Oxytocin increases autonomic cardiac control: Moderation by loneliness

Norman, Greg J.; Cacioppo, John T.; Morris, John S.; Malarkey, William B.; Berntson, Gary G.; DeVries, A. Courtney

doi:10.1016/j.biopsycho.2010.11.006

Cited by 211Heart Rate Variability and Autonomic ControlNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

Oxytocin increases autonomic cardiac control: Moderation by loneliness

Norman, Greg J., Cacioppo, John T., Morris, John S., Malarkey, William B., Berntson, Gary G., DeVries, A. Courtney·2011·Biological Psychology

DOI 10.1016/j.biopsycho.2010.11.006

Open this paper in CoChat — free account

Abstract

The current study examined the role of perceived social isolation in moderating the effects of oxytocin on cardiac autonomic control in humans. Intranasal administration of 20 IU oxytocin resulted in a significant increase in autonomic (parasympathetic and sympathetic) cardiac control. Specifically, oxytocin increased high frequency heart rate variability, a relatively pure measure of parasympathetic cardiac control, and decreased pre-ejection period, a well-validated marker of enhanced sympathetic cardiac control. Derived metrics of autonomic co-activity and reciprocity revealed that oxytocin significantly increased overall autonomic cardiac control. Furthermore, the effects of oxytocin on cardiac autonomic control were significantly associated with loneliness ratings. Higher levels of loneliness were associated with diminished parasympathetic cardiac reactivity to intranasal oxytocin. The effects of OT on autonomic cardiac control were independent of any effects on circulating pro-inflammatory cytokine or stress hormone levels. Thus, lonely individuals may be less responsive to the salubrious effects of oxytocin on cardiovascular responsivity.

Integrity signals

Registry

Crossref · 10.1016/j.biopsycho.2010.11.006

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Intranasally administered and naturally secreted oxytocin increases HF-HRV in humans.
“intranasally administered and naturally secreted oxytocin increases HF-HRV in humans27–30.”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [30]
Intranasal administration of oxytocin has been found to increase HF-HRV in humans.
“intranasal administration of oxytocin has been found to increase HF-HRV in humans27–30”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [30]
In humans, oxytocin can alleviate social stress by lowering salivary cortisol levels, increasing parasympathetic control of the heart, and attenuating amygdala activation in response to seeing faces.
“In humans, OT is mostly known for its functions in childbirth and breastfeeding, but it can also alleviate social stress, for example, by lowering salivary cortisol levels 4 , increasing parasympathetic control of the heart 5 , and attenuating amygdala activation in response to seeing faces 6,7 .”
From A registered replication study on oxytocin and trust (2020) · cites this paper as [5]
Intranasal oxytocin regulates responses of the HPA axis and the (para)sympathetic nervous system.
“Furthermore, intranasal oxytocin regulates responses of the HPA axis [42] and the (para)sympathetic nervous system [43].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [43]
Oxytocin significantly increased overall autonomic cardiac control by elevating high frequency heart rate variability and decreasing pre-ejection period.
“In the latter study, oxytocin significantly increased overall autonomic cardiac control because it elevated high frequency heart rate variability (HRV) and decreased the pre-ejection period (PEP), a well-known indicator of sympathetic cardiac control.”
From Intranasal oxytocin reduces provoked symptoms in female patients with posttraumatic stress disorder despite exerting sympathomimetic and positive chronotropic effects in a randomized controlled trial (2017) · cites this paper as [32]

