Cited by 604Barrier Structure and Function StudiesNanoparticle-Based Drug DeliveryDrug Transport and Resistance Mechanisms

The DOI matches its Crossref record; 234 of the 236 references it cites were found in a registry or an index.

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Open access

Xie, Jinbing, Shen, Zheyu, Anraku, Yasutaka, Kataoka, Kazunori, Chen, Xiaoyuan·2019·Biomaterials

DOI 10.1016/j.biomaterials.2019.119491PMC PMC6915305

Open this paper in CoChat — free account

Abstract

Increasing attention has been paid to the diseases of central nervous system (CNS). The penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to the existence of blood-brain barrier (BBB). Thus, BBB crossing for drug delivery to CNS remains a significant challenge in the development of neurological therapeutics. Because of the advantageous properties (e.g., relatively high drug loading content, controllable drug release, excellent passive and active targeting, good stability, biodegradability, biocompatibility, and low toxicity), nanomaterials with BBB-crossability have been widely developed for the treatment of CNS diseases. This review summarizes the current understanding of the physiological structure of BBB, and provides various nanomaterial-based BBB-crossing strategies for brain delivery of theranostic agents, including intranasal delivery, temporary disruption of BBB, local delivery, cell penetrating peptide (CPP) mediated BBB-crossing, receptor mediated BBB-crossing, shuttle peptide mediated BBB-crossing, and cells mediated BBB-crossing. Clinicians, biologists, material scientists and chemists are expected to be interested in this review.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biomaterials.2019.119491

Cites

234 of 234 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice
Sagare, A. P., Bell, R. D., Zhao, Z., Ma, Q., Winkler, E. A., Ramanathan, A., & Zlokovic, B. V. (2013) · Nature Communications · doi:10.1038/ncomms3932 · Cited by 589
Retracted
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
Louis, D. N., Perry, A., Reifenberger, G., von Deimling, A., Figarella‐Branger, D., Cavenee, W. K., Ohgaki, H., Wiestler, O. D., Kleihues, P., & Ellison, D. W. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1545-1 · Cited by 15,703
The 2007 WHO Classification of Tumours of the Central Nervous System
Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,675
Establishment and Dysfunction of the Blood-Brain Barrier
Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
Din, F. U., Aman, W., Ullah, I., Qureshi, O. S., Mustapha, O., Shafique, S., & Zeb, A. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s146315 · Cited by 1,625
Convection-enhanced delivery of macromolecules in the brain.
Bobo, R. H., Laske, D. W., Akbaşak, A., Morrison, P. F., Dedrick, R. L., & Oldfield, E. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2076 · Cited by 1,442
Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060
Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
Madani, F., Lindberg, S., Langel, Ü., Futaki, S., & Gräslund, A. (2011) · Journal of Biophysics · doi:10.1155/2011/414729 · Cited by 1,040
Modern methods for delivery of drugs across the blood–brain barrier
Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,038
Cloning by functional expression of a member of the glutamate receptor family
Hollmann, M., O'Shea-Greenfield, A., Rogers, S. W., & Heinemann, S. F. (1989) · Nature · doi:10.1038/342643a0 · Cited by 1,016

Show all 236 references

Research works printed but not linked: 1

Feng, 2017, Self-assembly of gold nanoparticles shows microenvironment-mediated dynamic switching and enhanced brain tumor targeting, Theranostics, 7, 1875, 10.7150/thno.18985 · DOI

