Peroxisome Proliferator-Activated Receptors-Alpha Modulate Dopamine Cell Activity Through Nicotinic Receptors
Open accessAbstract
Background Modulation of midbrain dopamine neurons by nicotinic acetylcholine receptors (nAChRs) plays an important role in behavior, cognition, motivation, and reward. Specifically, nAChRs containing beta2 subunits (beta2-nAChRs) switch dopamine cells from a resting to an excited state. However, how beta2-nAChRs can be modulated and thereby how dopamine firing activity is affected remains elusive. Because changes in dopamine cell activity are reflected in the dynamics of microcircuits generating altered responses to stimuli and inputs, factors regulating their state are fundamental. Among these, endogenous ligands to the nuclear receptor-transcription factor peroxisome proliferator-activated receptors type-alpha (PPARalpha) have been recently found to suppress nicotine-induced responses of dopamine neurons.Methods We used both in vitro and in vivo electrophysiological techniques together with behavioral analysis to investigate on the effects of modulation of PPARalpha in Sprague-Dawley rat and C57BLJ/6 mouse dopamine neurons and their interactions with beta2-nAChRs. To this aim, we took advantage of a selective reexpression of beta2-nAChR exclusively in dopamine cells by stereotaxically injecting a lentiviral vector in the mouse ventral tegmental area.Results We found that activation of PPARalpha decreases in vitro both dopamine cell activity and ventral tegmental area net output through negative modulation of beta2-nAChRs. Additionally, PPARalpha activation in vivo reduces both the number of spontaneously active dopamine neurons and nicotine-induced increased locomotion.Conclusions Our combined findings suggest PPARalpha ligands as important negative modulators of beta2-nAChRs on dopamine neurons. Thus, PPARalpha ligands might prove beneficial in treating disorders in which dopamine dysfunction plays a prominent role, such as schizophrenia and nicotine addiction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PPARα signaling increases β2-nAChR phosphorylation, which subsequently decreases ventral tegmental area dopamine neuron firing.
“Peroxisome proliferator-activated receptor α (PPARα) signaling increases β2-nAChR phosphorylation, which subsequently decreases VTA dopamine neuron firing [58].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [58]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125 · see citing works
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
Marzo, V. D., Fontana, A., Cadas, H., Schinelli, S., Cimino, G., Schwartz, J.-C., & Piomelli, D. (1994) · Nature · doi:10.1038/372686a0 · Cited by 1,585 · see citing works
Fu, J., Gaetani, S., Oveisi, F., Verme, J., Serrano, A., de Fonseca, F. D., Rosengarth, A., Luecke, H., Giacomo, B. D., Tarzia, G., et al. (2003) · Nature · doi:10.1038/nature01921 · Cited by 1,113 · see citing works
Clarke, P. B. S., Schwartz, R., Paul, S. M., Cb, P., & Pert, A. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-05-01307.1985 · Cited by 1,037 · see citing works
Schultz, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.007 · Cited by 1,028 · see citing works
Nicotine activates and desensitizes midbrain dopamine neurons
Pidoplichko, V. I., DeBiasi, M., Williams, J. T., & Dani, J. A. (1997) · Nature · doi:10.1038/37120 · Cited by 769 · see citing works
Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement
Fields, H. L., Hjelmstad, G. O., Margolis, E. B., & Nicola, S. M. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094341 · Cited by 611 · see citing works
Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
Maskos, U., Molles, B. E., Pons, S., Besson, M., Guiard, B. P., Guilloux, J.-P., Evrard, A., Cazala, P., Cormier, A., Mameli-Engvall, M., et al. (2005) · Nature · doi:10.1038/nature03694 · Cited by 566 · see citing works
Self-citationGlutamatergic Afferents of the Ventral Tegmental Area in the Rat
Geisler, S., Derst, C., Veh, R. W., & Zahm, D. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0012-07.2007 · Cited by 486 · see citing works
Oakman, S., Faris, P. L., Kerr, P., Cozzari, C., & Hartman, B. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-05859.1995 · Cited by 384 · see citing works
