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Cited by 167Obsessive-Compulsive Spectrum DisordersNeural and Behavioral Psychology StudiesDeep Brain Stimulation and Movement Disorders

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder

Rauch, Scott L., Wedig, Michelle M., Wright, Christopher I., Martis, Brian, McMullin, Katherine G., Shin, Lisa M., Cannistraro, Paul A., Wilhelm, Sabine·2007·Biological Psychiatry
DOI 10.1016/j.biopsych.2005.12.012
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Abstract

Background Corticostriatal circuitry has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD). The serial reaction time (SRT) task, a paradigm that tests implicit sequence learning, has been used with imaging to probe striatal function. Initial studies have indicated that OCD patients exhibit deficient striatal activation and aberrant hippocampal recruitment compared with healthy control (HC) subjects. Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions.Methods Using SPM99, fMRI-SRT data from 12 OCD and 12 matched HC subjects were analyzed. Symptom dimensions followed a four-factor model scored on a 0- to 10-point scale.Results For the implicit learning versus random contrast, group by condition interactions revealed aberrant recruitment within the hippocampus as well as orbitofrontal cortex (OCD > HC) but no striatal group differences. However, an inverse correlation was found between striatal activation and specific symptom factors.Conclusions These results replicate previous smaller studies showing aberrant hippocampal recruitment in OCD during SRT performance. Although findings of deficient striatal activation in OCD were not replicated, correlation results suggest that this inconsistency may be attributable to differences among OCD symptom dimensions.

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Metadata

Authors
Rauch, S. L., Wedig, M. M., Wright, C. I., Martis, B., McMullin, K. G., Shin, L. M., Cannistraro, P. A., & Wilhelm, S.
Affiliations
  • Harvard University (US)
  • Brigham and Women's Hospital (US)
  • University of Michigan (US)
  • Tufts University (US)
Corresponding author
Rauch, Scott L.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2007-02
Volume
61
Issue
3
Pages
330-336
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2005.12.012
OpenAlex
W2063217688
Cited by
167
References
57
Citations by year
2026: 2 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 10 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 12 · 2014: 11 · 2013: 11 · 2012: 7
FWCI
10.69
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5t32eb001632-05, 5r01mh060219-05)
  • National Institute of Mental Health (K23MH64806, K23MH064806, R01MH60219)
  • National Institute of Biomedical Imaging and Bioengineering (T32EB001632-01)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords
obsessive-compulsive disorder, implicit sequence learning, serial reaction time task, striatal activation, orbitofrontal cortex, corticostriatal circuits, OCD symptom dimensions, regional brain activation
MeSH terms
Adult, Brain, Cerebral Cortex, Female, Hippocampus, Humans, Learning, Magnetic Resonance Imaging, Male, Neural Pathways, Obsessive-Compulsive Disorder, Psychomotor Performance, Reaction Time, Recruitment, Neurophysiological, Cohort Studies, Neostriatum

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