Cited by 669Schizophrenia research and treatmentMental Health and PsychiatryVestibular and auditory disorders

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The Role of the Cerebellum in Schizophrenia

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Andreasen, Nancy C., Pierson, Ronald·2008·Biological Psychiatry

DOI 10.1016/j.biopsych.2008.01.003PMC PMC3175494

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Abstract

For many years the cerebellum has been considered to serve as a coordinator of motor function. Likewise, for many years schizophrenia has been considered to be a disease that primarily affects the cerebrum. This review summarizes recent evidence that both these views must be revised in the light of emerging evidence about cerebellar function and the mechanisms of schizophrenia. Evidence indicating that the cerebellum plays a role in higher cortical functions is summarized. Evidence indicating that cerebellar abnormalities occur in schizophrenia is also reviewed. These suggest interesting directions for future research.

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Authors: Andreasen, N. C., & Pierson, R.
Affiliations: University of Iowa (US)
Corresponding author: Andreasen, Nancy C.
ORCID: Andreasen, Nancy C.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2008-07
Volume: 64
Issue: 2
Pages: 81-88
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2008.01.003
PMC: PMC3175494
OpenAlex: W2079590167
Cited by: 669
References: 250
Citations by year: 2026: 22 · 2025: 33 · 2024: 52 · 2023: 35 · 2022: 46 · 2021: 60 · 2020: 31 · 2019: 47 · 2018: 50 · 2017: 41 · 2016: 27 · 2015: 36 · 2014: 36 · 2013: 26 · 2012: 25
FWCI: 4.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH060990, R01MH040856, 5 R01 MH 04856-20)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords: cerebellum, schizophrenia, cerebellar function, higher cortical functions, cerebellar abnormalities, motor coordination
MeSH terms: Brain Mapping, Cerebellum, Cerebral Cortex, Cognition Disorders, Higher Nervous Activity, Humans, Nerve Net, Neuropsychological Tests, Olivary Nucleus, Pons, Psychiatric Status Rating Scales, Psychomotor Performance, Schizophrenia, Schizophrenic Psychology, Thalamus, Long-Term Potentiation, Positron-Emission Tomography

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The Role of the Cerebellum in Schizophrenia

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