The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons
Lodge, D. J., & Grace, A. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510715103 · Cited by 349 · see citing works
Artmann, A., Petersen, G. L., Hellgren, L. I., Boberg, J., Skonberg, C., Nellemann, C., Hansen, S. H., & Hansen, H. S. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.01.006 · Cited by 323 · see citing works
Autoradiographic localization of M1 and M2 muscarine receptors in the rat brain
Mash, D. C., & Potter, L. T. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90280-0 · Cited by 316 · see citing works
Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors
Mameli-Engvall, M., Evrard, A., Pons, S., Maskos, U., Svensson, T. H., Changeux, J.-P., & Faure, P. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.007 · Cited by 296 · see citing works
Self-citationPreferential stimulation of ventral tegmental area dopaminergic neurons by nicotine
Mereu, G., Yoon, K.-W. P., Boi, V., Gessa, G. L., Naes, L., & Westfall, T. C. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90556-5 · Cited by 271 · see citing works
Cullingford, T. E., Bhakoo, K. K., Peuchen, S., Dolphin, C. T., Patel, R., & Clark, J. B. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041366.x · Cited by 234 · see citing works
Afferent modulation of dopamine neuron firing patterns
Kitai, S. T., Shepard, P. D., Callaway, J. C., & Scroggs, R. S. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00040-9 · Cited by 234 · see citing works
Margolis, E. B., Mitchell, J., Ishikawa, J., Hjelmstad, G. O., & Fields, H. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-08.2008 · Cited by 232 · see citing works
McClernon, F. J., & Kollins, S. H. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.016 · Cited by 188 · see citing works
Zhu, Y., Kan, L., Qi, C., Kanwar, Y. S., Yeldandi, A. V., Rao, M. S., & Reddy, J. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13510 · Cited by 187 · see citing works
Rebec, G. V., Grabner, C. P., Johnson, M., Pierce, R. C., & Bardo, M. T. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00382-x · Cited by 184 · see citing works
The phasic reward signal of primate dopamine neurons
Schultz, W. (1997) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)60841-8 · Cited by 169 · see citing works
Melis, M., Pillolla, G., Luchicchi, A., Muntoni, A. L., Yaşar, S., Goldberg, S. R., & Pistis, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3221-08.2008 · Cited by 169 · see citing works
Self-citationAvshalumov, M., Chen, B. T., Koos, T., Tepper, J., & Rice, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4701-04.2005 · Cited by 164 · see citing works
Charpantier, E., Wiesner, A., Huh, K.-H., Ogier, R., Hoda, J., Allaman, G., Raggenbass, M., Feuerbach, D., Bertrand, D., & Fuhrer, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3497-05.2005 · Cited by 152 · see citing works
Maskos, U. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.5 · Cited by 139 · see citing works
Self-citationCalorie Restriction and Ketogenic Diet Diminish Neuronal Excitability in Rat Dentate Gyrus In Vivo
Bough, K. J., Schwartzkroin, P. A., & Rho, J. M. (2003) · Epilepsia · doi:10.1046/j.1528-1157.2003.55502.x · Cited by 127 · see citing works
Functional implications of glutamatergic projections to the ventral tegmental area
Geisler, S., & Wise, R. A. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.4-5.227 · Cited by 125 · see citing works
Teissier, E., Nohara, A., Chinetti, G., Paumelle, R., Cariou, B., Fruchart, J., Brandes, R. P., Shah, A. M., & Staels, B. (2004) · Circulation Research · doi:10.1161/01.res.0000150594.95988.45 · Cited by 121 · see citing works
Analysis of dopamine transporter gene expression pattern − generation of DAT‐iCre transgenic mice
Turiault, M., Parnaudeau, S., Milet, A., Parlato, R., Rouzeau, J., Lazar, M., & Tronche, F. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05886.x · Cited by 114 · see citing works
Mesopontine neurons in schizophrenia
García‐Rill, E., Biedermann, J., Chambers, T. C., Skinner, R. D., Mrak, R. E., Husain, M., & Karson, C. N. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00564-l · Cited by 107 · see citing works
Examining the addictive-like properties of binge eating using an animal model of sugar dependence.
