The hormonal signature of energy deficit: Increasing the value of food reward

Lockie, Sarah H.; Andrews, Zane B.

doi:10.1016/j.molmet.2013.08.003

Cited by 50Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorEating Disorders and Behaviors

The hormonal signature of energy deficit: Increasing the value of food reward

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Lockie, Sarah H., Andrews, Zane B.·2013·Molecular Metabolism

DOI 10.1016/j.molmet.2013.08.003PMC PMC3854986

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Abstract

Energy deficit is characterised by high ghrelin levels, and low leptin and insulin levels and we suggest that this provides a metabolic signature sensed by the brain to increase motivated behaviour to obtain food. We believe that the hormonal profile of negative energy balance serves to increase the incentive salience (or the value) of a food reinforcer, which in turn leads to increased motivation to obtain this reinforcer. These processes are mediated by a number of alterations in the mesolimbic dopamine system which serves to increase dopamine availability in the forebrain during energy deficit. The currently available evidence suggests that changes in motivational state, rather than hedonic enjoyment of taste, are primarily affected by reduced energy availability. This review aims to clarify the term 'reward' in the metabolic literature and promote more focused discussion in future studies.

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Engagement of reward circuitry in social deficit may enhance the rewarding value of social contact, similar to how food deprivation enhances the rewarding properties of food.
“Engagement of reward circuitry in situations of social deficit may enhance the rewarding value of social contact—potentially similar to how food deprivation enhances the rewarding properties of food219–222.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [221]

