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A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration
Open accessAbstract
A multifaceted coating for hard tissue implants, with favorable osteogenesis, angiogenesis, and osteoimmunomodulation abilities, would be of great value since it could improve osseointegration and alleviate prosthesis loosening. However, to date there are few coatings that fully satisfy these criteria. Herein we describe a microporous TiO 2 coating decorated with hydroxyapatite (HA) nanoparticles that is generated by micro-arc oxidation of pure titanium (Ti) and followed annealing. By altering the annealing temperature, it is possible to simultaneously tune the coating's physical (morphology and wettability) and chemical (composites and crystallinity) properties. A coating produced with micro-arc oxidization (MAO) with an annealing temperature of 650 °C (MAO-650) exhibits numerous favorable physicochemical properties, such as hybrid micro-nano morphology, superhydrophilicity, and highly crystalline HA nanoparticles. In vitro experiments reveal that the MAO-650 coating not only supports proliferation and differentiation of both osteoblasts and endothelial cells, but also inhibits the inflammatory response of macrophages and enables a favorable osteoimmunomodulation to facilitate osteo/angio-genesis. In vivo evaluation mirrors these results, and shows that the MAO-650 coating results in ameliorative osseointegration when compared with the pristine MAO coating. These data highlight the profound effect of surface physicochemical properties on the regulation of osteo/angio-genesis and osteoimmunomodulation in the enhancement of osseointegration.
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Metadata
- Authors
- Bai, L., Du, Z., Du, J., Yao, W., Zhang, J., Weng, Z., Liu, S., Zhao, Y., Liu, Y., Zhang, X., Huang, X., Yao, X., Crawford, R., Hang, R., Huang, D., Tang, B., & Xiao, Y.
- Affiliations
- Queensland University of Technology (AU)
- Taiyuan University of Technology (CN)
- Shanxi Medical University (CN)
- Corresponding author
- Huang, Xiaobo
- Hang, Ruiqiang
- Huang, Di
- Xiao, Yin
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 162
- Pages
- 154-169
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2790044190
- Semantic Scholar
- 12df7ea7aecb42eda735391d73c614df26127aad
- Cited by
- 265
- References
- 84
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 30 · 2023: 33 · 2022: 51 · 2021: 54 · 2020: 34 · 2019: 25 · 2018: 9
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.qut.edu.au
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by-nc-nd)
- Griffith Research Online (submittedVersion, other-oa)
- Funders
- National Natural Science Foundation of China (31400815, 11502158, 31771025, 51671140, 11632013, 31700834)
- Prince Charles Hospital Research Foundation
- Australia-China Centre for Tissue Engineering and Regenerative Medicine at QUT
- China Scholarship Council (201606930017)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
- Keywords
- titanium implants, osseointegration, plasma electrolytic oxidation, TiO2 coating, hydroxyapatite nanoparticles, annealing temperature, osteoimmunomodulation, bone formation, angiogenesis, superhydrophilicity, macrophage inflammation, osteogenic differentiation, endothelial cell proliferation, implant loosening, hard tissue implants
- MeSH terms
- RAW 264.7 Cells, Animals, Cell Line, Cells, Cultured, Humans, Macrophages, Osteoblasts, Surface Properties, Titanium, Osseointegration, Durapatite, Neovascularization, Physiologic, Coated Materials, Biocompatible, Endothelial Cells, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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