Identifying and validating biomarkers for Alzheimer's disease
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The identification and validation of biomarkers for diagnosing Alzheimer's disease (AD) and other forms of dementia are increasingly important. To date, ELISA measurement of β-amyloid(1-42), total tau and phospho-tau-181 in cerebrospinal fluid (CSF) is the most advanced and accepted method to diagnose probable AD with high specificity and sensitivity. However, it is a great challenge to search for novel biomarkers in CSF and blood by using modern potent methods, such as microarrays and mass spectrometry, and to optimize the handling of samples (e.g. collection, transport, processing, and storage), as well as the interpretation using bioinformatics. It seems likely that only a combined analysis of several biomarkers will define a patient-specific signature to diagnose AD in the future.
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In the case of Alzheimer's disease, a biomarker can be used to assess the overall health and diseased condition of aged patients.
“In the case of AD, a biomarker can be used to assess the overall health and diseased condition of aged patients [39, 40].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [40]
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Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
Blennow, K., Hampel, H., Weiner, M., & Zetterberg, H. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.4 · Cited by 1,863 · see citing works
Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease
Clarke, R., Smith, A. D., Jobst, K. A., Refsum, H., Sutton, L., & Ueland, P. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.11.1449 · Cited by 1,408 · see citing works
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
Ray, S., Britschgi, M., Herbert, C., Takeda-Uchimura, Y., Boxer, A., Blennow, K., Friedman, L. F., Galasko, D. R., Jutel, M., Karydas, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1653 · Cited by 1,048 · see citing works
Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14103 · Cited by 943 · see citing works
A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking
Teunissen, C. E., Petzold, A., Bennett, J. L., Berven, F. S., Brundin, L., Comabella, M., Franciotta, D., Frederiksen, J. L., Fleming, J. O., Furlan, R., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c47cc2 · Cited by 845 · see citing works
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
Hampel, H. J., Frank, R., Broich, K., Teipel, S. J., Katz, R. G., Hardy, J., Herholz, K., Bokde, A. L. W., Jessen, F., Hoessler, Y. C., et al. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3115 · Cited by 630 · see citing works
Sjögren, M., Vanderstichele, H., Ågren, H., Zachrisson, O., Edsbagge, M., Wikkelsø, C., Skoog, I., Wallin, A., Wahlund, L.-O., Marcusson, J., et al. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.10.1776 · Cited by 436 · see citing works
Healthy Aging and Dementia: Findings from the Nun Study
Snowdon, D. A. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-5_part_2-200309021-00014 · Cited by 412 · see citing works
Telomere shortening in T cells correlates with Alzheimer's disease status
Panossian, L. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00043-x · Cited by 409 · see citing works
Kuo, H., Yen, C., Chang, C., Kuo, C.-K., Chen, J.-H., & Sorond, F. A. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70099-5 · Cited by 400 · see citing works
Total and phosphorylated tau protein as biological markers of Alzheimer’s disease
Hampel, H., Blennow, K., Shaw, L. M., Hoessler, Y. C., Zetterberg, H., & Trojanowski, J. Q. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.010 · Cited by 389 · see citing works
Abdi, F. A., Quinn, J. F., Jankovic, J. J., McIntosh, M. W., Leverenz, J. B., Peskind, E. R., Nixon, R., Nutt, J. G., Chung, K., Zabetian, C. P., et al. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9309 · Cited by 385 · see citing works
von Zglinicki, T., Serra, V., Lorenz, M., Saretzki, G. C., Lenzen-Großimlinghaus, R., Gessner, R. V., Risch, A., & Steinhagen‐Thiessen, E. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780184 · Cited by 305 · see citing works
MicroRNA Expression in Alzheimer Blood Mononuclear Cells
Schipper, H. M., Maes, O. C., Chertkow, H. M., & Wang, E. (2007) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s361 · Cited by 244 · see citing works
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in clinical chemistry
Marvin, L., Roberts, M., & Fay, L. B. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.08.008 · Cited by 226 · see citing works
Hutchinson, R. W., Cox, A. G., McLeod, C. W., Marshall, P. S., Harper, A. J., Dawson, E. L., & Howlett, D. R. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.08.024 · Cited by 189 · see citing works
Proteomic patterns: their potential for disease diagnosis
Xiao, Z., Prieto, D. A., Conrads, T. P., Veenstra, T. D., & Issaq, H. J. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.10.010 · Cited by 187 · see citing works
Transcriptional profiling of Alzheimer blood mononuclear cells by microarray
Maes, O. C., Xu, S., Yu, B., Chertkow, H. M., Wang, E., & Schipper, H. M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.004 · Cited by 182 · see citing works
Blood-Based Biomarkers of Alzheimer's Disease: Challenging but Feasible
Thambisetty, M., & Lovestone, S. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.84 · Cited by 182 · see citing works
Sunderland, T., Mirza, N., Putnam, K. T., Linker, G., Bhupali, D., Durham, R., Soares, H., Kimmel, L., Friedman, D., Bergeson, J., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.07.021 · Cited by 179 · see citing works
