Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression
Open accessAbstract
Background We investigated the use of deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) for treatment refractory depression.Methods Fifteen patients with chronic, severe, highly refractory depression received open-label DBS at three collaborating clinical sites. Electrodes were implanted bilaterally in the VC/VS region. Stimulation was titrated to therapeutic benefit and the absence of adverse effects. All patients received continuous stimulation and were followed for a minimum of 6 months to longer than 4 years. Outcome measures included the Hamilton Depression Rating Scale-24 item (HDRS), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Global Assessment of Function Scale (GAF).Results Significant improvements in depressive symptoms were observed during DBS treatment. Mean HDRS scores declined from 33.1 at baseline to 17.5 at 6 months and 14.3 at last follow-up. Similar improvements were seen with the MADRS (34.8, 17.9, and 15.7, respectively) and the GAF (43.4, 55.5, and 61.8, respectively). Responder rates with the HDRS were 40% at 6 months and 53.3% at last follow-up (MADRS: 46.7% and 53.3%, respectively). Remission rates were 20% at 6 months and 40% at last follow-up with the HDRS (MADRS: 26.6% and 33.3%, respectively). The DBS was well-tolerated in this group.Conclusions Deep brain stimulation of the VC/VS offers promise for the treatment of refractory major depression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Deep brain stimulation applied via electrodes situated in the accumbens area/ventral internal capsule improves depressive symptoms in treatment-refractory depression.
“deep brain stimulation applied via electrodes situated in the accumbens area/ventral internal capsule improves depressive symptoms in treatmentrefractory depression (Malone et al, 2009;Schlaepfer et al, 2008).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Malone et al, 2009
DBS for MDD targets the cingulate cortex or striatum (including NAc) and increases activity there and in connected anhedonia/motivation areas, plus the PFC and amygdala.
“DBS for MDD targets the cingulate cortex or the striatum, which includes the NAc, and has been shown to enhance activity in these regions and connected areas involved in anhedonia and motivation [145, 146], as well as activity in the PFC and amygdala [139].”
From Beyond the serotonin deficit hypothesis: Communicating a neuroplasticity framework of major depressive disorder (2024) · cites this paper as [145]
In a multi-center study, Malone and colleagues demonstrated antidepressant effects in 15 patients at a minimum of 6-month follow-up (RS: 53.3%, RM: 40%).
“In a multi-center study, Malone and colleagues demonstrated antidepressant effects in 15 patients at a minimum of 6-month follow-up (RS: 53.3%, RM: 40%) [57].”
From Deep brain stimulation for depression. (2022) · cites this paper as [57]
In the Malone et al 2009 open-label study of 15 patients with treatment-resistant depression, ventral capsule/ventral striatum deep brain stimulation yielded a 40.0% remission rate at 6 months, measured by HDRS.
“| | Malone et al | 2009 Open label | N = 15 | 6 | 53.3% | 40.0% | HDRS |”
From Deep brain stimulation for depression. (2022) · cites this paper as [57]
In the Malone et al 2009 open-label study of 15 patients with treatment-resistant depression, ventral capsule/ventral striatum deep brain stimulation yielded a 53.3% response rate at 6 months, measured by HDRS.
