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Cited by 219Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorBipolar Disorder and Treatment

Elevated Serotonin Transporter Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [11C]DASB; Comparison with Bipolar Disorder

Cannon, Dara M., Ichise, Masanori, Rollis, Denise, Klaver, Jacqueline M., Gandhi, Shilpa K., Charney, Dennis S., Manji, Husseini K., Drevets, Wayne C.·2007·Biological Psychiatry
DOI 10.1016/j.biopsych.2007.03.016
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Abstract

Background Altered serotonergic function is thought to play a role in the pathophysiology of major depressive episodes based upon evidence from neuroimaging, pharmacological, postmortem and genetic studies. It remains unclear, however, whether depressed samples that differ with respect to having shown a unipolar versus a bipolar illness course also would show distinct patterns of abnormalities within the serotonergic system. The current study compared serotonin transporter (5-HTT) binding between unipolar-depressives (MDD), bipolar-depressives (BD) and healthy-controls (HC) to assess whether the abnormalities in 5-HTT binding recently found in depressed subjects with BD extend to depressed subjects with MDD.Methods The 5-HTT binding-potential (BP) measured using positron emission tomography (PET) and [(11)C]DASB was compared between unmedicated, depressed subjects with MDD (n = 18) or BD (n = 18) and HC (n = 34).Results Relative to the healthy group both MDD and BD groups showed significantly increased 5-HTT BP in the thalamus (24%, 14%, respectively), insula (15%) and striatum (12%). The unipolar-depressives had elevated 5-HTT BP relative to both BD and HC groups in the vicinity of the periaqueductal gray (PAG, 20%, 22%, respectively). The bipolar-depressives had reduced 5-HTT BP relative to both HC and MDD groups in the vicinity of the pontine raphe nuclei. Depression-severity correlated negatively with 5-HTT BP in the thalamus in MDD-subjects.Conclusions The depressed phases of MDD and BD both were associated with elevated 5-HTT binding in the insula, thalamus and striatum, but showed distinct abnormalities in the brainstem. The latter findings conceivably could underlie differences in the patterns of illness symptoms and pharmacological sensitivity observed between MDD and BD.

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  • Some studies reported a higher density of 5-HT transporters in depressed patients.

    “Some studies have reported a higher density of transporters in depressed patients (Cannon et al., 2007) while others have reported lower density (Selvaraj et al. 2009).”

    From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Cannon et al., 2007

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Authors
Cannon, D. M., Ichise, M., Rollis, D., Klaver, J. M., Gandhi, S. K., Charney, D. S., Manji, H. K., & Drevets, W. C.
Affiliations
  • National Institutes of Health (US)
  • Brigham and Women's Hospital (US)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Cannon, Dara M.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2007-10
Volume
62
Issue
8
Pages
870-877
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2007.03.016
OpenAlex
W1993273089
Cited by
219
References
72
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 10 · 2015: 15 · 2014: 20 · 2013: 12 · 2012: 26
FWCI
11.52
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
serotonin transporter, major depressive disorder, bipolar disorder, [11C]DASB, binding potential, serotonergic system, thalamus, insula, striatum, periaqueductal gray, depression severity
MeSH terms
Adolescent, Adult, Aniline Compounds, Bipolar Disorder, Brain Stem, Carbon Radioisotopes, Cerebral Cortex, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Sulfides, Thalamus, Case-Control Studies, Matched-Pair Analysis, Neostriatum, Radiopharmaceuticals, Positron-Emission Tomography, Serotonin Plasma Membrane Transport Proteins

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