Cited by 211Heart Rate Variability and Autonomic ControlNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.

Oxytocin increases autonomic cardiac control: Moderation by loneliness

Abstract

The current study examined the role of perceived social isolation in moderating the effects of oxytocin on cardiac autonomic control in humans. Intranasal administration of 20 IU oxytocin resulted in a significant increase in autonomic (parasympathetic and sympathetic) cardiac control. Specifically, oxytocin increased high frequency heart rate variability, a relatively pure measure of parasympathetic cardiac control, and decreased pre-ejection period, a well-validated marker of enhanced sympathetic cardiac control. Derived metrics of autonomic co-activity and reciprocity revealed that oxytocin significantly increased overall autonomic cardiac control. Furthermore, the effects of oxytocin on cardiac autonomic control were significantly associated with loneliness ratings. Higher levels of loneliness were associated with diminished parasympathetic cardiac reactivity to intranasal oxytocin. The effects of OT on autonomic cardiac control were independent of any effects on circulating pro-inflammatory cytokine or stress hormone levels. Thus, lonely individuals may be less responsive to the salubrious effects of oxytocin on cardiovascular responsivity.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.biopsycho.2010.11.006

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 59 references

Cited by

Sorted by citations

Items 101–200 of 211

Metadata

Authors
Norman, G. J., Cacioppo, J. T., Morris, J. S., Malarkey, W. B., Berntson, G. G., & DeVries, A. C.
Affiliations
  • University of Chicago (US)
  • The Ohio State University (US)
Corresponding author
Norman, Greg J.
Venue
Biological Psychology
Publisher
Elsevier BV
Published
2011-03
Volume
86
Issue
3
Pages
174-180
ISSN
0301-0511 (ISSN-L)
OpenAlex
W2100442727
Cited by
211
References
59
Citations by year
2026: 7 · 2025: 13 · 2024: 9 · 2023: 10 · 2022: 11 · 2021: 22 · 2020: 21 · 2019: 6 · 2018: 14 · 2017: 22 · 2016: 11 · 2015: 13 · 2014: 14 · 2013: 15 · 2012: 9
FWCI
7.90
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Templeton Foundation
  • Clinical Research Center at The Ohio State University
  • National Center of Research Resources of the NIH (WM) (UL1-RR025755)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, loneliness, social isolation, cardiac autonomic control, heart rate variability, pre-ejection period, intranasal administration, inflammatory cytokines, stress hormones
MeSH terms
Adult, Autonomic Nervous System, Blood Pressure, Catecholamines, Electrocardiography, Female, Heart Rate, Humans, Hydrocortisone, Loneliness, Male, Models, Biological, Oxytocics, Oxytocin, Predictive Value of Tests, Time Factors, Cytokines, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review