Modulation of the neural network involved in the processing of anger prosody: the role of task-relevance and social phobia
Abstract
Individuals with social phobia display neural hyperactivation towards angry facial expressions. However, it is uncertain whether they also show abnormal brain responses when processing angry voices. In an event-related functional magnetic resonance imaging study, we investigated brain responses to neutral and angry voices in 12 healthy control participants and 12 individuals with social phobia when emotional prosody was either task-relevant or task-irrelevant. Regardless of task, both phobic and non-phobic participants recruited a network comprising frontotemporal regions, the amygdala, the insula, and the striatum, when listening to angry compared to neutral prosody. Across participants, increased activation in orbitofrontal cortex during task-relevant as compared to task-irrelevant emotional prosody processing was found. Compared to healthy controls, individuals with social phobia displayed significantly stronger orbitofrontal activation in response to angry versus neutral voices under both task conditions. These results suggest a disorder-associated increased involvement of the orbitofrontal cortex in response to threatening voices in social phobia.
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Neuroimaging studies in social anxiety have revealed predominantly increased cerebral activation to facial and vocal expressions signaling social threat in the limbic system, secondary visual cortices, mediofrontal cortex, and orbitofrontal cortex for threatening voices.
“While neuroimaging studies in SA revealed predominantly increased cerebral activation to facial [11]–[15] and vocal [16] expressions signaling social threat in the limbic system [12]–[15], as well as increased activation of secondary visual cortices [12], [15], the mediofrontal cortex [11], [12], [14] and the orbitofrontal cortex for threatening voices [16]”
From They are laughing at me: Cerebral mediation of cognitive biases in social anxiety (2014) · cites this paper as [16]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032 · see citing works
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900 · see citing works
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,767 · see citing works
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202 · see citing works
(1985) · Cited by 2,882 · see citing works
A cognitive model of social phobia
Adrian Wells, A. (1995) · Research Explorer (The University of Manchester) · Cited by 2,701 · see citing works
Acoustic profiles in vocal emotion expression.
Banse, R., & Scherer, K. R. (1996) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.70.3.614 · Cited by 2,253 · see citing works
The Orbitofrontal Cortex and Reward
Rolls, E. T. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.284 · Cited by 1,595 · see citing works
Social phobia: Diagnosis, assessment, and treatment
Franklin, M. E. (1996) · Clinical Psychology Review · doi:10.1016/s0272-7358(96)00036-0 · Cited by 1,389 · see citing works
Modulating emotional responses: effects of a neocortical network on the limbic system
Hariri, A. R., Bookheimer, S. Y., & Mazziotta, J. C. (2000) · NeuroReport · doi:10.1097/00001756-200001170-00009 · Cited by 1,277 · see citing works
Social phobia : diagnosis, assessment, and treatment
Heimberg, R. G. (1995) · Guilford Press eBooks · Cited by 1,067 · see citing works
Goebel, R., Esposito, F., & Formisano, E. (2006) · Human Brain Mapping · doi:10.1002/hbm.20249 · Cited by 1,053 · see citing works
Demmel, R. (1999) · Zeitschrift für Klinische Psychologie und Psychotherapie · doi:10.1026//0084-5345.28.1.68 · Cited by 1,010 · see citing works
Rolls, E. T., Hornak, J., Wade, D., & McGrath, J. (1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.12.1518 · Cited by 1,005 · see citing works
Impaired social response reversal. A case of 'acquired sociopathy'.
