The cholinergic mesopontine tegmentum is a relatively neglected nicotinic master modulator of the dopaminergic system: relevance to drugs of abuse and pathology
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The mammalian mesopontine tegmentum (MPT) contains two cholinergic nuclei, the pedunculopontine tegmental nucleus (PPTg) and the laterodorsal tegmental nucleus (LDTg). These provide the cholinergic innervation of, among other brain areas, the dopaminergic A9 and A10 cell groups. Their axons are thus the source of endogenous acetylcholine (ACh) acting on somato‐dendritic acetylcholine receptors in the substantia nigra (SN) and ventral tegmental area (VTA). The anatomy, physiology, functional and pathological implications of these interactions with the nicotinic subtype of acetylcholine receptors (nAChRs) are discussed with a view of the important role of the MPT as a master regulator of nicotinic dopaminergic signalling in the brain, including for nicotine addiction. British Journal of Pharmacology (2008) 153 , S438–S445; doi: 10.1038/bjp.2008.5 ; published online 28 January 2008
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Both the PPTg and laterodorsal tegmental (LDTg) nuclei send cholinergic projections to the midbrain ventral tegmental area (VTA), where they activate nAChRs on both DA and non-DA neurons.
“Both the PPTg and laterodorsal tegmental (LDTg) nuclei send cholinergic projections to the midbrain ventral tegmental area (VTA), where they activate nAChRs on both DA and non-DA neurons [40].”
From Nicotine on the developing brain. (2023) · cites this paper as [40]
PPT/LDT cholinergic afferents influence DA neurons via nAChRs.
“In addition, the PPT/LDT cholinergic afferents have important endogenous influences over DA neurons by acting via nAChRs (Maskos 2008, 2010).”
From Reward, addiction, withdrawal to nicotine (2011) · cites this paper as Maskos 2008
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- Avale ME, Pons S, Granon S, Faure P, Changeux JP, Maskos U.2007In vivo gene silencing of the nicotinic beta-2 subunit by lentiviral vector-mediated delivery of short interference RNA Society for Neuroscience 2007 Annual Meeting San Diego, California; 3–7 November. [Google Scholar]
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“In addition, the PPT/LDT cholinergic afferents have important endogenous influences over DA neurons by acting via nAChRs (Maskos 2008, 2010).”
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- Authors
- Maskos, U.
- Affiliations
- Institut Pasteur (FR)
- Corresponding author
- Maskos, U
- ORCID
- Maskos, U
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2008-03
- Volume
- 153
- Issue
- S1
- Pages
- S438-45
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC2268063
- OpenAlex
- W2147205016
- Cited by
- 139
- References
- 122
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 6 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 12 · 2014: 8 · 2013: 15 · 2012: 29
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Science Foundation
- Agence Nationale de la Recherche
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- mesopontine tegmentum, pedunculopontine nucleus, laterodorsal tegmental nucleus, nicotinic acetylcholine receptors, dopaminergic system, substantia nigra, ventral tegmental area, nicotine dependence, drugs of abuse, acetylcholine receptor
- MeSH terms
- Animals, Behavior, Dopamine, Humans, Neural Pathways, Parasympathetic Nervous System, Receptors, Nicotinic, Tegmentum Mesencephali, Substance-Related Disorders
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