Cited by 277Neural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeurotransmitter Receptor Influence on Behavior

The Role of Functional Neuroimaging in the Neuropsychology of Depression

Liotti, Mario, Mayberg, Helen S.·2001·Journal of Clinical and Experimental Neuropsychology

Abstract

Depressed individuals show impaired performance in tests of attention and concentration. They also exhibit PET resting state abnormalities in dorsal prefrontal cortex and anterior cingulate, regions known to be substrates of attentional processing in healthy individuals. This chapter outlines a strategy to study neuropsychological mechanisms in emotional disorders using functional imaging methods. It reviews evidence strongly implicating the dorsolateral prefrontal cortex, particularly in the right hemisphere, as a key brain structure in emotion/cognition interactions in negative mood states. It will be argued that this neocortical region is a crucial convergence zone, being the substrate of sustained attention to the external environment, and the main target of limbic-cortical influences during changes in mood state across health and disease.

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Crossref · 10.1076/jcen.23.1.121.1223

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47 of 47 references verified0 citation errors · 0 not checkable

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  • Human functional imaging and postmortem tissue studies have identified abnormalities in several brain regions, including nuclei within the brain's reward pathway, in major depressive disorder.

    “human functional imaging and postmortem tissue studies have identified abnormalities in several brain regions [2–6] including nuclei within the brain’s reward pathway.”

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Authors
Liotti, M., & Mayberg, H. S.
Venue
Journal of Clinical and Experimental Neuropsychology
Published
2001-02
Volume
23
Issue
1
Pages
121-136
ISSN
  • 0165-0475 (ISSN-L)
  • 1380-3395
  • 1744-411X
OpenAlex
W2160750591
Cited by
277
References
47
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 9 · 2017: 11 · 2016: 8 · 2015: 15 · 2014: 6 · 2013: 16 · 2012: 17
FWCI
8.02
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical and Experimental Neuropsychology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
depression, functional neuroimaging, attention, sustained attention, dorsolateral prefrontal cortex, right hemisphere, anterior cingulate cortex, resting-state brain activity, emotion-cognition interaction, mood states, PET
MeSH terms
Affect, Attention, Depression, Dominance, Cerebral, Electroencephalography, Humans, Limbic System, Tomography, Emission-Computed, Case-Control Studies, Prefrontal Cortex

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