Blair, R., & Cipolotti, L. (2000) · Brain : a journal of neurology · doi:10.1093/brain/123.6.1122 · Cited by 963 · see citing works
Optimized EPI for fMRI studies of the orbitofrontal cortex
Deichmann, R., Gottfried, J. A., Hutton, C., & Turner, R. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00073-9 · Cited by 821 · see citing works
Ross, E. D. (1981) · Archives of Neurology · doi:10.1001/archneur.1981.00510090055006 · Cited by 806 · see citing works
Hornak, J., Rolls, E. T., & Wade, D. (1996) · Neuropsychologia · doi:10.1016/0028-3932(95)00106-9 · Cited by 735 · see citing works
Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices
Hornak, J. (2003) · Brain · doi:10.1093/brain/awg168 · Cited by 725 · see citing works
Price, J. N. (1986) · Journal of Biosocial Science · doi:10.1017/s0021932000016369 · Cited by 715 · see citing works
Beyond the right hemisphere: brain mechanisms mediating vocal emotional processing
Schirmer, A., & Kotz, S. A. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.11.009 · Cited by 694 · see citing works
Hautzinger, M., Keller, F., & Kühner, C. (2006) · Cited by 663 · see citing works
Distinct functional substrates along the right superior temporal sulcus for the processing of voices
von Kriegstein, K., & Giraud, A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.02.020 · Cited by 632 · see citing works
Increased Amygdala Activation to Angry and Contemptuous Faces in Generalized Social Phobia
Stein, M. B., Goldin, P. R., Sareen, J., Zorrilla, L. T. E., & Brown, G. G. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.11.1027 · Cited by 582 · see citing works
Neural Correlates of the Automatic Processing of Threat Facial Signals
Anderson, A. K., Christoff, K., Panitz, D., De Rosa, E., & Gabrieli, J. D. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05627.2003 · Cited by 574 · see citing works
Phan, K. L., Fitzgerald, D. A., Nathan, P. J., & Tancer, M. E. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.012 · Cited by 539 · see citing works
Impaired auditory recognition of fear and anger following bilateral amygdala lesions
Scott, S. K., Young, A. W., Calder, A. J., Hellawell, D. J., Aggleton, J. P., & Johnsons, M. (1997) · Nature · doi:10.1038/385254a0 · Cited by 523 · see citing works
Communicating emotion: The role of prosodic features.
Frick, R. W. (1985) · Psychological Bulletin · doi:10.1037/0033-2909.97.3.412 · Cited by 467 · see citing works
The voices of wrath: brain responses to angry prosody in meaningless speech
Grandjean, D., Sander, D., Pourtois, G., Schwartz, S., Seghier, M. L., Scherer, K. R., & Vuilleumier, P. O. (2005) · Nature Neuroscience · doi:10.1038/nn1392 · Cited by 452 · see citing works
Event-related functional magnetic resonance imaging: modelling, inference and optimization
Josephs, O., & Henson, R. N. A. (1999) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1999.0475 · Cited by 425 · see citing works
Sander, D., Grandjean, D., Pourtois, G., Schwartz, S., Seghier, M. L., Scherer, K. R., & Vuilleumier, P. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.023 · Cited by 392 · see citing works
Imagery and interpretations in social phobia: support for the combined cognitive biases hypothesis.
Hirsch, C., Clark, D., & Mathews, A. (2006) · The Behavior Therapist · doi:10.1016/j.beth.2006.02.001 · Cited by 361 · see citing works
Information processing in social phobia: A critical review
Heinrichs, N., & Hofmann, S. G. (2001) · Clinical Psychology Review · doi:10.1016/s0272-7358(00)00067-2 · Cited by 351 · see citing works
Identification of emotional intonation evaluated by fMRI
Wildgruber, D., Riecker, A., Hertrich, I., Erb, M., Grodd, W., Ethofer, T., & Ackermann, H. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.10.034 · Cited by 336 · see citing works
Anxiety disorders and phobias—a cognitive perspective
Rachman, S. (1986) · Behaviour Research and Therapy · doi:10.1016/0005-7967(86)90157-9 · Cited by 328 · see citing works
Lesion localization in acquired deficits of emotional expression and comprehension
Cancelliere, A. E. B., & Kertesz, A. (1990) · Brain and Cognition · doi:10.1016/0278-2626(90)90046-q · Cited by 324 · see citing works
Cerebral processing of linguistic and emotional prosody: fMRI studies
Wildgruber, D., Ackermann, H., Kreifelts, B., & Ethofer, T. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)56013-3 · Cited by 297 · see citing works
Straube, T., Kolassa, I., Glauer, M., Mentzel, H.-J., & Miltner, W. H. R. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.024 · Cited by 273 · see citing works
Cerebral pathways in processing of affective prosody: A dynamic causal modeling study
Ethofer, T., Anders, S., Erb, M., Herbert, C., Wiethoff, S., Kissler, J. M., Grodd, W., & Wildgruber, D. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.09.059 · Cited by 243 · see citing works
Neural systems for recognition of emotional prosody: A 3-D lesion study.
