Ghrelin's role in the hypothalamic-pituitary-adrenal axis stress response: implications for mood disorders

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

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The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

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Biological studies of post-traumatic stress disorder

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The neuro-symphony of stress

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Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states

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Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.

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Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.

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Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research

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Expression of ghrelin receptor mRNA in the rat and the mouse brain

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Pattern and time course of immediate early gene expression in rat brain following acute stress

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Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction

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Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

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Dynamic adaptation of large-scale brain networks in response to acute stressors

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Ghrelin octanoylation mediated by an orphan lipid transferase

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Hair cortisol, stress exposure, and mental health in humans: A systematic review

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Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure

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Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression

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The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

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Endocrine Activities of Ghrelin, a Natural Growth Hormone Secretagogue (GHS), in Humans: Comparison and Interactions with Hexarelin, a Nonnatural Peptidyl GHS, and GH-Releasing Hormone1

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Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups

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Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway

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Ghrelin O -acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

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Requirement of central ghrelin signaling for alcohol reward

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Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens

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Stress-Induced Norepinephrine Release in the Hypothalamic Paraventricular Nucleus and Pituitary-Adrenocortical and Sympathoadrenal Activity: In Vivo Microdialysis Studies

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Altered Hypothalamic-Pituitary-Adrenocortical Regulation in Healthy Subjects at High Familial Risk for Affective Disorders

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Ghrelin increases anxiety-like behavior and memory retention in rats.

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Regulation of the Hypothalamic-Pituitary-Adrenal Axis

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Comfort food is comforting to those most stressed: Evidence of the chronic stress response network in high stress women

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Endocrine Activities of Ghrelin, a Natural Growth Hormone Secretagogue (GHS), in Humans: Comparison and Interactions with Hexarelin, a Nonnatural Peptidyl GHS, and GH-Releasing Hormone

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A Role of Ghrelin in Neuroendocrine and Behavioral Responses to Stress in Mice

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PRECLINICAL STUDY: Ghrelin stimulates locomotor activity and accumbal dopamine‐overflow via central cholinergic systems in mice: implications for its involvement in brain reward

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Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin.

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Ghrelin mediates stress-induced food-reward behavior in mice

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Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

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Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism

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Neuroendocrine responses to an emotional stressor: evidence for involvement of the medial but not the central amygdala

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Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers.

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Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus

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Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress

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Orexin Signaling Mediates the Antidepressant-Like Effect of Calorie Restriction

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Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats

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Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference

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The Edinger‐Westphal nucleus: A historical, structural, and functional perspective on a dichotomous terminology

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The extra-hypothalamic actions of ghrelin on neuronal function.

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Ghrelin secretion stimulated by β 1 -adrenergic receptors in cultured ghrelinoma cells and in fasted mice

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Ghrelin Stimulates Appetite, Imagination of Food, GH, ACTH, and Cortisol, but does not Affect Leptin in Normal Controls

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Acute psychological stress raises plasma ghrelin in the rat

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A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear

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The Amygdala as a Neurobiological Target for Ghrelin in Rats: Neuroanatomical, Electrophysiological and Behavioral Evidence

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The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis

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Molecular Forms of Hypothalamic Ghrelin and Its Regulation by Fasting and 2-Deoxy-d-Glucose Administration

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The acute ghrelin response to a psychological stress challenge does not predict the post-stress urge to eat

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Effects of Triglycerides, Obesity, and Starvation on Ghrelin Transport Across the Blood-Brain Barrier

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Brain Circuits Involved in Corticotropin‐Releasing Factor‐Norepinephrine Interactions during Stress

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Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse

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Promiscuous Dimerization of the Growth Hormone Secretagogue Receptor (GHS-R1a) Attenuates Ghrelin-mediated Signaling

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Persistent Cognitive Impairment in Depression: The Role of Psychopathology and Altered Hypothalamic-Pituitary-Adrenocortical (HPA) System Regulation

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Central stress-integrative circuits: forebrain glutamatergic and GABAergic projections to the dorsomedial hypothalamus, medial preoptic area, and bed nucleus of the stria terminalis

