Cited by 604Barrier Structure and Function StudiesNanoparticle-Based Drug DeliveryDrug Transport and Resistance Mechanisms

The DOI matches its Crossref record; 234 of the 236 references it cites were found in a registry or an index.

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Open access

Xie, Jinbing, Shen, Zheyu, Anraku, Yasutaka, Kataoka, Kazunori, Chen, Xiaoyuan·2019·Biomaterials

DOI 10.1016/j.biomaterials.2019.119491PMC PMC6915305

Open this paper in CoChat — free account

Abstract

Increasing attention has been paid to the diseases of central nervous system (CNS). The penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to the existence of blood-brain barrier (BBB). Thus, BBB crossing for drug delivery to CNS remains a significant challenge in the development of neurological therapeutics. Because of the advantageous properties (e.g., relatively high drug loading content, controllable drug release, excellent passive and active targeting, good stability, biodegradability, biocompatibility, and low toxicity), nanomaterials with BBB-crossability have been widely developed for the treatment of CNS diseases. This review summarizes the current understanding of the physiological structure of BBB, and provides various nanomaterial-based BBB-crossing strategies for brain delivery of theranostic agents, including intranasal delivery, temporary disruption of BBB, local delivery, cell penetrating peptide (CPP) mediated BBB-crossing, receptor mediated BBB-crossing, shuttle peptide mediated BBB-crossing, and cells mediated BBB-crossing. Clinicians, biologists, material scientists and chemists are expected to be interested in this review.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biomaterials.2019.119491

Cites

234 of 234 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice
Sagare, A. P., Bell, R. D., Zhao, Z., Ma, Q., Winkler, E. A., Ramanathan, A., & Zlokovic, B. V. (2013) · Nature Communications · doi:10.1038/ncomms3932 · Cited by 589
Retracted
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
Louis, D. N., Perry, A., Reifenberger, G., von Deimling, A., Figarella‐Branger, D., Cavenee, W. K., Ohgaki, H., Wiestler, O. D., Kleihues, P., & Ellison, D. W. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1545-1 · Cited by 15,703
The 2007 WHO Classification of Tumours of the Central Nervous System
Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,675
Establishment and Dysfunction of the Blood-Brain Barrier
Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
Din, F. U., Aman, W., Ullah, I., Qureshi, O. S., Mustapha, O., Shafique, S., & Zeb, A. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s146315 · Cited by 1,625
Convection-enhanced delivery of macromolecules in the brain.
Bobo, R. H., Laske, D. W., Akbaşak, A., Morrison, P. F., Dedrick, R. L., & Oldfield, E. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2076 · Cited by 1,442
Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060
Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
Madani, F., Lindberg, S., Langel, Ü., Futaki, S., & Gräslund, A. (2011) · Journal of Biophysics · doi:10.1155/2011/414729 · Cited by 1,040
Modern methods for delivery of drugs across the blood–brain barrier
Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,038
Cloning by functional expression of a member of the glutamate receptor family
Hollmann, M., O'Shea-Greenfield, A., Rogers, S. W., & Heinemann, S. F. (1989) · Nature · doi:10.1038/342643a0 · Cited by 1,016

Show all 236 references

Research works printed but not linked: 1

Feng, 2017, Self-assembly of gold nanoparticles shows microenvironment-mediated dynamic switching and enhanced brain tumor targeting, Theranostics, 7, 1875, 10.7150/thno.18985 · DOI