Biomarkers of aging and disease: Introduction and definitions
Sprott, R. L. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.07.008 · Cited by 179 · see citing works
Blasko, I., Lederer, W., OBERBAUER, H., Walch, T., Kemmler, G., Hinterhuber, H., Marksteiner, J., & Humpel, C. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000089137 · Cited by 170 · see citing works
Self-citationVerwey, N. A., van der Flier, W. M., Blennow, K., Clark, C. M., Sokolow, S., Deyn, P. P. D., Galasko, D. R., Hampel, H. J., Hartmann, T., Kapaki, E., et al. (2009) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2009.008232 · Cited by 169 · see citing works
Diagnosis and treatment of Alzheimer’s disease
Desai, A. K., & Grossberg, G. T. (2005) · Neurology · doi:10.1212/wnl.64.12_suppl_3.s34 · Cited by 169 · see citing works
Oe, T., Ackermann, B. L., Inoue, K., Berna, M. J., Garner, C. O., Gelfanova, V., Dean, R. A., Siemers, E., Holtzman, D. M., Farlow, M. R., et al. (2006) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.2787 · Cited by 166 · see citing works
Cerebrospinal fluid markers for prediction of Alzheimer's disease
Zetterberg, H., Wahlund, L., & Blennow, K. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.08.011 · Cited by 162 · see citing works
Teunissen, C. E., Petzold, A., Bennett, J. L., Berven, F. S., Brundin, L., Comabella, M., Franciotta, D. M., Federiksen, J. L., Fleming, J. O., Furlan, R., et al. (2010) · Journal of Laboratory Medicine · doi:10.1515/jlm.2010.001 · Cited by 162 · see citing works
Cedazo-Mı́nguez, Á., & Winblad, B. G. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.09.008 · Cited by 156 · see citing works
CSF biomarkers for mild cognitive impairment
Blennow, K. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01368.x · Cited by 151 · see citing works
Platelet amyloid precursor protein processing: A bio-marker for Alzheimer's disease
Tang, K., Hynan, L. S., Baskin, F., & Rosenberg, R. N. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.09.002 · Cited by 150 · see citing works
Marksteiner, J., Kemmler, G., Weiss, E. M., Knaus, G., Ullrich, C., Mechtcheriakov, S., OBERBAUER, H., Auffinger, S., Hinterhoelzl, J., Hinterhuber, H., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.011 · Cited by 142 · see citing works
Self-citationCSF biomarkers for Alzheimer’s disease: use in early diagnosis and evaluation of drug treatment
Blennow, K. (2005) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.5.5.661 · Cited by 130 · see citing works
Wittke, S., Mischak, H., Walden, M., Kölch, W., Rädler, T., & Wiedemann, K. (2005) · Electrophoresis · doi:10.1002/elps.200410140 · Cited by 128 · see citing works
Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease
Hye, A., Kerr, F., Archer, N. J., Foy, C., Poppe, M., Brown, R. G., Hamilton, G., Powell, J. F., Anderton, B. H., & Lovestone, S. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.10.031 · Cited by 125 · see citing works
Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's disease
Lukens, J. N., Deerlin, V. M. V., Clark, C. M., Xie, S. X., & Johnson, F. B. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.05.666 · Cited by 125 · see citing works
Blood-based biomarkers of microvascular pathology in Alzheimer’s disease
Ewers, M., Mielke, M. M., & Hampel, H. J. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.09.005 · Cited by 121 · see citing works
Amyloid β 38, 40, and 42 species in cerebrospinal fluid: More of the same?
Schoonenboom, N. S. M., Mulder, C., van Kamp, G. J., Mehta, S. P., Scheltens, P., Blankenstein, M. A., & Mehta, P. D. (2005) · Annals of Neurology · doi:10.1002/ana.20508 · Cited by 120 · see citing works
Soares, H. D., Chen, Y., Sabbagh, M. N., Rohrer, A., Schrijvers, E. M. C., & Breteler, M. M. B. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05066.x · Cited by 114 · see citing works
Autoantibodies against β‐amyloid are common in Alzheimer's disease and help control plaque burden
Kellner, A., Matschke, J., Bernreuther, C., Moch, H., Ferrer, I., & Glatzel, M. (2009) · Annals of Neurology · doi:10.1002/ana.21475 · Cited by 113 · see citing works
Amyloid β and APP as biomarkers for Alzheimer’s disease
Zetterberg, H., Blennow, K., & Hanse, E. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.08.002 · Cited by 113 · see citing works
Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer's disease.
Simonsen, A., Mcguire, J., Podust, V., Davies, H., Minthon, L., Skoog, I., Andreasen, N., Wallin, A., Waldemar, G., & Blennow, K. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.01.011 · Cited by 108 · see citing works
Plasma levels of amyloid β-protein 42 are increased in women with mild cognitive impairment
Assini, A., Cammarata, S., Vitali, A., Colucci, M. E. W., Giliberto, L., Borghi, R., Inglese, M. L., Volpe, S., Ratto, S., Dagna-Bricarelli, F., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000137040.64252.ed · Cited by 104 · see citing works
Lewczuk, P., Kornhuber, J., Vanderstichele, H., Vanmechelen, E., Esselmann, H., Bibl, M., Wolf, S., Otto, M., Reulbach, U., Kölsch, H., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.010 · Cited by 95 · see citing works
Biomarkers for neurodegenerative diseases
Henley, S. M. D., Bates, G. P., & Tabrizi, S. J. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000186842.51129.cb · Cited by 90 · see citing works
Brain ubiquitin is markedly elevated in Alzheimer disease
Wang, G. P., Khatoon, S., Iqbal, K., & Grundke, I. (1991) · Brain Research · doi:10.1016/0006-8993(91)91692-t · Cited by 89 · see citing works
Advances in the detection of Alzheimer's disease-use of cerebrospinal fluid biomarkers.