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347 · see citing works
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679 · see citing works
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578 · see citing works
The mysterious motivational functions of mesolimbic dopamine
Salamone, J. D., & Correa, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.021 · Cited by 1,418 · see citing works
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,238 · see citing works
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.
Guan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185 · see citing works
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,127 · see citing works
Expression of ghrelin receptor mRNA in the rat and the mouse brain
Zigman, J. M., Jones, J. E., Lee, C. E., Saper, C. B., & Elmquist, J. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20823 · Cited by 1,074 · see citing works
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Spanagel, R., Herz, A., & Shippenberg, T. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2046 · Cited by 1,005 · see citing works
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984 · see citing works
Self-citation
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902 · see citing works
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
Broberger, C., Johansen, J., Johansson, C., Schalling, M., & Hökfelt, T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15043 · Cited by 798 · see citing works
Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?
Peciña, S., & Berridge, K. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2329-05.2005 · Cited by 671 · see citing works
Leptin Regulation of the Mesoaccumbens Dopamine Pathway
Fulton, S., Pissios, P., Manchon, R. P., Stiles, L., Frank, L., Pothos, E. N., Maratos-Flier, E., & Flier, J. S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.006 · Cited by 644 · see citing works
REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview
Sanchis‐Segura, C., & Spanagel, R. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00012.x · Cited by 629 · see citing works
Opioid modulation of taste hedonics within the ventral striatum
Kelley, A. E., Bakshi, V. P., Haber, S. N., Steininger, T. L., Will, M. J., & Zhang, M. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00751-5 · Cited by 526 · see citing works
GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake
Alhadeff, A. L., Rupprecht, L. E., & Hayes, M. R. (2012) · Endocrinology · doi:10.1210/en.2011-1443 · Cited by 515 · see citing works
Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat
Figlewicz, D. P., Evans, S. B., Murphy, J., Hoen, M., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04087-8 · Cited by 482 · see citing works
A trans-dimensional approach to the behavioral aspects of depression
Bessa, J. M. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.001.2009 · Cited by 469 · see citing works
Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation
Wu, Q., Boyle, M. P., & Palmiter, R. D. (2009) · Cell · doi:10.1016/j.cell.2009.04.022 · Cited by 465 · see citing works
Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
Yang, Y., Atasoy, D., Su, H. H., & Sternson, S. M. (2011) · Cell · doi:10.1016/j.cell.2011.07.039 · Cited by 431 · see citing works
Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice
Qian, S., Chen, H., Weingarth, D. T., Trumbauer, M. E., Novi, D. E., Guan, X.-M., Yu, H., Shen, Z., Feng, Y., Frazier, E. G., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5027-5035.2002 · Cited by 430 · see citing works
Ghrelin O -acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
Zhao, T., Liang, G., Li, R. L., Xie, X., Sleeman, M. W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Goldstein, J. L., & Brown, M. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002271107 · Cited by 427 · see citing works
The Glucagon-Like Peptide 1 (GLP-1) Analogue, Exendin-4, Decreases the Rewarding Value of Food: A New Role for Mesolimbic GLP-1 Receptors
Dickson, S. L., Shirazi, R. H., Hansson, C., Bergquist, F., Nissbrandt, H., & Skibicka, K. P. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6326-11.2012 · Cited by 414 · see citing works
Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding
Leinninger, G. M., Jo, Y.-H., Leshan, R. L., Louis, G. W., Yang, H., Barrera, J. G., Wilson, H., Opland, D. M., Faouzi, M. A., Gong, Y., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.06.011 · Cited by 412 · see citing works
Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens
Naleid, A. M., Grace, M. K., Cummings, D. E., & Levine, A. S. (2005) · Peptides · doi:10.1016/j.peptides.2005.04.025 · Cited by 409 · see citing works
Does Pet Ownership in Infancy Lead to Asthma or Allergy at School Age? Pooled Analysis of Individual Participant Data from 11 European Birth Cohorts
Lødrup Carlsen, K. C., Roll, S., Carlsen, K.-H., Mowinckel, P., Wijga, A. H., Brunekreef, B., Torrent, M., Roberts, G., Arshad, S. H., Kull, I., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043214 · Cited by 400 · see citing works
The Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose “Liking” and Food Intake
Smith, K. S., & Berridge, K. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-05.2005 · Cited by 391 · see citing works
Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward
Mahler, S. V., Smith, K. S., & Berridge, K. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301376 · Cited by 377 · see citing works
Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
Perelló, M., Sakata, I., Birnbaum, S. G., Chuang, J.-C., Osborne-Lawrence, S. L., Rovinsky, S. A., Wołoszyn, J., Yanagisawa, M., Lutter, M. L., & Zigman, J. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.030 · Cited by 369 · see citing works
Deciphering a neuronal circuit that mediates appetite
Wu, Q., Clark, M. S., & Palmiter, R. D. (2012) · Nature · doi:10.1038/nature10899 · Cited by 359 · see citing works
