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Cited by 1,005Neural and Behavioral Psychology StudiesHistorical and Modern Theater StudiesNeurotransmitter Receptor Influence on Behavior

Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage.

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Rolls, E T, Hornak, J, Wade, D, McGrath, J·1994·Journal of Neurology, Neurosurgery & Psychiatry
DOI 10.1136/jnnp.57.12.1518PMC PMC1073235
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Abstract

A group of patients with damage to the ventral part of the frontal lobes was severely impaired relative to a group of patients without damage in this area (the non-ventral group) in the reversal and in the extinction of simple visual discrimination tests. In these tests they continued to make responses to a previously rewarded stimulus. Patients often reported verbally that the contingencies had changed, but were unable to alter their behaviour appropriately. These impairments occurred independently of IQ or verbal memory impairments. The perseverative touching of a previously rewarded stimulus is consistent with work with non-human primates showing impaired reversal and extinction after orbitofrontal lesions. Performance on these reversal and extinction tests was highly correlated with scores obtained on a behaviour questionnaire, which reflected the degree of disinhibited and socially inappropriate behaviour exhibited by patients. It is suggested that a difficulty in modifying responses, especially when followed by negative consequences, as manifested in these simple laboratory tests, may contribute to the inappropriate behaviour shown in daily life by patients with frontal lobe damage.

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Crossref · 10.1136/jnnp.57.12.1518

Cites

14 of 14 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The lateral and medial orbitofrontal cortex have been linked to associative learning, decision making, and reversal learning.

    “Consistent with the idea that the OFC unites internal and external sensory information, the lateral OFC and the medial OFC have been linked to associative learning (Rolls et al. 1994; 1996) decision making (e.g., Bechara et al. 1996; 2000; Koenigs et al. 2007) and reversal learning, in which the reward values associated with choice options are reversed and animals must learn the current reward”

    From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as Rolls et al. 1994

    The paper links the orbitofrontal cortex to learning associations between sensory stimuli and rewards, and the Discussion reports impaired reversal of those associations after ventral frontal damage. It does not distinguish lateral from medial orbitofrontal cortex, so it does not establish the claim for both subdivisions. The decision-making citations in the citing sentence point to other works, not Rolls et al. (1994). (LLM, conf=0.84)

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  • Orbitofrontal cortex lesions produce impulsive or perseverative behaviors.

    “Other consequences of OFC lesions include impulsive or perserverative behaviors (Bechara et al., 1994; Berlin et al., 2004; Rolls et al., 1994).”

    From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Rolls et al., 1994

  • Lesions of the OFC can impair behavioural changes to non-reward; in humans, reward reversal learning is impaired, with continued responding to the previously rewarded, now non-rewarded, stimulus.

    “Consistent with this neurophysiological and neuroimaging evidence, lesions of the OFC can impair behavioural changes to non-reward. For example, reward reversal learning is impaired during decision-making in humans, who continue responding to the previously rewarded, now non-rewarded, stimulus (Rolls et al., 1994; Hornak et al., 2004; Fellows, 2011).”

    From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Rolls et al., 1994

  • Humans with OFC lesions may be less sensitive to reward, as shown by reduced subjective emotional feelings, altered social and emotional behaviour, and problems with face and voice expression processing.

    “Humans with OFC lesions may also be less sensitive to reward, as shown by their reduced subjective emotional feelings and altered social and emotional behaviour and problems with face and voice expression processing (Rolls et al., 1994; Hornak et al., 1996, 2003; Rolls, 2021b).”

    From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Rolls et al., 1994

  • The OFC is involved in subjective emotional experience.

    “That is in strong contrast to the OFC, which is involved in subjective emotional experience, as shown by the evidence just cited.”

    From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Rolls et al., 1994

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Cites

Flagged first, then by citations

Research works printed but not linked: 5

  1. Rolls ET. Neurophysiology of feeding in primates. In: Booth DA, ed. Neurophysiology of ingestion. Oxford: Pergamon: 1993:137-69.
  2. Oscar-Berman M, Zola-Morgan SM. Comparative neu- ropsychology and Korsakoffs syndrome. 1-Spatial and visual reversal learning. Neuropsychologia 1980;18: 499-512.
  3. Shallice T. Specific impairments in planning. Philos Trans R Soc Lond 1982;298:211-26.
  4. Luria AR, Homskaya ED. Disturbance in the regulative role of speech with frontal lobe lesions. In: Warren JM, Akert K, eds. The frontal granular cortex and behaviour. New York: McGraw-Hill, 1964:28-55.
  5. Barbas H, Pandya DN. Patterns of connection of pre- frontal cortex in the rhesus monkey associated with corti- cal architecture. In: Levin HS, Eisenberg HM, Benton L, eds. Frontal lobe function and dysfunction 1991:35-58. 1 524 on July 30, 2023 by guest. Protected by copyright. http://jnnp.bmj.com/ J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.57.12.1518 on 1 December 1994. Downloaded from

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Authors
Rolls, E. T., Hornak, J., Wade, D., & McGrath, J.
Affiliations
University of Oxford (GB)
ORCID
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
1994-12-01
Volume
57
Issue
12
Pages
1518-1524
ISSN
0022-3050 (ISSN-L)
DOI
10.1136/jnnp.57.12.1518
PMC
PMC1073235
OpenAlex
W1971078086
Cited by
1,005
References
14
Citations by year
2026: 1 · 2025: 12 · 2024: 12 · 2023: 8 · 2022: 18 · 2021: 26 · 2020: 25 · 2019: 24 · 2018: 17 · 2017: 21 · 2016: 27 · 2015: 23 · 2014: 27 · 2013: 37 · 2012: 43
FWCI
5.58
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
frontal lobe damage, orbitofrontal cortex, reversal learning, extinction learning, visual discrimination learning, perseveration
MeSH terms
Activities of Daily Living, Adult, Aged, Mental Disorders, Brain Injuries, Discrimination, Psychological, Emotions, Extinction, Psychological, Female, Frontal Lobe, Humans, Inhibition, Psychological, Male, Middle Aged, Reinforcement, Psychology, Reversal Learning, Social Behavior, Visual Perception, Case-Control Studies

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