Sorted by citations

Items 401–500 of 604

Harnessing Reconstructed Macrophage Modulation of Infiltration-Excluded Immune Microenvironments To Delineate Glioma Infiltrative Region
Cheng, M., Hu, C., Yao, Z., Hao, D., Jin, T., Zhang, Z., Liu, X., Yu, Z., & Zhang, H. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c16586 · Cited by 7
Sensitive detection of extremely small iron oxide nanoparticles in living mice using MP2RAGE with advanced image co-registration
Kim, J. H., Dodd, S. J., Ye, F. Q., Knutsen, A. K., Nguyen, D., Wu, H., Su, S., Mastrogiacomo, S., Esparza, T. J., Swenson, R. E., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80181-9 · Cited by 8
Advances in Brain Delivery Systems Based on Biomimetic Nanoparticles
Li, C., Qian, J., & Chu, Y. (2022) · ChemNanoMat · doi:10.1002/cnma.202200066 · Cited by 7
Hybrid nanoparticles to cross the blood–brain barrier
Desai, H. R., & Shinde, U. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90773-6.00002-6 · Cited by 7
Axin1 participates in blood–brain barrier protection during experimental ischemic stroke via phosphorylation at Thr485 in rats
Wang, Y., Zhong, Y., Xu, X. M., Li, X., Li, H., Shen, H., Wang, W., & Fang, Q. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102204 · Cited by 7
GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway
Li, H., Zhang, Y., Han, X., Li, B., Liu, D., & Sun, G. (2025) · Scientific Reports · doi:10.1038/s41598-025-99685-3 · Cited by 6
Nano-enabled delivery of anesthetics: mechanistic insights, technological advances and translational challenges
Hu, X., He, T., Zhang, D., Zhou, C., & Liang, P. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01540e · Cited by 6
Natural polysaccharides in colloidal drug delivery systems for brain glioma therapy: Mechanisms and advancements
Li, C., Ma, W., Shen, H., Hou, Z., Chen, J., Yang, L., & Sun, W. Y. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115059 · Cited by 7
Biomimetic platinum–based nanoplatform for photoacoustic imaging–guided multimodal glioblastoma therapy
Chen, G., Ding, Y., Hu, X., Yang, L., Zhao, D., Kang, Y., Mou, X., Hou, C., & Cai, Y. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.139082 · Cited by 6
Tailored brain metastatic tumor cells-derived apoptotic bodies ameliorate Alzheimer’s disease by promoting microglia efferocytosis and neuroinflammation mitigation
Mu, Z., Chen, Y., Hu, Y., Wang, H., & Li, J. H. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03750-y · Cited by 7
Engineering Autonomous Micro‐/Nanorobots for Neurological Diseases: From Barrier Crossing to Neuroenergetic Restoration
Peng, S., Mao, M., & He, Q. Z. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202519696 · Cited by 8
Exploring the Potential of Non-Viral Nanocarriers for Improving Blood-Brain Barrier Permeability to Enhance the Treatment of Brain Diseases
Yu, Z., Sun, Z., Yuan, L., Wang, C., Li, W., Liu, J., Zhao, Q., Sun, Y., & Sun, C. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s545696 · Cited by 7
Cell-Mediated and Peptide-Based Delivery Systems: Emerging Frontiers in Targeted Therapeutics
Erdei, E., Deme, R., Balogh, B., & Mándity, I. M. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17121597 · Cited by 8
Engineering Nanomedicine for Non-Viral RNA-Based Gene Therapy of Glioblastoma
He, W., Wang, N., Wang, Y.-P., Liu, M., Qing, Q., Su, Q., Zou, Y., & Liu, Y. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040482 · Cited by 6
Inhibition of Aβ Aggregation by Cholesterol-End-Modified PEG Vesicles and Micelles
Watanabe, S., Ueda, M., & Asayama, S. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics17010001 · Cited by 8
