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Cited by 317Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.

Executive Dysfunction and the Course of Geriatric Depression

Alexopoulos, George S., Kiosses, Dimitris N., Heo, Moonseong, Murphy, Christopher F., Shanmugham, Bindu, Gunning-Dixon, Faith·2005·Biological Psychiatry
DOI 10.1016/j.biopsych.2005.04.024
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Abstract

Background Executive dysfunction is common in geriatric depression and persists after improvement of depressive symptoms. This study examined the relationship of executive impairment to the course of depressive symptoms among elderly patients with major depression.Methods A total of 112 nondemented elderly patients with major depression participated in an 8-week citalopram trial at a target daily dose of 40 mg. Executive functions were assessed with the initiation/perseveration subscale of the Dementia Rating Scale and the Stroop Color-Word test. Medical burden was rated with the Cumulative Illness Rating Scale.Results Both abnormal initiation/perseveration and abnormal Stroop Color-Word scores were associated with an unfavorable response of geriatric depression to citalopram. In particular, initiation/perseveration scores below the median (< or =35) and Stroop scores at the lowest quartile (< or =22) predicted limited change in depressive symptoms. Impairment in other Dementia Rating Scale cognitive domains did not significantly influence the outcome of depression.Conclusions Executive dysfunction increases the risk for poor response of geriatric depression to citalopram. Because executive functions require frontostriatal-limbic integrity, this observation provides the rationale for investigation of the role of specific frontostriatal-limbic pathways in perpetuating geriatric depression. Depressed elderly patients with executive dysfunction require vigilant clinical attention because they might be at risk to fail treatment with a selective serotonin reuptake inhibiting antidepressant.

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Research works printed but not linked: 2

  1. Bezchlibnyk-Butler, 2000, CitalopramA review of pharmacological and clinical effects, J Psychiatry Neurosci, 25, 241
  2. Sakai, 1998, Transition of brain activation from frontal to parietal areas in visuomotor sequence learning, J Neurosci, 18, 1827, 10.1523/JNEUROSCI.18-05-01827.1998 · DOI

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Metadata

Authors
Alexopoulos, G. S., Kiosses, D. N., Heo, M., Murphy, C. F., Shanmugham, B., & Gunning-Dixon, F.
Affiliations
Cornell University (US)
Corresponding author
Alexopoulos, George S.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-08
Volume
58
Issue
3
Pages
204-210
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2005.04.024
OpenAlex
W2030120831
Cited by
317
References
57
Citations by year
2026: 9 · 2025: 9 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 21 · 2017: 18 · 2016: 13 · 2015: 21 · 2014: 15 · 2013: 24 · 2012: 25
FWCI
9.20
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (P30MH068638, R01-MH51842, R01MH042819, R01MH065653)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
executive dysfunction, geriatric depression, citalopram, treatment response prediction, Stroop task, Mattis Dementia Rating Scale, medical burden, selective serotonin reuptake inhibitors, cognitive impairment
MeSH terms
Aged, Aged, 80 and over, Antidepressive Agents, Demography, Depression, Female, Humans, Learning Disabilities, Male, Neuropsychological Tests, Predictive Value of Tests, Problem Solving, Psychiatric Status Rating Scales, Time Factors, Citalopram, Geriatric Assessment, Multivariate Analysis

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