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Cited by 163Dementia and Cognitive Impairment ResearchTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function—data from the Berlin Aging Study II

Tegeler, Christina, O'Sullivan, Julie Lorraine, Bucholtz, Nina, Goldeck, David, Pawelec, Graham, Steinhagen-Thiessen, Elisabeth, Demuth, Ilja·2016·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2015.10.039
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Abstract

Inflammation may be an underlying mechanism in cognitive decline. The present study investigated the relationship between cognitive function and the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and IL-10 in a nonclinical sample of elderly adults. Serum levels of CRP, IL-6, and IL-10 were measured in n = 1312 elderly adults (60-85 years, 50.5% females) who underwent comprehensive neuropsychological testing. Multiple linear regression analysis was conducted and adjusted for various demographic and clinical factors. Levels of IL-6, IL-10, and CRP were negatively associated with a composite score of executive function and processing speed, whereas the IL-6 to IL-10 ratio was not predictive for executive function and processing speed. No associations were found between inflammatory markers and verbal episodic memory. These findings suggest a relationship between higher proinflammatory and anti-inflammatory activation of the innate immune system and executive function within the normal range. Further research is needed to examine the relevance of an inflammatory pathway as a potential therapeutic target.

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  • In humans, the distinguishing criteria for normal versus pathological aging are CNS injury, amyloid plaques, neurodegeneration, neuropsychiatric conditions, dementia, and impaired performance on cognitive tests.

    “In humans, the distinguishing criteria for normal vs pathological aging are: central nervous system (CNS) injury, amyloid plaques (based on positron emission tomography (PET)), neurodegeneration, neuropsychiatric conditions, dementia, and impaired performance on cognitive tests (Arani et al, 2015;Fabbri et al, 2016;Tegeler et al, 2016).”

    From Microglia Priming with Aging and Stress (2017) · cites this paper as Tegeler et al, 2016

  • An age-associated increase in serum expression of C-reactive protein (CRP), IL-6 and IL-10 in an elderly population was inversely associated with executive performance on neuropsychological tests.

    “For instance, a recent cross-sectional study investigating the association between inflammatory markers and executive functioning in an elderly population indicated an age-associated increase in the serum expression of C-reactive protein (CRP), IL-6 and IL-10.Elevated levels of these cytokines were inversely associated with executive performance on neuropsychological tests (Tegeler et al, 2016).”

    From Microglia Priming with Aging and Stress (2017) · cites this paper as Tegeler et al, 2016

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Authors
Tegeler, C., O'Sullivan, J. L., Bucholtz, N., Goldeck, D., Pawelec, G., Steinhagen-Thiessen, E., & Demuth, I.
Affiliations
  • Charité – Universitätsmedizin Berlin (DE)
  • University of Tübingen (DE)
Corresponding author
  • Tegeler, Christina
  • Demuth, Ilja
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2016-02
Volume
38
Pages
112-117
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2015.10.039
OpenAlex
W2167109574
Cited by
163
References
42
Citations by year
2026: 14 · 2025: 19 · 2024: 23 · 2023: 20 · 2022: 14 · 2021: 19 · 2020: 18 · 2019: 13 · 2018: 10 · 2017: 7 · 2016: 6
FWCI
6.23
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bundesministerium für Bildung und Forschung (16SV5536K)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
C-reactive protein, interleukin-6, IL-10, inflammation, cognitive function, executive function, processing speed, verbal episodic memory, cognitive decline, older adults, innate immune system
MeSH terms
Aged, Aged, 80 and over, C-Reactive Protein, Cognition, Female, Humans, Immunity, Innate, Male, Middle Aged, Interleukin-6, Linear Models, Interleukin-10, Inflammation Mediators, Executive Function

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