Adolphs, R., Damásio, H., & Tranel, D. (2002) · Emotion · doi:10.1037/1528-3542.2.1.23 · Cited by 237 · see citing works
Saying it with feeling: neural responses to emotional vocalizations
Morris, J. S., Scott, S. K., & Dolan, R. J. (1999) · Neuropsychologia · doi:10.1016/s0028-3932(99)00015-9 · Cited by 230 · see citing works
Amir, N., Klumpp, H., Elias, J., Bedwell, J. S., Yanasak, N., & Miller, L. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.044 · Cited by 229 · see citing works
Giraud, A. L. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhg124 · Cited by 213 · see citing works
Impaired recognition of anger following damage to the ventral striatum
Calder, A. J. (2004) · Brain · doi:10.1093/brain/awh214 · Cited by 190 · see citing works
Common and Distinct Brain Activation to Threat and Safety Signals in Social Phobia
Straube, T., Mentzel, H., & Miltner, W. H. R. (2005) · Neuropsychobiology · doi:10.1159/000087987 · Cited by 184 · see citing works
Neural Mechanisms of Automatic and Direct Processing of Phobogenic Stimuli in Specific Phobia
Straube, T., Mentzel, H., & Miltner, W. H. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.013 · Cited by 184 · see citing works
Wildgruber, D. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh099 · Cited by 177 · see citing works
Cerebral processing of emotional prosody—influence of acoustic parameters and arousal
Wiethoff, S., Wildgruber, D., Kreifelts, B., Becker, H. G. T., Herbert, C., Grodd, W., & Ethofer, T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.028 · Cited by 175 · see citing works
Vocal identification of speaker and emotion activates differerent brain regions
Imaizumi, S., Mori, K., Kiritani, S., Kawashima, R., Sugiura, M., Fukuda, H., Itoh, K., Kato, T., Nakamura, A., Hatano, K., et al. (1997) · Neuroreport · doi:10.1097/00001756-199708180-00031 · Cited by 170 · see citing works
Intact recognition of emotional prosody following amygdala damage
Adolphs, R. (1999) · Neuropsychologia · doi:10.1016/s0028-3932(99)00023-8 · Cited by 162 · see citing works
Convergence of sensory systems in the orbitofrontal cortex in primates and brain design for emotion
Rolls, E. T. (2004) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.20126 · Cited by 160 · see citing works
Perception of emotions from faces and voices following unilateral brain damage
Kucharska‐Pietura, K., Phillips, M. L., Gernand, W., & David, A. S. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(02)00294-4 · Cited by 156 · see citing works
Williams, L. M., Barton, M., Kemp, A. H., Liddell, B. J., Peduto, A. S., Gordon, E., & Bryant, R. A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.035 · Cited by 155 · see citing works
Focused and Nonfocused Attention in Verbal and Emotional Dichotic Listening: An FMRI Study
Jäncke, L., Buchanan, T. W., Lutz, K., & Shah, N. J. (2001) · Brain and Language · doi:10.1006/brln.2000.2476 · Cited by 152 · see citing works
Yoon, K. L., Fitzgerald, D. A., Angstadt, M., McCarron, R., & Phan, K. L. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.05.004 · Cited by 115 · see citing works
Orbitofrontal involvement in the processing of unpleasant auditory information
Frey, S., Kostopoulos, P., & Petrides, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00227.x · Cited by 111 · see citing works
Intact recognition of vocal expressions of fear following bilateral lesions of the human amygdala.
