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Cited by 168

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Mood Disorder Susceptibility Gene CACNA1C Modifies Mood-Related Behaviors in Mice and Interacts with Sex to Influence Behavior in Mice and Diagnosis in Humans

Open access
Dao, David T., Mahon, Pamela Belmonte, Cai, Xiang, Kovacsics, Colleen E., Blackwell, Robert A., Arad, Michal, Shi, Jianxin, Zandi, Peter P., O'Donnell, Patricio, Knowles, James A., Weissman, Myrna M., Coryell, William, Scheftner, William A., Lawson, William B., Levinson, Douglas F., Thompson, Scott M., Potash, James B., Gould, Todd D.·2010·Biological Psychiatry
DOI 10.1016/j.biopsych.2010.06.019
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Abstract

Background Recent genome-wide association studies have associated polymorphisms in the gene CACNA1C, which codes for Cav1.2, with a bipolar disorder and depression diagnosis. Methods The behaviors of wild type and Cacna1c heterozygous mice of both sexes were evaluated in a number of tests. Based upon sex differences in our mouse data, we assessed a gene x sex interaction for diagnosis of mood disorders in human subjects. Data from the NIMH-BP Consortium and the GenRED Consortium were examined utilizing a combined dataset that included 2,021 mood disorder cases (1,223 females) and 1,840 controls (837 females). Results In both male and female mice, Cacna1c haploinsufficiency is associated with lower exploratory behavior, decreased response to amphetamine, and antidepressant-like behavior in the forced swim and tail suspension tests. Female, but not male, heterozygous mice displayed decreased risk-taking behavior or increased anxiety in multiple tests, greater attenuation of amphetamine-induced hyperlocomotion, decreased development of learned helplessness, and a decreased acoustic startle response indicating a sex-specific role of Cacna1c. In humans, sex-specific genetic association was seen for two intronic single nucleotide polymorphisms (SNPs), rs2370419 and rs2470411, in CACNA1C, with effects in females (OR=1.64, 1.32), but not in males (OR=0.82, 0.86). The interactions by sex were significant after correction for testing 190 SNPs (P=1.4 x 10−4, 2.1 x 10−4; Pcorrected=0.03, 0.04), and were consistent across two large data sets. Conclusions Our preclinical results support a role for CACNA1C in mood disorder pathophysiology, and the combination of human genetic and preclinical data support an interaction between sex and genotype.

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Authors
Dao, D. T., Mahon, P. B., Cai, X., Kovacsics, C. E., Blackwell, R. A., Arad, M., Shi, J., Zandi, P. P., O'Donnell, P., Knowles, J. A., Weissman, M. M., Coryell, W., Scheftner, W. A., Lawson, W. B., Levinson, D. F., Thompson, S. M., Potash, J. B., & Gould, T. D.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2010-11
Volume
68
Issue
9
Pages
801-810
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2010.06.019
OpenAlex
W2074851919
Cited by
168
References
9
FWCI
6.38
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Mood Disorder Susceptibility Gene CACNA1C Modifies Mood-Related Behaviors in Mice and Interacts with Sex to Influence Behavior in Mice and Diagnosis in Humans. https://app.cochat.ai/papers/10.1016/j.biopsych.2010.06.019
The paper
Dao, D. T., Mahon, P. B., Cai, X., Kovacsics, C. E., Blackwell, R. A., Arad, M., Shi, J., Zandi, P. P., O'Donnell, P., Knowles, J. A., Weissman, M. M., Coryell, W., Scheftner, W. A., Lawson, W. B., Levinson, D. F., Thompson, S. M., Potash, J. B., & Gould, T. D. (2010). Mood Disorder Susceptibility Gene CACNA1C Modifies Mood-Related Behaviors in Mice and Interacts with Sex to Influence Behavior in Mice and Diagnosis in Humans. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2010.06.019

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.