“| | Malone et al | 2009 Open label | N = 15 | 6 | 53.3% | 40.0% | HDRS |”
From Deep brain stimulation for depression. (2022) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643 · see citing works
Higgins, S. M. F., Macken, A. P., Cullen, W., Saunders, J., Dunne, C. P., & O’Gorman, C. S. (2013) · PubMed · doi:10.34961/9953 · Cited by 4,806 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301408 · Cited by 1,027 · see citing works
Greenberg, B. D., Gabriels, L. A., Malone, D. A., Rezai, A. R., Friehs, G. M., Okun, M. S., Shapira, N. A., Foote, K. D., Cosyns, P. R., Kubu, C. S., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.55 · Cited by 867 · see citing works
Self-citationNuttin, B., Cosyns, P. R., Demeulemeester, H. G., Gybels, J., & Meyerson, B. A. (1999) · The Lancet · doi:10.1016/s0140-6736(99)02376-4 · Cited by 854 · see citing works
Three-Year Outcomes in Deep Brain Stimulation for Highly Resistant Obsessive–Compulsive Disorder
Greenberg, B. D., Malone, D. A., Friehs, G. M., Rezai, A. R., Kubu, C. S., Malloy, P. F., Salloway, S., Okun, M. S., Goodman, W. K., & Rasmussen, S. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301165 · Cited by 831 · see citing works
Self-citationNeuroimaging and frontal–subcortical circuitry in obsessive–compulsive disorder
Saxena, S., Brody, A. L., Schwartz, J. M., & Baxter, L. R. (1998) · British Journal of Psychiatry · doi:10.1192/s0007125000297870 · Cited by 831 · see citing works
Sackeim, H. A., Haskett, R. F., Mulsant, B. H., Thase, M. E., Mann, J. J., Pettinati, H. M., Greenberg, R. M., Crowe, R. R., Cooper, T. B., & Prudic, J. (2001) · JAMA · doi:10.1001/jama.285.10.1299 · Cited by 686 · see citing works
Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder
Breiter, H. C. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830070041008 · Cited by 626 · see citing works
Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder
(1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.12.1560 · Cited by 541 · see citing works
Deep brain stimulation for refractory obsessive-compulsive disorder
Abelson, J. L., Curtis, G. C., Sagher, O., Albucher, R. C., Harrigan, M., Taylor, S. F., Martis, B., & Giordani, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.042 · Cited by 522 · see citing works
Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects
Epstein, J., Pan, H., Kocsis, J. H., Yang, Y., Butler, T., Chusid, J., Hochberg, H., Murrough, J., Strohmayer, E., Stern, E., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.10.1784 · Cited by 464 · see citing works
Aouizerate, B., Cuny, E., Martin‐Guehl, C., Guehl, D., Amieva, H., Benazzouz, A., Fabrigoule, C., Michèle Allard, A., Rougier, A., Bioulac, B. H., et al. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.4.0682 · Cited by 359 · see citing works
Neurosurgery for intractable obsessive-compulsive disorder and depression: critical issues
Greenberg, B. D., Price, L. H., Rauch, S. L., Friehs, G., Noren, G., Malone, D., Carpenter, L. L., Rezai, A. R., & Rasmussen, S. A. (2003) · Neurosurgery Clinics of North America · doi:10.1016/s1042-3680(03)00005-6 · Cited by 300 · see citing works
Self-citationMedication resistance and clinical response to electroconvulsive therapy
Prudic, J., Sackeïm, H. A., & Devanand, D. P. (1990) · Psychiatry Research · doi:10.1016/0165-1781(90)90098-p · Cited by 266 · see citing works
Rauch, S. L., Dougherty, D. D., Malone, D., Rezai, A., Friehs, G., Fischman, A. J., Alpert, N. M., Haber, S. N., Stypulkowski, P. H., Rise, M. T., et al. (2006) · Journal of Neurosurgery · doi:10.3171/jns.2006.104.4.558 · Cited by 260 · see citing works
Self-citationThe Concept of the Ventral Striatum in Nonhuman Primates
HABER, S. N., & McFARLAND, N. R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09259.x · Cited by 253 · see citing works
Dunner, D. L., Rush, A. J., Russell, J. M., Burke, M., Woodard, S., Wingard, P., & Allen, J. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0501 · Cited by 234 · see citing works
Anderson, D. E., & Ahmed, A. S. (2003) · Journal of neurosurgery · doi:10.3171/jns.2003.98.5.1104 · Cited by 200 · see citing works
Dougherty, D. D., Weiss, A. P., Cosgrove, G. R., Alpert, N. M., Cassem, E. H., Nierenberg, A. A., Price, B. H., Mayberg, H. S., Fischman, A. J., & Rauch, S. L. (2003) · Journal of Neurosurgery · doi:10.3171/jns.2003.99.6.1010 · Cited by 193 · see citing works
Self-citationForray, M. I., & Gysling, K. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.011 · Cited by 191 · see citing works
