The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Deep Brain Stimulation for Depression Informed by Intracranial Recordings
Open accessAbstract
The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. We report results from the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. These recordings enabled calculation of individually optimized DBS stimulation parameters using a novel inverse solution approach. In the ensuing double-blind, randomized phase incorporating these bespoke parameter sets, DBS led to remission of symptoms and dramatic improvement in quality of life. Results from this initial case demonstrate the feasibility of this personalized platform, which may be used to improve surgical neuromodulation for a vast array of neurologic and psychiatric disorders.
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“A case study of combined VC/VS and SCC DBS reports remission until 75 weeks follow-up of combined stimulation and differential response-profiles.”
From Deep brain stimulation for depression. (2022) · cites this paper as [77]
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“SCC stimulation reduced “mental noise” and produced calmness and attention and VC/VS stimulation produced energy and motivation [77].”
From Deep brain stimulation for depression. (2022) · cites this paper as [77]
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Cites
Selective Cortical Undercutting As a Means of Modifying and Studying Frontal Lobe Function in Man
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“To fully investigate the distinct contributions of these networks, we targeted the DBS leads to two previously studied regions, the subcallosal cingulate (SCC) (2, 3) and the ventral capsule/ventral striatum (VC/VS) (4, 5).”
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“stimulation injected energy and motivation (5, 7, 14, 16, 22).”
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“Network-Minded Implant Surgery The initial surgery consisted of intracranially implanting 4 DBS leads (bilateral SCC and VC/VS) and 10 sEEG electrodes (Supplementary Information).”
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“[13] e pivot to LITT offers a paradigm of definitive focal ablation, potentially providing durable relief without the lifelong burden of implanted hardware, battery replacements, and continuous programming adjustments required for DBS. [15] Similarly, in refractory PTSD, pathological hyperactivity…”
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“Electrical stimulation can modulate neural circuit activity and has been used for therapeutic and research applications [1]-[11].”
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Self-citationAnatomic and physiologic correlates of deep brain stimulation-induced panic attack
Ghazavi, A., Alijanpourotaghsara, A., Tsolaki, E. C., Provenza, N. R., Bartoli, E., Rajesh, S., Kabotyanski, K. E., Bailey, K. J., Goodman, W. K., Sheth, S. A., et al. (2026) · Brain stimulation · doi:10.1016/j.brs.2026.103180
Self-citation
Metadata
- Authors
- Sheth, S. A., Bijanki, K. R., Metzger, B., Allawala, A., Pirtle, V., Adkinson, J. A., Myers, J., Mathura, R. K., Oswalt, D., Tsolaki, E., Xiao, J., Noecker, A., Strutt, A. M., Cohn, J. F., McIntyre, C. C., Mathew, S. J., Borton, D., Goodman, W., & Pouratian, N.
- Affiliations
- Baylor College of Medicine (US)
- Brown University (US)
- University of California, Los Angeles (US)
- Case Western Reserve University (US)
- University of Pittsburgh (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Sheth, Sameer A.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2022-08
- Volume
- 92
- Issue
- 3
- Pages
- 246-251
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC9124238
- OpenAlex
- W3215550599
- Cited by
- 158
- References
- 28
- Citations by year
- 2026: 26 · 2025: 32 · 2024: 51 · 2023: 39 · 2022: 10
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biological Psychiatry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons-TMC (Texas Medical Center) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Robert and Janice Mcnair Foundation
- Dana Foundation
- Medtronic
- National Institutes of Health (K01 MH116364, UH3 NS103549, R01 MH114854, R21 NS104953, R01 MH106700, R01 NS105690, UH3 NS100549)
- Sage Therapeutics
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, treatment-resistant depression, intracranial recordings, personalized neuromodulation, inverse solution, stimulation parameter optimization, depression remission
- MeSH terms
- Depression, Double-Blind Method, Humans, Parkinson Disease, Quality of Life, Deep Brain Stimulation, Depressive Disorder, Treatment-Resistant
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