Sorted by citations

Items 101–200 of 604

Nanotechnology Driven Innovations in Modern Pharmaceutics: Therapeutics, Imaging, and Regeneration
Parvin, N., Aslam, M., Alam, M. N., & Mandal, T. K. (2025) · Nanomaterials · doi:10.3390/nano15221733 · Cited by 65
Lipid-Based Nanocarriers via Nose-to-Brain Pathway for Central Nervous System Disorders
Nguyen, T. T., Nguyen, T. T. D., An, T. N. M., & Giau, V. V. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03488-7 · Cited by 53
A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory
Chen, Z., Wang, X., Du, S., Liu, Q., Xu, Z., Guo, Y., & Lin, X. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00900-6 · Cited by 59
Precision targeting of the CNS: recent progress in brain-directed nanodrug delivery
Senanayake, D., Yapa, P. N., Dabare, S., & Munaweera, I. (2025) · RSC Advances · doi:10.1039/d5ra03578c · Cited by 59
Recent advances in glioma microenvironment-response nanoplatforms for phototherapy and sonotherapy
Li, X., Geng, X., Chen, Z., & Yuan, Z. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106218 · Cited by 51
Receptor-Assisted Nanotherapeutics for Overcoming the Blood–Brain Barrier
Mhaske, A. S., Shukla, S., Ahirwar, K., Singh, K. K., & Shukla, R. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04015-9 · Cited by 54
Nanobiomimetic Medicine
Chang, M., Dong, C., Huang, H., Ding, L., Feng, W., & Chen, Y. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202204791 · Cited by 50
Two Birds, One Stone: Smart MOF Nanozymes for Dual Catalysis and Theranostics
Dheyab, M. A., Abdullah, W., Aziz, A. A., Razak, N. N. A. N. A., Suardi, N., Alanezi, S. T., Jameel, M. S., Braim, F. S., Fohely, F., Khaniabadi, P. M., et al. (2025) · Small · doi:10.1002/smll.202509992 · Cited by 51
Role of Nanomedicine-Based Therapeutics in the Treatment of CNS Disorders
Guo, Z.-H., Khattak, S., Rauf, M. A., Ansari, M. A., Alomary, M. N., Razak, S., Yang, C., Wu, D., & Ji, X. (2023) · Molecules · doi:10.3390/molecules28031283 · Cited by 49
Nanoparticles Mediated the Diagnosis and Therapy of Glioblastoma: Bypass or Cross the Blood–Brain Barrier
Song, X., Qian, H., & Yu, Y. (2023) · Small · doi:10.1002/smll.202302613 · Cited by 51
Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier
Wei, Y., Xia, X., Li, H., & Gao, H. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2245332 · Cited by 50
Treating Alzheimer’s disease using nanoparticle-mediated drug delivery strategies/systems
Roghani, A. K., Garcia, R. I., Roghani, A., Reddy, A. P., Khemka, S., Reddy, R. P., Pattoor, V., Jacob, M., Reddy, P. H., & Sehar, U. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102291 · Cited by 53
An Overview on the Physiopathology of the Blood–Brain Barrier and the Lipid-Based Nanocarriers for Central Nervous System Delivery
Susa, F., Arpicco, S., Pirri, C. F., & Limongi, T. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16070849 · Cited by 50
Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
Jia, C.-L., Gou, Y., Gao, Y., Pei, X., Jin, X., Li, B., Zhang, Z., He, Y., Ji, E., & Zhao, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155835 · Cited by 48
Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases
Pirhaghi, M., Mamashli, F., Moosavi-Movahedi, F., Arghavani, P., Amiri, A., Davaeil, B., Mohammad-Zaheri, M., Mousavi-Jarrahi, Z., Sharma, D., Langel, Ü., et al. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c01167 · Cited by 47
Recent Advances in Nanoenzymes Based Therapies for Glioblastoma: Overcoming Barriers and Enhancing Targeted Treatment
Wang, L., Gu, M., Zhang, X., Kong, T., Liao, J., Zhang, D., & Li, J. (2025) · Advanced Science · doi:10.1002/advs.202413367 · Cited by 47
Tuning the Elasticity of Polymersomes for Brain Tumor Targeting
Zheng, M., Du, Q., Wang, X., Zhou, Y., Li, J., Xia, X., Lu, Y., Yin, J., Zou, Y., Park, J. B., et al. (2021) · Advanced Science · doi:10.1002/advs.202102001 · Cited by 46
Nanomaterials-mediated photodynamic therapy and its applications in treating oral diseases
Yan, R., Liu, J., Dong, Z., & Peng, Q. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213218 · Cited by 47
