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A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

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Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

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Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

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Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

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Magnetic Resonance Spectroscopy Studies of Glutamate-Related Abnormalities in Mood Disorders

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Targeting glutamate signalling in depression: progress and prospects

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Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine

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Brain Metabolic Alterations in Medication-Free Patients With BipolarDisorder

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Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond

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Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept

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Pilot Randomized Controlled Trial of Titrated Subcutaneous Ketamine in Older Patients with Treatment-Resistant Depression

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Efficacy and Safety of Basimglurant as Adjunctive Therapy for Major Depression: A Randomized Clinical Trial

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Ketamine and Beyond: Investigations into the Potential of Glutamatergic Agents to Treat Depression

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Measuring the effects of ketamine on mGluR5 using [ ¹⁸ F]FPEB and PET

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Metabotropic glutamate receptor 5 in bulimia nervosa

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Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect

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Increased mGlu5 mRNA expression in BLA glutamate neurons facilitates resilience to the long-term effects of a single predator scent stress exposure

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A miR-137–Related Biological Pathway of Risk for Schizophrenia Is Associated With Human Brain Emotion Processing

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Alterations of BDNF, mGluR5, Homer1a, p11 and excitatory/inhibitory balance in corticolimbic brain regions of suicide decedents

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Targeting the dysfunction of glutamate receptors for the development of novel antidepressants

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Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression

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Differential Role of mGluR5 in Cognitive Processes in Posttraumatic Stress Disorder and Major Depression

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Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [11C]ABP688 PET study

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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex as a Molecular Determinant of Pain and Ensuing Depression

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Glutamate and Its Role in the Metabolism of Plants and Animals

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Reduced mGluR5 Activity Modulates Mitochondrial Function

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Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats

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Metabotropic glutamate receptor function and regulation of sleep-wake cycles

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Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder

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Striatal mGlu5-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways

Jong, Y.-J. I., Izumi, Y., Harmon, S. K., Zorumski, C. F., & O’Malley, K. L. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104949 · Cited by 5 · see citing works

Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female Rats

Asch, R., Fowles, K., Pietrzak, R. H., Taylor, J. R., & Esterlis, I. (2023) · Chronic Stress · doi:10.1177/24705470231215001 · Cited by 5 · see citing works

Enhanced mGluR5 availability marks the antidepressant efficacy in major depressive disorder: an [18F]FPEB PET study

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Boosting the ventrolateral periaqueductal gray-ventral tegmental area pathway by disinhibition of group II mGluRs alleviates chronic restraint stress-induced depression-like behavior in mice

Lee, M. T., Peng, W., Hsu, T., Chu, T., Teng, Y., Wu, C., Lee, Y., Lan, Y.-Y., & Ho, Y. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251351611 · Cited by 4 · see citing works

Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders

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Quantification of Metabotropic Glutamate Receptor 5 Availability With Both [11C]ABP688 and [18F]FPEB Positron Emission Tomography in the Sapap3 Knockout Mouse Model for Obsessive-Compulsive–like Behavior

Glorie, D., Verhaeghe, J. A. J., Miranda, A., Lombaerde, S. D., Stroobants, S. G., & Staelens, S. G. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.11.010 · Cited by 4 · see citing works

Differences in mGluR5 Availability Depending on the Level of Social Avoidance in Drug-Naïve Young Patients with Major Depressive Disorder

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Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders

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Molecular Imaging of Depressive Disorders

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Current Glutamatergic Treatments and Future Directions for Glutamate-Based Management of Chronic Stress and Stress-Related Disorders

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Integrative intrinsic brain activity and molecular analyses of the interaction between first-episode depression and age

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Neuroglia in mood disorders

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Mechanism of antidepressant action of ketamine and differences between its two enantiomers

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S-ketamine mitigates paclitaxel-induced pain-related anxiety-like behavior through downregulation of mGluR5 and activation of the BDNF/TrkB signaling pathway

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Metabotropic Glutamate Receptors in Anxiety Disorder

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Metabotropic Glutamate Receptor 5: A Potential Molecular Switch and Beyond

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Current Radioligands for the PET Imaging of Metabotropic Glutamate Receptors

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The Neuroanatomy, Etiopathogenesis, and Novel Therapeutic Targets in Depressive Disorders

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Acute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography

Raval, N. R., Smart, K. A., Angarita, G. A., Miller, R., Huang, Y. H., Krystal, J. H., Carson, R. E., Cosgrove, K., O’Malley, S. S., & Hillmer, A. T. (2025) · Addiction Biology · doi:10.1111/adb.70031

Valence-Driven Cognitive Flexibility: Neurochemical and Circuit-Level Insights from Animal Models and Their Relevance to Schizophrenia

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Agomelatine normalizes region-specific, diurnal mGluR5 dysregulation in a chronic mild stress rat model of depression

Knudsen, C., Thomsen, M. B., Højgaard, K., Christiansen, S. L., Wiborg, O., Müller, H. K., Landau, A. M., & Elfving, B. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111572

Medication status is associated with metabotropic glutamate receptor 5 availability in bipolar disorder and with measures of attention, anhedonia, and cognition

Moisieienko, K., Asch, R., Davis, M. T., DellaGioia, N., Boster, S., Pietrzak, R. H., & Esterlis, I. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121888

Nanobody-Functionalized AAV achieves Promoter-independent Neuronal Targeting in the CNS åPreprint

Extross, A., de Velasco, E. M. F., He, Y., Wickman, K., & Schmidt, D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.18.752817

The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders

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Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder

Holmes, S. E., Asch, R. H., Davis, M. T., DellaGioia, N., Pashankar, N., Gallezot, J.-D., Nabulsi, N., Matuskey, D., Sanacora, G., Carson, R. E., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.10.018 · Cited by 27 · see citing works

Targeting metabotropic glutamate receptors for the treatment of depression and other stress-related disorders

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Metabotropic Glutamate Receptor 5: A Potential Molecular Switch and Beyond

Liu, Z., Ma, H., Long, S., & Zhang, Y. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.05.001 · Cited by 1 · see citing works

Existence of monomer and dimer forms of mGluR5, under reducing conditions in studies of postmortem brain in various psychiatric disorders

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