Takahashi, A. (1998) · International Clinical Psychopharmacology · doi:10.1097/00004850-199801000-00048 · Cited by 185 · see citing works
Rauch, S. L. (2003) · Neurosurgery Clinics of North America · doi:10.1016/s1042-3680(02)00114-6 · Cited by 180 · see citing works
Self-citation(2006) · PubMed · Cited by 159 · see citing works
Self-citationStereotactic Limbic Leucotomy—A Follow-up at 16 Months
Mitchell-Heggs, N., Kelly, D., & Richardson, A. E. (1976) · The British Journal of Psychiatry · doi:10.1192/bjp.128.3.226 · Cited by 143 · see citing works
Deep brain stimulation in neurologic disorders
Halpern, C. H., Hurtig, H. I., Jaggi, J. L., Grossman, M., Won, M., & Baltuch, G. H. (2006) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2006.03.001 · Cited by 135 · see citing works
Bi-Frontal Stereotactic Tractotomy
Ström-Olsen, R., & Carlisle, S. (1971) · The British Journal of Psychiatry · doi:10.1192/bjp.118.543.141 · Cited by 127 · see citing works
Okun, M. S., Bowers, D., Springer, U., Shapira, N. A., Malone, D., Rezai, A. R., Nuttin, B., Heilman, K. M., Morecraft, R. J., Rasmussen, S. A., et al. (2004) · Neurocase · doi:10.1080/13554790490507632 · Cited by 123 · see citing works
Self-citationDeep Brain Stimulation for Psychiatric Disorders
Nuttin, B., Gybels, J., Cosyns, P. R., Gabriëls, L. A., Meyerson, B. A., Andréewitch, S., Rasmussen, S. A., Greenberg, B. D., Friehs, G. M., Rezai, A. R., et al. (2002) · Neurosurgery · doi:10.1227/00006123-200208000-00044 · Cited by 96 · see citing works
Self-citationEmotional responses to subcortical electrical stimulation in psychiatric patients
Laitinen, L. (1979) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(79)90002-7 · Cited by 51 · see citing works
Rush, A. J., Marangell, L. B., Sackeim, H. A., George, M. S., Brannan, S. K., Davis, S. M., Howland, R., Kling, M. A., Rittberg, B. R., Burke, W. J., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.025 · Cited by 44 · see citing works
STEREOTACTIC LESIONS IN THE KNEE OF THE CORPUS CALLOSUM IN THE TREATMENT OF EMOTIONAL DISORDERS
Laitinen, L. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90124-9 · Cited by 37 · see citing works
Neurosurgery for mental disorder
Christmas, D. M., Matthews, K., & Eljamel, S. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.185.2.173-a · Cited by 20 · see citing works
Neurosurgical Approaches to Intractable Obsessive-Compulsive Disorder
Rasmussen, S., Greenberg, B. D., Mindus, P., Friehs, G., & Noren, G. (2000) · CNS Spectrums · doi:10.1017/s1092852900021891 · Cited by 20 · see citing works
Self-citationDeep brain stimulation for psychiatric disorders.
(2002) · PubMed · Cited by 10 · see citing works
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [1]Murray C Lopez AD The Global Burden of Disease 1996 Cambridge, Massachusetts Harvard University Press
- [26]First MB Spitzer RL Gibbon M Williams JBW Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition 1995 New York New York State Psychiatric Institute, Biometrics Research
Cited by
Sorted by citations
Selective Cortical Undercutting As a Means of Modifying and Studying Frontal Lobe Function in Man
Scoville, W. B. (1949) · Journal of neurosurgery · doi:10.3171/jns.1949.6.1.0065 · Cited by 7,373 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Deep brain stimulation: current challenges and future directions
Lozano, A. M., Lipsman, N., Bergman, H., Brown, P., Chabardès, S., Chang, J. W., Matthews, K., McIntyre, C. C., Schlaepfer, T. E., Schulder, M., et al. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0128-2 · Cited by 1,475 · see citing works
Harnessing neuroplasticity for clinical applications
Cramer, S. C., Sur, M., Dobkin, B. H., O'Brien, C., Sanger, T. D., Trojanowski, J. Q., Rumsey, J. M., Hicks, R., Cameron, J., Chen, D., et al. (2011) · Brain · doi:10.1093/brain/awr039 · Cited by 1,259 · see citing works
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232 · see citing works
Self-citationThe neurobiology of anhedonia and other reward-related deficits
Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130 · see citing works
Major depressive disorder: new clinical, neurobiological, and treatment perspectives
Kupfer, D. J., Frank, E., & Phillips, M. L. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60602-8 · Cited by 894 · see citing works
Bewernick, B. H., Hurlemann, R., Matusch, A., Kayser, S., Grubert, C., Hadrysiewicz, B., Axmacher, N., Lemke, M., Cooper-Mahkorn, D., Cohen, M. X., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.013 · Cited by 865 · see citing works
Optogenetic investigation of neural circuits underlying brain disease in animal models