Avena, N. M. (2007) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.15.5.481 · Cited by 105 · see citing works
Protective activation of the endocannabinoid system during ischemia in dopamine neurons
Melis, M., Pillolla, G., Bisogno, T., Minassi, A., Petrosino, S., Perra, S., Muntoni, A. L., Lutz, B., Gessa, G. L., & Marsicano, G. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.010 · Cited by 101 · see citing works
Self-citationGardner, O., Dewar, B. J., & Graves, L. M. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.012260 · Cited by 100 · see citing works
Localization of the peroxisome proliferator-activated receptor in the brain
Kainu, T., Wikström, A., Gustafsson, J.-Α., & Pelto‐Huikko, M. (1994) · Neuroreport · doi:10.1097/00001756-199412000-00019 · Cited by 94 · see citing works
Hansen, H. S., Lauritzen, L., Strand, A. M., Vinggaard, A. M., Frandsen, A., & Schousboe, A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69020753.x · Cited by 88 · see citing works
King, S. L., Caldarone, B. J., & Picciotto, M. R. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.024 · Cited by 70 · see citing works
Galán-Rodríguez, B., Suárez, J., González-Aparicio, R., Bermúdez‐Silva, F. J., Maldonado, R. J., Robledo, P., de Fonseca, F. R., & Fernández‐Espejo, E. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.11.006 · Cited by 63 · see citing works
Porta, N., Vallée, L., Lecointe, C., Bouchaert, E., Staels, B., Bordet, R., & Auvin, S. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01901.x · Cited by 60 · see citing works
Role of the Central Cholinergic System in the Therapeutics of Schizophrenia
Terry, A. V. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777247 · Cited by 48 · see citing works
Wiesner, A., & Fuhrer, C. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6081-z · Cited by 41 · see citing works
A versatile system for the neuronal subtype specific expression of lentiviral vectors
Tolu, S., Avale, M. E., Nakatani, H., Pons, S., Parnaudeau, S., Tronche, F., Vogt, A., Monyer, H., Vogel, R., de Chaumont, F., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-139790 · Cited by 40 · see citing works
Self-citationHansen, S. L., Nielsen, A. H., Knudsen, K. E., Artmann, A., Petersen, G. L., Kristiansen, U., Hansen, S. H., & Hansen, H. S. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.012 · Cited by 39 · see citing works
Nugent, F. S., Hwong, A. R., Udaka, Y. T., & Kauer, J. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301561 · Cited by 36 · see citing works
Melis, M., Pillolla, G., Perra, S., Colombo, G., Muntoni, A. L., & Pistis, M. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1309-2 · Cited by 36 · see citing works
Self-citationNeuronal Nicotinic Receptors as Brain Targets for Pharmacotherapy of Drug Addiction
Rahman, S., López‐Hernández, G. Y., Corrigall, W. A., & Papke, R. L. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708786927831 · Cited by 34 · see citing works
Mineur, Y. S., Brunzell, D. H., Grady, S. R., Lindstrom, J. M., McIntosh, J. M., Marks, M. J., King, S. L., & Picciotto, M. R. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2008.00468.x · Cited by 33 · see citing works
Huang, J., Huang, A., Zhang, Q., Lin, Y., & Yu, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804205200 · Cited by 32 · see citing works
Ropero, A., Juan-Picó, P., Rafacho, A., Fuentes, E., Bermúdez-Silva, F., Roche, E., Quesada, I., de Fonseca, F. D., & Nadal, A. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0397 · Cited by 32 · see citing works
Peroxisome proliferator‐activated receptor alpha and the ketogenic diet
Cullingford, T. E. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01840.x · Cited by 29 · see citing works
Sarter, M. F., Bruno, J. P., Parikh, V., Martínez, V., Kozak, R., & Richards, J. B. (2006) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7772-4_4 · Cited by 16 · see citing works