Anderson, A. K., & Phelps, E. A. (1998) · PubMed · Cited by 107 · see citing works
Categorical and Dimensional Decoding of Emotional Intonations in Patients with Focal Brain Lesions
Peper, M., & Irle, E. (1997) · Brain and Language · doi:10.1006/brln.1997.1789 · Cited by 33 · see citing works
Activation of Broca's area by syntactic processing under conditions of concurrent articulation
Caplan, D., Alpert, N., Waters, G., & Olivieri, A. (2000) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(200002)9:2
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The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083 · see citing works
Brühl, A. B., Delsignore, A., Komossa, K., & Weidt, S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.003 · Cited by 439 · see citing works
The role of the insula in schizophrenia
Wylie, K. P., & Tregellas, J. R. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.08.027 · Cited by 362 · see citing works
Neuroimaging in social anxiety disorder: a systematic review of the literature
Freitas-Ferrari, M. C., Hallak, J. E. C., Trzesniak, C., Filho, A. S., Machado-de-Sousa, J. P., Chagas, M. H. N., Nardi, A. E., & Crippa, J. A. S. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.02.028 · Cited by 298 · see citing works
Phan, K. L., Orlichenko, A., Boyd, E., Angstadt, M., Coccaro, E. F., Liberzon, I., & Arfanakis, K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.028 · Cited by 226 · see citing works
The sound of emotions—Towards a unifying neural network perspective of affective sound processing
Frühholz, S., Trost, W. J., & Kotz, S. A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.002 · Cited by 196 · see citing works
Current status of brain imaging in anxiety disorders
Damsa, C., Kosel, M., & Moussally, J. (2009) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328319bd10 · Cited by 160 · see citing works
Emotional voices in context: A neurobiological model of multimodal affective information processing
Brück, C., Kreifelts, B., & Wildgruber, D. (2011) · Physics of Life Reviews · doi:10.1016/j.plrev.2011.10.002 · Cited by 155 · see citing works
The role of the medial temporal limbic system in processing emotions in voice and music
Frühholz, S., Trost, W. J., & Grandjean, D. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.09.003 · Cited by 155 · see citing works
Ethofer, T., Kreifelts, B., Wiethoff, S., Wolf, J., Grodd, W., Vuilleumier, P. O., & Wildgruber, D. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21099 · Cited by 131 · see citing works
Social fearfulness in the human brain
Miskovic, V., & Schmidt, L. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.08.002 · Cited by 126 · see citing works
Straube, T., & Miltner, W. H. R. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.010 · Cited by 105 · see citing works
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2011) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.9.3.foc311 · Cited by 104 · see citing works
Neural correlates of self-focused attention in social anxiety
Boehme, S., Miltner, W. H. R., & Straube, T. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu128 · Cited by 92 · see citing works
Gaebler, M., Daniels, J. K., Lamke, J.-P., Fydrich, T., & Walter, H. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.06.009 · Cited by 86 · see citing works
The transition from acute to chronic pain: might intensive care unit patients be at risk?