Tye, K. M., & Deisseroth, K. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3171 · Cited by 745 · see citing works
Linking Molecules to Mood: New Insight Into the Biology of Depression
Krishnan, V., & Nestler, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.10030434 · Cited by 643 · see citing works
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621 · see citing works
Sartorius, A., Kiening, K. L., Kirsch, P., von Gall, C. C., Haberkorn, U., Unterberg, A. W., Henn, F. A., & Meyer-Lindenberg, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.027 · Cited by 611 · see citing works
Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Unipolar and Bipolar Depression
Holtzheimer, P. E. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1456 · Cited by 608 · see citing works
A Review of the Clinical, Economic, and Societal Burden of Treatment-Resistant Depression: 1996–2013
Mrazek, D. A., Hornberger, J. C., Altar, C. A., & Degtiar, I. (2014) · Psychiatric Services · doi:10.1176/appi.ps.201300059 · Cited by 580 · see citing works
Rapid effects of deep brain stimulation for treatment-resistant major depression
Schlaepfer, T. E., Bewernick, B. H., Kayser, S., Mädler, B., & Coenen, V. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.034 · Cited by 563 · see citing works
Dougherty, D. D., Rezai, A. R., Carpenter, L. L., Howland, R. H., Bhati, M. T., O’Reardon, J. P., Eskandar, E. N., Baltuch, G. H., Machado, A. D., Kondziolka, D., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.023 · Cited by 558 · see citing works
Self-citationMechanisms of deep brain stimulation
Herrington, T. M., Cheng, J. J., & Eskandar, E. N. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00281.2015 · Cited by 551 · see citing works
Self-citationTargeted electrode-based modulation of neural circuits for depression.
Mayberg, H. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38454 · Cited by 542 · see citing works
Closed-loop neuromodulation in an individual with treatment-resistant depression
Scangos, K. W., Khambhati, A. N., Daly, P. M., Makhoul, G. S., Sugrue, L. P., Zamanian, H., Liu, T. X., Rao, V. R., Sellers, K. K., Dawes, H. E., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01480-w · Cited by 535 · see citing works
Kennedy, S. H., Lam, R. W. M., Parikh, S. V., Patten, S. B., & Ravindran, A. V. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.043 · Cited by 526 · see citing works
Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies
Keren, H., O’Callaghan, G., Vidal-Ribas, P., Buzzell, G. A., Brotman, M. A., Leibenluft, E., Pan, P. M., Meffert, L., Kaiser, A., Wolke, S., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17101124 · Cited by 521 · see citing works
The subcallosal cingulate gyrus in the context of major depression
Hamani, C., Mayberg, H., Stone, S., Laxton, A., Haber, S., & Lozano, A. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.034 · Cited by 508 · see citing works
The nucleus accumbens: a comprehensive review
Salgado, S., & Kaplitt, M. G. (2015) · Stereotactic and Functional Neurosurgery · doi:10.1159/000368279 · Cited by 489 · see citing works
Deep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 years
Kennedy, S. H., Giacobbe, P., Rizvi, S. J., Placenza, F. M., Nishikawa, Y., Mayberg, H. S., & Lozano, A. M. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10081187 · Cited by 481 · see citing works
Riva-Posse, P., Choi, K. S., Holtzheimer, P. E., McIntyre, C. C., Gross, R. E., Chaturvedi, A., Crowell, A. L., Garlow, S. J., Rajendra, J. K., & Mayberg, H. S. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.029 · Cited by 460 · see citing works
Risks of common complications in deep brain stimulation surgery: management and avoidance
Fenoy, A. J., & Simpson, R. K. (2013) · Journal of neurosurgery · doi:10.3171/2013.10.jns131225 · Cited by 458 · see citing works
Riva-Posse, P., Choi, K. S., Holtzheimer, P. E., Crowell, A. L., Garlow, S. J., Rajendra, J. K., McIntyre, C. C., Gross, R. E., & Mayberg, H. S. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.59 · Cited by 441 · see citing works
Stuck in a rut: rethinking depression and its treatment
Holtzheimer, P. E., & Mayberg, H. S. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.10.004 · Cited by 431 · see citing works
Fu, C. H. Y., Steiner, H., & Costafreda, S. G. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.008 · Cited by 399 · see citing works
Bewernick, B. H., Kayser, S., Sturm, V., & Schlaepfer, T. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.44 · Cited by 371 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression: Follow-Up After 3 to 6Years