Sjögren, M., Andreasen, N., & Blennow, K. (2003) · Clinica chimica acta; international journal of clinical chemistry · doi:10.1016/s0009-8981(03)00121-9 · Cited by 88 · see citing works
Blood cell markers in Alzheimer Disease: Amyloid Precursor Protein form ratio in platelets
Borroni, B., Agosti, C., Marcello, E. E., Luca, M. D., & Padovani, A. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.08.004 · Cited by 88 · see citing works
Single cell gene expression profiling in Alzheimer’s disease
Ginsberg, S. D., Che, S., Counts, S., & Mufson, E. J. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.05.007 · Cited by 76 · see citing works
Alzheimer disease: correlation of cerebro-spinal fluid and brain ubiquitin levels
Kudo, T., Iqbal, K., Ravid, R., Swaab, D. F., & Grundke, I. (1994) · Brain Research · doi:10.1016/0006-8993(94)91757-4 · Cited by 75 · see citing works
Leuner, K., Pantel, J., Frey, C., Schindowski, K., Schulz, K. L., Wegat, T., Maurer, K., Eckert, A., & Müller, W. E. G. (2007) · Springer eBooks · doi:10.1007/978-3-211-73574-9_27 · Cited by 74 · see citing works
Maddalena, A. S., Papassotiropoulos, A., Gonzalez-Agosti, C., Signorell, A., Hegi, T., Pasch, T., Nitsch, R. M., & Höck, C. (2004) · Neurodegenerative Diseases · doi:10.1159/000080991 · Cited by 74 · see citing works
Noguchi, M., Yoshita, M., Matsumoto, Y., Ono, K., Iwasa, K., & Yamada, M. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.05.015 · Cited by 72 · see citing works
Brettschneider, S., Morgenthaler, N. G., Teipel, S. J., Fischer-Schulz, C., Bürger, K., Dodel, R. C., Du, Y., Möller, H., Bergmann, A., & Hampel, H. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.008 · Cited by 70 · see citing works
Stefani, A., Bernardini, S., Panella, M., Pierantozzi, M., Nuccetelli, M., Koch, G., Urbani, A., Giordano, A., Martorana, A., Orlacchio, A., et al. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.05.016 · Cited by 63 · see citing works
Gene Expression as Peripheral Biomarkers for Sporadic Alzheimer's Disease
Grünblatt, E., Bartl, J., Zehetmayer, S., Ringel, T. M., Bauer, P., Riederer, P. F., & Jacob, C. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0996 · Cited by 59 · see citing works
Olson, L., & Humpel, C. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.011 · Cited by 57 · see citing works
Self-citationUnfolded p53: A Potential Biomarker for Alzheimer's Disease
Lanni, C., Uberti, D. L., Racchi, M., Govoni, S. M., & Memo, M. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12109 · Cited by 55 · see citing works
Marksteiner, J., Hinterhuber, H., & Hinterhuber, C. (2007) · Drugs of today · doi:10.1358/dot.2007.43.6.1067341 · Cited by 52 · see citing works
Increased CSF levels of nerve growth factor in patients with Alzheimer’s disease
Hock, C., Heese, K., Müller-Spahn, F., Huber, P., Riesen, W., Nitsch, R. M., & Otten, U. (2000) · Neurology · doi:10.1212/wnl.54.10.2009 · Cited by 52 · see citing works
Predicting Alzheimer dementia in mild cognitive impairment patients
Borroni, B., Luca, M. D., & Padovani, A. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.06.023 · Cited by 51 · see citing works
Soluble cell adhesion molecules in monocytes of Alzheimer’s disease and mild cognitive impairment
Hochstrasser, T., Weiss, E. M., Marksteiner, J., & Humpel, C. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.005 · Cited by 49 · see citing works
Self-citationBiomarkers for apoptosis in Alzheimer's disease
Ankarcrona, M., & Winblad, B. G. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1260 · Cited by 46 · see citing works
Blasko, I., Kemmler, G., Krampla, W. W., Jungwirth, S., Wichart, I., Jellinger, K. A., Tragl, K. H., & Fischer, P. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.006 · Cited by 46 · see citing works
Biomarkers of inflammation and amyloid-β phagocytosis in patients at risk of Alzheimer disease
Fiala, M., & Veerhuis, R. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.08.003 · Cited by 45 · see citing works
Protein kinase C as a peripheral biomarker for Alzheimer’s disease
de Barry, J., Mbebi, C., & Janoshazi, A. K. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.015 · Cited by 45 · see citing works
Tacconi, S., Perri, R., Balestrieri, E., Grelli, S., Bernardini, S., Annichiarico, R., Mastino, A., Caltagirone, C., & Macchi, B. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.07.009 · Cited by 44 · see citing works
Ubiquitin–proteasome pathway is compromised in CD45RO+ and CD45RA+ T lymphocyte subsets during aging
Ponnappan, U. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00203-0 · Cited by 41 · see citing works
Apoptosis of CD4+ T and Natural Killer Cells in Alzheimer's Disease
Schindowski, K., Peters, J., Gorriz, C., Schramm, U., Weinandi, T., Leutner, S., Maurer, K., Frölich, L., Müller, W. E. G., & Eckert, A. (2006) · Pharmacopsychiatry · doi:10.1055/s-2006-954591 · Cited by 39 · see citing works
Gustaw‐Rothenberg, K., Siedlak, S. L., Bonda, D., Lerner, A. J., Tabaton, M., Perry, G. L., & Smith, M. A. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.003 · Cited by 39 · see citing works
Ho, L., Fivecoat, H. C., Wang, J., & Pasinetti, G. M. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.09.007 · Cited by 37 · see citing works
Problems Associated with Biological Markers of Alzheimer’s Disease
Frey, H. J., Mattila, K. M., Korolainen, M. A., & Pirttilä, T. (2005) · Neurochemical Research · doi:10.1007/s11064-005-8827-7 · Cited by 36 · see citing works
Baird, D. M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.09.009 · Cited by 30 · see citing works
Ullrich, C., Mlekusch, R., Kuschnig, A., Marksteiner, J., & Humpel, C. (2010) · Current Alzheimer Research · doi:10.2174/156720510792231766 · Cited by 29 · see citing works
Self-citationAre Peripheral Blood Cells From Patients With Alzheimer Disease More Sensitive to Apoptotic Stimuli?