PRECLINICAL STUDY: Ghrelin stimulates locomotor activity and accumbal dopamine‐overflow via central cholinergic systems in mice: implications for its involvement in brain reward
Jerlhag, E., Egecioglu, E., Dickson, S. L., Andersson, M. A., Svensson, L., & Engel, J. A. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00002.x · Cited by 352 · see citing works
Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance
Leinninger, G. M., Opland, D. M., Jo, Y., Faouzi, M., Christensen, L., Cappellucci, L., Rhodes, C. J., Gnegy, M. E., Becker, J. B., Pothos, E. N., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.016 · Cited by 346 · see citing works
Physiological Changes in Glucose Differentially Modulate the Excitability of Hypothalamic Melanin-Concentrating Hormone and Orexin NeuronsIn Situ
Burdakov, D., Gerasimenko, O. V., & Verkhratsky, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4925-04.2005 · Cited by 337 · see citing works
Ghrelin directly targets the ventral tegmental area to increase food motivation.
Skibicka, K., Hansson, C., Álvarez-Crespo, M., Friberg, P., & Dickson, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.016 · Cited by 323 · see citing works
Fasting Induces a Large, Leptin-Dependent Increase in the Intrinsic Action Potential Frequency of Orexigenic Arcuate Nucleus Neuropeptide Y/Agouti-Related Protein Neurons
Takahashi, K. A., & Cone, R. D. (2005) · Endocrinology · doi:10.1210/en.2004-1397 · Cited by 308 · see citing works
Reward without dopamine
Cannon, C. M., & Palmiter, R. D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10827.2003 · Cited by 280 · see citing works
Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers.
Jiang, H., Betancourt, L., & Smith, R. G. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0084 · Cited by 279 · see citing works
Dopamine, behavioral economics, and effort
Salamone, J. D. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.013.2009 · Cited by 277 · see citing works
Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia
Moriguchi, T., Sakurai, T., Nambu, T., Yanagisawa, M., & Goto, K. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00177-9 · Cited by 271 · see citing works
Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression
Skibicka, K., Hansson, C., Egecioglu, E., & Dickson, S. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00294.x · Cited by 258 · see citing works
Toward a new neurobiology of energy balance, appetite, and obesity: The anatomists weigh in
Sawchenko, P. E. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981228)402:4 · Cited by 248 · see citing works
The lateral hypothalamus as integrator of metabolic and environmental needs: From electrical self-stimulation to opto-genetics
Berthoud, H.-R., & Münzberg, H. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.051 · Cited by 248 · see citing works
Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards
Robinson, S., Sandstrom, S. M., Denenberg, V. H., & Palmiter, R. D. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.1.5 · Cited by 247 · see citing works
Feeding behavior in dopamine-deficient mice
Szczypka, M. S., Rainey, M. A., Kim, D. S., Alaynick, W. A., Marck, B. T., Matsumoto, A. M., & Palmiter, R. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12138 · Cited by 242 · see citing works
Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats
Tang-Christensen, M., Vrang, N., Ortmann, S., Bidlingmaier, M., Horvath, T. L., & Tschöp, M. (2004) · Endocrinology · doi:10.1210/en.2004-0529 · Cited by 226 · see citing works
Nucleus Accumbens μ-Opioids Regulate Intake of a High-Fat Diet via Activation of a Distributed Brain Network
Will, M. J., Franzblau, E. B., & Kelley, A. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02882.2003 · Cited by 223 · see citing works
Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue‐triggered ‘wanting’ for reward: entire core and medial shell mapped as substrates for <scp>PIT</scp> enhancement
Peciña, S., & Berridge, K. C. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12174 · Cited by 216 · see citing works
Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake
Mebel, D. M., Wong, J. C. Y., Dong, Y., & Borgland, S. L. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08168.x · Cited by 215 · see citing works
Regulation of Opioid Receptor Activities
Law, P., & Loh, H. H. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38179-0 · Cited by 206 · see citing works
Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis
Könner, A. C., Hess, S., Tovar, S., Mesaros, A., Sánchez-Lasheras, C., Evers, N., Verhagen, L. A. W., Brönneke, H. S., Kleinridders, A., Hampel, B., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.021 · Cited by 194 · see citing works
Intraventricular Insulin and Leptin Reverse Place Preference Conditioned With High-Fat Diet in Rats.
Figlewicz, D. P., Bennett, J. L., Evans, S. B., Kaiyala, K. J., Sipols, A. J., & Benoit, S. C. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.3.479 · Cited by 172 · see citing works
Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin
Krügel, U., Schraft, T., Kittner, H., Kieß, W., & Illés, P. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.09.047 · Cited by 171 · see citing works
Intraventricular insulin and leptin decrease sucrose self-administration in rats
Figlewicz, D. P., Bennett, J. L., Naleid, A. M., Davis, C. D., & Grimm, J. W. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.07.023 · Cited by 170 · see citing works
Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits
Davis, J. F., Choi, D. L., Schurdak, J. D., Fitzgerald, M. F., Clegg, D. J., Lipton, J. W., Figlewicz, D. P., & Benoit, S. C. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.028 · Cited by 169 · see citing works
Functional brain imaging of appetite
Dagher, A. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.02.009 · Cited by 164 · see citing works
Diurnal Variation of Human Sweet Taste Recognition Thresholds Is Correlated With Plasma Leptin Levels