Kyranou, M., & Puntillo, K. (2012) · Annals of Intensive Care · doi:10.1186/2110-5820-2-36 · Cited by 87 · see citing works
Increased amygdala activation to emotional auditory stimuli in the blind
Klinge, C., Röder, B., & Büchel, C. (2010) · Brain · doi:10.1093/brain/awq102 · Cited by 85 · see citing works
Brain Networks of Emotional Prosody Processing
Grandjean, D. (2020) · Emotion Review · doi:10.1177/1754073919898522 · Cited by 81 · see citing works
Gilboa‐Schechtman, E., & Shachar‐Lavie, I. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00904 · Cited by 70 · see citing works
Response and habituation of the amygdala during processing of emotional prosody
Wiethoff, S., Wildgruber, D., Grodd, W., & Ethofer, T. (2009) · Neuroreport · doi:10.1097/wnr.0b013e328330eb83 · Cited by 72 · see citing works
Zhang, D., Zhou, Y., & Yuan, J. (2018) · Scientific Reports · doi:10.1038/s41598-017-18683-2 · Cited by 72 · see citing works
Task-dependent neural correlates of the processing of verbal threat-related stimuli in social phobia
Schmidt, S. N. L., Mohr, A., Miltner, W. H. R., & Straube, T. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.03.005 · Cited by 66 · see citing works
Behavioural and neural correlates of self-focused emotion regulation in social anxiety disorder
Gaebler, M., Daniels, J. K., Lamke, J.-P., Fydrich, T., & Walter, H. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130080 · Cited by 64 · see citing works
Liang, B., & Du, Y. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00495 · Cited by 61 · see citing works
Early sensory encoding of affective prosody: Neuromagnetic tomography of emotional category changes
Thönneßen, H., Boers, F., Dammers, J., Chen, Y., Norra, C., & Mathiak, K. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.082 · Cited by 63 · see citing works
Structural Alterations of the Social Brain: A Comparison between Schizophrenia and Autism
Radeloff, D., Ciaramidaro, A., Siniatchkin, M., Hainz, D., Schlitt, S., Weber, B., Poustka, F., Bölte, S., Walter, H., & Freitag, C. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106539 · Cited by 63 · see citing works
Is the voice an auditory face? An ALE meta-analysis comparing vocal and facial emotion processing
Schirmer, A. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx142 · Cited by 62 · see citing works
Heitmann, C. Y., Feldker, K., Neumeister, P., Zepp, B. M., Peterburs, J., Zwitserlood, P., & Straube, T. (2016) · Human Brain Mapping · doi:10.1002/hbm.23120 · Cited by 56 · see citing works
Neurobiological correlates of social anxiety disorder: an update
Marazziti, D., Abelli, M., Baroni, S., Carpita, B., Ramacciotti, C., & Dell’Osso, L. (2014) · CNS Spectrums · doi:10.1017/s109285291400008x · Cited by 57 · see citing works
Adolph, D., Meister, L., & Pause, B. M. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00283 · Cited by 54 · see citing works
. Neural response to the observable self in social anxiety disorder
Pujol, J., Giménez, M., Ortiz, H., Soriano-Mas, C., López-Solà, M., Farré, M., Deus, J., Merlo-Pich, E., Harrison, B. J., Cardoner, N., et al. (2013) · Psychological Medicine · doi:10.1017/s0033291712001857 · Cited by 52 · see citing works
Impact of personality on the cerebral processing of emotional prosody
Brück, C., Kreifelts, B., Kaza, E., Lotze, M., & Wildgruber, D. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.005 · Cited by 52 · see citing works
Vicente, S., Biseul, I., Péron, J., Philippot, P., Drapier, S., Drapier, D., Sauleau, P., Haegelen, C., & Vérin, M. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.03.003 · Cited by 53 · see citing works
Young, K. S., Parsons, C. E., Elmholdt, E.-M. J., Woolrich, M. W., van Hartevelt, T. J., Stevner, A. B. A., Stein, A. L., & Kringelbach, M. L. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv306 · Cited by 53 · see citing works
An ERP study of vocal emotion processing in asymmetric Parkinson’s disease
Garrido‐Vásquez, P., Pell, M. D., Paulmann, S., Strecker, K., Schwarz, J., & Kotz, S. A. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss094 · Cited by 51 · see citing works
Visual Attention Modulates Brain Activation to Angry Voices
Mothes‐Lasch, M., Mentzel, H., Miltner, W. H. R., & Straube, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6665-10.2011 · Cited by 50 · see citing works
Automatic Neural Processing of Disorder-Related Stimuli in Social Anxiety Disorder: Faces and More
Schulz, C., Mothes‐Lasch, M., & Straube, T. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00282 · Cited by 47 · see citing works
Overestimation of threat from neutral faces and voices in social anxiety.
