Cited by 348Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersStress Responses and Cortisol

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Interleukin-6 Covaries Inversely with Hippocampal Grey Matter Volume in Middle-Aged Adults

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Marsland, Anna L., Gianaros, Peter J., Abramowitch, Sarah M., Manuck, Stephen B., Hariri, Ahmad R.·2008·Biological Psychiatry

DOI 10.1016/j.biopsych.2008.04.016PMC PMC2562462

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Abstract

Background Converging animal findings suggest that higher peripheral levels of inflammation are associated with activation of central inflammatory mechanisms that result in hippocampal neurodegeneration and related impairment of memory function. We have recently shown, consistent with animal findings, an inverse association between peripheral levels of interleukin-6 (IL-6), a relatively stable marker of systemic inflammation, and memory function in mid-life adults. In the current study, we extend this work to test whether systemic inflammation is associated with reduced grey matter volume of the hippocampus.Methods For this purpose, we used a computational structural neuroimaging method (optimized voxel-based morphometry) to evaluate the relationship between plasma IL-6 levels and hippocampal grey matter volume in a sample of 76 relatively healthy community volunteers ages 30-54.Results Peripheral levels of IL-6 covaried inversely with hippocampal grey matter volume, and this relationship persisted after accounting for several possible confounders, including age, gender, race, years of education, percent body fat, blood pressure, smoking, physical activity, hours of sleep, alcohol use, and total grey matter volume.Conclusions To our knowledge, this is the first report of a relationship between a peripheral marker of IL-6 and hippocampal grey matter volume, raising the possibility that low-grade systemic inflammation could plausibly presage subclinical cognitive decline in part via structural neural pathways.

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Authors: Marsland, A. L., Gianaros, P. J., Abramowitch, S. M., Manuck, S. B., & Hariri, A. R.
Affiliations: University of Pittsburgh (US)
Corresponding author: Marsland, Anna L.
ORCID: Marsland, Anna L.
Gianaros, Peter J.
Manuck, Stephen B.
Hariri, Ahmad R.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2008-09
Volume: 64
Issue: 6
Pages: 484-490
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2008.04.016
PMC: PMC2562462
OpenAlex: W2010397126
Cited by: 348
References: 64
Citations by year: 2026: 11 · 2025: 17 · 2024: 22 · 2023: 22 · 2022: 14 · 2021: 26 · 2020: 26 · 2019: 26 · 2018: 19 · 2017: 13 · 2016: 22 · 2015: 20 · 2014: 31 · 2013: 25 · 2012: 16
FWCI: 8.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart and Lung Institute
National Institute of Mental Health
National Institute of Nursing Research
Australian Rotary Health
John D. and Catherine T. MacArthur Foundation
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: interleukin-6, systemic inflammation, hippocampal neurodegeneration, memory function, middle-aged adults, plasma biomarkers, neuroinflammation
MeSH terms: Adipose Tissue, Adult, Cognition Disorders, Female, Hippocampus, Humans, Hypertension, Inflammation, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Registries, Severity of Illness Index, Wechsler Scales, Interleukin-6, Diagnostic and Statistical Manual of Mental Disorders

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Interleukin-6 Covaries Inversely with Hippocampal Grey Matter Volume in Middle-Aged Adults

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