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Cited by 126Tryptophan and brain disordersStress Responses and CortisolPsychosomatic Disorders and Their Treatments

Interoception and Inflammation in Psychiatric Disorders

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Savitz, Jonathan, Harrison, Neil A.·2018·Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
DOI 10.1016/j.bpsc.2017.12.011PMC PMC5995132
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Abstract

Despite a historical focus on neurally mediated interoceptive signaling mechanisms, humoral (and even cellular) signals also play an important role in communicating bodily physiological state to the brain. These signaling pathways can perturb neuronal structure, chemistry, and function, leading to discrete changes in behavior. They are also increasingly implicated in the pathophysiology of psychiatric disorders. The importance of these humoral signaling pathways is perhaps most powerfully illustrated in the context of infection and inflammation. Here we provide an overview of how interaction of immune activation of neural and humoral interoceptive mechanisms mediates discrete changes in brain and behavior and highlight how activation of these pathways at specific points in neural development may predispose to psychiatric disorder. As our mechanistic understanding of these interoceptive pathways continues to emerge, it is revealing novel therapeutic targets, potentially heralding an exciting new era of immunotherapies in psychiatry.

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  • The physiological timescales and amplitudes of interoceptive signaling vary dramatically, with even slower changes in humoral mediators.

    “The physiological timescales and amplitudes of interoceptive signaling vary dramatically (e.g., heart rate [0.5–3.3 Hz], respiratory rate [0.08–1 Hz], gastric contractility [0.05–0.1 Hz], urinary frequency [0.000045–0.00012 Hz]), with even slower changes in humoral mediators (50) (Figure 2C, D).”

    From Interoception and Mental Health: A Roadmap. (2018) · cites this paper as [50]

    The “Visceral afferents” section describes rapid neural interoceptive signaling, and “Humoral pathways” identifies circulating inflammatory mediators as another interoceptive route. Neither section establishes that changes in humoral mediators are slower than the physiological rhythms listed in the citing sentence; the paper also does not provide those frequencies or address signal amplitudes. Page numbers are unavailable in our copy. (LLM, conf=0.78)

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  • The CNS senses somatic states and uses them to shape and guide behaviour.

    “In turn, somatic states are sensed by the CNS to shape and guide behaviour2.”

    From Central regulation of stress-evoked peripheral immune responses (2023) · cites this paper as [2]

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Authors
Savitz, J., & Harrison, N. A.
Affiliations
  • Laureate Institute for Brain Research (US)
  • Brighton and Sussex Medical School (GB)
Corresponding author
Harrison, Neil A.
ORCID
Venue
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Publisher
Elsevier BV
Published
2018-06
Volume
3
Issue
6
Pages
514-524
ISSN
2451-9022 (ISSN-L)
DOI
10.1016/j.bpsc.2017.12.011
PMC
PMC5995132
OpenAlex
W2781869532
Cited by
126
References
42
Citations by year
2026: 2 · 2025: 11 · 2024: 31 · 2023: 14 · 2022: 16 · 2021: 20 · 2020: 17 · 2019: 11 · 2018: 3 · 2017: 1
FWCI
1.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Biological Psychiatry Cognitive Neuroscience and Neuroimaging (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Sussex Research Online (University of Sussex) (submittedVersion, cc-by-nc-nd)
  • Figshare (submittedVersion, cc-by-nc-nd)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders
  • Wellcome Trust
  • UK Medical Research Council
  • Arthritis Research UK
  • National Institute of General Medical Sciences (P20GM121312)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
interoception, inflammation, mental illness, humoral signaling, immune activation, infection, neuroimmune interactions, brain-behavior relationship, neural development, immunotherapy, pathophysiology
MeSH terms
Awareness, Mental Disorders, Brain, Humans, Inflammation, Magnetic Resonance Imaging, Interoception

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