Peschard, V., & Philippot, P. (2017) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2017.06.003 · Cited by 42 · see citing works
Ewbank, M. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00056 · Cited by 47 · see citing works
Neural correlates of anticipation and processing of performance feedback in social anxiety
Heitmann, C. Y., Peterburs, J., Mothes-Lasch, M., Hallfarth, M. C., Böhme, S., Miltner, W., & Straube, T. (2014) · Human Brain Mapping · doi:10.1002/hbm.22602 · Cited by 34 · see citing works
Topography of the Anxious Self: Abnormal Rest-Task Modulation in Social Anxiety Disorder
Angeletti, L. L., Scalabrini, A., Ricca, V., & Northoff, G. (2021) · The Neuroscientist · doi:10.1177/10738584211030497 · Cited by 35 · see citing works
Neural mechanisms of the automatic processing of emotional information from faces and voices
Straube, T., Mothes‐Lasch, M., & Miltner, W. H. R. (2011) · British Journal of Psychology · doi:10.1111/j.2044-8295.2011.02056.x · Cited by 35 · see citing works
Heitmann, C. Y., Feldker, K., Neumeister, P., Brinkmann, L., Schrammen, E., Zwitserlood, P., & Straube, T. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.01.020 · Cited by 34 · see citing works
Ziv, M., Goldin, P. R., Jazaieri, H., Hahn, K. S., & Gross, J. J. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-5 · Cited by 33 · see citing works
Carré, A., Gierski, F., Lemogne, C., Tran, E., Raucher‐Chéné, D., Bera‐Potelle, C., Portefaix, C., Kaladjian, A., Pierot, L., Besche‐Richard, C., et al. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst061 · Cited by 33 · see citing works
The effects of anxiety on the interpretation of emotion in the face–voice pairs
Koizumi, A., Tanaka, A., Imai, H., Hiramatsu, S., Hiramoto, E., Satô, T., & de Gelder, B. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2668-1 · Cited by 33 · see citing works
The volatility of the amygdala response to masked fearful eyes
Straube, T., Dietrich, C., Mothes‐Lasch, M., Mentzel, H., & Miltner, W. H. R. (2010) · Human Brain Mapping · doi:10.1002/hbm.20960 · Cited by 33 · see citing works
Looking at the self in front of others: Neural correlates of attentional bias in social anxiety
Choi, S., Shin, J.-E., Ku, J. H., & Kim, J. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.01.001 · Cited by 33 · see citing works
Evolutionary Perspective on Social Anxiety
Gilboa-Schechtman, E., Shachar, I., & Helpman, L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-394427-6.00021-2 · Cited by 32 · see citing works
They are laughing at me: Cerebral mediation of cognitive biases in social anxiety
Kreifelts, B., Brück, C., Ritter, J., Ethofer, T., Domin, M., Lotze, M., Jacob, H., Schlipf, S., & Wildgruber, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099815 · Cited by 31 · see citing works
“While neuroimaging studies in SA revealed predominantly increased cerebral activation to facial [11–15] and vocal [16] expressions signaling social threat in the limbic system [12–15], as well as increased activation of secondary visual cortices [12,15], the mediofrontal cortex [11,12,14] and the orbitofrontal cortex…”
BackgroundWeidt, S., Lutz, J., Rufer, M., Delsignore, A., Jakob, N. J., Herwig, U., & Bruehl, A. B. (2016) · Psychological Medicine · doi:10.1017/s0033291715002998 · Cited by 30 · see citing works
Recent findings on the pathophysiology of social anxiety disorder
Marazziti, D., Abelli, M., Baroni, S., Carpita, B., Piccinni, A., & Dell’Osso, L. (2014) · Cited by 26 · see citing works
Neuroanthropology: evolution and emotional embodiment
Campbell, B. (2009) · Frontiers in Evolutionary Neuroscience · doi:10.3389/neuro.18.004.2009 · Cited by 26 · see citing works
Neurocircuitry of impaired affective sound processing: A clinical disorders perspective