Bergman, M., Salman, H., Beloosesky, Y., Djaldetti, M., & Bessler, H. (2002) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200207000-00005 · Cited by 26 · see citing works
Singer, D. L., Soininen, H. S., Alafuzoff, I. I., & Hoffmann, R. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-3208-8 · Cited by 21 · see citing works
Marksteiner, J., & Humpel, C. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.02.007 · Cited by 16 · see citing works
Self-citationBlasko, I., Kemmler, J., Krampla, W. W., Jungwirt, S., Wichard, I., Jellinger, K. A., Tragl, K. H., & Fischer, P. A. (2005) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2005.06.081 · Cited by 15 · see citing works
Frankfort, S. V., van Campen, J., Tulner, L. R., & Beijnen, J. H. (2008) · Current Clinical Pharmacology · doi:10.2174/157488408785747665 · Cited by 11 · see citing works
Oh, J. H., Pan, S., Zhang, J., & Gao, J. (2010) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4407 · Cited by 8 · see citing works
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Hamley, I. W. (2012) · Chemical Reviews · doi:10.1021/cr3000994 · Cited by 881 · see citing works
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820 · see citing works
“In the case of AD, a biomarker can be used to assess the overall health and diseased condition of aged patients [39, 40].”
BackgroundCirculating miRNA Biomarkers for Alzheimer's Disease
Kumar, P., Dezső, Z., MacKenzie, C. J., Oestreicher, J., Agoulnik, S. I., Byrne, M., Bernier, F., Yanagimachi, M., Aoshima, K., & Oda, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069807 · Cited by 386 · see citing works
Advances in the development of biomarkers for epilepsy
Pitkänen, A., Löscher, W., Vezzani, A., Becker, A. J., Simonato, M., Łukasiuk, K., Gröhn, O. H. J., Bankstahl, J. P., Friedman, A., Aronica, E., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00112-5 · Cited by 370 · see citing works
Recent Advances in 2D Material Theory, Synthesis, Properties, and Applications
Lin, Y., Torsi, R., Younas, R., Hinkle, C. L., Rigosi, A. F., Hill, H. M., Zhang, K., Huang, S., Shuck, C. E., Chen, C., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c12759 · Cited by 354 · see citing works
Lewczuk, P., Riederer, P. F., O’Bryant, S. E., Verbeek, M. M., Dubois, B., Visser, P. J., Jellinger, K. A., Engelborghs, S., Ramı́rez, A., Parnetti, L., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1375556 · Cited by 308 · see citing works
Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment
Folch, J., Petrov, D., Ettcheto, M., Abad, S., Sánchez-López, E., García, M. L., Olloquequi, J., Beas-Zarate, C., Auladell, C., & Camins, A. (2016) · Neural Plasticity · doi:10.1155/2016/8501693 · Cited by 270 · see citing works
(2012) · PubMed Central · Cited by 248 · see citing works
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Baru, P. C. R. (2014) · ADVANCED SCIENCES INDEX · Cited by 236 · see citing works
Adefegha, S. A. (2017) · Journal of Dietary Supplements · doi:10.1080/19390211.2017.1401573 · Cited by 226 · see citing works
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Devitt, G., Howard, K., Mudher, A. K., & Mahajan, S. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00413 · Cited by 208 · see citing works
Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain
Raj, D., Yin, Z., Breur, M., Doorduin, J., Holtman, I. R., Olah, M., Mantingh-Otter, I. J., Van Dam, D., De Deyn, P. P., den Dunnen, W., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00206 · Cited by 180 · see citing works
Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease: Current Evidence and Future Perspectives
McGrowder, D. A., Miller, F. G., Vaz, K., Nwokocha, C. R., Wilson-Clarke, C. F., Anderson, M., Brown, J., Anderson-Jackson, L., Williams, L., Latore, L., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11020215 · Cited by 167 · see citing works
Differential diagnosis of Alzheimer’s disease using spectrochemical analysis of blood
Paraskevaidi, M., Morais, C. L. M., Lima, K. M. G., Snowden, J. S., Saxon, J. A., Richardson, A. M. T., Jones, M. S., Mann, D. M. A., Allsop, D., Martin‐Hirsch, P. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701517114 · Cited by 163 · see citing works
Marksteiner, J., Blasko, I., Kemmler, G., Koal, T., & Humpel, C. (2017) · Metabolomics · doi:10.1007/s11306-017-1297-5 · Cited by 158 · see citing works
Self-citationCosín‐Tomás, M., Antonell, A., Lladó, A., Alcolea, D. A., Fortea, J., Ezquerra, M., Lleó, A., Martı́, M. J., Pallàs, M., Sánchez‐Valle, R., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0088-8 · Cited by 157 · see citing works
Townley, R. A., Graff-Radford, J., Mantyh, W. G., Botha, H., Polsinelli, A. J., Przybelski, S. A., Machulda, M. M., Makhlouf, A. T., Senjem, M. L., Murray, M. E., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa068 · Cited by 145 · see citing works
Rotman, M., Welling, M. M., Bunschoten, A., de Backer, M. E., Rip, J., Nabuurs, R. J. A., Gaillard, P. J., van Buchem, M. A., van der Maarel, S. M., & van der Weerd, L. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.02.012 · Cited by 152 · see citing works
The diagnostic value of FDG and amyloid PET in Alzheimer’s disease—A systematic review
Rice, L., & Bisdas, S. (2017) · European Journal of Radiology · doi:10.1016/j.ejrad.2017.07.014 · Cited by 150 · see citing works
Mitochondrial Dysfunction in Alzheimer’s Disease: A Biomarker of the Future?
Bell, S., Barnes, K., Marco, M. D., Shaw, P. J., Ferraiuolo, L., Blackburn, D. J., Venneri, A., & Mortiboys, H. (2021) · Biomedicines · doi:10.3390/biomedicines9010063 · Cited by 136 · see citing works
Biosensors for Alzheimer's disease biomarker detection: A review
Shui, B., Tao, D., Florea, A., Cheng, J., Zhao, Q., Gu, Y., Li, W., Jaffrezic-Renault, N. J., Mei, Y., & Guo, Z. (2018) · Biochimie · doi:10.1016/j.biochi.2017.12.015 · Cited by 136 · see citing works
Retinal imaging in Alzheimer’s disease
Cheung, C. Y.-L., Mok, V., Foster, P. J., Trucco, E., Chen, C., & Wong, T. Y. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-325347 · Cited by 134 · see citing works
Animal models of Alzheimer disease: historical pitfalls and a path forward
Cavanaugh, S. E. (2014) · ALTEX · doi:10.14573/altex.1310071 · Cited by 132 · see citing works
When Does Alzheimer′s Disease Really Start? The Role of Biomarkers
Lloret, A., Esteve, D., Lloret, M.-A., Cervera-Ferri, A., Lopez, B., Nepomuceno, M., & Monllor, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225536 · Cited by 131 · see citing works
Telomere length is age-dependent and reduced in monocytes of Alzheimer patients
Hochstrasser, T., Marksteiner, J., & Humpel, C. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.11.012 · Cited by 132 · see citing works
Self-citationRyzhikova, E., Ralbovsky, N. M., Sikirzhytski, V., Kazakov, O., Halámková, L., Quinn, J. F., Zimmerman, E. A., & Lednev, I. K. (2020) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2020.119188 · Cited by 131 · see citing works
Neurotheranostics as Personalized Medicines
Kevadiya, B. D., Ottemann, B. M., Thomas, M. B., Mukadam, I., Nigam, S., McMillan, J., Gorantla, S., Bronich, T. K., Edagwa, B., & Gendelman, H. E. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.011 · Cited by 124 · see citing works
Molecular and cellular pathophysiology of preclinical Alzheimer’s disease
Mufson, E. J., Ikonomović, M. D., Counts, S., Perez, S. E., Malek‐Ahmadi, M. H., Scheff, S. W., & Ginsberg, S. D. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.030 · Cited by 129 · see citing works
A Review of Fermented Foods with Beneficial Effects on Brain and Cognitive Function
Kim, B., Hong, V. M., Yang, J., Hyun, H., Im, J. J., Hwang, J., Yoon, S. J., & Kim, J. E. (2016) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2016.21.4.297 · Cited by 128 · see citing works
Yang, C., Yang, S., Chieh, J.-J., Horng, H. E., Hong, C., Yang, H.-C., Chen, K. H., Shih, B.-Y., Chen, T., & Chiu, M. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn200028j · Cited by 123 · see citing works
Byun, M. S., Yi, D., Lee, J. H., Choe, Y. M., Sohn, B. K., Lee, J., Choi, H. J., Baek, H., Kim, Y. K., Lee, Y., et al. (2017) · Psychiatry Investigation · doi:10.4306/pi.2017.14.6.851 · Cited by 116 · see citing works
Current applications of antibody microarrays
Chen, Z., Dodig‐Crnković, T., Schwenk, J. M., & Tao, S. (2018) · Clinical Proteomics · doi:10.1186/s12014-018-9184-2 · Cited by 121 · see citing works
Rezabakhsh, A., Rahbarghazi, R., & Fathi, F. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112511 · Cited by 120 · see citing works
Kim, D., Baik, S. H., Kang, S., Cho, S. W., Bae, J., Cha, M.-Y., Sailor, M. J., Mook‐Jung, I., & Ahn, K. H. (2016) · ACS Central Science · doi:10.1021/acscentsci.6b00309 · Cited by 112 · see citing works
MicroRNA in Alzheimer’s disease: an exploratory study in brain, cerebrospinal fluid and plasma
Bekris, L. M., Lutz, F., Montine, T. J., Yu, C., Tsuang, D. W., Peskind, E. R., & Leverenz, J. B. (2013) · Biomarkers · doi:10.3109/1354750x.2013.814073 · Cited by 112 · see citing works
Klavins, K., Koal, T., Dallmann, G., Marksteiner, J., Kemmler, G., & Humpel, C. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.05.003 · Cited by 110 · see citing works
Self-citationBrain-age is associated with progression to dementia in memory clinic patients
Biondo, F., Jewell, A., Pritchard, M., Aarsland, D., Steves, C. J., Mueller, C., & Cole, J. H. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103175 · Cited by 110 · see citing works
Alzheimer’s Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid
Huynh, R. A., & Mohan, C. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00102 · Cited by 109 · see citing works
Biomarkers in Sporadic and Familial Alzheimer’s Disease
Lista, S., O’Bryant, S. E., Blennow, K., Dubois, B., Hugon, J., Zetterberg, H., & Hampel, H. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-143006 · Cited by 106 · see citing works
Plasma Aβ but Not Tau is Related to Brain PiB Retention in Early Alzheimer’s Disease
Tzen, K., Yang, S., Chen, T., Cheng, T.-W., Horng, H. E., Wen, H.-P., Huang, Y.-Y., Shiue, C., & Chiu, M. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500101j · Cited by 103 · see citing works
Cascaded multi-modal mixing transformers for Alzheimer’s disease classification with incomplete data
Liu, L., Liu, S., Zhang, L., To, X. V., Nasrallah, F., & Chandra, S. S. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120267 · Cited by 101 · see citing works
Puthiyedth, N., Riveros, C., Berretta, R. E., & Moscato, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152342 · Cited by 103 · see citing works
García-Morales, V., González-Acedo, A., Melguizo-Rodríguez, L., Pardo-Moreno, T., Costela-Ruiz, V. J., Montiel-Troya, M., & Ramos-Rodríguez, J. J. (2021) · Biomedicines · doi:10.3390/biomedicines9121910 · Cited by 104 · see citing works
Alosco, M. L., Tripodis, Y., Jarnagin, J., Baugh, C. M., Martin, B. M., Chaisson, C. E., Estochen, N., Song, L., Cantu, R. C., Jeromin, A., et al. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.11.003 · Cited by 100 · see citing works
Chemical sensing platforms for detecting trace-level Alzheimer's core biomarkers
Kim, K., Lee, C. H., & Park, C. B. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00107d · Cited by 101 · see citing works
Koal, T., Klavins, K., Seppi, D., Kemmler, G., & Humpel, C. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142319 · Cited by 98 · see citing works
Self-citationVanda, D., Zajdel, P., & Soural, M. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111569 · Cited by 97 · see citing works
Mak, A. C. Y., Pullinger, C. R., Tang, L. F., Wong, J. S., Deo, R. C., Schwarz, J.-M., Gugliucci, A., Movsesyan, I., Ishida, B. Y., Chu, C., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2011 · Cited by 96 · see citing works
Recent trends in analytical approaches for detecting neurotransmitters in Alzheimer's disease
Sangubotla, R., & Kim, J. (2018) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.05.014 · Cited by 95 · see citing works
Biosensors for detection of Tau protein as an Alzheimer's disease marker
Ameri, M., Shabaninejad, Z., Movahedpour, A., Sahebkar, A., Mohammadi, S., Hosseindoost, S., Ebrahimi, M. S., Savardashtaki, A., Karimipour, M., & Mirzaei, H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.239 · Cited by 95 · see citing works
Amylin Uncovered: A Review on the Polypeptide Responsible for Type II Diabetes
Pillay, K., & Govender, P. (2013) · BioMed Research International · doi:10.1155/2013/826706 · Cited by 94 · see citing works
Plasma biomarkers predict Alzheimer’s disease before clinical onset in Chinese cohorts
Cai, H., Pang, Y., Fu, X., Ren, Z., & Jia, L. (2023) · Nature Communications · doi:10.1038/s41467-023-42596-6 · Cited by 92 · see citing works
Raman Spectroscopy to Diagnose Alzheimer’s Disease and Dementia with Lewy Bodies in Blood
Paraskevaidi, M., Morais, C. L. M., Halliwell, D. E., Mann, D. M. A., Allsop, D., Martin‐Hirsch, P. L., & Martin, F. L. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00198 · Cited by 90 · see citing works
The MiRNA Journey from Theory to Practice as a CNS Biomarker
Stoicea, N., Du, A., Lakis, D. C., Tipton, C. B., Arias-Morales, C. E., & Bergese, S. D. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00011 · Cited by 89 · see citing works
Amyloid-beta and depression in healthy older adults: A systematic review
Harrington, K., Lim, Y. Y., Gould, E., & Maruff, P. T. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414557161 · Cited by 88 · see citing works
Exploring Biomarkers for Alzheimer’s Disease
Sharma, N. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/18828.8166 · Cited by 86 · see citing works
Protein microarray technology: how far off is routine diagnostics?