Multiple regression: testing and interpreting interactions
(1992) · Choice Reviews Online · doi:10.5860/choice.29-3352 · Cited by 36,644 · see citing works
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807 · see citing works
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433 · see citing works
An inventory for measuring clinical anxiety: Psychometric properties.
Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.56.6.893 · Cited by 14,407 · see citing works
Beck Depression Inventory–II
Beck, A. T., Steer, R. A., & Brown, G. (2011) · PsycTESTS Dataset · doi:10.1037/t00742-000 · Cited by 7,535 · see citing works
Social Relationships and Health
House, J. S., Landis, K. R., & Umberson, D. (1988) · Science · doi:10.1126/science.3399889 · Cited by 7,073 · see citing works
The Revised UCLA Loneliness Scale: concurrent and discriminant validity evidence
Russell, D., Peplau, L. A., & Cutrona, C. E. (1980) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.39.3.472 · Cited by 5,173 · see citing works
Heart rate variability: origins, methods, and interpretive caveats
BERNTSON, G. G., THOMAS BIGGER, J., ECKBERG, D. L., GROSSMAN, P., KAUFMANN, P. G., MALIK, M., NAGARAJA, H. N., PORGES, S. W., SAUL, J. P., STONE, P. H., et al. (1997) · Psychophysiology · doi:10.1111/j.1469-8986.1997.tb02140.x · Cited by 3,962 · see citing works
Self-citation
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Manual for the state-trait anxiety inventory (form Y) : "self-evaluation questionnaire"
Spielberger, C. D., Gorsuch, R. L., & Lushene, R. E. (1970) · Consulting Psychologists Press eBooks · Cited by 2,352 · see citing works
The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors
Thayer, J. F., Yamamoto, S. S., & Brosschot, J. F. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.09.543 · Cited by 2,276 · see citing works
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Post-hoc Probing of Significant Moderational and Mediational Effects in Studies of Pediatric Populations
Holmbeck, G. N. (2002) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/27.1.87 · Cited by 1,819 · see citing works
The polyvagal theory: phylogenetic substrates of a social nervous system.
Porges, S. W. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00162-3 · Cited by 1,582 · see citing works
Loneliness: human nature and the need for social connection
(2008) · Choice Reviews Online · doi:10.5860/choice.46-1765 · Cited by 1,572 · see citing works
Self-citation
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · see citing works
Methodological Guidelines for Impedance Cardiography
Sherwood, A., Allen, M. T., Fahrenberg, J., Kelsey, R. M., Lovallo, W. R., & van Doornen, L. J. P. (1990) · Psychophysiology · doi:10.1111/j.1469-8986.1990.tb02171.x · Cited by 1,169 · see citing works
Loneliness and health: potential mechanisms
Cacioppo, J. T., Hawkley, L. C., Crawford, L. E., Ernst, J. M., Burleson, M. H., Kowalewski, R. B., Malarkey, W. B., Van Cauter, E., & Berntson, G. G. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200205000-00005 · Cited by 1,149 · see citing works
Self-citation
The role of vagal function in the risk for cardiovascular disease and mortality
Thayer, J. F., & Lane, R. D. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2005.11.013 · Cited by 1,033 · see citing works
Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909579106 · Cited by 812 · see citing works
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · see citing works
Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels During Couple Conflict
Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.011 · Cited by 784 · cited 3× · see citing works
“OT administration also facilitates positive communication (Ditzen et al., 2009; Gouin et al., 2010), reduces psychological arousal to social threat (Norman et al., 2010a) and interacts with social support to decrease physiological stress reactivity (Heinrichs et al., 2003).”
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · see citing works
Beyond Heart Rate Variability: Vagal Regulation of Allostatic Systems
THAYER, J. F., & STERNBERG, E. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1366.014 · Cited by 703 · see citing works
Effects of Partner Support on Resting Oxytocin, Cortisol, Norepinephrine, and Blood Pressure Before and After Warm Partner Contact