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Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice

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Ghrelin's Roles in Stress, Mood, and Anxiety Regulation

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Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats

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The glucocorticoid contribution to obesity

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Unacylated Ghrelin Rapidly Modulates Lipogenic and Insulin Signaling Pathway Gene Expression in Metabolically Active Tissues of GHSR Deleted Mice

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Central Ghrelin Signaling Mediates the Metabolic Response of C57BL/6 Male Mice to Chronic Social Defeat Stress

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Psychosocial stressor effects on cortisol and ghrelin in emotional and non-emotional eaters: Influence of anger and shame

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Ghrelin Indirectly Activates Hypophysiotropic CRF Neurons in Rodents

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Activation of the Locus Ceruleus Brain Noradrenergic System during Stress: Circuitry, Consequences, and Regulation

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Ghrelin Receptor Antagonism Decreases Alcohol Consumption and Activation of Perioculomotor Urocortin‐Containing Neurons

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Effects of repeated restraint stress on gastric motility in rats

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Investigation of the presence of ghrelin in the central nervous system of the rat and mouse

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Chemical stimulation of the dorsomedial hypothalamus elevates plasma ACTH in conscious rats

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Ghrelin regulates hippocampal neurogenesis in adult mice.

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Des-Acyl Ghrelin: A Metabolically Active Peptide

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Divergent Neuronal Circuitries Underlying Acute Orexigenic Effects of Peripheral or Central Ghrelin: Critical Role of Brain Accessibility

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Ghrelin-containing neuron in cerebral cortex and hypothalamus linked with the DVC of brainstem in rat

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Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment

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Ghrelin is an orexigenic peptide and elicits anxiety-like behaviors following administration into discrete regions of the hypothalamus

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Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice

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Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward

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Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression

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Functional Implications of Limited Leptin Receptor and Ghrelin Receptor Coexpression in the Brain

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Peripheral injection of ghrelin induces Fos expression in the dorsomedial hypothalamic nucleus in rats

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Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluid

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Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents

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Local Integration of Glutamate Signaling in the Hypothalamic Paraventricular Region: Regulation of Glucocorticoid Stress Reponses

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Attenuation of cocaine‐induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors

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Hypothalamic and brainstem sources of pituitary adenylate cyclase‐activating polypeptide nerve fibers innervating the hypothalamic paraventricular nucleus in the rat

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Reduced locomotor responses to cocaine in ghrelin-deficient mice

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Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat

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The Role of Corticotropin-Releasing Hormone in the Pathophysiology of Depression: Therapeutic Implications

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Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse

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Behavioral effects of local microinfusion of pituitary adenylate cyclase activating polypeptide (PACAP) into the paraventricular nucleus of the hypothalamus (PVN)

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Growth Hormone Secretagogue Receptor (GHS-R1a) Knockout Mice Exhibit Improved Spatial Memory and Deficits in Contextual Memory

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Ghrelin Plasma Levels Are Not Altered in Major Depression

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The effects of electroconvulsive therapy on ghrelin, leptin and cholesterol levels in patients with mood disorders

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Ghrelin gene polymorphism is associated with depression, but not panic disorder

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Systemic ghrelin sensitizes cocaine-induced hyperlocomotion in rats

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Ghrelin and Eating Disturbances in Psychiatric Disorders

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Pharmacologic antagonism of ghrelin receptors attenuates development of nicotine induced locomotor sensitization in rats

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The hormonal signature of energy deficit: Increasing the value of food reward

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Ghrelin Receptor Expression and Colocalization with Anterior Pituitary Hormones Using a GHSR-GFP Mouse Line

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Serum Ghrelin Levels and the Effects of Antidepressants in Major Depressive Disorder and Panic Disorder

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Neural correlates of plasma acylated ghrelin level in individuals with major depressive disorder

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Direction of post-prandial ghrelin response associated with cortisol response, perceived stress and anxiety, and self-reported coping and hunger in obese women

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An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice

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Regulation of Hypophysiotrophic Corticotrophin‐Releasing Hormone‐ and Thyrotrophin‐Releasing Hormone‐Synthesising Neurones by Brainstem Catecholaminergic Neurones

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A possible association between panic disorder and a polymorphism in the preproghrelingene

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Substance induced plasticity in noradrenergic innervation of the paraventricular hypothalamic nucleus

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BIOMARKERS IN PEDIATRIC DEPRESSION

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Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

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Anxiety, depression, and the microbiome: A role for gut peptides

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Posttraumatic stress disorder: A metabolic disorder in disguise?