How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature
Mohapatra, P., Gopikrishnan, M., Doss, C. G. P., & Chandrasekaran, N. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s442520 · Cited by 49
From blood to brain: blood cell-based biomimetic drug delivery systems
Li, Y., Wu, J., Liu, J., Qiu, X., Xu, W., Tang, T., & Xiang, D. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1937384 · Cited by 46
Brain‐targeting drug delivery systems
Liu, P., & Jiang, C. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1818 · Cited by 47
Mitochondrial Transplantation: A Novel Therapeutic Approach for Treating Diseases
Miao, X., Jiang, P., Wang, Z., Kong, W., & Feng, L. (2025) · MedComm · doi:10.1002/mco2.70253 · Cited by 54
Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage
Li, M., Liu, G., Wang, K., Wang, L., Fu, X., Lim, L. Y., Chen, W., & Mo, J. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00616-3 · Cited by 45
Getting drugs to the brain: advances and prospects of organic nanoparticle delivery systems for assisting drugs to cross the blood–brain barrier
Tan, Q., Zhao, S., Xu, T., Wang, Q., Lan, M., Li, Y., & Chen, X. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01440h · Cited by 47
Self-citation
Ultrasound-assisted brain delivery of nanomedicines for brain tumor therapy: advance and prospect
Zhang, S., Zhang, S., Luo, S., Tang, P., Wan, M., Wu, D., & Gao, W. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01464-z · Cited by 46
Functionalized Nanomaterials as Tailored Theranostic Agents in Brain Imaging
Thangam, R., Paulmurugan, R., & Kang, H. (2021) · Nanomaterials · doi:10.3390/nano12010018 · Cited by 45
Tailored Borneol-Modified Lipid Nanoparticles Nasal Spray for Enhanced Nose-to-Brain Delivery to Central Nervous System Diseases
Wang, G., Zhai, Z., Wang, W., Xia, X., Guo, H., Xiao, Y., Wang, X., Zhu, B., Huang, Z., Pan, X., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c08279 · Cited by 44
Smart nanomaterials for multimodal theranostics and tissue regeneration
Lee, H., Kim, K. S., Zare, I., Bang, S., Kang, H. S., Moon, C. H., Gwon, J. Y., Seo, J. H., Joo, H., Cho, Y., et al. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216801 · Cited by 49
Intranasal Pathway for Nanoparticles to Enter the Central Nervous System
Kou, D., Gao, Y. L., Li, C., Zhou, D., Lu, K., Wang, N., Zhang, R., Yang, Z., Zhou, Y., Chen, L., et al. (2023) · Nano Letters · doi:10.1021/acs.nanolett.2c05056 · Cited by 42
Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges
Usmani, S. M., Bremer‐Hoffmann, S., Cheyns, K., Cubadda, F., Dumit, V. I., Escher, S. E., Fessard, V., Gutleb, A. C., Léger, T., Liu, Y., et al. (2024) · EFSA Supporting Publications · doi:10.2903/sp.efsa.2024.en-8826 · Cited by 47
Polymer-based nanocarriers to transport therapeutic biomacromolecules across the blood-brain barrier
Romero‐Ben, E., Goswami, U., Soto-Cruz, J., Mansoori-Kermani, A., Mishra, D., Martín‐Saldaña, S., Ugartemendia, J. M., Sosnik, A., Calderón, M., Beloqui, A., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.02.065 · Cited by 48
Hypocrellin-Based Multifunctional Phototheranostic Agent for NIR-Triggered Targeted Chemo/Photodynamic/Photothermal Synergistic Therapy against Glioblastoma
Zhang, C., Wu, J., Liu, W., Zheng, X., Zhang, W., Lee, C., & Wang, P. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00386 · Cited by 41
Functional gadolinium-based nanoscale systems for cancer theranostics
Li, H., Zeng, Y., Zhang, H., Gu, Z., Gong, Q., & Luo, K. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.064 · Cited by 45
A Dual Receptor Targeting- and BBB Penetrating- Peptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma
Lu, L., Chen, H., Wang, L., Zhao, L., Cheng, Y., Wang, A., Wang, F., & Zhang, X. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s270208 · Cited by 41
Cell-based intelligent micro/nanorobots for precise regulation and active biotherapy
Huang, G., Yin, T., Zhang, B., Ma, A.-Q., Kang, T., He, Y., Long, Y., Zheng, S., Pan, H., & Cai, L. (2023) · Matter · doi:10.1016/j.matt.2023.09.013 · Cited by 40
A Water‐Soluble Quercetin Conjugate with Triple Targeting Exerts Neuron‐Protective Effect on Cerebral Ischemia by Mitophagy Activation
Cen, J., Zhang, R., Zhao, T., Zhang, X., Zhang, C., Cui, J., Zhao, K., Duan, S., & Guo, Y. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200817 · Cited by 40
Recent Progress of Surface Modified Nanomaterials for Scavenging Reactive Oxygen Species in Organism
Liu, J., Ma, L., Zhang, G., Chen, Y., & Wang, Z. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00402 · Cited by 39
Penetration and translocation of functional inorganic nanomaterials into biological barriers
Cong, Y., Baimanov, D., Zhou, Y., Chen, C., & Wang, L. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114615 · Cited by 40
Spatiotemporal tracking of gold nanorods after intranasal administration for brain targeting
Han, S., Wang, J. T.-W., Yavuz, E., Zam, A., Rouatbi, N., Utami, R. N., Liam‐Or, R., Griffiths, A., Dickson, W., Sosabowski, J. K., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.04.022 · Cited by 41
Challenges and advances for glioma therapy based on inorganic nanoparticles
Hu, D., Xia, M., Wu, L., Liu, H., Chen, Z., Xu, H., He, C., Wen, J., & Xu, X. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100673 · Cited by 40
Protein corona on brain targeted nanocarriers: Challenges and prospects
Jiang, K., Yu, Y., Qiu, W., Tian, K., Guo, Z., Qian, J., Lu, H., & Zhan, C. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115114 · Cited by 41
Multifaceted applications of micro/nanorobots in pharmaceutical drug delivery systems: a comprehensive review
Das, T., & Sultana, S. (2024) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-023-00577-y · Cited by 39
A Peptide‐Drug Conjugate‐Based Nanoplatform for Immunometabolic Activation and In Situ Nerve Regeneration in Advanced‐Stage Alzheimer's Disease
Liu, P., Zhang, T., Wu, Y., Chen, Q., Sun, T., & Jiang, C. (2024) · Advanced Materials · doi:10.1002/adma.202408729 · Cited by 42
Assessment of Nasal-Brain-Targeting Efficiency of New Developed Mucoadhesive Emulsomes Encapsulating an Anti-Migraine Drug for Effective Treatment of One of the Major Psychiatric Disorders Symptoms
El-Enin, H. A. A., Mostafa, R. E., Ahmed, M. F. E., Naguib, I. A., Abdelgawad, M. A., Ghoneim, M. M., & Abdou, E. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020410 · Cited by 39
Targeting Brain Drug Delivery with Macromolecules Through Receptor-Mediated Transcytosis
Li, Y., Liu, R., & Zhao, Z. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17010109 · Cited by 41
Bio-nanomaterials: Promising anticancer properties and treatment strategies
Elemike, E. E., Onunkwo, I. C., Ughumiakpor, O., Alawuru, F., Mukoro, A., Ishom, P., Obarakpor, F., Hossain, I., & Aziza, A. E. (2025) · Nano TransMed · doi:10.1016/j.ntm.2025.100076 · Cited by 42
Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer’s Disease, a Potential Therapeutic Target
Puranik, N., & Song, M. (2024) · Molecules · doi:10.3390/molecules29235744 · Cited by 49
Inorganic nanoparticles and blood-brain barrier modulation: Advancing targeted neurological therapies
Razavi, Z. S., Razavi, F. S., & Alizadeh, S. S. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117357 · Cited by 39
Adeno‐associated virus (AAV)-based gene therapy for glioblastoma
Xu, X., Chen, W., Zhu, W., Chen, J., Ma, B., Ding, J., Wang, Z., Li, Y., Wang, Y., & Zhang, X. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01776-4 · Cited by 43
TfR Aptamer Enhanced Blood‐Brain Barrier Penetration of Biomimetic Nanocomplexes for Intracellular Transglutaminase 2 Imaging and Silencing in Glioma
Su, J., Yao, Z., Chen, Z., Zhou, S., Wang, Z., Xia, H., Liu, S., & Wu, Y. (2022) · Small · doi:10.1002/smll.202203448 · Cited by 37
Interactions of Graphene Oxide and Few-Layer Graphene with the Blood–Brain Barrier
Castagnola, V., Deleye, L., Podestà, A., Jaho, E., Loiacono, F., Debellis, D., Trevisani, M., Ciobanu, D. Z., Armirotti, A., Pisani, F., et al. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c00377 · Cited by 40
Nose to brain delivery of Astragaloside IV by β-Asarone modified chitosan nanoparticles for multiple sclerosis therapy
Zhao, X. G., Sun, L., Wang, J., Xu, X., Ni, S., Liu, M., & Hu, K. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123351 · Cited by 36
Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders
Yadav, D. K., Vijayalakshmi, R., Sahu, K. K., Sure, P., Chahal, K., Yadav, R. K., Sucheta, Dubey, A., Jha, M., & Pradhan, M. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114298 · Cited by 38
Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases
Zhao, P., Wu, T., Tian, Y., You, J. E., & Cui, X. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115323 · Cited by 44
Utilization of nanotechnology to surmount the blood-brain barrier in disorders of the central nervous system
Luo, Q., Yang, J., Yang, M., Wang, Y., Liu, Y., Liu, J., Kalvakolanu, D. V., Cong, X., Zhang, J., Zhang, L., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101457 · Cited by 41
Recent advances on peptide‐based theranostic nanomaterials
Rong, L., Lei, Q., & Zhang, X. (2020) · Open Research (University of Surrey) · doi:10.1002/viw.20200050 · Cited by 36
Recent advances in polymeric core–shell nanocarriers for targeted delivery of chemotherapeutic drugs
Yang, X., & Xie, Y. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121094 · Cited by 33
Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-β Deposition in an Alzheimer's Disease Model
Mi, X., Du, H., Guo, X., Wu, Y., Shen, L., Luo, Y., Wang, D., Su, Q., Xiang, R., Yue, S., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.01.023 · Cited by 36
Nanobiotechnology-based treatment strategies for malignant relapsed glioma
Qiu, Q., Ding, X., Chen, J., Chen, S., & Wang, J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.05.016 · Cited by 37
Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective
Guan, Y., Li, L., Yang, R., Lü, Y., & Tang, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06605-0 · Cited by 41
Current strategies of detecting Aβ species and inhibiting Aβ aggregation: Status and prospects
Li, J., Liao, W., Huang, D., Ou, M., Chen, T., Wang, X., Zhao, R., Zhang, L., Mei, L., Liu, J., et al. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215375 · Cited by 37
Recent Strategies for Targeted Brain Drug Delivery
Ogawa, K., Kato, N., & Kawakami, S. (2020) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c20-00041 · Cited by 34
Iodine nanoparticle radiotherapy of human breast cancer growing in the brains of athymic mice
Hainfeld, J. F., Ridwan, S. M., Stanishevskiy, F. Y., & Smilowitz, H. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-72268-0 · Cited by 34
Monosodium urate crystals with controlled shape and aspect ratio for elucidating the pathological progress of acute gout
Chen, C., Wang, J., Liang, Z., Li, M., Fu, D., Zhang, L., Yang, X., Guo, Y., Ge, D., Liu, Y., et al. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213005 · Cited by 34
Recent advances in targeted drug delivery for the treatment of glioblastoma
Mao, M., Wu, Y., & He, Q. Z. (2024) · Nanoscale · doi:10.1039/d4nr01056f · Cited by 34
Nanomaterials that Aid in the Diagnosis and Treatment of Alzheimer's Disease, Resolving Blood–Brain Barrier Crossing Ability
Song, Q., Li, J., Li, T., & Li, H. (2024) · Advanced Science · doi:10.1002/advs.202403473 · Cited by 35
Clinical translation of nanomedicines for brain diseases: Current challenges and future directions
Wang, G., Wang, N., Xia, X., Ismail, M., & Shi, B. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114426 · Cited by 33
Fluorination and Betaine Modification Augment the Blood–Brain Barrier‐Crossing Ability of Cylindrical Polymer Brushes
Wang, R., Yang, S., Xiao, P., Sun, Y., Li, J., Jiang, X., & Wu, W. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202201390 · Cited by 34
Current treatments after spinal cord injury: Cell engineering, tissue engineering, and combined therapies
Shen, Y., Cao, X., Lu, M., Gu, H., Li, M., & Posner, D. A. (2022) · Smart Medicine · doi:10.1002/smmd.20220017 · Cited by 35
Nanoparticle Targeting with Antibodies in the Central Nervous System
Lee, J.-H., Chapman, D. V., & Saltzman, W. M. (2023) · BME Frontiers · doi:10.34133/bmef.0012 · Cited by 36
Advances in nanotechnology for the treatment of GBM
Wei, D., Zhang, N., Qu, S., Wang, H., & Li, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1180943 · Cited by 32
Chitosan-PLGA mucoadhesive nanoparticles for gemcitabine repurposing for glioblastoma therapy
Ramalho, M. J., Serra, É., Lima, J. P., Loureiro, J. A., & Pereira, M. D. C. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114326 · Cited by 32
Inhibiting protein aggregation with nanomaterials: The underlying mechanisms and impact factors
Wang, S., Zheng, J., Ma, L., Petersen, R. B., Xu, L., & Huang, K. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.130061 · Cited by 32
Ligands for oral delivery of peptides across the blood-brain-barrier
Gailani, M. A., Liu, M., & Wen, J. (2022) · Acta Materia Medica · doi:10.15212/amm-2021-0007 · Cited by 31
Borneol-modified PEGylated graphene oxide as a nanocarrier for brain-targeted delivery of ginsenoside Rg1 against depression
Yu, S., Wang, X., Lv, L., Liu, T., & Guan, Q. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123284 · Cited by 31
Biotin and glucose co-modified multi-targeting liposomes for efficient delivery of chemotherapeutics for the treatment of glioma
Liu, Q., Zhou, L., Lu, R., Yang, C., Wang, S., Hai, L., & Wu, Y. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115852 · Cited by 32
Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice
Ouyang, J., Jiang, Y., Deng, C., Zhong, Z., & Lan, Q. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s314895 · Cited by 33
Bioinspired Adaptive Microdrugs Enhance the Chemotherapy of Malignant Glioma: Beyond Their Nanodrugs
Wang, X., Hao, X., Zhang, Y., Wu, Q., Zhou, J., Cheng, Z., Chen, J., Liu, S., Pan, J., Wang, Y., et al. (2024) · Advanced Materials · doi:10.1002/adma.202405165 · Cited by 31
Exosome‐Based Therapeutics: A Natural Solution to Overcoming the Blood–Brain Barrier in Neurodegenerative Diseases
Sun, M., Qin, F., Bu, Q., Zhao, Y., Yang, X., Zhang, D., & Cen, X. (2025) · MedComm · doi:10.1002/mco2.70386 · Cited by 39
NIR-II-Activated Yolk–Shell Nanostructures as an Intelligent Platform for Parkinsonian Therapy
Liu, Y., Zhu, D., Luo, J., Chen, X., Gao, L., Liu, W., & Chen, T. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00794 · Cited by 30
Self-citation
In vitro model for predicting the access and distribution of drugs in the brain using hCMEC/D3 cells
Sánchez-Dengra, B., González‐Álvarez, I., Sousa, F., Bermejo, M., González‐Álvarez, M., & Sarmento, B. F. C. C. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.04.002 · Cited by 30
Application of nanomaterials in diagnosis and treatment of glioblastoma
Yu, S., Chen, L., Xu, H., Long, S., Jiang, J., Wei, W., Niu, X., & Li, X. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.1063152 · Cited by 30
Pterostilbene as a Therapeutic Alternative for Central Nervous System Disorders: A Review of the Current Status and Perspectives
Qu, X., Zhang, L., & Wang, L. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06238 · Cited by 29
In vitro assays and nanothermometry studies of infrared-to-visible upconversion of nanocrystalline Er3+,Yb3+ co-doped Y2O3 nanoparticles for theranostic applications
dos Santos, L. F., Martins, J. C., Lima, K. D. O., Gomes, L. F., de Melo, M. T., Tedesco, A. C., Carlos, L. D., Ferreira, R. A. S., & Gonçalves, R. R. (2021) · Physica B Condensed Matter · doi:10.1016/j.physb.2021.413447 · Cited by 29
Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines
Tang, Y., Yu, Z., Lü, X., Fan, Q., & Huang, W. (2022) · Advanced Science · doi:10.1002/advs.202103148 · Cited by 26
Asiaticoside Mitigates Alzheimer’s Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function
Liu, S., Chen, L., Li, J., Sun, Y., Xu, Y., Li, Z., Zhu, Z., & Li, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511976 · Cited by 28
The role of platelets in the blood-brain barrier during brain pathology
Lv, W., Jiang, X., & Zhang, Y. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1298314 · Cited by 30
Nanomedicine in Neuroprotection, Neuroregeneration, and Blood–Brain Barrier Modulation: A Narrative Review
Kršek, A., Jagodic, A., & Batičić, L. (2024) · Medicina · doi:10.3390/medicina60091384 · Cited by 31
An Overview of Nanomedicines for Neuron Targeting
García-Chica, J., Paraiso, W. K. D., Tanabe, S., Serra, D., Herrero, L., Casals, N., García, J., Ariza, X., Quader, S., & Rodríguez‐Rodríguez, R. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0088 · Cited by 28
Multifunctional nano-enabled delivery systems in Alzheimer's disease management
Qian, C., Yuan, C., Li, C., Liu, H., & Wang, X. (2020) · Biomaterials Science · doi:10.1039/d0bm00756k · Cited by 28
Macrophage membrane modified baicalin liposomes improve brain targeting for alleviating cerebral ischemia reperfusion injury
Long, Y., Yan, X., Liu, S., Zhang, Y., Wan, J., Ci, Z., Cui, M., Shen, L., Li, N., & Guan, Y. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102547 · Cited by 30
Combined Biomimetic MOF-RVG15 Nanoformulation Efficient Over BBB for Effective Anti-Glioblastoma in Mice Model
Wu, H., Liu, Y., Chen, L., Wang, S., Liu, C., Zhao, H., Jin, M., Chang, S.-Y., Quan, X., Cui, M., et al. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s387715 · Cited by 28
Mitochondrial quality control in the brain: The physiological and pathological roles
Shen, X., Sun, P., Zhang, H., & Yang, H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1075141 · Cited by 30
Nanotechnology in Stroke: New Trails with Smaller Scales
Toljan, K., Ashok, A., Labhasetwar, V. D., & Hussain, M. S. (2023) · Biomedicines · doi:10.3390/biomedicines11030780 · Cited by 29
Drug-Loaded Zwitterion-Based Nanomotors for the Treatment of Spinal Cord Injury
Bao, T., Li, N., Chen, H., Zhao, Z., Fan, J., Tao, Y., Chen, C., Wan, M., Yin, G., & Mao, C. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c05866 · Cited by 29
Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration
Wu, D., Salah, Y. A., Ngowi, E. E., Zhang, Y., Khattak, S., Khan, N. H., Wang, Y., Li, T., Guo, Z.-H., Wang, Y., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107321 · Cited by 30
The prescription design and key properties of nasal gel for CNS drug delivery: A review
Wang, M., Ma, X., Zong, S., Su, Y., Su, R., Zhang, H., Liu, Y., Wang, C., & Li, Y. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106623 · Cited by 30
Recent advances of nanomaterials for intervention in Parkinson’s disease in the context of anti-inflammation
Zhang, R., Chen, X., Cheng, Y., Chen, Z., Li, X., & Deng, Y. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215616 · Cited by 27
Self-citation
Challenges and strategies in progress of drug delivery system for traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma (Danshen)
Wang, R.-N., Zhao, H., Huang, J., Wang, H., Li, J., Lu, Y., & Di, L. (2020) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2020.08.001 · Cited by 27
Dynamic nanoassemblies for imaging and therapy of neurological disorders
Zhang, L., Sun, H., Zhao, J., Lee, J., Low, L. E., Gong, L., Chen, Y., Wang, N., Zhu, C., Lin, P., et al. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113832 · Cited by 27

Authors: Xie, J., Shen, Z., Anraku, Y., Kataoka, K., & Chen, X.
Affiliations: Innovation Center of NanoMedicine (JP)
National Institutes of Health (US)
Corresponding author: Shen, Zheyu
Kataoka, Kazunori
Chen, Xiaoyuan
ORCID: Xie, Jinbing
Shen, Zheyu
Anraku, Yasutaka
Kataoka, Kazunori
Chen, Xiaoyuan
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2019-12
Volume: 224
Pages: 119491
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2019.119491
PMC: PMC6915305
OpenAlex: W2973160898
Cited by: 604
References: 236
Citations by year: 2026: 64 · 2025: 131 · 2024: 116 · 2023: 104 · 2022: 92 · 2021: 57 · 2020: 38 · 2019: 2
FWCI: 4.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: blood-brain barrier, BBB crossing, nanomaterials, brain drug delivery, central nervous system disorders, intranasal drug delivery, blood-brain barrier disruption, cell-penetrating peptides, receptor-mediated transcytosis, theranostic agents
MeSH terms: Animals, Blood-Brain Barrier, Central Nervous System Diseases, Clinical Trials as Topic, Disease Models, Animal, Humans, Drug Delivery Systems, Nanostructures

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks