Cited by 604Barrier Structure and Function StudiesNanoparticle-Based Drug DeliveryDrug Transport and Resistance Mechanisms

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Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

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Xie, Jinbing, Shen, Zheyu, Anraku, Yasutaka, Kataoka, Kazunori, Chen, Xiaoyuan·2019·Biomaterials

DOI 10.1016/j.biomaterials.2019.119491PMC PMC6915305

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Abstract

Increasing attention has been paid to the diseases of central nervous system (CNS). The penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to the existence of blood-brain barrier (BBB). Thus, BBB crossing for drug delivery to CNS remains a significant challenge in the development of neurological therapeutics. Because of the advantageous properties (e.g., relatively high drug loading content, controllable drug release, excellent passive and active targeting, good stability, biodegradability, biocompatibility, and low toxicity), nanomaterials with BBB-crossability have been widely developed for the treatment of CNS diseases. This review summarizes the current understanding of the physiological structure of BBB, and provides various nanomaterial-based BBB-crossing strategies for brain delivery of theranostic agents, including intranasal delivery, temporary disruption of BBB, local delivery, cell penetrating peptide (CPP) mediated BBB-crossing, receptor mediated BBB-crossing, shuttle peptide mediated BBB-crossing, and cells mediated BBB-crossing. Clinicians, biologists, material scientists and chemists are expected to be interested in this review.

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Authors: Xie, J., Shen, Z., Anraku, Y., Kataoka, K., & Chen, X.
Affiliations: Innovation Center of NanoMedicine (JP)
National Institutes of Health (US)
Corresponding author: Shen, Zheyu
Kataoka, Kazunori
Chen, Xiaoyuan
ORCID: Xie, Jinbing
Shen, Zheyu
Anraku, Yasutaka
Kataoka, Kazunori
Chen, Xiaoyuan
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2019-12
Volume: 224
Pages: 119491
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2019.119491
PMC: PMC6915305
OpenAlex: W2973160898
Cited by: 604
References: 236
Citations by year: 2026: 64 · 2025: 131 · 2024: 116 · 2023: 104 · 2022: 92 · 2021: 57 · 2020: 38 · 2019: 2
FWCI: 4.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: blood-brain barrier, BBB crossing, nanomaterials, brain drug delivery, central nervous system disorders, intranasal drug delivery, blood-brain barrier disruption, cell-penetrating peptides, receptor-mediated transcytosis, theranostic agents
MeSH terms: Animals, Blood-Brain Barrier, Central Nervous System Diseases, Clinical Trials as Topic, Disease Models, Animal, Humans, Drug Delivery Systems, Nanostructures

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