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Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals

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Physiological Effect of Ghrelin on Body Systems

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Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder

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The Role of the Ghrelin System in Drug Addiction

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The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective

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Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now?

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Linking Stress and Infertility: A Novel Role for Ghrelin

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The hormesis principle of neuroplasticity and neuroprotection

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Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus

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Central Ghrelin Resistance Permits the Overconsolidation of Fear Memory

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Mood‐related central and peripheral clocks

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Diet-induced obesity causes ghrelin resistance in reward processing tasks

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Ghrelin receptor deletion reduces binge‐like alcohol drinking in rats

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The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting

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Evaluating the Levels of Nesfatin-1 and Ghrelin Hormones in Patients with Moderate and Severe Major Depressive Disorders

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Metabolic and Microbiota Measures as Peripheral Biomarkers in Major Depressive Disorder

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Des-Acyl Ghrelin and Ghrelin O-Acyltransferase Regulate Hypothalamic-Pituitary-Adrenal Axis Activation and Anxiety in Response to Acute Stress

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Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin.

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The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders

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Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior

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A new understanding of GHSR1a——independent of ghrelin activation

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GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

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β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress

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Leptin and ghrelin: Sewing metabolism onto neurodegeneration

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Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model

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The Ghrelin-AgRP Neuron Nexus in Anorexia Nervosa: Implications for Metabolic and Behavioral Adaptations

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GHS-R1a Deficiency Alleviates Depression-Related Behaviors After Chronic Social Defeat Stress

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Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice

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Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial

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Intermittent access to a nutritionally complete high-fat diet attenuates alcohol drinking in rats

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Hypothalamic carnitine metabolism integrates nutrient and hormonal feedback to regulate energy homeostasis

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Vulnerability to psychological stress‐induced anorexia in female mice depends on blockade of ghrelin signal in nucleus tractus solitarius

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Acute But Not Chronic Calorie Restriction Defends against Stress-Related Anxiety and Despair in a GHS-R1a-Dependent Manner.

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Acyl-ghrelin Is Permissive for the Normal Counterregulatory Response to Insulin-Induced Hypoglycemia

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The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities

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Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants

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Pharmacological manipulation of the ghrelin system and alcohol hangover symptoms in heavy drinking individuals: Is there a link?

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Ghrelin Receptor Agonist Rescues Excess Neonatal Mortality in a Prader-Willi Syndrome Mouse Model

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Effects of exogenous ghrelin administration and ghrelin receptor blockade, in combination with alcohol, on peripheral inflammatory markers in heavy-drinking individuals: Results from two human laboratory studies

Farokhnia, M., Portelli, J., Lee, M. R., McDiarmid, G. R., Munjal, V., Abshire, K. M., Battista, J. T., Browning, B. D., Deschaine, S. L., Akhlaghi, F., et al. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146851 · Cited by 17 · see citing works

The association of short-term memory and cognitive impairment with ghrelin, leptin, and cortisol levels in non-diabetic and diabetic elderly individuals

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Ghrelin signaling in dCA1 suppresses neuronal excitability and impairs memory acquisition via PI3K/Akt/GSK-3β cascades.