Cretich, M., Damin, F., & Chiari, M. (2013) · The Analyst · doi:10.1039/c3an01619f · Cited by 85 · see citing works
Song, L., Lachno, D. R., Hanlon, D., Shepro, A., Jeromin, A., Gemani, D., Talbot, J. A., Racke, M. M., Dage, J. L., & Dean, R. A. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0225-7 · Cited by 85 · see citing works
Complexity Measures for Quantifying Changes in Electroencephalogram in Alzheimer’s Disease
Al-Nuaimi, A. H. H., Jammeh, E., Sun, L., & Ifeachor, E. (2018) · Complexity · doi:10.1155/2018/8915079 · Cited by 82 · see citing works
Olfactory Dysfunction as a Global Biomarker for Sniffing out Alzheimer’s Disease: A Meta-Analysis
Kotecha, A., Corrêa, A., Fisher, K., & Rushworth, J. V. (2018) · Biosensors · doi:10.3390/bios8020041 · Cited by 82 · see citing works
Lisi, S., Scarano, S., Fedeli, S., Pascale, E., Cicchi, S., Ravelet, C., Peyrin, É., & Minunni, M. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.08.078 · Cited by 81 · see citing works
Sharma, S., & Mandal, P. K. (2022) · ACM Computing Surveys · doi:10.1145/3492865 · Cited by 86 · see citing works
Ji, M., Yuan, H., Zhang, G.-F., Li, X., Dong, L., Li, W., Zhou, Z., & Yang, J. (2012) · Journal of Anesthesia · doi:10.1007/s00540-012-1506-3 · Cited by 78 · see citing works
Gagni, P., Solá, L., Cretich, M., & Chiari, M. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.03.077 · Cited by 78 · see citing works
Role of Hemichannels in CNS Inflammation and the Inflammasome Pathway
Kim, Y., Davidson, J. O., Gunn, K. C., Phillips, A. R. J., Green, C. R., & Gunn, A. J. (2015) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2015.12.001 · Cited by 75 · see citing works
Recent advances in optical biosensing approaches for biomarkers detection
Akgönüllü, S., & Deni̇zli̇, A. (2022) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2022.100269 · Cited by 75 · see citing works
Piubelli, L., Pollegioni, L., Rabattoni, V., Mauri, M. F., Cariddi, L. P., Versino, M., & Sacchi, S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01202-3 · Cited by 74 · see citing works
Cholinesterases as Biomarkers for Parasympathetic Dysfunction and Inflammation-Related Disease
Shenhar‐Tsarfaty, S., Berliner, S., Bornstein, N. M., & Soreq, H. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0176-4 · Cited by 73 · see citing works
Adav, S. S., & Sze, S. K. (2016) · Molecular Brain · doi:10.1186/s13041-016-0272-9 · Cited by 72 · see citing works
Fekete, Z., & Pongracz, A. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.12.096 · Cited by 72 · see citing works
Li, S., Lin, C.-W., Wei, K., Huang, C.-Y., Hsu, P., Liu, H.-L., Lin, Y.-J., Lin, S.-C., Yang, H., & Ma, C.-C. M. (2016) · Scientific Reports · doi:10.1038/srep25155 · Cited by 70 · see citing works
Lee, J., Fu, Z., Chung, M. C., Jang, D.-J., & Lee, H. (2018) · Nutrition Journal · doi:10.1186/s12937-018-0387-1 · Cited by 71 · see citing works
Gene therapy for neurological disorders
Choong, C., Baba, K., & Mochizuki, H. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2016.1114096 · Cited by 69 · see citing works
Kim, C.-B., Choi, Y. Y., Song, W. K., & Song, K. (2013) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.5.051205 · Cited by 66 · see citing works
Recent advances in biosensors for neurodegenerative disease detection
Ganesh, H. V. S., Chow, A. M., & Kerman, K. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2016.02.012 · Cited by 68 · see citing works
Mai, T. D., Ferraro, D., Aboud, N., Renault, R., Serra, M., Tran, N. T., Viovy, J., Smadja, C., Descroix, S., & Taverna, M. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.09.003 · Cited by 68 · see citing works
Lloret, M.-A., Cervera-Ferri, A., Nepomuceno, M., Monllor, P., Esteve, D., & Lloret, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031168 · Cited by 68 · see citing works
Lichtenegger, A., Harper, D. J., Augustin, M., Eugui, P., Muck, M., Gesperger, J., Hitzenberger, C. K. F., Wöehrer, A., & Baumann, B. (2017) · Biomedical Optics Express · doi:10.1364/boe.8.004007 · Cited by 67 · see citing works
Sharma, A., Pachauri, V., & Flora, S. J. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01247 · Cited by 67 · see citing works
Amor-Gutiérrez, O., Costa‐Rama, E., Varas, N. A., Martínez-Rodríguez, C., Novelli, A., Fernández‐Sánchez, M. T., & Costa‐García, A. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.09.042 · Cited by 67 · see citing works
Mordechai, S., Shufan, E., Katz, B. S. P., & Salman, A. (2016) · The Analyst · doi:10.1039/c6an01580h · Cited by 66 · see citing works
