The orexin system regulates alcohol-seeking in rats
Open accessAbstract
1. Orexin-containing neurons have been implicated in feeding, sleep-wake cycles and more recently in drug-seeking behaviour. 2. Pretreatment of alcohol-preferring (iP) rats with an orexin1 receptor antagonist (SB-334867, 20 mg kg(-1), intraperitoneally) completely abolished an olfactory cue-induced reinstatement of alcohol-seeking behaviour, and also attenuated alcohol responding under an operant fixed ratio regimen without affecting water responding. 3. The mRNA encoding orexin within the hypothalamus was expressed at a similar density in iP and non-preferring (NP) rats; chronic consumption of ethanol in iP rats did not significantly regulate the density of this expression, but did increase the area of expression within the lateral, but not medial, hypothalamus. 4. These data indicate that while orexin may not be implicated in the development of an alcohol preference, re-exposure of cues previously associated with alcohol availability is sufficient and adequate to activate orexin-containing neurons and drive reinstatement of alcohol-seeking.
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Both Hcrt-1 and Hcrt-2 receptor blockade decreased alcohol self-administration in alcohol-preferring rats.
“Both Hcrt-1 and Hcrt-2 receptor blockade decreased alcohol self-administration in alcohol-preferring rats(Lawrence et al., 2006;Brown et al., 2013).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Lawrence et al., 2006
Prepro-Hcrt mRNA increased in the lateral hypothalamus in inbred alcohol-preferring rats after chronic alcohol consumption but decreased in the perifornical area in Sprague-Dawley rats.
“For alcohol, prepro-Hcrt mRNA increased in the lateral hypothalamus in inbred alcohol-preferring rats after chronic alcohol consumption(Lawrence et al., 2006) but decreased in the perifornical area in Sprague-Dawley rats(Morganstern et al., 2010).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Lawrence et al., 2006
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- Authors
- Lawrence, A. J., Cowen, M. S., Yang, H., Chen, F., & Oldfield, B.
- Affiliations
- The University of Melbourne (AU)
- Monash University (AU)
- Corresponding author
- Lawrence, Andrew J
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2006-07
- Volume
- 148
- Issue
- 6
- Pages
- 752-759
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC1617074
- OpenAlex
- W1482425500
- Cited by
- 392
- References
- 57
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 11 · 2023: 9 · 2022: 17 · 2021: 13 · 2020: 19 · 2019: 21 · 2018: 23 · 2017: 12 · 2016: 25 · 2015: 21 · 2014: 27 · 2013: 26 · 2012: 42
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- orexin, alcohol seeking, alcohol preference, reinstatement, SB-334867, alcohol-preferring rats, hypothalamus, ethanol consumption, drug-seeking behavior
- MeSH terms
- Orexins, Alcohol Drinking, Animals, Benzoxazoles, Conditioning, Operant, Cues, Male, Naphthyridines, Neuropeptides, RNA, Messenger, Urea, Ventral Tegmental Area, Intracellular Signaling Peptides and Proteins, Rats
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