Li, N., Xiao, K., Mi, X., Li, N., Guo, L., Wang, X., Sun, Y.-X., Li, G.-D., & Zhou, Y. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108871 · Cited by 20 · see citing works

Early life stress and metabolism

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Evidence that hydrogen peroxide, a component of oxidative stress, induces high-anxiety-related behaviour in mice

Bouayed, J., & Soulimani, R. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.009 · Cited by 20 · see citing works

Acylated Ghrelin Supports the Ovarian Transcriptome and Follicles in the Mouse: Implications for Fertility

Sominsky, L., Goularte, J. F., Andrews, Z. B., & Spencer, S. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00815 · Cited by 20 · see citing works

Ghrelin, leptin and high-molecular-weight adiponectin in relation to depressive symptoms in older adults: Results from the Longitudinal Aging Study Amsterdam

van Andel, M., van Schoor, N. M., Korten, N. C. M., Heijboer, A. C., & Drent, M. L. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.069 · Cited by 20 · see citing works

Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment

Odeón, M. M., & Acosta, G. B. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109726 · Cited by 19 · see citing works

Intracerebroventricular Ghrelin Administration Increases Depressive-Like Behavior in Male Juvenile Rats

Jackson, T. M., Ostrowski, T. D., & Middlemas, D. S. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00077 · Cited by 18 · see citing works

Exendin-4 antagonizes the metabolic action of acylated ghrelinergic signaling in the hypothalamic paraventricular nucleus

Abtahi, S., Howell, E., Salvucci, J. T., Bastacky, J. M. R., Dunn, D. P., & Currie, P. J. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.10.008 · Cited by 17 · see citing works

Prospective associations of multimodal serum biomarkers with 12-week and 12-month remission in patients with depressive disorders receiving stepwise psychopharmacotherapy

Kim, J., Kang, H., Kim, J., Jhon, M., Choi, W., Lee, J., Kim, S., Shin, I., Kim, M., & Stewart, R. J. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.05.012 · Cited by 17 · see citing works

Chronic predator stress in female mice reduces primordial follicle numbers: implications for the role of ghrelin

Natale, M. R. D., Soch, A., Ziko, I., Luca, S. N. D., Spencer, S. J., & Sominsky, L. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0109 · Cited by 16 · see citing works

Ghrelin, Neuroinflammation, Oxidative Stress, and Mood Disorders: What Are the Connections?

Mingardi, J., Meanti, R., Paoli, C., Cifani, C., Torsello, A., Popoli, M., & Musazzi, L. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22999240722095039 · Cited by 16 · see citing works

Neuroendocrine drivers of risk and resilience: The influence of metabolism & mitochondria

Turkson, S., Kloster, A., Hamilton, P. J., & Neigh, G. N. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100770 · Cited by 16 · see citing works

Neonatal overfeeding disrupts pituitary ghrelin signalling in female rats long-term; Implications for the stress response

Sominsky, L., Ziko, I., & Spencer, S. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173498 · Cited by 15 · see citing works

Serum ghrelin is positively associated with physiological anxiety but negatively associated with pathological anxiety in humans: Data from a large community-based study

Wittekind, D. A., Kratzsch, J., Mergl, R., Riedel-Heller, S. G., Witte, A. V., Villringer, A., & Kluge, M. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105728 · Cited by 15 · see citing works

The octanoylated energy regulating hormone ghrelin: An expanded view of ghrelin’s biological interactions and avenues for controlling ghrelin signaling

Cleverdon, E. R., McGovern-Gooch, K. R., & Hougland, J. L. (2016) · Molecular Membrane Biology · doi:10.1080/09687688.2017.1388930 · Cited by 15 · see citing works

Acylated ghrelin suppresses the cytokine response to lipopolysaccharide and does so independently of the hypothalamic-pituitary-adrenal axis

Ziko, I., Sominsky, L., Luca, S. N. D., Lelngei, F., & Spencer, S. J. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.011 · Cited by 15 · see citing works

The effect of obestatin on anxiety-like behaviour in mice

Szakács, J., Csabafi, K., Lipták, N., & Szabó, G. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.042 · Cited by 15 · see citing works

A randomized, double-blind, placebo-controlled study of a GHSR blocker in people with alcohol use disorder

