Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

Louis, D. N., Perry, A., Reifenberger, G., von Deimling, A., Figarella‐Branger, D., Cavenee, W. K., Ohgaki, H., Wiestler, O. D., Kleihues, P., & Ellison, D. W. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1545-1 · Cited by 15,703

The 2007 WHO Classification of Tumours of the Central Nervous System

Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,675

Establishment and Dysfunction of the Blood-Brain Barrier

Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Din, F. U., Aman, W., Ullah, I., Qureshi, O. S., Mustapha, O., Shafique, S., & Zeb, A. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s146315 · Cited by 1,625

Convection-enhanced delivery of macromolecules in the brain.

Bobo, R. H., Laske, D. W., Akbaşak, A., Morrison, P. F., Dedrick, R. L., & Oldfield, E. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2076 · Cited by 1,442

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat

Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060

Mechanisms of Cellular Uptake of Cell-Penetrating Peptides

Madani, F., Lindberg, S., Langel, Ü., Futaki, S., & Gräslund, A. (2011) · Journal of Biophysics · doi:10.1155/2011/414729 · Cited by 1,040

Modern methods for delivery of drugs across the blood–brain barrier

Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,038

Cloning by functional expression of a member of the glutamate receptor family

Hollmann, M., O'Shea-Greenfield, A., Rogers, S. W., & Heinemann, S. F. (1989) · Nature · doi:10.1038/342643a0 · Cited by 1,016

Cell membrane-based nanomaterials for theranostics of central nervous system diseases

Li, W., Cheng, J., He, F., Zhang, P., Zhang, N., Wang, J., Song, Q., Hou, Y., & Gan, Z. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02004-z · Cited by 27

Navigating the brain: the role of exosomal shuttles in precision therapeutics

Fatima, S., Qaiser, A., Andleeb, S., Hashmi, A. H., & Manzoor, S. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2023.1324216 · Cited by 27

Polyamidoamine Dendrimers: Brain-Targeted Drug Delivery Systems in Glioma Therapy

Yan, X., & Chen, Q. (2024) · Polymers · doi:10.3390/polym16142022 · Cited by 28

Cancer brain metastasis: molecular mechanisms and therapeutic strategies

Lu, Y., Huang, Y., Zhu, C., Li, Z., Zhang, B., Sheng, H., Li, H., Liu, X., Xu, Z., Wen, Y., et al. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00251-0 · Cited by 29

A D-peptide ligand of neuropeptide Y receptor Y1 serves as nanocarrier traversing of the blood brain barrier and targets glioma

Li, Y., Pan, Y., Wang, Y., Jiang, Z., Akakuru, O. U., Li, M., Zhang, X., Yuan, B., Xing, J., Luo, L., et al. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101465 · Cited by 26

Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery

Mohi-ud-din, R., Mir, R. H., Mir, P. A., Banday, N., Shah, A. J., Sawhney, G., Bhat, M. M., Batiha, G. E., & Pottoo, F. H. (2022) · Current Drug Metabolism · doi:10.2174/1389200223666220817115003 · Cited by 26

Polylactic-Co-Glycolic Acid-Based Nanoparticles Modified with Peptides and Other Linkers Cross The Blood–Brain Barrier for Targeted Drug Delivery

Na, Y., Zhang, N., Zhong, X., Gu, J., Yan, C., Yin, S., Lei, X., Zhao, J., & Geng, F. (2023) · Nanomedicine · doi:10.2217/nnm-2022-0287 · Cited by 27

Nanosystems, Drug Molecule Functionalization and Intranasal Delivery: An Update on the Most Promising Strategies for Increasing the Therapeutic Efficacy of Antidepressant and Anxiolytic Drugs

Antunes, J. L., Amado, J., Veiga, F., Paiva‐Santos, A. C., & Pires, P. C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030998 · Cited by 26

Recent advances in brain delivery of synthetic and natural nano therapeutics: Reviving hope for Alzheimer's disease patients

Nady, D. S., Bakowsky, U., & Fahmy, S. A. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105047 · Cited by 27

Simultaneous Modulation of Hypoxia And Metabolism in Glioblastoma for Enhanced Radio‐Immunotherapy

Xie, Y., Zhang, C., Zhao, Y., Li, T., Shen, W., Hu, L. T., Yang, K., Pei, P., & Liu, T. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202312197 · Cited by 26