Nakamura, Y., Sanematsu, K., Ohta, R., Shirosaki, S., Koyano, K., Nonaka, K., Shigemura, N., & Ninomiya, Y. (2008) · Diabetes · doi:10.2337/db07-1103 · Cited by 161 · cited 1× · see citing works
“Diurnal leptin levels have been linked to the ability to detect sweet taste, with greater sensitivity achieved when leptin levels are low [96].”
Background
Ghrelin Enhances Olfactory Sensitivity and Exploratory Sniffing in Rodents and Humans
Tong, J., Mannea, E., Aimé, P., Pfluger, P. T., Yi, C., Castañeda, T. R., Davis, H. W., Ren, X., Pixley, S. K., Benoit, S. C., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5680-10.2011 · Cited by 160 · see citing works
Increased food intake after opioid microinjections into nucleus accumbens and ventral tegmental area of rat
Mucha, R. F., & Iversen, S. D. (1986) · Brain Research · doi:10.1016/0006-8993(86)90622-0 · Cited by 159 · see citing works
Central mechanisms involved in the orexigenic actions of ghrelin
Andrews, Z. B. (2011) · Peptides · doi:10.1016/j.peptides.2011.05.014 · Cited by 158 · see citing works
Self-citation
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors
Dietrich, M. O., Bober, J., Ferreira, J. G., Tellez, L. A., Mineur, Y. S., Souza, D. O., Gao, X.-B., Picciotto, M. R., Araújo, I., Liu, Z.-W., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3147 · Cited by 158 · see citing works
Food Deprivation Decreases mRNA and Activity of the Rat Dopamine Transporter
Patterson, T. A., Brot, M. D., Zavosh, A., Schenk, J. O., Szot, P., & Figlewicz, D. P. (1998) · Neuroendocrinology · doi:10.1159/000054345 · Cited by 151 · see citing works
Fasting increases and satiation decreases olfactory detection for a neutral odor in rats
Aimé, P., Duchamp‐Viret, P., Chaput, M. A., Savigner, A., Mahfouz, M., & Julliard, A. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.012 · Cited by 146 · see citing works
Opioid receptor involvement in the effect of AgRP- (83–132) on food intake and food selection
Hagan, M. M., Rushing, P. A., Benoit, S. C., Woods, S. C., & Seeley, R. J. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.3.r814 · Cited by 143 · see citing works
Altered Expression of Agouti-Related Protein and Its Colocalization with Neuropeptide Y in the Arcuate Nucleus of the Hypothalamus during Lactation
Chen, P., Li, C., Haskell‐Luevano, C., Cone, R. D., & Smith, M. S. (1999) · Endocrinology · doi:10.1210/endo.140.6.6829 · Cited by 139 · see citing works
Divergent circuitry underlying food reward and intake effects of ghrelin: Dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake
Skibicka, K. P., Shirazi, R. H., Rabasa, C., Álvarez-Crespo, M., Neuber, C., Vogel, H., & Dickson, S. L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.004 · Cited by 136 · see citing works
Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in‐vivo μPET imaging ([<sup>11</sup>C] raclopride) and in‐vitro ([<sup>3</sup>H] spiperone) autoradiography
Thanos, P. K., Michaelides, M., Piyis, Y. K., Wang, G., & Volkow, N. D. (2008) · Synapse · doi:10.1002/syn.20468 · Cited by 135 · see citing works
Dopamine is required for hyperphagia in Lepob/ob mice
Szczypka, M. S., Rainey, M. A., & Palmiter, R. D. (2000) · Nature Genetics · doi:10.1038/75484 · Cited by 134 · see citing works
Hunger enhances the expression of calorie- but not taste-mediated conditioned flavor preferences.
Fedorchak, P. M., & Bolles, R. C. (1987) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.13.1.73 · Cited by 125 · see citing works
The rat arcuate nucleus integrates peripheral signals provided by leptin, insulin, and a ghrelin mimetic.
Hewson, A. K., Tung, L. Y. C., Connell, D. W., Tookman, L., & Dickson, S. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3412 · Cited by 125 · see citing works
Dynamic Computation of Incentive Salience: “Wanting” What Was Never “Liked”
Tindell, A. J., Smith, K. S., Berridge, K. C., & Aldridge, J. W. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2499-09.2009 · Cited by 124 · see citing works
Metabolic Status Regulates Ghrelin Function on Energy Homeostasis
Briggs, D. I., & Andrews, Z. B. (2010) · Neuroendocrinology · doi:10.1159/000322589 · Cited by 123 · see citing works
Self-citation
Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala
Liu, J., Perez, S. M., Zhang, W., Lodge, D. J., & Lu, X.-Y. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.36 · Cited by 118 · see citing works
PSYCHOPHARMACOLOGY OF DOPAMINE: THE CONTRIBUTION OF COMPARATIVE STUDIES IN INBRED STRAINS OF MICE
Puglisi‐Allegra, S., & Cabib, S. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00008-7 · Cited by 112 · see citing works
Hedonic and motivational roles of opioids in food reward: Implications for overeating disorders
Peciña, S., & Smith, K. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.016 · Cited by 104 · see citing works
Ghrelin Interacts with Neuropeptide Y Y1 and Opioid Receptors to Increase Food Reward
Skibicka, K. P., Shirazi, R. H., Hansson, C., & Dickson, S. L. (2011) · Endocrinology · doi:10.1210/en.2011-1606 · Cited by 103 · see citing works
Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake
Mietlicki‐Baase, E. G., Rupprecht, L. E., Olivos, D. R., Zimmer, D. J., Alter, M. D., Pierce, R. C., Schmidt, H. D., & Hayes, M. R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.66 · Cited by 97 · see citing works
Increased or decreased locomotor response in rats following repeated administration of apomorphine depends on dosage interval
Castro, R., Abreu, P. M., Calzadilla, C. H., & Rodrı́guez, M. (1985) · Psychopharmacology · doi:10.1007/bf00428198 · Cited by 95 · see citing works
Increased rewarding properties of morphine in dopamine‐transporter knockout mice
Spielewoy, C., Gonon, F., Roubert, C., Fauchey, V., Jaber, M., Caron, M. G., Roques, B. P., Hamon, M., Betancur, C., Maldonado, R. J., et al. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00063.x · Cited by 93 · see citing works