Lisi, S., Fiore, E., Scarano, S., Pascale, E., Boehman, Y., Ducongè, F., Chierici, S., Minunni, M., Peyrin, É., & Ravelet, C. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.07.029 · Cited by 66 · see citing works
Scarano, S., Lisi, S., Ravelet, C., Peyrin, É., & Minunni, M. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.08.008 · Cited by 65 · see citing works
Moguilner, S., García, A. M., Perl, Y. S., Tagliazucchi, E., Piguet, O., Kumfor, F., Reyes, P., Matallana, D., Sedeño, L., & Ibáñez, A. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2020.117522 · Cited by 63 · see citing works
Giacomelli, C., Daniele, S., & Martini, C. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.01.017 · Cited by 64 · see citing works
BACE1 as a Potential Biomarker for Alzheimer's Disease
Decourt, B., & Sabbagh, M. N. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110017 · Cited by 61 · see citing works
Smailagic, N., Lafortune, L., Kelly, S., Hyde, C., & Brayne, C. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-171125 · Cited by 61 · see citing works
Yang, S. J., Lee, J. U., Jeon, M. J., & Sim, S. J. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.339445 · Cited by 59 · see citing works
Blood-based biomarkers of cerebral small vessel disease
Wu, L., Chai, Y. L., Cheah, I. K.-M., Chia, R. S. L., Hilal, S., Arumugam, T. V., Chen, C., & Lai, M. K. P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102247 · Cited by 62 · see citing works
Detection of Aβ Monomers and Oligomers: Early Diagnosis of Alzheimer's Disease
Zhou, Y., Liu, L., Hao, Y., & Xu, M. (2016) · Chemistry - An Asian Journal · doi:10.1002/asia.201501355 · Cited by 61 · see citing works
Clinical applications of MALDI imaging technologies in cancer and neurodegenerative diseases
Uçal, Y., Durer, Z. A. O., Atak, H., Kadioglu, E., Şahin, B., Coşkun, A., Baykal, A. T., & Özpınar, A. (2017) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2017.01.005 · Cited by 57 · see citing works
Bachli, M. B., Sedeño, L., Ochab, J. K., Piguet, O., Kumfor, F., Reyes, P., Torralva, T., Roca, M., Cardona, J. F., Campo, C. G., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2019.116456 · Cited by 57 · see citing works
Biosensor approaches on the diagnosis of neurodegenerative diseases: Sensing the past to the future
Karaboğa, M. N. S., & Sezgintürk, M. K. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114479 · Cited by 58 · see citing works
Xu, X., Huang, Y. M., Wang, G., & Chen, S. (2012) · Neuroscience Bulletin · doi:10.1007/s12264-012-1272-0 · Cited by 57 · see citing works
Plagg, B., Ehrlich, D., Kniewallner, K. M., Marksteiner, J., & Humpel, C. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150710114256 · Cited by 58 · see citing works
Self-citationLeko, M. B., Borovečki, F., Dejanović, N., Hof, P. R., & Šimić, G. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150705 · Cited by 56 · see citing works
Sedeño, L., Piguet, O., Abrevaya, S., Desmaras, H., García‐Cordero, I., Baez, S., Alethia de la Fuente, L., Reyes, P., Tu, S., Moguilner, S., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23627 · Cited by 55 · see citing works
Epilepsy and its neurobehavioral comorbidities: Insights gained from animal models
Löscher, W., & Stafstrom, C. E. (2022) · Epilepsia · doi:10.1111/epi.17433 · Cited by 61 · see citing works
A review of neuroimaging biomarkers of Alzheimer's disease.
Varghese, T., Sheelakumari, R., James, J. S., & Mathuranath, P. S. (2013) · PubMed · Cited by 55 · see citing works
Murakami, K., Tokuda, M., Suzuki, T., Irie, Y., Hanaki, M., Izuo, N., Monobe, Y., Akagi, K., Ishii, R., Tatebe, H., et al. (2016) · Scientific Reports · doi:10.1038/srep29038 · Cited by 55 · see citing works
- Authors
- Humpel, C.
- Affiliations
- Innsbruck Medical University (AT)
- Corresponding author
- Humpel, Christian
- ORCID
- Humpel, Christian
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 29
- Issue
- 1
- Pages
- 26-32
- ISSN
- 0167-7799 (ISSN-L)
- PMC
- PMC3016495
- OpenAlex
- W1964869332
- Cited by
- 484
- References
- 79
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 14 · 2023: 35 · 2022: 33 · 2021: 47 · 2020: 29 · 2019: 38 · 2018: 48 · 2017: 46 · 2016: 53 · 2015: 33 · 2014: 29 · 2013: 22 · 2012: 16
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in biotechnology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- Alzheimer's disease, biomarkers, dementia diagnosis, cerebrospinal fluid, blood biomarkers, amyloid-beta 42, total tau, phosphorylated tau 181, sample handling, mass spectrometry, microarray, bioinformatics, combined biomarker detection
- MeSH terms
- Alzheimer Disease, Humans, Biomarkers, Amyloid beta-Peptides, tau Proteins
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