Frühholz, S., & Staib, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.009 · Cited by 23 · see citing works
Boehme, S., Mohr, A., Becker, M. P., Miltner, W. H., & Straube, T. (2014) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-4-6 · Cited by 23 · see citing works
Self-citationProcessing of angry voices is modulated by visual load
Mothes‐Lasch, M., Miltner, W. H. R., & Straube, T. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.005 · Cited by 18 · see citing works
Simon, D., Becker, M. P. I., Mothes‐Lasch, M., Miltner, W. H. R., & Straube, T. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw131 · Cited by 18 · see citing works
Peschard, V., Maurage, P., & Philippot, P. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00322 · Cited by 18 · see citing works
Tschacher, W., Schildt, M., & Sander, K. (2010) · Psychotherapy Research · doi:10.1080/10503307.2010.493538 · Cited by 18 · see citing works
Cognitive Neural Mechanism of Social Anxiety Disorder: A Meta-Analysis Based on fMRI Studies
Yu, X., Ruan, Y., Yawen, Z., Wang, J., Liu, Y., Zhang, J., & Zhang, L. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115556 · Cited by 17 · see citing works
Amygdala activation to threat under attentional load in individuals with anxiety disorder
Straube, T., Lipka, J., Sauer, A., Mothes‐Lasch, M., & Miltner, W. H. R. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-12 · Cited by 16 · see citing works
Mitchell, R. L. C., Jazdzyk, A., Stets, M., & Kotz, S. A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00518 · Cited by 17 · see citing works
Linguistic and emotional prosody: A systematic review and ALE meta-analysis
Themistocleous, C. K. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106210 · Cited by 15 · see citing works
Selective attention to emotional prosody in social anxiety: a dichotic listening study
Peschard, V., Gilboa‐Schechtman, E., & Philippot, P. (2016) · Cognition & Emotion · doi:10.1080/02699931.2016.1261012 · Cited by 14 · see citing works
Smith, K. W., Balkwill, L.-L., Vartanian, O., & Goel, V. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00273 · Cited by 12 · see citing works
Laeger, I., Dobel, C., Radenz, B., Kugel, H., Roesmann, K., Eden, A. S., Arolt, V., Zwitserlood, P., Dannlowski, U., & Zwanzger, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109949 · Cited by 12 · see citing works
Tuned to voices and faces: Cerebral responses linked to social anxiety
Kreifelts, B., Eckstein, K. N., Ethofer, T., Wiegand, A., Wächter, S., Brück, C., Erb, M., Lotze, M., & Wildgruber, D. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.05.018 · Cited by 11 · see citing works
Neural basis of processing threatening voices in a crowded auditory world
Mothes‐Lasch, M., Becker, M. P. I., Miltner, W. H. R., & Straube, T. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw022 · Cited by 9 · see citing works
The Neural Correlates of Face-Voice-Integration in Social Anxiety Disorder
Kreifelts, B., Ethofer, T., Wiegand, A., Brück, C., Wächter, S., Erb, M., Lotze, M., & Wildgruber, D. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00657 · Cited by 8 · see citing works
Neuroendocrinology and Neuroimaging Studies of Social Anxiety Disorder
Phan, K. L., & Klumpp, H. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375096-9.00010-9 · Cited by 8 · see citing works
Moffat, R., Başkent, D., Luke, R., McAlpine, D., & Yper, L. N. V. (2023) · Human Brain Mapping · doi:10.1002/hbm.26305 · Cited by 7 · see citing works
Roßkopf, S., Mühlberger, A., Stärz, F., van de Par, S., Blau, M., & Kroczek, L. O. H. (2025) · IEEE Transactions on Visualization and Computer Graphics · doi:10.1109/tvcg.2025.3549855 · Cited by 6 · see citing works
Coussement, C., & Heeren, A. (2015) · L’Année psychologique · doi:10.4074/s0003503315000202 · Cited by 6 · see citing works