Ghrelin increases the motivation to eat, but does not alter food palatability
Overduin, J., Figlewicz, D. P., Jay, J. L., Kittleson, S., & Cummings, D. E. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00488.2011 · Cited by 93 · see citing works
Functional Implications of Limited Leptin Receptor and Ghrelin Receptor Coexpression in the Brain
Perelló, M., Scott, M. M., Sakata, I., Lee, C. E., Chuang, J., Osborne-Lawrence, S., Rovinsky, S. A., Elmquist, J., & Zigman, J. (2012) · The Journal of comparative neurology · doi:10.1002/cne.22690 · Cited by 91 · see citing works
Opioids Hyperpolarize β-Endorphin Neurons via μ-Receptor Activation of a Potassium Conductance
Kelly, M. J., Loose, M. D., & Rønnekleiv, O. K. (2008) · Neuroendocrinology · doi:10.1159/000125597 · Cited by 86 · see citing works
Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine
Owens, W. A., Sevak, R. J., Galici, R., Chang, X., Javors, M. A., Galli, A., France, C. P., & Daws, L. C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03289.x · Cited by 80 · see citing works
A Physiological Increase of Insulin in the Olfactory Bulb Decreases Detection of a Learned Aversive Odor and Abolishes Food Odor-Induced Sniffing Behavior in Rats
Aimé, P., Hegoburu, C., Jaillard, T., Dégletagne, C., Garcia, S., Messaoudi, B., Thévenet, M., Lorsignol, A., Duchamp, C., Mouly, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051227 · Cited by 77 · see citing works
Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP
Zheng, H., Corkern, M. M., Crousillac, S. M., Patterson, L. M., Phifer, C. B., & Berthoud, H. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00019.2002 · Cited by 74 · see citing works
Effects of caloric deprivation and satiety on sensitivity of the gustatory system
Zverev, Y. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-5 · Cited by 71 · see citing works
Dopamine and Food Addiction: Lexicon Badly Needed
Salamone, J. D., & Correa, M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.027 · Cited by 71 · see citing works
An anatomic basis for the communication of hypothalamic, cortical and mesolimbic circuitry in the regulation of energy balance
Kampe, J., Tschöp, M. H., Hollis, J. H., & Oldfield, B. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06818.x · Cited by 69 · see citing works
Neurons in the Rat Arcuate Nucleus Are Hyperpolarized by GABA B and μ-Opioid Receptor Agonists: Evidence for Convergence at a Ligand-Gated Potassium Conductance
Loose, M. D., Rønnekleiv, O. K., & Kelly, M. J. (2008) · Neuroendocrinology · doi:10.1159/000125979 · Cited by 66 · see citing works
Combined Blockade of Both μ- and κ-Opioid Receptors Prevents the Acute Orexigenic Action ofAgouti-Related Protein
Brugman, S., Clegg, D. J., Woods, S. C., & Seeley, R. J. (2002) · Endocrinology · doi:10.1210/en.2002-220230 · Cited by 53 · see citing works
Central melanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat
Davis, J. F., Choi, D. L., Schurdak, J. D., Krause, E. G., Fitzgerald, M. F., Lipton, J. W., Sakai, R. R., & Benoit, S. C. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.017 · Cited by 49 · see citing works
The melanocortin antagonist AgRP (83–132) increases appetitive responding for a fat, but not a carbohydrate, reinforcer
Tracy, A. L., Clegg, D. J., Johnson, J. D., Davidson, T. L., & Benoit, S. C. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.12.018 · Cited by 48 · see citing works
Hypothalamic κ-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin
Romero, A., Vazquez, M. J., González-Touceda, D., Folgueira, C., Skibicka, K. P., Álvarez-Crespo, M., van Gestel, M. A., Velasquez, D., Schwarzer, C., Herzog, H., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.28 · Cited by 48 · see citing works
Relationship between taste thresholds and hunger under debate
Pasquet, P., Monneuse, M.-O., Simmen, B., Marez, A., & Hladik, C. M. (2005) · Appetite · doi:10.1016/j.appet.2005.09.004 · Cited by 38 · see citing works
Ghrelin At the Interface of Obesity and Reward
Schellekens, H., Dinan, T. G., & Cryan, J. F. (2013) · Vitamins and hormones · doi:10.1016/b978-0-12-407766-9.00013-4 · Cited by 37 · see citing works
Ventral tegmental injections of morphine but not U-50,488H enhance feeding in food-deprived rats
Noel, M. B., & Wise, R. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)91139-j · Cited by 37 · see citing works
Central ghrelin induces feeding driven by energy needs not by reward
Bomberg, E. M., Grace, M. K., Wirth, M. M., Levine, A. S., & Olszewski, P. K. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3280b07bb5 · Cited by 31 · see citing works
Pharmacological identification of the K+ currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones
Marinelli, S., Bernardi, G., Giacomini, P., & Mercuri, N. B. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00186-0 · Cited by 29 · see citing works
Nutritive expectancies mediate cholecystokinin's suppression-of-intake effect.
Fedorchak, P. M., & Bolles, R. C. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.3.451 · Cited by 27 · see citing works
Nutritive expectancies mediate cholecystokinin's suppression-of-intake effect.
Fedorchak, P. M., & Bolles, R. C. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.3.451 · Cited by 21 · see citing works
Caffeine-reinforced conditioned flavor preferences in rats.
Fedorchak, P. M., Mesita, J., Plater, S. A., & Brougham, K. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.2.334 · Cited by 19 · see citing works
Streptozotocin-induced diabetes affects the development and maintenance of morphine reward in rats
Samandari, R., Chizari, A., Hassanpour, R., Mousavi, Z., & Haghparast, A. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.03.024 · Cited by 17 · see citing works
Hydration level is an internal variable for computing motivation to obtain water rewards in monkeys
Minamimoto, T., Yamada, H., Hori, Y., & Suhara, T. (2012) · Experimental Brain Research · doi:10.1007/s00221-012-3054-3 · Cited by 15 · see citing works