Faulkner, M. L., Farokhnia, M., Lee, M. R., Farinelli, L., Browning, B. D., Abshire, K. M., Daurio, A. M., Munjal, V., Deschaine, S. L., Boukabara, S. R., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.182331 · Cited by 14 · see citing works

Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

Masule, M. V., Rathod, S., Agrawal, Y. O., Patil, C. R., Nakhate, K. T., Ojha, S. K., Goyal, S. N., & Mahajan, U. B. (2022) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2022.100113 · Cited by 14 · see citing works

Perinatal programming of depressive-like behavior by inflammation in adult offspring mice whose mothers were fed polluted eels: Gender selective effects

Soualeh, N., Dridi, I., Eppe, G., Némos, C., Soulimani, R., & Bouayed, J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.029 · Cited by 13 · see citing works

The role of ghrelin/GHS-R1A signaling in nonalcohol drug addictions

Sustkova-Fiserova, M., Charalambous, C., Khryakova, A., Certilina, A., Lapka, M., & Šlamberová, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020761 · Cited by 12 · see citing works

Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice

Wellman, M. K., Patterson, Z. R., MacKay, H., Darling, J. E., Mani, B. K., Zigman, J. M., Hougland, J. L., & Abizaid, A. B. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00144 · Cited by 11 · see citing works

Ghrelin infusion into the basolateral amygdala suppresses CTA memory formation in rats via the PI3K/Akt/mTOR and PLC/PKC signaling pathways

Yu, M., Zhu, Q., Niu, M., Li, N., Ren, B.-Q., Yu, T., Zhou, Z., Guo, J., & Zhou, Y. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00859-w · Cited by 11 · see citing works

Systemic oscillator-driven and nutrient-responsive hormonal regulation of daily expression rhythms for gluconeogenic enzyme genes in the mouse liver

Taira, A., Arita, E., Matsumoto, E., Oohira, A., Iwase, K., Hiwasa, T., Yokote, K., Shibata, S., & Takiguchi, M. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1570246 · Cited by 11 · see citing works

Ghrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis

Zhang, C., Dong, Y., Li, S., Li, M., Gao, Y., Liu, Y. S., Liu, X., Zhou, C., & Li, J. (2024) · Asia-Pacific Psychiatry · doi:10.1111/appy.12552 · Cited by 10 · see citing works

GHSR blockade, but not reduction of peripherally circulating ghrelin via β1-adrenergic receptor antagonism, decreases binge-like alcohol drinking in mice

Richardson, R. S., Kryszak, L. A., Vendruscolo, J. C. M., Koob, G. F., Vendruscolo, L. F., & Leggio, L. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02713-3 · Cited by 10 · see citing works

Ghrelin is associated with an elevated mood after an overnight fast in depression

Fahed, R., Schulz, C., Klaus, J., Ellinger, S., Walter, M., & Kroemer, N. B. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.04.053 · Cited by 10 · see citing works

Effects of Isolation and Social Subchronic Stresses on Food Intake and Levels of Leptin, Ghrelin, and Glucose in Male Rats

Izadi, M. S., Radahmadi, M., Ghasemi, M., & Rayatpour, A. (2018) · Advanced Biomedical Research · doi:10.4103/abr.abr_28_18 · Cited by 11 · see citing works

Effects of ghrelin receptor activation on forebrain dopamine release, conditioned fear and fear extinction in C57BL/6J mice

Pierre, A., Schuerbeek, A. V., Allaoui, W., Laere, S. V., Singewald, N., Eeckhaut, A. V., Smolders, I. J., & Bundel, D. D. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14996 · Cited by 10 · see citing works

Does physical activity associated with chronic food restriction alleviate anxiety like behaviour, in female mice?

Duriez, P., Eddarkaoui, S., Blum, D. L., Dickson, S. L., Gorwood, P. A. P. M., Tolle, V., & Viltart, O. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104807 · Cited by 10 · see citing works

Octanoic acid-rich enteral nutrition attenuated hypercatabolism through the acylated ghrelin-POMC pathway in endotoxemic rats

Zhang, Z., Li, X., & Cao, C. (2023) · Nutrition · doi:10.1016/j.nut.2023.112329 · Cited by 9 · see citing works

Ghrelin/GHS-R1a signaling plays different roles in anxiety-related behaviors after acute and chronic caloric restriction.

