Cited by 484Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCerebrospinal fluid and hydrocephalus

Identifying and validating biomarkers for Alzheimer's disease

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Humpel, Christian·2011·Trends in Biotechnology

Abstract

The identification and validation of biomarkers for diagnosing Alzheimer's disease (AD) and other forms of dementia are increasingly important. To date, ELISA measurement of β-amyloid(1-42), total tau and phospho-tau-181 in cerebrospinal fluid (CSF) is the most advanced and accepted method to diagnose probable AD with high specificity and sensitivity. However, it is a great challenge to search for novel biomarkers in CSF and blood by using modern potent methods, such as microarrays and mass spectrometry, and to optimize the handling of samples (e.g. collection, transport, processing, and storage), as well as the interpretation using bioinformatics. It seems likely that only a combined analysis of several biomarkers will define a patient-specific signature to diagnose AD in the future.

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Authors
Humpel, C.
Affiliations
Innsbruck Medical University (AT)
Corresponding author
Humpel, Christian
Venue
Trends in Biotechnology
Publisher
Elsevier BV
Published
2011-01
Volume
29
Issue
1
Pages
26-32
ISSN
0167-7799 (ISSN-L)
OpenAlex
W1964869332
Cited by
484
References
79
Citations by year
2026: 10 · 2025: 21 · 2024: 14 · 2023: 35 · 2022: 33 · 2021: 47 · 2020: 29 · 2019: 38 · 2018: 48 · 2017: 46 · 2016: 53 · 2015: 33 · 2014: 29 · 2013: 22 · 2012: 16
FWCI
2.11
Type
journal article
Language
en
Open access
Locations
  • Trends in biotechnology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
Keywords
Alzheimer's disease, biomarkers, dementia diagnosis, cerebrospinal fluid, blood biomarkers, amyloid-beta 42, total tau, phosphorylated tau 181, sample handling, mass spectrometry, microarray, bioinformatics, combined biomarker detection
MeSH terms
Alzheimer Disease, Humans, Biomarkers, Amyloid beta-Peptides, tau Proteins

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