Matsubayashi, H., Amano, T., Seki, T., Sasa, M., & Sakai, N. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.93.143 · Cited by 14 · see citing works
Wu, Y.-N., Martella, G., & Johnson, S. W. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3282f0d28f · Cited by 9 · see citing works
The cyclo-oxygenase inhibitor nimesulide induces conditioned place preference in rats
Fattore, L., Melis, M., Diana, M., Fratta, W., & Gessa, G. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00665-8 · Cited by 7 · see citing works
Self-citationZheng, Y., Sudou, K., Nawa, H., & Namba, H. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.04.013 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Wójtowicz, S., Strosznajder, A. K., Jeżyna, M. J., & Strosznajder, J. B. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02993-5 · Cited by 325 · see citing works
The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
Effects of endocannabinoid system modulation on cognitive and emotional behavior
Zanettini, C. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00057 · Cited by 214 · see citing works
Piomelli, D. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.03.001 · Cited by 185 · see citing works
Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors
Serrano, A., & Parsons, L. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.005 · Cited by 180 · see citing works
Palmitoylethanolamide in CNS health and disease
Raso, G. M., Russo, R., Calignano, A., & Meli, R. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.05.006 · Cited by 148 · see citing works
Stopponi, S., Somaini, L., Cippitelli, A., Cannella, N., Braconi, S., Kallupi, M., Ruggeri, B., Heilig, M. A., Demopulos, G. A., Gaitanaris, G., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.010 · Cited by 134 · see citing works
Iannotti, F. A., & Vitale, R. M. (2021) · Cells · doi:10.3390/cells10030586 · Cited by 132 · see citing works
Mascia, P., Pistis, M., Justinová, Z., Panlilio, L. V., Luchicchi, A., Lecca, S., Scherma, M., Fratta, W., Fadda, P., Barnes, C., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.009 · Cited by 118 · see citing works
Self-citationPanlilio, L. V., Justinová, Z., & Goldberg, S. R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.003 · Cited by 106 · see citing works
Self-citationMelis, M., Scheggi, S., Carta, G., Madeddu, C., Lecca, S., Luchicchi, A., Cadeddu, F., Frau, R., Fattore, L., Fadda, P., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4647-12.2013 · Cited by 94 · see citing works
Self-citationCognitive Enhancers (Nootropics). Part 1: Drugs Interacting with Receptors
Froestl, W., Muhs, A., & Pfeifer, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121186 · Cited by 91 · see citing works
Justinová, Z., Panlilio, L. V., Moreno‐Sanz, G., Redhi, G. H., Auber, A., Secci, M. E., Mascia, P., Bandiera, T., Armirotti, A., Bertorelli, R., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.62 · Cited by 89 · see citing works
Self-citationHub and switches: endocannabinoid signalling in midbrain dopamine neurons
Melis, M., & Pistis, M. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0383 · Cited by 79 · see citing works
Self-citationPPAR agonists regulate brain gene expression: Relationship to their effects on ethanol consumption
Ferguson, L. B., Most, D., Blednov, Y. A., & Harris, R. A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.06.024 · Cited by 78 · see citing works
Carter, C. (2013) · Journal of Pathogens · doi:10.1155/2013/965046 · Cited by 68 · see citing works
Panlilio, L. V., Justinová, Z., Mascia, P., Pistis, M., Luchicchi, A., Lecca, S., Barnes, C., Redhi, G. H., Adair, J. E., Heishman, S. J., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.31 · Cited by 67 · see citing works
Self-citationFoll, B. L., Ciano, P. D., Panlilio, L. V., Goldberg, S. R., & Ciccocioppo, R. (2013) · Current Drug Targets · doi:10.2174/1389450111314070006 · Cited by 66 · see citing works