Ballenger, J. C. (2012) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/j.ypsy.2011.08.041 · Cited by 365 · see citing works
Goodman, W. K., Foote, K. D., Greenberg, B. D., Ricciuti, N., Bauer, R., Ward, H., Shapira, N. A., Wu, S. S., Hill, C. L., Rasmussen, S. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.028 · Cited by 362 · see citing works
Self-citationInvasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD
Greenberg, B. D., Rauch, S. L., & Haber, S. N. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.128 · Cited by 359 · see citing works
Self-citationLozano, A. M., Giacobbe, P., Hamani, C., Rizvi, S. J., Kennedy, S. H., Kolivakis, T. T., Debonnel, G., Sadikot, A. F., Lam, R. W., Howard, A. K., et al. (2012) · Journal of Neurosurgery · doi:10.3171/2011.10.jns102122 · Cited by 356 · see citing works
Dysfunctional reward processing in depression
Admon, R., & Pizzagalli, D. A. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2014.12.011 · Cited by 343 · see citing works
Coenen, V. A., Panksepp, J., Hurwitz, T. A., Urbach, H., & Mädler, B. (2012) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.11080180 · Cited by 342 · see citing works
Bergfeld, I. O., Mantione, M., Hoogendoorn, M. L. C., Ruhé, H. G., Notten, P., van Laarhoven, J., Visser, I., Figee, M., de Kwaasteniet, B. P., Horst, F., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0152 · Cited by 336 · see citing works
Deep Brain Stimulation for Psychiatric Disorders
Holtzheimer, P., & Mayberg, H. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113638 · Cited by 65 · see citing works
Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
Levy, M. J. F., Boulle, F., Steinbusch, H. W., van den Hove, D. L. A., Kenis, G., & Lanfumey, L. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4950-4 · Cited by 308 · see citing works
Coil design considerations for deep transcranial magnetic stimulation
Deng, Z.-D., Lisanby, S. H., & Peterchev, A. V. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2013.11.038 · Cited by 308 · see citing works
Deep brain stimulation: from neurology to psychiatry?
Krack, P., Hariz, M. I., Baunez, C., Guridi, J., & Obeso, J. A. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.07.002 · Cited by 305 · see citing works
Where in the Brain Is Depression?
Pandya, M. A., Altinay, M. I., Malone, D. A., & Anand, A. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0322-7 · Cited by 302 · see citing works
Self-citationFettes, P., Schulze, L., & Downar, J. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00025 · Cited by 299 · see citing works
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works
Dandekar, M. P., Fenoy, A. J., Carvalho, A. F., Soares, J. C., & Quevedo, J. (2018) · Molecular Psychiatry · doi:10.1038/mp.2018.2 · Cited by 264 · see citing works
Brain–machine interfaces from motor to mood
Shanechi, M. M. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0488-y · Cited by 263 · see citing works
Treatment-resistant depression and suicidality
Bergfeld, I. O., Mantione, M., Figee, M., Schuurman, P. R., Lok, A., & Denys, D. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.04.016 · Cited by 256 · see citing works
Neuromodulation for Brain Disorders: Challenges and Opportunities
Johnson, M. D., Lim, H. H., Netoff, T. I., Connolly, A. T., Johnson, N., Roy, A. V., Holt, A. B., Lim, K. O., Carey, J. R., Vitek, J. L., et al. (2013) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2013.2244890 · Cited by 250 · see citing works
Coenen, V. A., Schlaepfer, T. E., Maedler, B., & Panksepp, J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.009 · Cited by 246 · see citing works
State-dependent responses to intracranial brain stimulation in a patient with depression
Scangos, K. W., Makhoul, G. S., Sugrue, L. P., Chang, E. F., & Krystal, A. D. (2021) · Nature Medicine · doi:10.1038/s41591-020-01175-8 · Cited by 243 · see citing works
Puigdemont, D., Pérez‐Egea, R., Portella, M. J., Molet, J., de Diego-Adeliño, J., Gironell, A., Raduà, J., Gómez‐Ansón, B., Rodríguez, R. R., Serra-Blasco, M., et al. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001088 · Cited by 235 · see citing works
Reinforcement learning in depression: a review of computational research
Chen, C., Takahashi, T., Nakagawa, S., Inoue, T., & Kusumi, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.005 · Cited by 233 · see citing works
Meta-analytic evidence for neuroimaging models of depression: State or trait?