Zhang, F., Xu, F., Mi, X., Dong, L.-F., Xiao, Y.-H., Jiang, S., Li, G.-D., & Zhou, Y. (2020) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2020.05.227 · Cited by 8 · see citing works

Correlation of lower 2 h C-peptide and elevated evening cortisol with high levels of depression in type 2 diabetes mellitus

Sang, Y.-M., Wang, L.-J., Mao, H.-X., Lou, X., Zhu, Y.-J., & Zhu, Y.-H. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02901-9 · Cited by 9 · see citing works

GHSR1a deficiency suppresses inhibitory drive on dCA1 pyramidal neurons and contributes to memory reinforcement.

Li, N., Li, N., Yang, L., Gu, H.-T., Ji, J., Zhou, H.-L., Zhu, Q., Yu, M., Sun, Y.-X., & Zhou, Y. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac230 · Cited by 8 · see citing works

Brain transcriptome profile after CRISPR-induced ghrelin mutations in zebrafish

Blanco, A. M., Cortés, R., Bertucci, J. I., Soletto, L., Sánchez, E., Valenciano, A. I., Cerdá‐Reverter, J. M., & Delgado, M. J. (2019) · Fish Physiology and Biochemistry · doi:10.1007/s10695-019-00687-6 · Cited by 8 · see citing works

Experimental biology can inform our understanding of food insecurity

Wilbrecht, L., Lin, W. C., Callahan, K., Melissa Bateson, B., Myers, K. P., & Ross, R. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.246215 · Cited by 7 · see citing works

Baseline and postprandial concentrations of cortisol and ghrelin in companion dogs with chronic stress-related behavioural problems: A preliminary study

Luño, I., Palacio, J., García-Belenguer, S., & Rosado, B. (2019) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2019.04.011 · Cited by 7 · see citing works

Ghrelin receptor antagonist attenuated sickness behavior and activation of HPA-axis induced by immunological challenge in male rats

de Paula, D. E., Vilela, F. C., & Giusti‐Paiva, A. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120173 · Cited by 7 · see citing works

Increased GHS-R1a expression in the hippocampus impairs memory encoding and contributes to AD-associated memory deficits

Zhang, M., Yang, L., Jia, J., Xu, F., Gao, S.-S., Han, F.-B., Deng, M., Wang, J., Li, V., Yu, M., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06914-y · Cited by 6 · see citing works

Leptin Intake at Physiological Doses Throughout Lactation in Male Wistar Rats Normalizes the Decreased Density of Tyrosine Hydroxylase-Immunoreactive Fibers in the Stomach Caused by Mild Gestational Calorie Restriction

Szostaczuk, N., Sánchez, J., Konieczna, J., Palou, A., & Picó, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00256 · Cited by 6 · see citing works

Synergistic effects of resilience and serum ghrelin levels on the 12-week pharmacotherapeutic response in patients with depressive disorders

Choi, W., Kim, J., Kang, H., Kim, H. K., Kang, H., Lee, J., Kim, S., Stewart, R. J., & Kim, J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.039 · Cited by 6 · see citing works

The Neurobiological Impact of Ghrelin Suppression after Oesophagectomy

Murphy, C. F., & le Roux, C. W. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010035 · Cited by 6 · see citing works

Effect of Ghrelin Administration on Serum Corticostrone, T3, T4 and Some Biochemical Indices in the Turkey (Meleagridis gallopova)

Shahryar, H. A., & Lotfi, A. (2017) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-017-9588-2 · Cited by 5 · see citing works

Ghrelin/GHSR signaling in the lateral septum ameliorates chronic stress-induced depressive-like behaviors

Chang, L., Niu, F., & Li, B. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.110953 · Cited by 5 · see citing works

Pepsinogen II and a no-pickled food diet are risk factors for female patients with anxiety: a cross-sectional study

