Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy

Dunne, Michael; Regenold, Maximilian; Allen, Christine

doi:10.1016/j.addr.2020.07.007

Cited by 150Ultrasound and Hyperthermia ApplicationsNanoplatforms for cancer theranosticsCancer, Hypoxia, and Metabolism

Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy

Dunne, Michael, Regenold, Maximilian, Allen, Christine·2020·Advanced Drug Delivery Reviews

DOI 10.1016/j.addr.2020.07.007

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Abstract

Hyperthermia has demonstrated clinical success in improving the efficacy of both chemo- and radio-therapy in solid tumors. Pre-clinical and clinical research studies have demonstrated that targeted hyperthermia can increase tumor blood flow and increase the perfused fraction of the tumor in a temperature and time dependent manner. Changes in tumor blood circulation can produce significant physiological changes including enhanced vascular permeability, increased oxygenation, decreased interstitial fluid pressure, and reestablishment of normal physiological pH conditions. These alterations in tumor physiology can positively impact both small molecule and nanomedicine chemotherapy accumulation and distribution within the tumor, as well as the fraction of the tumor susceptible to radiation therapy. Hyperthermia can trigger drug release from thermosensitive formulations and further improve the accumulation, distribution, and efficacy of chemotherapy.

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In solid tumors, hyperthermia increases tumor blood flow and the tumor perfusion fraction in a temperature- and time-dependent manner.
“In solid tumors, hyperthermia increases tumor blood flow and increases the tumor perfusion fraction in a temperature‐ and time‐dependent manner.”
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4 of the 423 references couldn’t be matched to a known paper.

Sorted by citations

The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives
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“As an adjunct to cancer treatment, heat therapy (HT) has a synergistic effect on chemotherapy and radiotherapy (Dunne et al., 2020).”
Background
Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
Ikeda-Imafuku, M., Wang, L. L.-W., Rodrigues, D., Shaha, S., Zhao, Z., & Mitragotri, S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.043 · Cited by 330 · see citing works
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Nanomedicine-based tumor photothermal therapy synergized immunotherapy
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Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors
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Curcumin-Microsphere/IR820 Hybrid Bifunctional Hydrogels for In Situ Osteosarcoma Chemo-co-Thermal Therapy and Bone Reconstruction
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Targeting endothelial permeability in the EPR effect
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Turning down the heat: The case for mild hyperthermia and thermosensitive liposomes
Regenold, M., Bannigan, P., Evans, J. C., Waspe, A. C., Temple, M. J., & Allen, C. J. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102484 · Cited by 103 · see citing works
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Transcytosis-enabled active extravasation of tumor nanomedicine
Zhou, Q., Li, J., Xiang, J., Shao, S., Zhou, Z., Tang, J., & Shen, Y. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114480 · Cited by 101 · see citing works
Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment
Pan, Y., Liu, L., Mou, X., & Cai, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c07763 · Cited by 98 · see citing works
Shape Transformable Strategies for Drug Delivery
Jia, W., Wang, Y., Liu, R., Yu, X., & Gao, H. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009765 · Cited by 95 · see citing works
Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing
Shan, Y., Tan, B., Zhang, M., Xie, X., & Liao, J. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01426-5 · Cited by 80 · see citing works
Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation
Li, T., Jiang, S., Zhang, Y., Luo, J., Li, M., Ke, H., Deng, Y., Yang, T., Sun, X., & Chen, H. (2023) · Nature Communications · doi:10.1038/s41467-023-38128-x · Cited by 80 · see citing works
Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy
Zhang, Y., Zheng, J., Jin, F., Xiao, J., Lan, N., Xu, Z., Xu, Y., Li, Z., Li, C., Cao, D., et al. (2024) · Light Science & Applications · doi:10.1038/s41377-024-01586-z · Cited by 75 · see citing works
Tumor microenvironment-responsive nanozymes achieve photothermal-enhanced multiple catalysis against tumor hypoxia
Lv, W., Cao, M., Liu, J., Hei, Y., & Bai, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.08.015 · Cited by 71 · see citing works
Programmed Lung Metastasis Immunotherapy via Cascade‐Responsive Cell Membrane‐Mimetic Copolymer‐Wrapped Nanoraspberry‐Mediated Elesclomol‐Copper Delivery
Huynh, T. M. H., Luc, V., Chiang, M., Weng, W., Chang, C., Chiang, W., Liu, Y., Chuang, C., Chang, C., & Hu, S. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202401806 · Cited by 69 · see citing works
Safe and efficient 2D molybdenum disulfide platform for cooperative imaging-guided photothermal-selective chemotherapy: A preclinical study
Li, X., Kong, L., Hu, W., Zhang, C., Pich, A., Shi, X., Wang, X., & Xing, L. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.08.004 · Cited by 68 · see citing works
Anti-Tumor Strategies of Photothermal Therapy Combined with Other Therapies Using Nanoplatforms
Xu, R., Wang, S., Guo, Q., Zhong, R., Chen, X., & Xia, X. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030306 · Cited by 67 · see citing works
“Increase of radiosensitivity PTT-induced hyperthermia can improve the sensitivity of tumor cells to radiation by inhibiting DNA repair mechanisms and increasing oxidative stress.”
Influential
An optimal portfolio of photothermal combined immunotherapy
Zeng, W., Li, Z., Chen, H., Zeng, X., & Mei, L. (2022) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2022.100898 · Cited by 65 · see citing works
From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy
Vaupel, P. W., Piazena, H., Notter, M., Thomsen, A. R., Grosu, A., Scholkmann, F., Pockley, A. G., & Multhoff, G. (2023) · Cancers · doi:10.3390/cancers15051394 · Cited by 62 · see citing works
“Based on experimental preclinical and clinical data, it is often concluded that heatinduced increases in TBF are the principal (or even exclusive) drivers of concurrent (“secondary”) changes in the oxygenation status [26] and are principally involved in most of the heat-induced sensitizing mechanisms described above.”
Background
Pyroelectric Janus nanomotors to promote cell internalization and synergistic tumor therapy
Meng, J., Wei, K., Xie, S., Zhang, Z., Ran, P., Zhang, P., & Li, X. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.04.007 · Cited by 58 · see citing works
Image-guided drug delivery in nanosystem-based cancer therapies
Priester, M. I., & ten Hagen, T. L. M. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114621 · Cited by 57 · see citing works
Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality
Xie, X., Zhai, J., Zhou, X., Guo, Z., Lo, P., Zhu, G., Chan, K. W. Y., & Yang, M. (2023) · Advanced Materials · doi:10.1002/adma.202306450 · Cited by 57 · see citing works
Multifunctional stimuli-responsive hybrid nanogels for cancer therapy: Current status and challenges
Ali, A. A., Al–Othman, A., & Al-Sayah, M. H. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.033 · Cited by 57 · see citing works
Recent progress in tannic acid based approaches as a natural polyphenolic biomaterial for cancer therapy: A review
Ghasemian, M., Kazeminava, F., Naseri, A., Mohebzadeh, S., Abbaszadeh, M., Kafil, H. S., & Ahmadian, Z. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115328 · Cited by 55 · see citing works
Cell membrane-based biomimetic technology for cancer phototherapy: Mechanisms, recent advances and perspectives
Li, S., Meng, X., Peng, B., Huang, J., Liu, J., Xiao, H., Li, M., Liu, Y., & Tang, J. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.11.029 · Cited by 54 · see citing works
Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment
Zhang, N., Wang, J., Foiret, J. L., Dai, Z., & Ferrara, K. W. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113906 · Cited by 52 · see citing works
Combination Therapy of Radiation and Hyperthermia, Focusing on the Synergistic Anti-Cancer Effects and Research Trends
Kwon, S., Jung, S., & Baek, S. H. (2023) · Antioxidants · doi:10.3390/antiox12040924 · Cited by 51 · see citing works
“In addition, targeted HT can increase tumor perfusion and blood flow in a temperature- and time-dependent way [5].”
Background
Homogenous multifunctional microspheres induce ferroptosis to promote the anti-hepatocarcinoma effect of chemoembolization
Chen, M., Li, J., Shu, G., Shen, L., Qiao, E., Zhang, N., Fang, S., Chen, X., Zhao, Z., Tu, J., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01385-x · Cited by 52 · see citing works
“The sensitization occurs mostly via increased blood perfusion, increased oxygenation, inhibition of chemotherapy-induced DNA damage repair, and boosting local/systemic immune response according to previous researches [26, 27].”
Background
Tannic acid/Fe3+ complex coated mesoporous silica nanoparticles for controlled drug release and combined chemo-photothermal therapy
Shi, Q., Wu, K., Huang, X., Xu, R., Zhang, W., Bai, J., Du, S., & Han, N. (2021) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2021.126475 · Cited by 48 · see citing works
Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy
Ali, A. A., Abuwatfa, W. H., Al-Sayah, M. H., & Husseini, G. A. (2022) · Nanomaterials · doi:10.3390/nano12203706 · Cited by 50 · see citing works
Dye‐Sensitized Rare Earth Nanoparticles with Up/Down Conversion Luminescence for On‐Demand Gas Therapy of Glioblastoma Guided by NIR‐II Fluorescence Imaging
Liu, Z., Yun, B., Han, Y., Jiang, Z., Zhu, H., Ren, F. Z., & Li, Z. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202102042 · Cited by 46 · see citing works
Electromagnetic Field‐Programmed Magnetic Vortex Nanodelivery System for Efficacious Cancer Therapy
Liu, X., Zhang, Y., Guo, Y. L., Jiao, W., Gao, X., Lee, W. S. V., Wang, Y., Deng, X., He, Y., Jiao, J., et al. (2021) · Advanced Science · doi:10.1002/advs.202100950 · Cited by 44 · see citing works
Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial photothermal therapy
Lima‐Sousa, R., Alves, C. G., Melo, B. L., Costa, F. J. P., Nave, M., Moreira, A. F., Mendonça, A., Correia, I. J., & de Melo‐Diogo, D. (2023) · Biomaterials Science · doi:10.1039/d3bm00845b · Cited by 43 · see citing works
Cutting-Edge Therapies for Lung Cancer
La’ah, A. S., & Chiou, S. (2024) · Cells · doi:10.3390/cells13050436 · Cited by 36 · see citing works
“This process aims to eliminate cancer cells or inhibit their growth without causing harm to normal tissues [147].”
Background
Hyperthermia combined with immune checkpoint inhibitor therapy in the treatment of primary and metastatic tumors
Yang, X., Gao, M., Xu, R., Tao, Y., Wang, L., Wang, B., Zhong, W., He, L., & He, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.969447 · Cited by 36 · see citing works
“At the same time, thermal ablation is similar to surgical treatment, mostly disposable treatment; mild hyperthermia, due to the low energy input, usually requires repeated, longer heating time (> 30 min) to achieve any effect (15).”
Background
In vivo fiber-optic fluorescent sensor for real-time pH monitoring of tumor microenvironment
Li, Z., Lan, N., Cheng, Z., Jin, F., Song, E., Xu, Z., Zhang, Y., Feng, Y., Cai, X., Ran, Y., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152495 · Cited by 34 · see citing works
Ultrasound‐mediated nano‐sized drug delivery systems for cancer treatment: Multi‐scale and multi‐physics computational modeling
Kashkooli, F. M., Hornsby, T. K., Kolios, M. C., & Tavakkoli, J. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1913 · Cited by 33 · see citing works
Synthesis of a versatile mitochondria-targeting small molecule for cancer near-infrared fluorescent imaging and radio/photodynamic/photothermal synergistic therapies
Gao, M., Huang, X., Wu, Z., Wang, L., Yuan, S., Du, Z., Luo, S., Li, R., & Wang, W. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100316 · Cited by 32 · see citing works
Engineered bacteria breach tumor physical barriers to enhance radio-immunotherapy
Zhang, Y., Liu, Y., Li, T., Yang, X., Lang, S., Pei, P., Pei, H., Chang, L., Hu, L. T., Liu, T., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.07.076 · Cited by 30 · see citing works
Triggered release from thermosensitive liposomes improves tumor targeting of vinorelbine
Regenold, M., Kaneko, K., Wang, X., Peng, H., Evans, J. C., Bannigan, P., & Allen, C. J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.010 · Cited by 30 · see citing works
Self-citation
External Basic Hyperthermia Devices for Preclinical Studies in Small Animals
Priester, M. I., Curto, S., van Rhoon, G. C., & ten Hagen, T. L. M. (2021) · Cancers · doi:10.3390/cancers13184628 · Cited by 28 · see citing works
“Application of mild hyperthermia (40–43 ◦C) is able to induce sublethal effects to the target region, which can induce beneficial mechanisms on both a tissue- and cellular level [1,2].”
Background
The Refined Application and Evolution of Nanotechnology in Enhancing Radiosensitivity During Radiotherapy: Transitioning from Gold Nanoparticles to Multifunctional Nanomaterials
Zhang, A., & Gao, L. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s436268 · Cited by 29 · see citing works
“19,20 It serves as a comprehensive cancer treatment approach, supplementing surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy.”
Background
Improving Tumor Targeting and Penetration for Nanoparticle‐Mediated Cancer Therapy
Luo, Z., Chen, C., & Li, S. (2025) · Small Methods · doi:10.1002/smtd.202401860 · Cited by 27 · see citing works
Synergetic Thermal Therapy for Cancer: State-of-the-Art and the Future
Dai, Q., Cao, B., Zhao, S., & Zhang, A. (2022) · Bioengineering · doi:10.3390/bioengineering9090474 · Cited by 26 · see citing works
“(2) Heating enhances vascular permeability, increases oxygenation, decreases interstitial fluid pressure, reestablishes normal physiological pH conditions, thus increases extravasation of the nano-drugs from the bloodstream and cellular uptake of the chemotherapeutic agents, and, finally, enhances the killing effect […”
Background
Improving the Efficacy of Magnetic Nanoparticle-Mediated Hyperthermia Using Trapezoidal Pulsed Electromagnetic Fields as an In Vitro Anticancer Treatment in Melanoma and Glioblastoma Multiforme Cell Lines
Souiade, L., Domingo-Diez, J., Alcaide, C., Gámez, B., Gámez, L., Ramos, M., & Olmedo, J. J. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115933 · Cited by 26 · see citing works
Research progress of hyperthermia in tumor therapy by influencing metabolic reprogramming of tumor cells
Yang, Y., Huangfu, L., Li, H., & Yang, D. (2023) · International Journal of Hyperthermia · doi:10.1080/02656736.2023.2270654 · Cited by 23 · see citing works
“In clinical practice, local hyperthermia raises the intra-tumor temperature to 39–45 � C or higher by external energy, including ultrasound (US), radiofrequency, and microwaves [5].”
Background
Effectiveness of Gold Nanorods of Different Sizes in Photothermal Therapy to Eliminate Melanoma and Glioblastoma Cells
Domingo-Diez, J., Souiade, L., Marta, S., Manzaneda‐González, V., Guerrero‐Martínez, A., Breton, L. M., Isidoro, M. R., Ramírez‐Castillejo, C., Serrano Olmedo, J. J., & Ramos, M. (2023) · Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB) · doi:10.31428/10317/13474 · Cited by 25 · see citing works
Advances in screening hyperthermic nanomedicines in 3D tumor models
Soeiro, J. F., Sousa, F. L., Monteiro, M. V., Gaspar, V. M., Silva, N. J. O., & Mano, J. F. (2024) · Nanoscale Horizons · doi:10.1039/d3nh00305a · Cited by 26 · see citing works
Mechanistic Insights on Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer
Huffman, O. G., Chau, D. B., Dinicu, A., Debernardo, R. L., & Reizes, O. (2023) · Cancers · doi:10.3390/cancers15051402 · Cited by 23 · see citing works
“Hyperthermic treatment involves the administration of controlled heat above the physiologically normal range, ideally targeting the malignant tissue [43,44].”
Background
Photothermal Therapy: A New Approach to Eradicate Cancer
Dash, S. R., & Kundu, C. N. (2021) · Current Nanoscience · doi:10.2174/1573413717666210301112058 · Cited by 23 · see citing works
Influence of lung cancer model characteristics on tumor targeting behavior of nanodrugs
Xu, W., Yang, S., Lu, L., Xu, Q., Wu, S., Zhou, J., Lu, J., Fan, X., Meng, N., Ding, Y., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.026 · Cited by 23 · see citing works
Nanostructure-reinforced multifunctional hydrogels for synergistic cancer therapy
Yousefiasl, S., Ghovvati, M., Mirshafiei, M., Hakimi, F., Azadi, A., Moezzi, S. M. I., Yuan, M., Sefat, F., Zare, I., Maleki, A., et al. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216207 · Cited by 22 · see citing works
Modulating tumor mechanics with nanomedicine for cancer therapy
Zhao, Q., Chen, J., Zhang, Z., Xiao, C., Zeng, H., Chen, X., Yang, X., & Li, Z. (2023) · Biomaterials Science · doi:10.1039/d3bm00363a · Cited by 22 · see citing works
Redox/NIR dual-responsive glutathione extended polyurethane urea electrospun membranes for synergistic chemo-photothermal therapy
Martorana, A., Puleo, G., Miceli, G. C., Cancilla, F., Licciardi, M., Pitarresi, G. L., Tranchina, L., Marrale, M., & Palumbo, F. S. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.125108 · Cited by 21 · see citing works
Unravelling the Triad of Lung Cancer, Drug Resistance, and Metabolic Pathways
Mohanty, P., Pande, B., Acharya, R. K., Bhaskar, L. V., & Verma, H. K. (2024) · Diseases · doi:10.3390/diseases12050093 · Cited by 20 · see citing works
“The goal of this procedure is to eradicate cancer cells or stop their proliferation without endangering healthy tissues [107,108].”
Background
Combined Photothermal Therapy and Cancer Immunotherapy by Immunogenic Hollow Mesoporous Silicon-Shelled Gold Nanorods
Cao, K., Zhou, Y., Shen, Y., Wang, Y., Huang, H., & Zhu, H. (2024) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2024.03.007 · Cited by 20 · see citing works
Multicomponent thermosensitive lipid complexes enhance desmoplastic tumor therapy through boosting anti-angiogenesis and synergistic strategy
Guo, J. X., Zeng, H., Liu, Y., Shi, X., Liu, Y., Liu, C., & Chen, Y. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120533 · Cited by 20 · see citing works
Systematic review of the registered clinical trials for oncological hyperthermia treatment
Peeters, H., van Zwol, E., Brancato, L., da Cunha, M. G. M. C. M., & Bogers, J. (2022) · International Journal of Hyperthermia · doi:10.1080/02656736.2022.2076292 · Cited by 19 · see citing works
“increases the tumor blood flow, permeability, pO2, pH and tumor nutritional status [5].”
Background
Reaching new lights: a review on photo-controlled nanomedicines and their in vivo evaluation
Remmers, R. C. P. A., & Neumann, K. (2023) · Biomaterials Science · doi:10.1039/d2bm01621d · Cited by 20 · see citing works
Hyperthermia and radiotherapy: physiological basis for a synergistic effect
Righini, M. F., Durham, A., & Tsoutsou, P. P. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1428065 · Cited by 19 · see citing works
Advances and applications of hyperthermia in tumor therapy: Mechanisms, techniques, and clinical integration
Gu, C.-H., Zhang, J., Gao, W., Wang, J., Mou, K., Zhang, X., & Qi, J. (2025) · International Communications in Heat and Mass Transfer · doi:10.1016/j.icheatmasstransfer.2025.108895 · Cited by 18 · see citing works
Heat-activated nanomedicine formulation improves the anticancer potential of the HSP90 inhibitor luminespib in vitro
Epp-Ducharme, B., Dunne, M., Fan, L., Evans, J. C., Ahmed, L., Bannigan, P., & Allen, C. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-90585-w · Cited by 18 · see citing works
Self-citation
Progress and potential of nanobubbles for ultrasound-mediated drug delivery
Chen, L. E., Nittayacharn, P., & Exner, A. A. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2505044 · Cited by 16 · see citing works
“On a broader tissue level, mild hyperthermia increases vessel dilation, permeability, and blood flow, which can increase drug penetration into solid tumors [101].”
Thermoelectric and pyroelectric cancer therapy
Kim, H., Kim, C., Hur, S., Song, G., Song, H., Kang, H., & Yoon, J. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217132 · Cited by 16 · see citing works
Unveiling the potential of inorganic nanoarchitecture-mediated photothermal therapy: An illustration on melanoma
Hedaoo, A., Khairnar, P., Vambhurkar, G. B., Srinivasarao, D. A., Negi, M., Shinde, A., & Srivastava, S. (2024) · European Polymer Journal · doi:10.1016/j.eurpolymj.2024.113282 · Cited by 16 · see citing works
Biodegradable photothermal thermosensitive hydrogels treat osteosarcoma by reprogramming macrophages
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Authors: Dunne, M., Regenold, M., & Allen, C.
Affiliations: University of Toronto (CA)
Corresponding author: Dunne, Michael
ORCID: Dunne, Michael
Regenold, Maximilian
Allen, Christine
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2020
Volume: 163-164
Pages: 98-124
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/j.addr.2020.07.007
OpenAlex: W3042726211
Cited by: 150
References: 423
Citations by year: 2026: 22 · 2025: 25 · 2024: 31 · 2023: 29 · 2022: 19 · 2021: 22 · 2020: 2
FWCI: 1.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: hyperthermia, tumor physiology, tumor perfusion, vascular permeability, tumor oxygenation, interstitial fluid pressure, tumor pH, nanomedicine, thermosensitive drug release, radiosensitization, combination therapy
MeSH terms: Hyperthermia, Antineoplastic Agents, Capillary Permeability, Combined Modality Therapy, Humans, Hydrogen-Ion Concentration, Hyperthermia, Induced, Neoplasms, Oxygen, Radiotherapy, Time Factors, Drug Delivery Systems, Tumor Microenvironment, Drug Liberation

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Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy

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