Intranasal Delivery of Hydrophobic AC5216 Loaded Nanoemulsion into Brain To Alleviate Chronic Unpredictable Stress-Induced Depressive-like Behaviors
Zhang, Y., Wang, Y., Wang, H., Bian, L., Gao, F., Yao, H., & Xie, J. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c19377 · Cited by 6
Self-citation
In Vivo Evaluation of BBB Integrity in the Post-stroke Brain
Zhang, Y., Nozohouri, S., & Abbruscato, T. J. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-2926-0_15 · Cited by 6
Combined Core Stability and Degradability of Nanomedicine via Amorphous PDLLA-Dextran Bottlebrush Copolymer for Alzheimer’s Disease Combination Treatment
Dai, F., Li, X., Lv, K., Wang, J., & Zhao, Y. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c03174 · Cited by 6
Breaking Barriers in Alzheimer’s Disease: the Role of Advanced Drug Delivery Systems
Shekho, D., Mishra, R., Kamal, R., Bhatia, R., & Awasthi, A. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02923-6 · Cited by 6
Assessment of Mannitol-Induced Chronic Blood–Brain Barrier Dysfunction In Vivo Using Magnetic Resonance
Sampedro‐Viana, A., Fernández‐Rodicio, S., Castillo, J., Hervella, P., Alonso-Alonso, M. L., & Iglesias‐Rey, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189792 · Cited by 5
Phyto-Active Components Delivered through Lipid Nanodrug Carriers as a Promising Avenue for the Treatment of Alzheimer’s Disease: Their Present Status and Industrial Viability
Mishra, M. A., Sahu, P. K., Satapathy, B. S., & Biswal, B. (2024) · Current Nanomaterials · doi:10.2174/0124054615322050240817172547 · Cited by 5
Diagnosis of neurological and non-neurological disorders via bimodal/multimodal imaging with lanthanide based nanoparticles
Gautam, A. K., & Komal, P. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216527 · Cited by 5
Development of blood-brain barrier-penetrating antibodies for neutralizing tick-borne encephalitis virus in the brain
Fukuta, M., Fukano, S., Maekawa, N., Kobayashi, S., Okamoto, S., Hirano, M., Nio‐Kobayashi, J., Kariwa, H., Kawakami, S., Konnai, S., et al. (2025) · mSphere · doi:10.1128/msphere.00184-25 · Cited by 4
Tea and Blood–Brain Barrier Homeostasis: Potential Mechanisms and Improvement Strategies
Yue, R., Wen, H., He, L., Liu, Y., Zeng, L., & Luo, L. (2025) · Food Frontiers · doi:10.1002/fft2.70125 · Cited by 6
Chemically Designed Functional Nanomicelles for Blood–Brain Barrier Crossing
Sarkar, A. K., Jana, S., Kaur, G., Arora, H., Barman, S., Mukherjee, N., Shaw, S., Maity, A. R., Seth, P., Jana, N. R., et al. (2025) · Nano Letters · doi:10.1021/acs.nanolett.5c03705 · Cited by 5
Neurotoxicity and mechanism of metal and metal oxide nanoparticles
Cao, S., Tang, M., & Bai, C. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.111953 · Cited by 6
Biomacromolecule-tagged nanoscale constructs for crossing the blood–brain barrier
Odom, T. L., LeBroc, H. D., & Callmann, C. E. (2024) · Nanoscale · doi:10.1039/d3nr06154j · Cited by 5
Discovery of a Novel Dual Targeting Peptide for Human Glioma: From In Silico Simulation to Acting as Targeting Ligand
Aminabad, N. S., Saeedi, Y., Adiban, J., Nemati, M., Shaterabadi, D., Najafi, F., Rahbarghazi‬, R., Talebi, M., & Zarebkohan, A. (2024) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2024.033 · Cited by 5
Lifibrate attenuates blood-brain barrier damage following ischemic stroke via the MLCK/p-MLC/ZO-1 axis
Duan, Y., Deng, Y., Tang, F., & Li, J. (2024) · Aging · doi:10.18632/aging.205692 · Cited by 5
Designing biomaterials for the treatment of autoimmune diseases
Tang, B., Xie, X., Lu, J., Huang, W., Yang, J., Tian, J., & Lei, L. (2024) · Applied Materials Today · doi:10.1016/j.apmt.2024.102278 · Cited by 5
Cerium oxide-modified Pd nanosheets encapsulated by red blood cell membranes for high-efficiency RONS scavenging in depression treatment
Hu, X., Zhang, X., Zhang, G., Cao, D., Ye, Z., & Chen, X. (2024) · Nanoscale · doi:10.1039/d4nr03410d · Cited by 5
Self-citation
Angiopep-2 modified naringin nanoparticles for Alzheimer’s disease therapy overcoming BBB
Jiang, J. S., Xing, Y., Liu, S., Na, Y., Xia, L., Geng, F., Zhang, Y., Yang, L., & Zhang, N. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2025.2514575 · Cited by 5
Liposomes - Recent Advances, New Perspectives and Applications
Tyagi, R. K. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102167 · Cited by 5
Drug Delivery Strategies in Multiple Sclerosis, Huntington’s Disease and Other Neurodegenerative Diseases
Tarannum, S., & Jain, K. (2023) · Springer eBooks · doi:10.1007/978-981-99-6807-7_16 · Cited by 5
Development and In vitro and In vivo efficacy investigation of multifunctional, targeted, theranostic liposomes for imaging and photodynamic therapy of glioblastoma
ONARAL, F. G., Silindir‐Gunay, M., Ulutürk, S., Öztürk, S. C., Cakir-Aktas, C., & Esendağlı, G. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106236 · Cited by 5
Immune cell targeting-mediated cytomimetic drug delivery system for BBB-penetrating and precise therapy of in situ glioma
Wang, X., Song, B., Wu, M., Qin, L., & Liang, W. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101694 · Cited by 6
Hybrid Se/melanin-like nanoparticles as ROS quenchers and inhibitors of amyloid aggregation
Pota, G., Natale, C. D., Puzone, A., Cascone, A., Manna, S. L., Licciardi, F., Vitiello, G., Panzetta, V., Netti, P. A., Luciani, G., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144175 · Cited by 4
Rational Design of Zwitterionic Nanosystems to Overcome Biological Barriers for Drug Delivery by Various Administration Routes
Ma, J., Ding, D., Xu, R. D., Ma, S., Zhong, Y., Liu, W., Gao, L., & Chen, W. (2025) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.70037 · Cited by 4
Platinum nanoparticles combined with temozolomide enhance radiosensitivity of U87 glioblastoma cells under megavoltage X-Ray irradiation
Soonthornchookiat, P., Suwannasing, C., Suwannasom, N., Bäumler, H., Pattaweerakul, C., Songjang, W., Kumphune, S., & Prapan, A. (2025) · Cancer Nanotechnology · doi:10.1186/s12645-025-00351-0 · Cited by 4
Nanomedicines: an update of diagnostic and therapeutic applications in multiple cancers
Shinde, S. J., Priyanka, Jakhar, M., Arora, I., Sehgal, D., Mahak, Kumari, A., Dhiman, T., Priya, Kumar, N., et al. (2026) · Journal of drug targeting · doi:10.1080/1061186x.2026.2613059 · Cited by 4
Insights into the potential pathogenesis and therapeutic implications of ferroptosis in brain microvascular endothelial cells during stroke
Qin, W., Zhao, Y., Du, J., Zhang, Q., Wei, G., Wang, S., Yu, Z., Xu, J., Yang, J., & Gao, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1787418 · Cited by 4
Nanoparticles Loaded with Pralidoxime Wrapped in Tumor Cell Membranes: A New Strategy to Counteract the Central Nervous System Effects of Organophosphate Poisoning
Jiang, H., Liu, Y., Wang, C., Song, Y., Wu, F., Yin, Y., & Yang, Z. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s516233 · Cited by 4
Recent Advancements in Phyto Component Based Nanocarriers for Improved Treatment of Brain Disorders
Satapathy, B. S., Pattnaik, S., Biswal, S. K., Biswal, B., Sahoo, P. K., Samal, H. B., & Barik, B. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110585 · Cited by 4
Temperature induces brain-intake shift of recombinant high-density lipoprotein after traumatic brain injury
Huang, J., Peng, Y., Wang, X., Gu, X., Yao, Y., Wang, W., He, Z., Ma, Z., Feng, Q., Qi, W., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-03016-z · Cited by 5
The therapeutic efficacy and application prospects of tumor-treating fields (TTFields) in resolving malignant tumors of central nervous system
Han, W., & Chen, L. (2025) · Clinical & Translational Oncology · doi:10.1007/s12094-025-03909-x · Cited by 5
Effective approaches in conquering chemoresistance of glioblastoma: potential for nanoformulations
Mandal, M., Banerjee, I., & Mandal, M. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01859-z · Cited by 6
Gold nanoparticles: diagnostic and therapeutic applications in neurodegenerative disorders
Hu, X., Cheng, J., Yuan, R., Zhou, Y., Rao, J., Wan, Y., Li, Y., Zhang, X., & Li, R. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2025.2509287 · Cited by 4
Nanomedicine Applications in Treatment of Primary Central Nervous System Lymphoma: Current State of the Art
Wang, M., Qu, Y., Hu, D., Niu, T., & Qian, Z. (2021) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2021.3133 · Cited by 4
Molecular Communication-Based Intelligent Dopamine Rate Modulator for Parkinson’s Disease Treatment
Baradari, E., & Akan, Ö. B. (2024) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2024.3456031 · Cited by 3
Phenolic-enabled nanotechnology: a new strategy for central nervous system disease therapy
Zheng, Y., Chen, X., Wang, Y., Chen, Z., & Wu, D. (2024) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2300839 · Cited by 4
Self-citation
Advanced Nanopharmaceutical Intervention for the Reduction of Inflammatory Responses and the Enhancement of Behavioral Outcomes in APP/PS1 Transgenic Mouse Models
Li, J., Huang, D., Liao, W., Wang, Y., Liu, Y., & Luan, P. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020177 · Cited by 3
Dynein-regulated brain transduction of AAV.CAP-B10 via cerebral lateral ventricle enhances hippocampal function after traumatic brain injury through Ngf gene delivery in mice
Wang, J.-C., Ding, S., He, Z.-H., Huang, J., Weng, W., Gao, Y.-W., Jiang, J., Lin, Y., & Feng, J. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115285 · Cited by 3
Pharmacokinetics and tissue distribution analysis of ginsenoside Rh3 in rats using a novel LC-MS/MS quantification strategy
Hu, C., Wang, Y., Liu, Y., Wang, X., Song, P., Ma, H., & Yang, L. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1582644 · Cited by 3
Cognitive impairment and dementia by pollutant exposure: a review
Hu, L., & Li, D. (2025) · Environmental Chemistry Letters · doi:10.1007/s10311-025-01870-3 · Cited by 3
Gastrodia elata Polysaccharide Ameliorates Parkinson’s Disease by Enhancing Dopamine Levels, Inhibiting NLRP3 Inflammasome Activation, and Promoting Mitochondrial Autophagy
Li, S., Li, M., Li, Y., Liang, S., Ling, L., Wang, H., & Guo, J. (2025) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x25500673 · Cited by 3
Biomimetic membrane nanotechnology in cerebral ischemic stroke:a promising technology for therapeutic treatment and diagnosis
Long, Y., Zou, Z., Wu, Y., Feng, H., Chen, T., Yang, Z., Jian, X., Yin, Y., & Li, X. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1605377 · Cited by 3
Bone-Derived Factors: Regulating Brain and Treating Alzheimer’s Disease
Guan, Q., Cao, Y., Zou, J., & Zhang, L. (2025) · Biology · doi:10.3390/biology14091112 · Cited by 3
ER-Aβ dual-targeting NIRF/photoacoustic probe reveals Aβ-induced ER-stress via real-time viscosity imaging for early Alzheimer's disease diagnosis
Zhang, X., Cao, J., Li, X., Zhao, Z., Zhang, Z., Li, N., Jing, Y., & Wang, B. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123800 · Cited by 3
Construction and In Vitro Evaluation of Brain-Targeted Lutein Liposomes
You, T., Na, Z., Zhao, R., & Ma, Y. (2025) · Foods · doi:10.3390/foods14213611 · Cited by 3
α6 nicotinic acetylcholine receptors: A pharmacological challenge with untapped therapeutic promise
Zhang, B., Mao, K., Ma, L., Chen, Y.-S., Ren, M., Xiong, Y., Zhangsun, D., Dong, S., Luo, S., & Gao, B. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118300 · Cited by 3
Bionanoconjugates in Neurodegeneration: Peptide–Nanoparticle Alliances for Next-Generation Therapies
Ranjitha, V. R., Kumar, P. S. A., & Kaalappa, P. (2025) · Pharmaceutical Research · doi:10.1007/s11095-025-03941-0 · Cited by 3
Nanotechnology for diagnosis and therapy of idiopathic pulmonary fibrosis: Recent advances and future perspectives
Zhao, C., Xiao, A., Chen, C., Mu, W., Li, W.-Y., & Chang, L. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102889 · Cited by 3
Novel liquid-based approaches for transmucosal drug delivery
van Staden, D., Lemmer, H. J. R., Liebenberg, W., & Hamman, J. H. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.12.042 · Cited by 3
The application of CRISPR-Cas9 system in brain diseases
Miao, Y., Li, C., Su, Y., Peng, T., Wang, J., Liu, S., Ma, C., Li, L., & Wang, Y. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2629031 · Cited by 3
Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics
Wu, Y., Ma, H., Zhu, T., Huang, S., Lu, M., Wang, Q., & Chi, Z. (2026) · Advanced Science · doi:10.1002/advs.202521802 · Cited by 3
Emerging role of cell membrane-coated nanoparticles in targeted therapy for brain disorders
Kumari, V., Shahrukh, M., Jabin, K., Ali, N., Hasan, N., Aqil, M., & Ahmad, F. J. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.214822 · Cited by 4
Protective effect of nanoemulsions containing CdTe quantum dots with potential application as a diagnostic agent
Gusmão, L. A., Köster, R. W., & Tedesco, A. C. (2024) · Microchimica Acta · doi:10.1007/s00604-024-06690-w · Cited by 3
Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy
Akbar, M. U., Guo, W., Shen, X. M., Fang, Y., Liu, Y., Wang, P., Elnathan, R., & Chen, Y. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202500124 · Cited by 3
Investigation of functionalised nanoplatforms using branched-ligands with different chain lengths for glioblastoma targeting
Wang, S., Yang, Z., Yang, C., Chen, J., Zhou, L., Wu, Y., & Lu, R. (2022) · Journal of drug targeting · doi:10.1080/1061186x.2022.2077948 · Cited by 3
A Hydroxyquinoline Polymer with Excellent Amyloidosis Inhibition and Protein Delivery Ability to Combat Amyloid-β-Mediated Neurotoxicity
Chen, L., Hu, Y., Cheng, Y., & Wang, H. (2024) · Nano Letters · doi:10.1021/acs.nanolett.4c03275 · Cited by 4
Development and Characterization of Oral Efavirenz-Loaded Nanostructured Lipid Carriers and Their Optimization with Box–Behnken Design Approach for the Neurological Disorder
Sartaj, A., Nabi, B., Iqubal, A., Aggarwal, N., Haider, K., Baboota, S., & Ali, J. (2025) · Assay and Drug Development Technologies · doi:10.1089/adt.2024.115 · Cited by 3
Research Progress on the pathogenic mechanism of Streptococcus suis 2
Liu, M., Xia, X., Liu, X., & Kasianenko, O. (2021) · Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького · doi:10.32718/nvlvet10405 · Cited by 3
Advanced Polymeric Nanoparticles for the Treatment of Neurodegenerative Diseases
Ferrão, R., & Rai, A. (2024) · Wiley eBooks · doi:10.1002/9783527837021.ch27 · Cited by 3
Construction of Nicotinamide Mononucleotide-Loaded Liposomes and Their In Vitro Transport Across the Blood–Brain Barrier
Wang, T., Wu, Q., Wang, L., Lan, T., Yun, Z., Zhao, L., & Wu, X. (2024) · Applied Sciences · doi:10.3390/app142411732 · Cited by 2
A Critical Review of CAR-T Therapies for Glioblastoma: What’s Wrong with the Current Attempts?
Belokon, S. V., Kukarskaia, V. A., Klabukov, I., Shestakova, V. A., Иванов, С. А., Шегай, П. В., Каприн, А. Д., & Baranovskii, D. (2025) · Hematology/Oncology and Stem Cell Therapy · doi:10.4103/hemoncstem.hemoncstem-d-24-00040 · Cited by 3
Evolution of glioma exosome research: emerging trends and global collaborations (2005–2025)
Zeng, Y., Liu, T., Jing, S., Wang, Y., He, J., Cao, H., Liu, X., & Zhang, L. (2025) · Discover Oncology · doi:10.1007/s12672-025-03167-x · Cited by 2
ACSL4 in Alzheimer's disease: Pathogenetic mechanisms and potential therapeutic targets
Guo, Y. X., Jiang, Q., Gu, Z., Cao, H., Zuo, C., Huang, Y., Song, Y., Chen, X., & Wang, F. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101858 · Cited by 4
Self-citation
Bacterial infection hypothesis-based therapies for Alzheimer's disease
Teng, M., Ma, R., Liu, S., Zhang, G., Zou, J., & Fu, Q. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169535 · Cited by 3
Cell membrane-camouflaged nanomedicines for enhanced thrombolysis and blood-brain barrier penetration in ischemic stroke therapy
Chen, X., Liu, Y., Zou, J., Chen, H., Zhang, H., Guo, Y. P., & Zan, X. (2025) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2025.100404 · Cited by 2
Self-citation
A surrogate barrier model for high-throughput blood-brain barrier permeability prediction: integrating LLC-PK1-MOCK/MDR1 Cells and lysosomal trapping correction
Hu, J., Jiang, X. S., Li, C., Zhang, Q., Wu, X., Zhang, W., & Zhuang, X. (2025) · Drug Delivery · doi:10.1080/10717544.2025.2585612 · Cited by 2
Omeprazole-mediated nanodelivery of copper for synchronous remodeling of copper influx and efflux in cuproptotic glioblastoma therapy
Feng, W., Weng, C., Chen, L., Yang, R., Shi, W., Liu, Y., Ge, P., & Zhang, H. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.12.002 · Cited by 2
Luteolin-loaded nanocomposites target microglia for sepsis-associated encephalopathy therapy via intranasal delivery
Guo, W., Liu, T., Peng, X., Zhang, J., Chen, Z., Xia, C., Yang, C., Xie, S., & Lü, T. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115433 · Cited by 2
Application of Plant Based Nanomaterial for Treating Dementia
Asuku, A. O., Adebayo, P. O., Ajibare, A. J., & Ayoola, S. A. (2026) · Nanotechnology in the life sciences · doi:10.1007/978-3-032-13086-0_8 · Cited by 2
Design Strategies and Therapeutic Potential of Functionalized Carbon Dots in Nanomedicine
Sethuraman, V., Janakiraman, K., Subramanian, K., & Sampath, G. (2026) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00556-0 · Cited by 2
Brain-targeting nanoplatform repurposing silymarin for enhanced GBM immunotherapy via synergistic mitochondrial suppression
Liu, J., Cheng, W., Tian, H., Wang, Z., Huang, C., & Li, Q. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102951 · Cited by 2
Recent advances in self-assembled nanoplatforms for central nervous system disorders therapy: Design principles, multifunctional strategies, and therapeutic applications
Zhang, W., Wan, L., Chen, Y., Li, S., & Mao, Y. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103083 · Cited by 3
Nanotechnology for efficient delivery of TCM active ingredients in treating brain diseases
Yang, Y., Gao, Y., Li, J., Zou, J., Luan, F., Shi, Y., Zhai, B., & Huang, Q. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103265 · Cited by 2
Microelectrodes enable dynamic biointerfaces for closed-loop organs-on-chips
Luo, H., Zhou, L., Jin, F., Bian, S., Jiang, C., Chen, Y., Li, C., Tuan, R. S., & Li, Z. A. (2026) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2026.103407 · Cited by 2
Reprogramming the oxidative microenvironment: Antioxidant nanoplatforms for central nervous system repair
Lee, J. M., Kim, H. O., Byun, S. W., Kim, Y.-J., Singh, M. K., Kim, S. S., & Yeo, S. G. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103543 · Cited by 2