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Research works printed but not linked: 3

Fedorchak, P.M., and Bolles, R.C., 1988. Nutritive expectancies mediate cholecystokinins suppression-of-intake effect. Behavioral Neuroscience 102 (3):451-455.
Broberger, C., et al., 1998. Hypocretin/orexin-and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and Agouti gene-related protein systems. Journal of Comparative Neurology 402 (4):460-474.

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Plasse, G., van Zessen, R., Luijendijk, M. C. M., Erkan, H., Stuber, G. D., Ramakers, G. M. J., & Adan, R. A. H. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.131 · Cited by 79 · see citing works
OPEN ORIGINAL ARTICLE Modulation of cue-induced firing of ventral tegmental area
(2016)
Contribution of the mesolimbic dopamine system in mediating the effects of leptin and ghrelin on feeding
van Zessen, R., Plasse, G., & Adan, R. A. H. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000614 · Cited by 70 · see citing works

Authors: Lockie, S. H., & Andrews, Z. B.
Affiliations: Monash University (AU)
Corresponding author: Lockie, Sarah H.
ORCID: Lockie, Sarah H.
Andrews, Zane B.
Venue: Molecular Metabolism
Publisher: Elsevier BV
Published: 2013-11
Volume: 2
Issue: 4
Pages: 329-336
ISSN: 2212-8778 (ISSN-L)
DOI: 10.1016/j.molmet.2013.08.003
PMC: PMC3854986
OpenAlex: W2078057092
Cited by: 50
References: 104
Citations by year: 2026: 1 · 2025: 7 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 9 · 2014: 6
FWCI: 0.76
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-sa/3.0/ (vor)
Locations: Molecular Metabolism (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: negative energy balance, food reward, ghrelin, leptin, insulin, incentive salience, mesolimbic dopamine system, motivation, motivational states

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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The hormonal signature of energy deficit: Increasing the value of food reward

Abstract

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Claims the paper makes

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Cites

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Record

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