Wang, Y. (2024) · American Journal of Translational Research · doi:10.62347/tzrm6783 · Cited by 5 · see citing works

Effect of Xiaoyao San on the brain-gut axis in rats after chronic immobilization stress

Liu, Q., Ma, Q., Liu, Y., Li, X., Jiang, Y.-M., Yan, Z., Pan, Q., Li, N., Bai, X., & Chen, J. (2017) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2017.09.005 · Cited by 5 · see citing works

Stress-induced GHS-R1a expression in medial prefrontal cortical neurons promotes vulnerability to anxiety in mice

Yang, L., Zhang, M., Sun, X., Du, A.-Q., Jia, J., Li, N., Hu, G., Lu, Y., Wang, S., Zhang, J., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07802-9 · Cited by 4 · see citing works

Ghrelin in Depression: A Promising Therapeutic Target

Kore, M. S., Mamsa, R., Patil, D., & Bhatt, L. K. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04554-1 · Cited by 4 · see citing works

Role of dorsal raphe nucleus GHS-R1a receptors in the regulation of inhibitory avoidance and escape behaviors in rats

Cavalcante, D. P., Turones, L. C., Camargo-Silva, G., Santana, J. S., Colugnati, D. B., Pansani, A. P., Xavier, C. H., & Pobbe, R. L. H. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.03.017 · Cited by 4 · see citing works

Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review

Hu, G., Zhang, M., Wang, Y., Yu, M., & Zhou, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213776 · Cited by 4 · see citing works

Towards a greater understanding of the psychosocial impact of the symptoms of pituitary conditions

Norman, A., Jackson, S., Ferrario, H., Percuklievska, N., & McBride, P. (2021) · British Journal of Community Nursing · doi:10.12968/bjcn.2021.26.5.236 · Cited by 4 · see citing works

Circulating ghrelin changes as a biomarker of the stress response and craving in abstinent smokers

Potretzke, S., Lemieux, A. M., Nakajima, M., & Al’Absi, M. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173423 · Cited by 4 · see citing works

Job Stress and Neuropeptide Response Contributing to Food Intake Regulation

Kim, K.-W., Won, Y. L., Ko, K. S., & Kang, S. (2015) · Toxicological Research · doi:10.5487/tr.2015.31.4.415 · Cited by 3 · see citing works

Hidden disability: a study of the psychosocial impact of living with pituitary conditions

Norman, A., Jackson, S., Ferrario, H., & McBride, P. (2022) · British Journal of Nursing · doi:10.12968/bjon.2022.31.11.590 · Cited by 3 · see citing works

Increased mRNA grelin receptor expression in rat cubs brain structures in models of separation from mother and social isolation

Pyurveev, S. S., Aa, L., Sekste, E. A., Бычков, Э. Р., Dedanishvili, N. S., Tagirov, N. S., & Shabanov, P. D. (2023) · Pediatrician (St Petersburg) · doi:10.17816/ped14249-58 · Cited by 3 · see citing works

GHS-R1a signaling drives anxiety-related behavior by shaping excitability of ventromedial hypothalamic neurons

Zhang, M., Yang, L., Mi, X., Hu, G., Lu, Y., Wang, C., Yang, J., Sun, X., Niu, M., Li, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59116-3 · Cited by 2 · see citing works

Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress

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An Integrative Review on Role and Mechanisms of Ghrelin in Stress, Anxiety and Depression

Bali, A., & Jaggi, A. S. (2016) · Current Drug Targets · doi:10.2174/1389450116666150518095650 · Cited by 80 · see citing works

The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders

Fritz, E. M., Singewald, N., & Bundel, D. D. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.594484 · Cited by 42 · see citing works

Ghrelin's Roles in Stress, Mood, and Anxiety Regulation

Chuang, J.-C., & Zigman, J. M. (2010) · International Journal of Peptides · doi:10.1155/2010/460549 · Cited by 135 · see citing works

Ghrelin Plays a Role in Various Physiological and Pathophysiological Brain Functions

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