Nanocarrier-based targeted drug delivery for Alzheimer’s disease: addressing neuroinflammation and enhancing clinical translation

Wang, K., Yang, R., Li, J., Wang, H., Wan, L., & He, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1591438 · Cited by 27

Living Cells and Cell-Derived Vesicles: A Trojan Horse Technique for Brain Delivery

Ou, A., Wang, Y., Zhang, J., & Huang, Y. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041257 · Cited by 26

Cell membrane-based nanomaterials for therapeutics of neurodegenerative diseases

Nguyen‐Thi, P., Nguyen, T. T., Phan, H. L., Ho, T.-T., Toi, V. V., & Giau, V. V. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105612 · Cited by 25

Intranasal administration nanosystems for brain-targeted drug delivery

Jiang, Y., Pan, X., Yu, T., & Wang, H. (2023) · Nano Research · doi:10.1007/s12274-023-6026-y · Cited by 30

Recent advances in stimuli-responsive controlled release systems for neuromodulation

Shi, J., Tan, C., Ge, X., Qin, Z., & Xiong, H. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00720d · Cited by 25

Recent advances in biomimetic strategies for the immunotherapy of glioblastoma

You, H., Geng, S., Li, S., Imani, M., Brambilla, D., Sun, T., & Jiang, C. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122694 · Cited by 27

Nanoprobe-mediated precise imaging and therapy of glioma

Tang, T., Chang, B., Zhang, M., & Sun, T. (2021) · Nanoscale Horizons · doi:10.1039/d1nh00182e · Cited by 25

Silibinin-loaded nanostructured lipid carriers (NLCs) ameliorated cognitive deficits and oxidative damages in aluminum chloride-induced neurotoxicity in male mice

Makhdoomi, S., Mahboobian, M. M., Haddadi, R., Komaki‬, A., & Mohammadi, M. (2022) · Toxicology · doi:10.1016/j.tox.2022.153260 · Cited by 24

Preoperative administration of a biomimetic platelet nanodrug enhances postoperative drug delivery by bypassing thrombus

Ji, J., Lian, W., Zhang, Y., Lin, D., Wang, J., Mo, Y., Xu, X., Hou, C., Ma, C., Zheng, Y., et al. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122851 · Cited by 25

Development and characterization of pH-responsive nanocarriers for chemo-photothermal combination therapy of acidic tumors

Husni, P., Shin, Y., Jeon, H., Lee, E. S., Youn, Y. S., Poon, C., Lim, C., & Oh, K. T. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.05.025 · Cited by 25

Super-small zwitterionic micelles enable the improvement of blood-brain barrier crossing for efficient orthotopic glioblastoma combinational therapy

Wang, K., Zhao, B., Ao, Y., Zhu, J., Zhao, C., Wang, W. J., Zou, Y., Huang, D., Zhong, Y., Chen, W., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.10.019 · Cited by 25

Nanomaterial-Based Drug Delivery Systems for Ischemic Stroke

Jiang, C., Zhou, Y., Chen, R., Yang, M., Zhou, H., Tang, Z., Shi, H., & Qin, D. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122669 · Cited by 25

Advancements in strategies for overcoming the blood–brain barrier to deliver brain-targeted drugs

Qu, Z., Luo, J., Li, Z., Yang, R., Zhao, J., Chen, X., Yu, S., & Shu, H. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1353003 · Cited by 28

The role of ACSL4 in stroke: mechanisms and potential therapeutic target

Zhuo, B., Qin, C., Deng, S., Jiang, H., Si, S., Tao, F., Cai, F., & Meng, Z. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05150-6 · Cited by 25

Oxidative stress induced paclitaxel-derived carbon dots inhibit glioblastoma proliferation and EMT process

Yan, H., Miao, H., Hu, J., Pan, J., Ge, M., Yao, J., Du, Y., Li, X., Li, L., Dong, W., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03406-x · Cited by 23

Changes in plasma IL-1β, TNF-α and IL-4 levels are involved in chemotherapy-related cognitive impairment in early-stage breast cancer patients.

Zhao, J., Zuo, H., Ding, K., Zhang, X., Bi, Z., & Cheng, H. (2020) · PubMed Central · Cited by 24

Matrine treatment induced an A2 astrocyte phenotype and protected the blood-brain barrier in CNS autoimmunity

Jing, Y., Ma, R., Chu, Y., Dou, M., Wang, M., Li, X., & Zhu, L. D. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.102004 · Cited by 24

Functionalized nanoparticles crossing the brain–blood barrier to target glioma cells

Wu, Y., Qian, Y., Peng, W., & Qi, X. (2023) · PeerJ · doi:10.7717/peerj.15571 · Cited by 24

Dual drug-loaded calabash-like nanomotor as an active therapeutic for enhanced chemo-photothermal therapy of orthotopic glioblastoma

Li, H., Zhang, X., Miao, J., Shi, Z. Y., Li, Z., Wen, M., Wang, L., Liang, J., Gao, J., Ye, Y., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.145413 · Cited by 24

Insights on Quercetin Therapeutic Potential for Neurodegenerative Diseases and its Nano-technological Perspectives

Goyal, R., Mittal, G., Khurana, S., Malik, N., Kumar, V., Soni, A., Chopra, H., & Kamal, M. A. (2023) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201025666230830125410 · Cited by 26

Versatile Nanoparticulate Systems as a Prosperous Platform for Targeted Nose–Brain Drug Delivery

Taha, E., Shetta, A., Nour, S. A. E.-K., Naguib, M. J., & Mamdouh, W. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00588 · Cited by 26

Gene therapy in glioblastoma multiforme: Can it be a role changer?

Rayati, M., Mansouri, V., & Ahmadbeigi, N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27087 · Cited by 27

Exploring intranasal drug delivery via nanocarriers: A promising glioblastoma therapy

Deshmukh, V., Pathan, N. S., Haldar, N., Nalawade, S., Narwade, M., Gajbhiye, K. R., & Gajbhiye, V. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114285 · Cited by 23

Unveiling the hidden risks of human exposure to nanomedicine and nanopollutants: Nanoparticle-induced blood barrier disruption and tissue toxicity

Fathian-Nasab, M.-H., Manavi, M. A., Gelivarisarshari, M., Daghighi, S. M., Beyer, C., Baeeri, M., & Sanadgol, N. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114909 · Cited by 24

A Nanoantidote Alleviates Glioblastoma Chemotoxicity without Efficacy Compromise

Tian, M., Xing, R., Guan, J., Yang, B., Zhao, X. S., Yang, J., Zhan, C., & Zhang, S. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01201 · Cited by 23

Activatable luminescent probes for imaging brain diseases

Li, Z., Wang, C., Zhang, M., Li, S., Mao, Z., & Liu, Z. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101239 · Cited by 23

Stem Cell-derived Extracellular Vesicles: A Promising Nano Delivery Platform to the Brain?

Guo, Y., Hu, D., Lian, L., Zhao, L., Li, M., Bao, H., & Xu, S. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10455-4 · Cited by 25

Exploring the synergic mechanism of Ligusticum striatum DC. and borneol in attenuating BMECs injury and maintaining tight junctions against cerebral ischaemia based on the HIF-1α/VEGF signalling pathway

Song, X., Xing, W., Zhang, X., Wang, X., Ji, J., Lu, J., Yu, B., & Ruan, M. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115764 · Cited by 23

Engineering advanced nanomedicines against central nervous system diseases

Shi, S., Ren, H., Xie, Y., Yu, M., Chen, Y., & Yang, L. (2023) · Materials Today · doi:10.1016/j.mattod.2023.08.005 · Cited by 25

Versatile Copper-Chalcogenide-Based Nanoparticles for the Treatment of Brain Diseases

Xie, S., Liu, H., Yang, K., Wang, T., Zhang, H., & Li, Z. (2025) · Nano Biomedicine and Engineering · doi:10.26599/nbe.2025.9290117 · Cited by 22

Spectroscopic study of L-DOPA and dopamine binding on novel gold nanoparticles towards more efficient drug-delivery system for Parkinson’s disease

Kalčec, N., Peranić, N., Barbir, R., Hall, C. R., Smith, T. A., Sani, M., Frkanec, R., Separovic, F., & Vrček, I. V. (2021) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2021.120707 · Cited by 24

Glioma stem cell membrane-camouflaged photothermal nanozyme for synergistic antitumor via dual-targeted drug delivery across blood-brain barrier

Lin, J., Sun, Z., Huang, Y., Liu, Q., Shen, M., Shao, C., Liao, W., Yang, Y., Song, Y., Wang, Y., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160181 · Cited by 21

Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites

Cheng, C., Chan, M., Feng, S.-J., Hsiao, M., & Liu, R. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c22489 · Cited by 21

Advances in the research of nano delivery systems in ischemic stroke

Li, Y., Wang, H., Jin, J., Yang, C., Hu, J., & Li, J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.984424 · Cited by 21

Understanding drug nanocarrier and blood–brain barrier interaction based on a microfluidic microphysiological model

Fan, Y., Xu, C., Deng, N., Gao, Z., Jiang, Z., Li, X., Zhou, Y., Pei, H., Li, L., & Tang, B. (2023) · Lab on a Chip · doi:10.1039/d2lc01077a · Cited by 21

Molecular Engineering of AIE Photosensitizers for Inactivation of Rabies Virus

Bai, Y., Yu, E. Y., Liu, Y., Jin, H., Liu, X., Wu, X., Zhang, M., Feng, N., Huang, P., Zhang, H., et al. (2023) · Small · doi:10.1002/smll.202303542 · Cited by 21

Advancements in neurotherapeutics: nanoparticles overcoming the blood–brain barrier for precise CNS targeting

Alqudah, A. M. M., Aljabali, A. A. A., Gammoh, O., & Tambuwala, M. M. (2024) · Journal of Nanoparticle Research · doi:10.1007/s11051-024-05983-8 · Cited by 23

Blood Cell Membrane-Coated Nanomaterials as a Versatile Biomimetic Nanoplatform for Antitumor Applications

Shen, H., Ouyang, Y., Zhang, L., Li, J., & Wang, S. (2024) · Nanomaterials · doi:10.3390/nano14211757 · Cited by 21

Enhanced nasal-to-brain drug delivery by multivalent bioadhesive nanoparticle clusters for cerebral ischemic reperfusion injury protection

Jia, Y., Kong, X., Li, R., Wang, H., Chu-jie, L., Cheng, S., Duan, W., Xiao, Y., Mai, Y., Deng, W., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.01.036 · Cited by 20

Challenges and material innovations in drug delivery to central nervous system tumors

Gong, Z., Zhou, D., Wu, D., Han, Y., Yu, H. Q., Shen, H., Feng, W., Hou, L., Chen, Y., & Xu, T. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123180 · Cited by 23

Extracellular Vesicle Lipids and Their Role in Delivery

Brent, A., Shirmast, P., & McMillan, N. A. J. (2025) · Journal of Extracellular Biology · doi:10.1002/jex2.70064 · Cited by 21

Multifunctional nanomedicine strategies to manage brain diseases

Faria, P. D. P., Pacheco, C., Moura, R. P., Sarmento, B. F. C. C., & Martins, C. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01256-w · Cited by 22

Nanotechnology Meets Stem Cell Therapy for Treating Glioblastomas: A Review

Ghosh, A. K., Ghosh, A., & Das, P. K. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c04714 · Cited by 20

Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer’s disease

Gunawan, C., Fleming, C. L., Irga, P. J., Wong, R. J., Amal, R., Torpy, F. R., Golzan, M., & McGrath, K. C. Y. (2024) · Environment International · doi:10.1016/j.envint.2024.108512 · Cited by 23

Expression and function of nicotinic acetylcholine receptors in specific neuronal populations: Focus on striatal and prefrontal circuits

Abbondanza, A., Urushadze, A., Alves-Barboza, A. R., & Janíčková, H. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107190 · Cited by 20

The biological roles of exosome-encapsulated traditional Chinese medicine monomers in neuronal disorders

Pang, C., Zhang, J., Gu, Y., Zhang, Q., & Zhao, Y. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101131 · Cited by 19

Macrophage membrane-camouflaged pure-drug nanomedicine for synergistic chemo- and interstitial photodynamic therapy against glioblastoma

Cheng, W., Duan, Z., Chen, H., Wang, Y., Wang, C., Pan, Y., Wu, J., Wang, N., Qu, H., & Xue, X. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.01.016 · Cited by 19

Advances in Non-Animal Testing Approaches towards Accelerated Clinical Translation of Novel Nanotheranostic Therapeutics for Central Nervous System Disorders

Lynch, M. J., & Gobbo, O. L. (2021) · Nanomaterials · doi:10.3390/nano11102632 · Cited by 19

Recent Synergy of Nanodiamonds: Role in Brain-Targeted Drug Delivery for the Management of Neurological Disorders

Bhogale, D., Mazahir, F., & Yadav, A. K. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02882-8 · Cited by 19

Nanotechnological Advancements in the Brain Tumor Therapy: a Novel Approach

Angolkar, M., Paramshetti, S., Halagali, P., Jain, V. K., Patil, A. B., & Somanna, P. (2022) · Therapeutic Delivery · doi:10.4155/tde-2022-0035 · Cited by 21

A state-of-the-art liposome technology for glioblastoma treatment

Hasan, I., Roy, S., Ehexige, E., Wu, R., Chen, Y., Gao, Z., Guo, B., & Chang, C. (2023) · Nanoscale · doi:10.1039/d3nr04241c · Cited by 19

Pleiotropic Potential of Evernia prunastri Extracts and Their Main Compounds Evernic Acid and Atranorin: In Vitro and In Silico Studies

Studzińska-Sroka, E., Bulicz, M., Henkel, M., Rosiak, N., Paczkowska‐Walendowska, M., Szwajgier, D., Baranowska‐Wójcik, E., Korybalska, K., & Cielecka‐Piontek, J. (2023) · Molecules · doi:10.3390/molecules29010233 · Cited by 19

Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS‐induced Depressive‐Like Behaviors

Ju, M., Zhang, Z., Gao, F., Chen, G., Zhao, S., Wang, D., Wang, H., Jia, Y., Shen, L., Yuan, Y., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402219 · Cited by 19

Application of Carbon Nanomaterials to Enhancing Tumor Immunotherapy: Current Advances and Prospects

Li, Y., Xu, Z., Qi, Z., Huang, X., Li, M., Liu, S., Yan, Y., & Gao, M. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s480799 · Cited by 19

Targeting NRF2 to suppress ferroptosis in brain injury.

Song, S., Gao, Y., Sheng, Y., Rui, T., & Luo, C. (2021) · PubMed · doi:10.14670/hh-18-286 · Cited by 20

Nicotine exposure in adolescence triggers the activation and subsequent damage of microglia in the dentate gyrus and promotes depression later in life

Fang, Y., Yang, R., Song, R., Gu, Y., Lu, X., Chen, Z., Hu, W., Cao, Z., Sun, M., Wang, H., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115060 · Cited by 18

The lipid composition of few layers graphene and graphene oxide biomolecular corona

Braccia, C., Castagnola, V., Vázquez, E., González, V. J., Loiacono, F., Benfenati, F., & Armirotti, A. (2021) · Carbon · doi:10.1016/j.carbon.2021.09.052 · Cited by 18

Systematic and Bibliometric Analysis of Magnetite Nanoparticles and Their Applications in (Biomedical) Research

Fleming, C. L., Golzan, M., Gunawan, C., & McGrath, K. C. Y. (2022) · Global Challenges · doi:10.1002/gch2.202200009 · Cited by 18

Mathematical Optimisation of Magnetic Nanoparticle Diffusion in the Brain White Matter

Tian, Y., Yang, Y., Zhan, W., & Dini, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032534 · Cited by 18

Immunoregulatory liposomes hitchhiking on neutrophils for enhanced carbon ion radiotherapy-assisted immunotherapy of glioblastoma

Liu, X., Yi, X., Gu, J., Ji, Z., Zhu, M., Shen, M., Ren, Y., Guo, L., Liu, T., Ding, N., et al. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102037 · Cited by 18

Virus-Inspired Glucose and Polydopamine (GPDA)-Coating as an Effective Strategy for the Construction of Brain Delivery Platforms

Duan, Q.-J., Liu, R., Luo, J., Zhang, J., Zhou, Y., Zhao, J., & Du, J. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c04175 · Cited by 19

A tailored phytosomes based nose-to-brain drug delivery strategy: Silver bullet for Alzheimer's disease

Xiao, Y., Guo, H., Wang, G., Li, J., Zhai, Z., Wang, Z., Wang, W., Zhao, Z., Xia, X., Chen, C., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.039 · Cited by 20

Starting points for the development of new targeted therapies for glioblastoma multiforme

Rusak, A., Wiatrak, B., Krawczyńska, K., Górnicki, T., Zagórski, K., Zadka, Ł., & Fortuna, W. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102187 · Cited by 18

Cabergoline possesses a beneficial effect on blood-brain barrier (BBB) integrity against lipopolysaccharide (LPS)

You, L., & Jiang, H. (2021) · Bioengineered · doi:10.1080/21655979.2021.1987066 · Cited by 17

Melatonin and the nervous system: nanomedicine perspectives

Luo, F., Deng, Y., Angelov, B., & Angelova, A. (2025) · Biomaterials Science · doi:10.1039/d4bm01609b · Cited by 17

Potential Applications of Natural Components of Traditional Chinese Medicine Delivery via Nanoparticle Drug Delivery Systems in the Treatment of Alzheimer’s Disease

Lai, G., Wu, H., Yang, K., Hu, K., Zhao, W., Chen, X., Li, J., Haifeng, W., Lv, Z., Xie, G., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s525960 · Cited by 19

Smart micro/nanorobots for drug delivery in the brain

Shi, D., Wang, X., Deng, Y., Zhou, H., Wang, Y., Chu, P. K.-H., & Li, J. (2025) · Progress in Materials Science · doi:10.1016/j.pmatsci.2025.101533 · Cited by 17

Harnessing Organoid Platforms for Nanoparticle Drug Development

Chen, L., Luo, X., Zhang, J., Zhang, J., Yang, C., & Zhao, Y. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s530999 · Cited by 19

Aspirin curcumin ester loaded biomimetic nanodrug improves cognitive deficits in a mouse model of Alzheimer's disease by regulating M1/M2 microglial polarization

Li, Z., Song, Z., He, C., Fan, J., Yu, W., Miao, Y., Li, P., Luo, R., Zhou, J., Xu, S., et al. (2022) · Materials Today Advances · doi:10.1016/j.mtadv.2022.100321 · Cited by 17

Research Progress of Nanomaterials in Chemotherapy of Osteosarcoma

Yu, T., Cai, Z., Chang, X., Xing, C., White, S., Guo, X., & Jin, J. (2023) · Orthopaedic Surgery · doi:10.1111/os.13806 · Cited by 17

Virus-Based Biological Systems as Next-Generation Carriers for the Therapy of Central Nervous System Diseases

Nowak, I., Madej, M., Secemska, J., Sarna, R., & Strzałka‐Mrozik, B. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071931 · Cited by 18

Enhancement of Microglia Functions by Developed Nano‐Immuno‐Synergist to Ameliorate Immunodeficiency for Malignant Glioma Treatment

Xu, M., Cheng, Y., Meng, R., Yang, P., Chen, J., Qiao, Z., Wu, J., Qian, K., Li, Y., Wang, P., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301861 · Cited by 18

Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

Lu, B. F., Wei, L., Shi, G., & Du, J. (2024) · Advanced Science · doi:10.1002/advs.202308241 · Cited by 16

Delivering DNA Aptamers Across the Blood–Brain Barrier Reveals Heterogeneous Decreased ATP in Different Brain Regions of Alzheimer’s Disease Mouse Models

Banik, M., Ledray, A. P., Wu, Y., & Lu, Y. (2024) · ACS Central Science · doi:10.1021/acscentsci.4c00563 · Cited by 17

AD16 attenuates neuroinflammation induced by cerebral ischemia through down-regulating astrocytes A1 polarization

Zhang, L., Zhao, G., Luo, Z., Yu, Z., Liu, G., Su, G., Tang, X., Yuan, Z., Huang, C., Sun, H., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117209 · Cited by 17

Engendered nanoparticles for treatment of brain tumors

Soleymani, S., Asgari, K., Mobarakshahi, A., Aghaeipour, A., Doroudian, M., Soezi, M., Beladi, A., & MacLoughlin, R. J. (2024) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2024.053069 · Cited by 17

Peptide-based inhibitors and nanoparticles: Emerging therapeutics for Alzheimer’s disease

Mojarad-Jabali, S., & Roh, K. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.125055 · Cited by 17

Intranasal anti‐caspase‐1 therapy preserves myelin and glucose metabolism in a model of progressive multiple sclerosis

Saito, L. B., Fernandes, J. P., Smith, M. J., Doan, M. A. L., Branton, W. G., Schmitt, L. M., Wuest, M., Monaco, M. C., Major, E. O., Wuest, F., et al. (2021) · Glia · doi:10.1002/glia.23896 · Cited by 18

The influence of protein corona on liposomal delivery systems: A comprehensive review

Mojarad-Jabali, S., Fatahi, Y., & Dinarvand, R. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107166 · Cited by 17

Advancing through the blood-brain barrier: mechanisms, challenges and drug delivery strategies

Vargas, R., Martínez-Martínez, N., Lizano-Barrantes, C., Molina, J. A. P., García‐Montoya, E., Pérez‐Lozano, P., Suñé-Negre, J. M., Suñé, C., & Suñé-Pou, M. (2025) · ADMET & DMPK · doi:10.5599/admet.2988 · Cited by 22

Engineered biomimetic drug-delivery systems for ischemic stroke therapy

Yang, Y., Yin, N., Gu, Z., Zhao, Y., Liu, C., Zhou, T., Zhang, K., Zhang, Z., Liu, J., & Shi, J. (2022) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2022.100129 · Cited by 17

Analysis of Nanomaterials on Biological and Environmental Systems and New Analytical Methods for Improved Detection

Reagen, S., & Zhao, J. X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116331 · Cited by 16

Application of Therapeutic Nanoplatforms as a Potential Candidate for the Treatment of CNS Disorders: Challenges and Possibilities

Sa, P., Singh, P., Dilnawaz, F., & Sahoo, S. K. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220729104433 · Cited by 16

Penetrating the Blood–Brain Barrier for Targeted Treatment of Neurotoxicant Poisoning by Nanosustained-Released 2-PAM@VB1-MIL-101-NH2(Fe)

Zhao, D., Liu, J., Zhou, Y., Zhang, L., Zhong, Y., Yang, Y., Zhao, B., Yang, M., & Wang, Y. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c18929 · Cited by 16

Recent progresses in natural based therapeutic materials for Alzheimer's disease

Zivari‐Ghader, T., Valioğlu, F., Eftekhari, A., Aliyeva, I., Beylerli, O., Davran, S., Cho, W. C. S., Beilerli, A., Khalilov, R. I., & Javadov, S. A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26351 · Cited by 17

Brain-targeted intranasal delivery of biologics: a perspective for Alzheimer's disease treatment

Li, H., Shen, X., Zhang, B., Li, Y., Alexander, C., Harvey, P., & Zhu, Z. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00148j · Cited by 18

Therapy of rheumatoid arthritis by reactive oxygen species-responsive celastrol-loaded nanomedicines via targeting macrophages apoptosis

Lin, S., Wang, D., Xu, C., Zhang, P., Gao, K., Liu, C., & Mei, X. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.111298 · Cited by 17

Drug Repurposing - Advances, Scopes and Opportunities in Drug Discovery

Rudrapal, M. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106301 · Cited by 15

Theoretical and applied concepts of nanocarriers for the treatment of Parkinson's diseases

Bhosale, A., Paul, G., Mazahir, F., & Yadav, A. K. (2022) · OpenNano · doi:10.1016/j.onano.2022.100111 · Cited by 15

Regulation of pathological blood-brain barrier for intracranial enhanced drug delivery and anti-glioblastoma therapeutics

Wang, K., Zhang, F., WEN, C., HUANG, Z., ZHANG, Y., HU, Z., HU, F., & Wen, L. (2021) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2022.025696 · Cited by 14

Advances in CNS drug delivery strategies to cross the blood-brain barrier

Li, G., Li, Z., Sun, Y., Bu, T., Chen, S., Yang, L., Li, Z., Mao, W., & Jia, Y. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.111524 · Cited by 10

Harnessing nanotechnology for improved drug delivery across the blood-brain barrier and enhanced neural repair

Xu, M., Wang, H., Wang, C., Wang, C., Hu, S., & Weng, L. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126221 · Cited by 2

Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708

The Route of Nanomaterials Entering Brain

Liu, Y., & He, Q. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804598-5.00002-7 · Cited by 14

Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review

Kulkarni, M., Patel, K., Patel, A. K., Patel, S., Desai, J. L., Patel, M. M., Shah, U., Patel, A. D., & Solanki, N. D. (2023) · ADMET & DMPK · doi:10.5599/admet.2043 · Cited by 46