Self-citationPPAR-Alpha Agonists as Novel Antiepileptic Drugs: Preclinical Findings
Puligheddu, M., Pillolla, G., Melis, M., Lecca, S., Marrosu, F., Montis, M. G. D., Scheggi, S., Carta, G., Murru, E., Aroni, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064541 · Cited by 65 · see citing works
Self-citationMurru, E., Carta, G., Manca, C., Sogos, V., Pistis, M., Melis, M., & Banni, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.587140 · Cited by 63 · see citing works
Self-citationD’Agostino, G., Cristiano, C., Lyons, D. J., Citraro, R., Russo, E., Avagliano, C., Russo, R., Raso, G. M., Meli, R., Sarro, G. D., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.04.005 · Cited by 62 · see citing works
Role of the endogenous cannabinoid system in nicotine addiction: novel insights
Gamaleddin, I. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00041 · Cited by 58 · see citing works
Opportunities for the Development of Neuroimmune Therapies in Addiction
Ray, L. A., Roche, D. J. O., Heinzerling, K. G., & SHOPTAW, S. J. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00012-9 · Cited by 58 · see citing works
PPARα modulation of mesolimbic dopamine transmission rescues depression-related behaviors
Scheggi, S., Melis, M., De Felice, M., Aroni, S., Muntoni, A. L., Pelliccia, T., Gambarana, C., De Montis, M. G., & Pistis, M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.024 · Cited by 56 · see citing works
Self-citationThe Role of Nuclear Hormone Receptors in Cannabinoid Function
Pistis, M., & O’Sullivan, S. E. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.03.008 · Cited by 56 · see citing works
Self-citationScherma, M., Muntoni, A. L., Melis, M., Fattore, L., Fadda, P., Fratta, W., & Pistis, M. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4196-3 · Cited by 57 · see citing works
Self-citationMelis, M., Carboni, E., Caboni, P., & Acquas, E. (2013) · Addiction Biology · doi:10.1111/adb.12097 · Cited by 52 · see citing works
Self-citationBuczynski, M. W., Polis, I. Y., & Parsons, L. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.210 · Cited by 49 · see citing works
Saha, L., Bhandari, S., Bhatia, A., Banerjee, D., & Chakrabarti, A. (2014) · Journal of Epilepsy Research · doi:10.14581/jer.14011 · Cited by 45 · see citing works
RetractedPuligheddu, M., Melis, M., Pillolla, G., Milioli, G., Parrino, L., Terzano, G., Aroni, S., Sagheddu, C., Marrosu, F., Pistis, M., et al. (2017) · Epilepsia · doi:10.1111/epi.13863 · Cited by 44 · see citing works
Self-citationCannabidiol and substance use disorder: Dream or reality
Karimi‐Haghighi, S., Razavi, Y., Iezzi, D., Scheyer, A. F., Manzoni, O. J., & Haghparast, A. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.108948 · Cited by 45 · see citing works
Matheson, J., & Foll, B. L. (2020) · Cells · doi:10.3390/cells9051196 · Cited by 40 · see citing works
Non‐endocannabinoid N‐acylethanolamines and 2‐monoacylglycerols in the intestine
Hansen, H. S., & Vana, V. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14175 · Cited by 40 · see citing works
Bilbao, A., Blanco, E., Rojas, M. J. L., Suárez, J., Palomino, A., Vida, M., Araos, P. F., Bermúdez‐Silva, F. J., Fernández‐Espejo, E., Spanagel, R., et al. (2012) · Addiction Biology · doi:10.1111/adb.12006 · Cited by 39 · see citing works
Endocannabinoids and the Processing of Value-Related Signals
Melis, M., Muntoni, A. L., & Pistis, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00007 · Cited by 36 · see citing works
Self-citationJackson, A. B., Bağdaş, D., Muldoon, P. P., Lichtman, A. H., Carroll, F. I., Greenwald, M. K., Miles, M. F., & Damaj, M. I. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.005 · Cited by 33 · see citing works
Therapeutic Prospects of PPARs in Psychiatric Disorders: A Comprehensive Review
Rolland, B., Deguil, J., Jardri, R., Cottencin, O., Thomas, P., & Bordet, R. (2013) · Current Drug Targets · doi:10.2174/1389450111314070002 · Cited by 32 · see citing works