Ziereis, A. C., & Schacht, A. (2023) · Psychophysiology · doi:10.1111/psyp.14380 · Cited by 5 · see citing works
Brück, C., Kreifelts, B., Ethofer, T., & Wildgruber, D. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9780511843716.015 · Cited by 2 · see citing works
The Social Neuroscience of Social Anxiety Disorder
Syal, S., & Stein, D. J. (2014) · Wiley eBooks · doi:10.1002/9781118653920.ch4 · Cited by 2 · see citing works
An integrative model of brain processes for the decoding of emotional prosody
Grandjean, D., & Frühholz, S. (2013) · doi:10.1093/acprof:oso/9780199583560.003.0013 · Cited by 1 · see citing works
Emotion Recognition Ability in Older Adults
Dimelow, N. A. (2019) · Sheffield Hallam University · doi:10.7190/shu-thesis-00199 · Cited by 1 · see citing works
The influence of affective voice on sound distance perceptionPreprint
Kroczek, L. O. H., Roßkopf, S., Stärz, F., Blau, M., van de Par, S., & Mühlberger, A. (2023) · doi:10.31234/osf.io/qdw9p · Cited by 1 · see citing works
Emotional Processing in the Amygdala: Integration of Automatic Process and Attentional Modulation
Du, Y., Wu, X. H., & Li, L. (2013) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2013.01020
The effects of anxiety on the perception of emotion in the face and voice.
Koizumi, A., Tanaka, A., Imai, H., Hiramatsu, S., Hiramoto, E., Satô, T., & de Gelder, B. (2010) · AVSP
The affective neuroscience of human social anxiety
Miskovic, V., & Schmidt, L. A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139012850.011
Neuroendocrinology and Neuroimaging Studies of Social Anxiety Disorder
Phan, K. L., & Klumpp, H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-394427-6.00012-1
Brain activity discriminates acoustic simulations of the same environmentPreprint
Matten, V., Stirnberg, R., van de Par, S., Ewert, S. D., & Flanagin, V. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.29.610373
Themistocleous, C. K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.29.620829
Imaging Studies of Anxiety Disorders
Mann, J. J., & Yin, H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00120-2
Ghaznavi, S., Deckersbach, T., & Dougherty, D. D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418677-4.00017-8
Evolutionary model of social anxiety
Gilboa‐Schechtman, E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-14146-1.00011-5
Witteman, J. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106638 · Cited by 1 · see citing works
Neural activation by vocal threat requires attention
Witteman, J., Axioti, S., & van Tol, A. (2026) · Cortex · doi:10.1016/j.cortex.2026.04.009
Yuan, J., Xu, X., Sun, W., Song, L., & Guo, H. (2026) · Biological Psychology · doi:10.1016/j.biopsycho.2026.109368
Exploring executive attention in emotion : ERP and fMRI evidence
Kanske, P. (2008) · Max Planck Digital Library
- Authors
- Quadflieg, S., Mohr, A., Mentzel, H.-J., Miltner, W. H. R., & Straube, T.
- Affiliations
- Friedrich Schiller University Jena (DE)
- Corresponding author
- Straube, Thomas
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 78
- Issue
- 2
- Pages
- 129-137
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W2056721047
- Cited by
- 94
- References
- 61
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 16 · 2013: 9 · 2012: 5
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- Explore Bristol Research (submittedVersion)
- Funders
- Friedrich-Schiller-Universität Jena
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- social anxiety disorder, task relevance, orbitofrontal cortex, amygdala, insula, striatum, fronto-temporal network
- MeSH terms
- Acoustic Stimulation, Adult, Anger, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Linguistics, Magnetic Resonance Imaging, Male, Oxygen, Phobic Disorders, Task Performance and Analysis
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