resorption [66].”
BackgroundA role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,498
Molecular mechanisms and clinical applications of angiogenesis
Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467
Anatase TiO2 single crystals with a large percentage of reactive facets
Yang, H. G., Sun, C., Qiao, S., Zou, J., Liu, G., Smith, S. C., Cheng, H., & Lu, G. Q. (2008) · Nature · doi:10.1038/nature06964 · Cited by 4,129
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
Angiogenesis in life, disease and medicine
Carmeliet, P. (2005) · Nature · doi:10.1038/nature04478 · Cited by 3,551
Third-Generation Biomedical Materials
Hench, L. L., & Polak, J. M. (2002) · Science · doi:10.1126/science.1067404 · Cited by 2,794
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
Research works printed but not linked: 1
- Boyle, 2003, Osteoclast differentiation and activation, Nature, 423, 337, 10.1038/nature01658 · DOI · Paper page
Cited by
Sorted by citations
Wang, R., Shi, M., Xu, F., Qiu, Y., Zhang, P., Shen, K., Zhao, Q. P., Yu, J., & Zhang, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-18267-1 · Cited by 443
Surface functionalization – The way for advanced applications of smart materials
Wieszczycka, K., Staszak, K., Woźniak-Budych, M., Litowczenko, J., Maciejewska, B. M., & Jurga, S. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.213846 · Cited by 391
Bioinspired surface modification of orthopedic implants for bone tissue engineering
Hu, C. Q., Ashok, D., Nisbet, D. R., & Gautam, V. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119366 · Cited by 330
Liu, W. X., Li, J., Cheng, M., Wang, Q., Yeung, K., Chu, P. K.-H., & Zhang, X. (2018) · Advanced Science · doi:10.1002/advs.201800749 · Cited by 301
Self-citationWang, Y., Wang, J., Gao, R., Liu, X., Feng, Z., Zhang, C., Huang, P., Dong, A., Kong, D., & Wang, W. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121538 · Cited by 270
Metadata
- Authors
- Bai, L., Du, Z., Du, J., Yao, W., Zhang, J., Weng, Z., Liu, S., Zhao, Y., Liu, Y., Zhang, X., Huang, X., Yao, X., Crawford, R., Hang, R., Huang, D., Tang, B., & Xiao, Y.
- Affiliations
- Queensland University of Technology (AU)
- Taiyuan University of Technology (CN)
- Shanxi Medical University (CN)
- Corresponding author
- Huang, Xiaobo
- Hang, Ruiqiang
- Huang, Di
- Xiao, Yin
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 162
- Pages
- 154-169
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2790044190
- Semantic Scholar
- 12df7ea7aecb42eda735391d73c614df26127aad
- Cited by
- 265
- References
- 84
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 30 · 2023: 33 · 2022: 51 · 2021: 54 · 2020: 34 · 2019: 25 · 2018: 9
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.qut.edu.au
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by-nc-nd)
- Griffith Research Online (submittedVersion, other-oa)
- Funders
- National Natural Science Foundation of China (31400815, 11502158, 31771025, 51671140, 11632013, 31700834)
- Prince Charles Hospital Research Foundation
- Australia-China Centre for Tissue Engineering and Regenerative Medicine at QUT
- China Scholarship Council (201606930017)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
- Keywords
- titanium implants, osseointegration, plasma electrolytic oxidation, TiO2 coating, hydroxyapatite nanoparticles, annealing temperature, osteoimmunomodulation, bone formation, angiogenesis, superhydrophilicity, macrophage inflammation, osteogenic differentiation, endothelial cell proliferation, implant loosening, hard tissue implants
- MeSH terms
- RAW 264.7 Cells, Animals, Cell Line, Cells, Cultured, Humans, Macrophages, Osteoblasts, Surface Properties, Titanium, Osseointegration, Durapatite, Neovascularization, Physiologic, Coated Materials, Biocompatible, Endothelial Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