Costa, M. F., Squassina, A., Congiu, D., Chillotti, C., Niola, P., Galderisi, S., Pistis, M., & Zompo, M. D. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.07.007 · Cited by 31 · see citing works
Self-citationA cholinergic circuit that relieves pain despite opioid tolerance
Sullere, S., Kunczt, A., & McGehee, D. S. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.017 · Cited by 30 · see citing works
Oleamide activates peroxisome proliferator-activated receptor gamma (PPARγ) in vitro
Dionisi, M., Alexander, S. P. H., & Bennett, A. J. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-51 · Cited by 30 · see citing works
Haile, C. N., & Kosten, T. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.007 · Cited by 29 · see citing works
Sagheddu, C., Scherma, M., Congiu, M., Fadda, P., Carta, G., Banni, S., Wood, J. T., Makriyannis, A., Malamas, M. S., & Pistis, M. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.013 · Cited by 27 · see citing works
Self-citationGanesh, G. S., Konduri, P., Kolusu, A. S., Namburi, S. V., Chunduru, B. T. C., Nemmani, K. V. S., & Samudrala, P. K. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00320 · Cited by 28 · see citing works
Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a Gαi/o protein inhibitor
Porcu, A., Melis, M., Tureček, R., Ullrich, C., Mocci, I., Bettler, B., Gessa, G. L., & Castelli, M. P. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.024 · Cited by 28 · see citing works
Self-citationGalaj, E., Bi, G.-H., Moore, A. R., Chen, K., He, Y., Gardner, E., & Xi, Z.-X. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00885-4 · Cited by 23 · see citing works
Melis, M., & Pistis, M. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.03.009 · Cited by 26 · see citing works
Self-citationSleep Related Epilepsy and Pharmacotherapy: An Insight
Kumar, J., Solaiman, A., Mahakkanukrauh, P., Mohamed, R., & Das, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01088 · Cited by 23 · see citing works
Sagheddu, C., Melis, M., Muntoni, A. L., & Pistis, M. (2021) · Pharmaceuticals · doi:10.3390/ph14101025 · Cited by 25 · see citing works
Self-citationPPARα Signaling: A Candidate Target in Psychiatric Disorder Management
Scheggi, S., Pinna, G., Braccagni, G., Montis, M. G. D., & Gambarana, C. (2022) · Biomolecules · doi:10.3390/biom12050723 · Cited by 25 · see citing works
Maulik, M., Mitra, S., Basmayor, A. M., Lu, B., Taylor, B. E., & Bult‐Ito, A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00207 · Cited by 25 · see citing works
Rivera‐Meza, M., Muñoz, D., Jerez, E., Quintanilla, M. E., Salinas‐Luypaert, C., Fernández, K., & Karahanian, E. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00133 · Cited by 24 · see citing works
Cannabinoids in Health and Disease
Meccariello, R., & Chianese, R. (2016) · InTech eBooks · doi:10.5772/61595 · Cited by 21 · see citing works
Rolland, B., Marche, K., Cottencin, O., & Bordet, R. (2012) · Schizophrenia Research and Treatment · doi:10.1155/2012/839853 · Cited by 20 · see citing works
Initial Evaluation of Fenofibrate for Efficacy in Aiding Smoking Abstinence
Perkins, K. A., Karelitz, J. L., Michael, V. C., Fromuth, M., Conklin, C. A., Chengappa, K. N. R., Hope, C., & Lerman, C. E. (2015) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntv085 · Cited by 18 · see citing works
Mijangos-Moreno, S., Poot-Aké, A., Guzmán, K., Arankowsky‐Sandoval, G., Arias-Carrión, Ó., Zaldívar-Rae, J., Sarro-Ramírez, A., & Murillo‐Rodríguez, E. (2015) · Neuroscience Research · doi:10.1016/j.neures.2015.09.005 · Cited by 18 · see citing works
Sagheddu, C., Torres, L. H., Marcourakis, T., & Pistis, M. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.588660 · Cited by 15 · see citing works
Self-citationNAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis
Castel, J., Li, G., Onimus, O., Leishman, E., Cani, P. D., Bradshaw, H. B., Mackie, K., Everard, A., Luquet, S. H., & Gangarossa, G. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02427-6 · Cited by 15 · see citing works
Jung, T., Hudson, R., Rushlow, W. J., & Laviolette, S. R. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15023 · Cited by 17 · see citing works
Olive oil-derived endocannabinoid-like mediators inhibit palatable food-induced reward and obesity
Forte, N. R., Roussel, C., Marfella, B., Lauritano, A., Villano, R., Leonibus, E. D., Salviati, E., Khalilzadehsabet, T., Giorgini, G., Silvestri, C., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05295-y · Cited by 15 · see citing works
Luján, M. Á., Cheer, J. F., & Melis, M. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.08.014 · Cited by 12 · see citing works
Self-citationCOR758, a negative allosteric modulator of GABAB receptors
Porcu, A., Mostallino, R., Serra, V., Melis, M., Sogos, V., Beggiato, S., Ferraro, L., Manetti, F., Gianibbi, B., Bettler, B., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108537 · Cited by 13 · see citing works
Self-citationRoles of N-Acylethanolamines in Brain Functions and Neuropsychiatric Diseases
Pistis, M., & Muntoni, A. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-57371-7_11 · Cited by 12 · see citing works
Self-citationNew medications development for smoking cessation
Lengel, D., & Kenny, P. J. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100103 · Cited by 12 · see citing works
Emerging targets for addiction neuropharmacology
Ubaldi, M., Cannella, N., & Ciccocioppo, R. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.07.018 · Cited by 11 · see citing works
Ferguson, L. B., Zhang, L., Wang, S., Bridges, C. R., Harris, R. A., & Ponomarev, I. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00331 · Cited by 11 · see citing works
Enhancement of fear learning in PPARα knockout mice
Chikahisa, S., Chida, D., Shiuchi, T., Harada, S., Shimizu, N., Otsuka, A., Tanioka, D., & Séi, H. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.09.020 · Cited by 10 · see citing works
Chang, G., Karatayev, O., Lukatskaya, O., & LEIBOWITZ, S. F. (2016) · Peptides · doi:10.1016/j.peptides.2016.03.007 · Cited by 9 · see citing works
Nadalin, S., Buretić‐Tomljanović, A., Rebić, J., Pleša, I., & Jengić, V. Š. (2016) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2016.07.004 · Cited by 9 · see citing works
Murillo‐Rodríguez, E., Guzmán, K., Arankowsky‐Sandoval, G., Salas-Crisóstomo, M., Jiménez-Moreno, R., & Arias-Carrión, Ó. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.09.007 · Cited by 8 · see citing works
Ciccocioppo, R., de Guglielmo, G., Li, H., Melis, M., Caffino, L., Shen, Q., Domi, A., Fumagalli, F., Demopulos, G. A., & Gaitanaris, G. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3180-20.2021 · Cited by 7 · see citing works
Self-citationPassani, M. B., & Coccurello, R. (2016) · InTech eBooks · doi:10.5772/63147 · Cited by 5 · see citing works
Vergori, L., Lauret, É., Soleti, R., Andriantsitohaina, R., & Martínez, M. C. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0098 · Cited by 6 · see citing works
Mostallino, R., Santoni, M., Sagheddu, C., Serra, V., Orrù, V., Pistis, M., & Castelli, M. P. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176172 · Cited by 5 · see citing works
Self-citationKaratayev, O., & LEIBOWITZ, S. F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157143 · Cited by 4 · see citing works
Cannabinoid-Nicotine Interactions
Auber, A., Justinová, Z., Scherma, M., Goldberg, S. R., & Panlilio, L. V. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_13 · Cited by 4 · see citing works
Self-citationCannabinoid-based Pharmacology for the Management of Substance Use Disorders
Luján, M. Á., Kim, Y., Zhang, L., & Cheer, J. F. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_551 · Cited by 2 · see citing works
Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction
Mascia, P., Tanda, G., Yaşar, S., Heishman, S. J., & Goldberg, S. R. (2012) · The Receptors · doi:10.1007/978-1-4614-4669-9_11 · Cited by 2 · see citing works
Self-citationLunerti, V., Li, H., Benvenuti, F., Shen, Q., Domi, A., Soverchia, L., Martino, R. M. C. D., Bottegoni, G., Haass‐Koffler, C. L., & Cannella, N. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175088 · Cited by 2 · see citing works
Sose, P. M., Kale, P. P., & Doshi, G. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527323666230904150841 · Cited by 2 · see citing works
Present and Future Pharmacological Treatments for Opioid Addiction
Blanco-Gandía, M. C., Montagud‐Romero, S., & Rodríguez‐Arias, M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82443 · Cited by 1 · see citing works
Novel Therapeutic Targets for Treating Alzheimer’s Disease
Varshini, M. S., Kiran, A. V. V. V. R., Garikapati, K. K., Krishnamurthy, P. T., Patil, V. M., & Khaydarov, R. R. (2023) · Springer eBooks · doi:10.1007/978-981-99-2657-2_2 · Cited by 1 · see citing works
Gavzan, H., Sayyah, M., Asgari, T., & Mobaraki, M. (2025) · Epilepsy Research · doi:10.1016/j.eplepsyres.2025.107655 · Cited by 1 · see citing works
L1-79 and the Role of Catecholamines in Autism
Rothman, J. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95052 · Cited by 1 · see citing works
Gendy, M. N. S. (2019) · TSpace (University of Toronto) · Cited by 1 · see citing works
Mostallino, R., Santoni, M., Sagheddu, C., Serra, V., Orrù, V., Pistis, M., & Castelli, M. P. (2023) · Preprints.org · doi:10.20944/preprints202306.0539.v1
Self-citationCannabinoid-Dopamine Interactions: Modulation of Midbrain DA Neurons by Endocannabinoids
Georges, F. E., & Melis, M. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_17
Self-citationCannabinoid–Nicotine Interactions in Nicotine Addiction: Preclinical Evidence
Rodríguez‐Borillo, O., & Scherma, M. (2026) · Springer eBooks · doi:10.1007/978-3-032-12239-1_13
Salviati, S., Braccagni, G., Corridori, E., Sabatini, G., Fanti, F., Guzzi, F., M, P., Battista, N., Scheggi, S., & Gambarana, C. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110996
- Authors
- Melis, M., Carta, S., Fattore, L., Tolu, S., Yasar, S., Goldberg, S. R., Fratta, W., Maskos, U., & Pistis, M.
- Affiliations
- University of Cagliari (IT)
- National Research Council (IT)
- National Institutes of Health (US)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Melis, Miriam
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 68
- Issue
- 3
- Pages
- 256-264
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2907468
- OpenAlex
- W2021982247
- Cited by
- 89
- References
- 55
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 8 · 2012: 11
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Funders
- Division of Geriatric Medicine and Gerontology of Johns Hopkins University School of Medicine
- Intramural Research Program of the National Institute on Drug Abuse
- National Institutes of Health
- Department of Health and Human Services
- European Commission 7th Framework Programme Neurocypres Project
- Agence Nationale de la Recherche Blanc
- Agence Nationale de la Recherche Maladies Neurologiques et Psychiatriques 2009
- Institut Pasteur
- Centre National de la Recherche Scientifique Unit́e de Recherche Assocíee 2182
- Institut National du Cancer BIO-SILC
- Fondation pour la Recherche Ḿedicale
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- PPARα, nicotinic acetylcholine receptors, beta2 nAChR, dopaminergic neurons, ventral tegmental area, nicotine, schizophrenia, nicotine dependence, negative modulation
- MeSH terms
- Analysis of Variance, Animals, Dopamine, Male, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Neurons, Receptors, Nicotinic, Signal Transduction, Rats, Sprague-Dawley, Ventral Tegmental Area, Mice, Knockout, Receptor Cross-Talk, PPAR alpha, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