Graham, J., Salimi‐Khorshidi, G., Hagan, C. C., Walsh, N., Goodyer, I. M., Lennox, B., & Suckling, J. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.07.002 · Cited by 231 · see citing works
Mood variations decoded from multi-site intracranial human brain activity
Sani, O. G., Yang, Y., Lee, M. B., Dawes, H. E., Chang, E. F., & Shanechi, M. M. (2018) · Nature Biotechnology · doi:10.1038/nbt.4200 · Cited by 226 · see citing works
Kennedy, S. H., Milev, R. V., Giacobbe, P., Ramasubbu, R., Lam, R. W. M., Parikh, S. V., Patten, S. B., & Ravindran, A. V. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.039 · Cited by 225 · see citing works
Sex differences in antidepressant efficacy
LeGates, T. A., Kvarta, M. D., & Thompson, S. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0156-z · Cited by 225 · see citing works
de Haan, S., Rietveld, E., Stokhof, M., & Denys, D. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00653 · Cited by 221 · see citing works
A tractography analysis of two deep brain stimulation white matter targets for depression
Gutman, D. A., Holtzheimer, P. E., Behrens, T. E. J., Johansen-Berg, H., & Mayberg, H. S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.021 · Cited by 220 · see citing works
Deep brain stimulation for treatment-resistant depression: systematic review of clinical outcomes
Morishita, T., Fayad, S. M., Higuchi, M.-A., Nestor, K. A., & Foote, K. D. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0282-1 · Cited by 216 · see citing works
Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala
Murray, E. A., Wise, S. P., & Drevets, W. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.041 · Cited by 208 · see citing works
Probabilistic analysis of activation volumes generated during deep brain stimulation
Butson, C. R., Cooper, S. E., Henderson, J. M., Wolgamuth, B. R., & McIntyre, C. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.059 · Cited by 185 · see citing works
Synofzik, M., & Schlaepfer, T. E. (2008) · Biotechnology Journal · doi:10.1002/biot.200800187 · Cited by 182 · see citing works
Rao, V. R., Sellers, K. K., Wallace, D. L., Lee, M. B., Bijanzadeh, M., Sani, O. G., Yang, Y., Shanechi, M. M., Dawes, H. E., & Chang, E. F. (2018) · Current Biology · doi:10.1016/j.cub.2018.10.026 · Cited by 181 · see citing works
Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial
Coenen, V. A., Bewernick, B. H., Kayser, S., Kilian, H., Boström, J., Greschus, S., Hurlemann, R., Klein, M. E., Spanier, S., Sajonz, B., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0369-9 · Cited by 176 · see citing works
Deep brain stimulation for depression.
Figee, M., Riva-Posse, P., Choi, K. S., Bederson, L., Mayberg, H. S., & Kopell, B. H. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01270-3 · Cited by 175 · see citing works
Deep brain stimulation for treatment-resistant depression
Holtzheimer, P. E., & Hamani, C. (2014) · doi:10.2217/ebo.13.577 · Cited by 172 · see citing works
Wright, J. S., & Panksepp, J. (2012) · Neuropsychoanalysis · doi:10.1080/15294145.2012.10773683 · Cited by 153 · see citing works
Schlaepfer, T. E., Bewernick, B. H., Kayser, S., Hurlemann, R., & Coenen, V. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.28 · Cited by 160 · see citing works
Gubellini, P., Salin, P., Goff, L. K., & Baunez, C. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.06.003 · Cited by 160 · see citing works
Deep brain stimulation targets for treating depression
Drobisz, D., & Damborská, A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.004 · Cited by 159 · see citing works
Deep Brain Stimulation for Depression Informed by Intracranial Recordings
Sheth, S. A., Bijanki, K. R., Metzger, B., Allawala, A., Pirtle, V., Adkinson, J. A., Myers, J., Mathura, R. K., Oswalt, D., Tsolaki, E., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.007 · Cited by 158 · see citing works
“To fully investigate the distinct contributions of these networks, we targeted the DBS leads to two previously studied regions, the subcallosal cingulate (SCC) (2, 3) and the ventral capsule/ventral striatum (VC/VS) (4, 5).”
Deep Brain Stimulation for Psychiatric Disease: Contributions and Validity of Animal Models
Hamani, C., & Temel, Y. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003722 · Cited by 157 · see citing works
Bewernick, B. H., Kayser, S., Gippert, S. M., Switala, C., Coenen, V. A., & Schlaepfer, T. E. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.01.581 · Cited by 156 · see citing works
New targets for rapid antidepressant action
Machado‐Vieira, R., Henter, I. D., & Zarate, C. A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.001 · Cited by 156 · see citing works
Bai, S., Dokos, S., Ho, K.-A., & Loo, C. K. A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.11.015 · Cited by 155 · see citing works
CB1 receptor-deficient mice as a model for depression
Valverde, O., & Torrens, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.031 · Cited by 153 · see citing works
Authenticity, Depression, and Deep Brain Stimulation
Johansson, V. M., Garwicz, M., Kanje, M., Schouenborg, J., Tingström, A., & Görman, U. (2011) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2011.00021 · Cited by 152 · see citing works
Deep Brain Stimulation Results in Local Glutamate and Adenosine Release
Tawfik, V. L., Chang, S.-Y., Hitti, F. L., Roberts, D. W., Leiter, J. C., Jovanovic, S., & Lee, K. H. (2010) · Neurosurgery · doi:10.1227/01.neu.0000371988.73620.4c · Cited by 149 · see citing works
The Economic Burden of Treatment-Resistant Depression
Olchanski, N., McInnis Myers, M., Halseth, M., Cyr, P. L., Bockstedt, L., Goss, T. F., & Howland, R. H. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2012.09.001 · Cited by 146 · see citing works
New and emerging approaches to treat psychiatric disorders
Scangos, K. W., State, M. W., Miller, A. H., Baker, J. T., & Williams, L. M. (2023) · Nature Medicine · doi:10.1038/s41591-022-02197-0 · Cited by 147 · see citing works
Hamani, C., Diwan, M., Isabella, S., Lozano, A. M., & Nobrega, J. N. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.12.010 · Cited by 145 · see citing works
Herringa, R., Phillips, M., Almeida, J., Insana, S., & Germain, A. (2012) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2012.02.005 · Cited by 143 · see citing works
Klein, E. P., Goering, S., Gagne, J., Shea, C. V., Franklin, R., Zorowitz, S., Dougherty, D. D., & Widge, A. S. (2016) · Brain-Computer Interfaces · doi:10.1080/2326263x.2016.1207497 · Cited by 142 · see citing works
Self-citationThe role of adenosine receptors in mood and anxiety disorders
van Calker, D., Biber, K. P. H., Domschke, K., & Serchov, T. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14841 · Cited by 142 · see citing works
Closing the Loop on Deep Brain Stimulation for Treatment-Resistant Depression
Widge, A. S., Malone, D. A., & Dougherty, D. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00175 · Cited by 138 · see citing works
Self-citationDeep brain stimulation for treatment-resistant depression: Efficacy, safety and mechanisms of action
