Cited by 300Sleep and related disordersCircadian rhythm and melatoninAttention Deficit Hyperactivity Disorder

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Delayed Circadian Rhythm in Adults with Attention-Deficit/Hyperactivity Disorder and Chronic Sleep-Onset Insomnia

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Van Veen, Maaike M., Kooij, J.J. Sandra, Boonstra, A. Marije, Gordijn, Marijke C.M., Van Someren, Eus J.W.·2010·Biological Psychiatry

DOI 10.1016/j.biopsych.2009.12.032

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Abstract

Background Previous studies suggest circadian rhythm disturbances in children with attention-deficit/hyperactivity disorder (ADHD) and sleep-onset insomnia (SOI). We investigate here sleep and rhythms in activity and melatonin in adults with ADHD.Methods Sleep logs and actigraphy data were collected during 1 week in 40 adults with ADHD, of whom 31 reported SOI. Salivary melatonin levels were assessed during 1 night. Sleep measures, circadian activity variables, and dim light melatonin onset were compared between groups of ADHD adults with and without SOI and with matched healthy control subjects.Results Compared with control subjects, both groups of ADHD adults had longer sleep-onset latency and lower sleep efficiency. Adults with ADHD and SOI showed a delayed start and end of their sleep period and a delayed melatonin onset compared with adults with ADHD without SOI (p = .006; p = .023; p = .02) and compared with healthy control subjects (p = .014; p = .019; p = .000). Adults with ADHD and SOI also showed an attenuated 24-hour amplitude in their rest-activity pattern, in contrast to those without SOI, who showed a higher day-to-day stability.Conclusions These findings demonstrate diurnal rhythm deviations during everyday life in the majority of adults with ADHD that have SOI and suggest that potential benefits of rhythm-improving measures should be evaluated.

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Authors: Van Veen, M. M., Kooij, J. J. S., Boonstra, A. M., Gordijn, M. C. M., & Van Someren, E. J. W.
Affiliations: PsyQ (NL)
University of Groningen (NL)
ORCID: Kooij, J.J. Sandra
Gordijn, Marijke C.M.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2010-06
Volume: 67
Issue: 11
Pages: 1091-1096
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2009.12.032
OpenAlex: W2105759166
Cited by: 300
References: 52
Citations by year: 2026: 10 · 2025: 21 · 2024: 19 · 2023: 16 · 2022: 16 · 2021: 27 · 2020: 21 · 2019: 19 · 2018: 18 · 2017: 16 · 2016: 25 · 2015: 17 · 2014: 18 · 2013: 14 · 2012: 22
FWCI: 22.89
Type: journal article
Language: en
Open access: green
research.rug.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
VU Research Portal (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: Janssen Cilag BV
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Keywords: attention deficit hyperactivity disorder, sleep onset insomnia, circadian rhythm, melatonin onset, sleep latency, sleep efficiency, rest-activity rhythm, actigraphy, salivary melatonin, adult ADHD
MeSH terms: Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Circadian Rhythm, Humans, Sleep Initiation and Maintenance Disorders, Melatonin, Middle Aged, Surveys and Questionnaires, Saliva, Sleep, Chi-Square Distribution, Actigraphy

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Delayed Circadian Rhythm in Adults with Attention-Deficit/Hyperactivity Disorder and Chronic Sleep-Onset Insomnia

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