Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing
Open accessAbstract
The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is the solvatochromism-caused quenching in aqueous solution for the long-wavelength absorbing fluorophores. Herein, we develop a series of anti-quenching pentamethine cyanine fluorophores that significantly overcome the severe solvatochromism, thus affording stable absorption/emission beyond 1000 nm with up to ~ 44-fold enhanced brightness and superior photostability in aqueous solution. These advantages allow for deep optical penetration (8 mm) as well as high-contrast and highly-stable lymphatic imaging superior to clinical-approved indocyanine green. Additionally, these fluorophores exhibit pH-responsive fluorescence, allowing for noninvasive ratiometric fluorescence imaging and quantification of gastric pH in vivo. The results demonstrate reliable accuracy in tissue as deep as 4 mm, comparable to standard pH electrode method. This work unlocks the potential of anti-quenching pentamethine cyanines for NIR-II biological applications.
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Cyanine dyes with varied energy gaps have been designed through structure modifications that allowed the development of fluorophores with emission greater than 1000 nm.
“Cyanine dyes with varied energy gaps have been designed through structure modifications that allowed the development of fluorophores with emission greater than 1000 nm.34−36”
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- Authors
- Wang, S., Fan, Y., Li, D., Sun, C., Lei, Z., Lu, L., Wang, T., & Zhang, F.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Zhang, Fan
- Venue
- Nature Communications
- Published
- 2019-03-05
- Volume
- 10
- Issue
- 1
- Pages
- 1058-1058
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6401027
- OpenAlex
- W2919109663
- Cited by
- 510
- References
- 46
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- FWCI
- 25.26
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- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science and Technology Commission of Shanghai Municipality (17JC1400100, 2017YFA0207303)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- NIR-II fluorescence imaging, solvatochromism, pH-dependent fluorescence, ratiometric pH sensing, lymphatic imaging, photostability, deep tissue imaging, indocyanine green
- MeSH terms
- Animals, Electrodes, Female, Fluorescent Dyes, Gastric Acidity Determination, Hydrogen-Ion Concentration, Injections, Intradermal, Lymph Nodes, Mice, Inbred BALB C, Mice, Inbred ICR, Mice, Nude, Stomach, Tissue Distribution, Phantoms, Imaging, Spectroscopy, Near-Infrared, Models, Animal, Lymphatic Vessels, Mice, Optical Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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