Anderson, R. J., Frye, M. A., Abulseoud, O. A., Lee, K. H., McGillivray, J., Berk, M., & Tye, S. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.001 · Cited by 137 · see citing works
Somatic Treatments for Mood Disorders
Rosa, M. A., & Lisanby, S. H. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.225 · Cited by 137 · see citing works
Deep Brain Stimulation in the Treatment of Obsessive-Compulsive Disorder
Blomstedt, P. C., Sjöberg, R. L., Hansson, M., Bodlund, O., & Hariz, M. I. (2012) · World Neurosurgery · doi:10.1016/j.wneu.2012.10.006 · Cited by 137 · see citing works
Berlim, M. T., McGirr, A., den Eynde, F. V., Fleck, M. P., & Giacobbe, P. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.02.016 · Cited by 136 · see citing works
Deer, T. R., Krames, E. S., Mekhail, N. A., Pope, J. E., Leong, M. S., Stanton-Hicks, M. D., Golovac, S., Kapural, L., Alo, K., Anderson, J., et al. (2014) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12204 · Cited by 135 · see citing works
McCracken, C. B., & Grace, A. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0131-09.2009 · Cited by 127 · see citing works
Staying in the Loop: Relational Agency and Identity in Next-Generation DBS for Psychiatry
Goering, S., Klein, E. P., Dougherty, D. D., & Widge, A. S. (2017) · AJOB Neuroscience · doi:10.1080/21507740.2017.1320320 · Cited by 127 · see citing works
Self-citationDeep brain stimulation of the medial forebrain bundle: Distinctive responses in resistant depression
Fenoy, A. J., Schulz, P., Selvaraj, S., Burrows, C., Spiker, D., Cao, B., Zunta-Soares, G., Gajwani, P., Quevedo, J., & Soares, J. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.064 · Cited by 125 · see citing works
Deep brain stimulation (DBS) at the interface of neurology and psychiatry
Williams, N., & Okun, M. S. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68341 · Cited by 125 · see citing works
Closed-loop neuromodulation systems: next-generation treatments for psychiatric illness
Lo, M.-C., & Widge, A. S. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1282438 · Cited by 125 · see citing works
Optimized programming algorithm for cylindrical and directional deep brain stimulation electrodes
Anderson, D. N., Osting, B., Vorwerk, J., Dorval, A. D., & Butson, C. R. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aaa14b · Cited by 124 · see citing works
Neurogenic hippocampal targets of deep brain stimulation
Encinas, J. M., Hamani, C., Lozano, A. M., & Enikolopov, G. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22503 · Cited by 122 · see citing works
Widge, A. S., Ellard, K. K., Paulk, A. C., Basu, I., Yousefi, A., Zorowitz, S., Gilmour, A., Afzal, A., Deckersbach, T., Cash, S. S., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.021 · Cited by 118 · see citing works
Self-citation
- Authors
- Malone, D. A., Dougherty, D. D., Rezai, A. R., Carpenter, L. L., Friehs, G. M., Eskandar, E. N., Rauch, S. L., Rasmussen, S. A., Machado, A. G., Kubu, C. S., Tyrka, A. R., Price, L. H., Stypulkowski, P. H., Giftakis, J. E., Rise, M. T., Malloy, P. F., Salloway, S. P., & Greenberg, B. D.
- Affiliations
- Cleveland Clinic (US)
- McLean Hospital (US)
- Butler Hospital (US)
- Brown University (US)
- Massachusetts General Hospital (US)
- Medtronic (United States) (US)
- Corresponding author
- Malone, Donald A.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 65
- Issue
- 4
- Pages
- 267-275
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3486635
- OpenAlex
- W2014786844
- Cited by
- 897
- References
- 39
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 41 · 2023: 46 · 2022: 37 · 2021: 38 · 2020: 34 · 2019: 51 · 2018: 45 · 2017: 57 · 2016: 58 · 2015: 70 · 2014: 70 · 2013: 64 · 2012: 81
- FWCI
- 35.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p50mh086400-05)
- National Institute of Mental Health (P-50-MH-086400)
- National Eye Institute (R01EY017658)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- deep brain stimulation, ventral capsule/ventral striatum, treatment-resistant depression, depression remission, long-term outcomes
- MeSH terms
- Adolescent, Adult, Chronic Disease, Cognition, Depressive Disorder, Drug Resistance, Electrodes, Implanted, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Recurrence, Treatment Outcome, Neostriatum, Deep Brain Stimulation, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