Recent Advances in Nanocarrier-Based Brain-Targeted Drug Delivery for Effective Treatment of Central Nervous System Disorders
Sarwal, A., Singh, G., Prasad, P., Sharma, S., & Ali, W. (2020) · Springer eBooks · doi:10.1007/978-3-030-41858-8_9 · Cited by 2
Efficient Detection of Droxidopa in the Presence of Carbidopa Using a Modified Screen-Printed Graphite Electrode
Ahmadi, S. A., & Tajik, S. (2023) · Topics in Catalysis · doi:10.1007/s11244-023-01866-9 · Cited by 2
Design of a Novel Drug Delivery Nanosystem that Simultaneously Realizes Real‐Time Tracing and Drug Delivery Across the Blood–Brain Barrier
Wang, X., Qin, L., Song, B., Wu, M., & Liang, W. (2023) · Advanced Materials Interfaces · doi:10.1002/admi.202300738 · Cited by 2
Overcoming Brain Barriers Through Surface-Functionalized Liposomes for Glioblastoma Therapy; Current Status, Challenges and Future Perspective
Dong, C., Yu, X., Jin, K., & Qian, J. (2023) · Nanomedicine · doi:10.2217/nnm-2023-0172 · Cited by 3
Targeted Nano-based Drug Delivery in Alzheimer's Disease and Dementia
Mal, P., Rath, S. K., & Halder, T. (2024) · Smart nanomaterials technology · doi:10.1007/978-981-97-0308-1_12 · Cited by 2
Nanomaterials for Diagnosis and Treatment of Common Neurological Disorders
Kaur, G., Chirayimmel, A. J., Rana, P., Sharma, S., Bose, J. C., Rath, S. K., & Dwibedi, V. (2024) · Smart nanomaterials technology · doi:10.1007/978-981-97-0308-1_8 · Cited by 2
Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review
La, Q. D., Baloch, A., & Lo, D. F. (2025) · Aging and Cancer · doi:10.1002/aac2.70002 · Cited by 3
Living Cell Materials for Advanced Biomedical Applications in Disease Diagnosis, Treatment, and Prevention
Kong, F., Jiang, J., Chernova, E. A., Wuttke, S., Zhu, W., & Lei, Q. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502358 · Cited by 2
Emerging role of gene therapy in stroke recovery
Aderinto, N., Abraham, I. C., Ukoaka, B. M., Moradeyo, A. A., Udam, N. G., Aboje, J. E., Oluwakorede, A. T., Adejumo, F. A., Ojapah, E., Babalola, A. E., et al. (2025) · Brain Network Disorders · doi:10.1016/j.bnd.2025.03.002 · Cited by 2
Effect of Slp4-a on Membrane Bending During Prefusion of Vesicles in Blood-Brain Barrier
Dinh, Q. V., Liu, J., & Dutta, P. (2022) · Journal of Biomechanical Engineering · doi:10.1115/1.4054985 · Cited by 2
Surface Active Ligands for Enhanced Brain Targeting of Nanoparticles
Prabakaran, A., Vashist, R., Sangave, S. D., & Alexander, A. (2024) · Springer eBooks · doi:10.1007/978-981-97-2859-6_9 · Cited by 2

Authors: Xie, J., Shen, Z., Anraku, Y., Kataoka, K., & Chen, X.
Affiliations: Innovation Center of NanoMedicine (JP)
National Institutes of Health (US)
Corresponding author: Shen, Zheyu
Kataoka, Kazunori
Chen, Xiaoyuan
ORCID: Xie, Jinbing
Shen, Zheyu
Anraku, Yasutaka
Kataoka, Kazunori
Chen, Xiaoyuan
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2019-12
Volume: 224
Pages: 119491
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2019.119491
PMC: PMC6915305
OpenAlex: W2973160898
Cited by: 604
References: 236
Citations by year: 2026: 64 · 2025: 131 · 2024: 116 · 2023: 104 · 2022: 92 · 2021: 57 · 2020: 38 · 2019: 2
FWCI: 4.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: blood-brain barrier, BBB crossing, nanomaterials, brain drug delivery, central nervous system disorders, intranasal drug delivery, blood-brain barrier disruption, cell-penetrating peptides, receptor-mediated transcytosis, theranostic agents
MeSH terms: Animals, Blood-Brain Barrier, Central Nervous System Diseases, Clinical Trials as Topic, Disease Models, Animal, Humans, Drug Delivery Systems, Nanostructures

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks