Positron Emission Tomography Quantification of Serotonin Transporter in Suicide Attempters with Major Depressive Disorder

Miller, Jeffrey M.; Hesselgrave, Natalie; Ogden, R. Todd; Sullivan, Gregory M.; Oquendo, Maria A.; Mann, J. John; Parsey, Ramin V.

doi:10.1016/j.biopsych.2013.01.024

Cited by 102Neurotransmitter Receptor Influence on BehaviorSuicide and Self-Harm StudiesTreatment of Major Depression

Positron Emission Tomography Quantification of Serotonin Transporter in Suicide Attempters with Major Depressive Disorder

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Miller, Jeffrey M., Hesselgrave, Natalie, Ogden, R. Todd, Sullivan, Gregory M., Oquendo, Maria A., Mann, J. John, Parsey, Ramin V.·2013·Biological Psychiatry

DOI 10.1016/j.biopsych.2013.01.024PMC PMC3725207

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Abstract

Background Several lines of evidence implicate abnormal serotonergic function in suicidal behavior and completed suicide, including low serotonin transporter binding in postmortem studies of completed suicide. We have also reported low in vivo serotonin transporter binding in major depressive disorder (MDD) during a major depressive episode using positron emission tomography (PET) with [(11)C]McN5652. We quantified regional brain serotonin transporter binding in vivo in depressed suicide attempters, depressed nonattempters, and healthy controls using PET and a superior radiotracer, [(11)C]DASB.Methods Fifty-one subjects with DSM-IV current MDD, 15 of whom were past suicide attempters, and 32 healthy control subjects underwent PET scanning with [(11)C]DASB to quantify in vivo regional brain serotonin transporter binding. Metabolite-corrected arterial input functions and plasma free-fraction were acquired to improve quantification.Results Depressed suicide attempters had lower serotonin transporter binding in midbrain compared with depressed nonattempters (p = .031) and control subjects (p = .0093). There was no difference in serotonin transporter binding comparing all depressed subjects with healthy control subjects considering six a priori regions of interest simultaneously (p = .41).Conclusions Low midbrain serotonin transporter binding appears to be related to the pathophysiology of suicidal behavior rather than of major depressive disorder. This is consistent with postmortem work showing low midbrain serotonin transporter binding capacity in depressed suicides and may partially explain discrepant in vivo findings quantifying serotonin transporter in depression. Future studies should investigate midbrain serotonin transporter binding as a predictor of suicidal behavior in MDD and determine the cause of low binding.

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Less presynaptic serotonin transporter binding in major depression is seen throughout most of the PFC, but in suicide an additional deficit is confined to the ventral PFC and ACC, suggesting a role in decision making.
“Less presynaptic serotonin transporter binding in major depression is seen throughout most of the PFC, but in suicide an additional deficit is confined to the ventral PFC and ACC, suggesting a role in decision making (115, 116).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [115]

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Authors: Miller, J. M., Hesselgrave, N., Ogden, R. T., Sullivan, G. M., Oquendo, M. A., Mann, J. J., & Parsey, R. V.
Affiliations: New York State Psychiatric Institute (US)
Stony Brook School (US)
Corresponding author: Miller, Jeffrey M.
ORCID: Miller, Jeffrey M.
Ogden, R. Todd
Sullivan, Gregory M.
Parsey, Ramin V.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2013-08
Volume: 74
Issue: 4
Pages: 287-295
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2013.01.024
PMC: PMC3725207
OpenAlex: W2002221330
Cited by: 102
References: 94
Citations by year: 2026: 2 · 2025: 9 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 14 · 2014: 12 · 2013: 4
FWCI: 6.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (2 R01 MH040695, 5P50 MH62185)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: serotonin transporter, suicide attempters, major depressive disorder, midbrain, serotonin transporter binding, suicidal behavior
MeSH terms: Adult, Brain, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Suicide, Attempted, Positron-Emission Tomography, Serotonin Plasma Membrane Transport Proteins

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Positron Emission Tomography Quantification of Serotonin Transporter in Suicide Attempters with Major Depressive Disorder

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