Grewen, K. M., Girdler, S. S., Amico, J., & Light, K. C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000170341.88395.47 · Cited by 513 · cited 1× · see citing works
“OT is a nonapeptide hormone and neurotransmitter that is released during social interaction and contact (Grewen et al., 2005).”
Heart Rate Variability from Short Electrocardiographic Recordings Predicts Mortality from All Causes in Middle-aged and Elderly Men: The Zutphen Study
Dekker, J. M., Schouten, E. G., Klootwijk, P., Pool, J., Swenne, C. A., & Kromhout, D. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009049 · Cited by 510 · see citing works
Lack of social support and incidence of coronary heart disease in middle-aged Swedish men.
Orth‐Gomér, K., Rosengren, A., & Wilhelmsen, L. (1993) · Psychosomatic Medicine · doi:10.1097/00006842-199301000-00007 · Cited by 386 · see citing works
The sympathetic nervous system and the metabolic syndrome
Mancia, G., Bousquet, P., Elghozi, J. L., Esler, M., Grassi, G., Julius, S., Reid, J., & Van Zwieten, P. A. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328048d004 · Cited by 385 · see citing works
Oxytocin, vasopressin and sociality
CARTER, C., GRIPPO, A., POURNAJAFINAZARLOO, H., RUSCIO, M., & PORGES, S. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00427-5 · Cited by 380 · see citing works
Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study
Loup, F., Tribollet, E., Dubois-Dauphin, M., & Dreifuss, J. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90345-v · Cited by 378 · see citing works
In the Eye of the Beholder: Individual Differences in Perceived Social Isolation Predict Regional Brain Activation to Social Stimuli
Cacioppo, J. T., Norris, C. J., Decety, J., Monteleone, G., & Nusbaum, H. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21007 · Cited by 322 · see citing works
Self-citation
Oxytocin and social perception: oxytocin increases perceived facial trustworthiness and attractiveness
Theodoridou, A., Rowe, A. C., Penton-Voak, I. S., & Rogers, P. J. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.019 · Cited by 318 · see citing works
Cardiac autonomic balance versus cardiac regulatory capacity
Berntson, G. G., Norman, G. J., Hawkley, L. C., & Cacioppo, J. T. (2008) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00652.x · Cited by 290 · see citing works
Self-citation
Autonomic space and psychophysiological response
BERNTSON, G. G., CACIOPPO, J. T., QUIGLEY, K. S., & FABRO, V. T. (1994) · Psychophysiology · doi:10.1111/j.1469-8986.1994.tb01024.x · Cited by 289 · see citing works
Self-citation
Oxytocin receptor polymorphisms and adult attachment style in patients with depression
Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A., Muti, M., Gesi, C., Landi, S., Galderisi, S., et al. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.006 · Cited by 282 · see citing works
Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects
Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., Völzke, H., Freyberger, H. J., Herrmann, F. H., Kroemer, H., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.004 · Cited by 271 · see citing works
Social facilitation of wound healing
Detillion, C. E., Craft, T. K. S., Glasper, E. R., Prendergast, B. J., & DeVries, A. C. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.10.003 · Cited by 259 · see citing works
Self-citation
Loneliness and risk of mortality: A longitudinal investigation in Alameda County, California
Patterson, A. C., & Veenstra, G. (2010) · Social Science & Medicine · doi:10.1016/j.socscimed.2010.03.024 · Cited by 255 · see citing works
Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation
Grippo, A. J., Trahanas, D. M., Zimmerman, R. R., Porges, S. W., & Carter, C. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.017 · Cited by 240 · see citing works
Critical Review of Dietary Caffeine and Blood Pressure: A Relationship That Should Be Taken More Seriously
James, J. E. (2004) · Psychosomatic Medicine · doi:10.1097/10.psy.0000107884.78247.f9 · Cited by 232 · see citing works
Marital behavior, oxytocin, vasopressin, and wound healing
Gouin, J.-P., Carter, C. S., Pournajafi-Nazarloo, H., Glaser, R., Malarkey, W. B., Loving, T. J., Stowell, J., & Kiecolt-Glaser, J. K. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.01.009 · Cited by 227 · see citing works
Self-citation
Sensitivity to Intranasal Oxytocin in Adult Men with Early Parental Separation
Meinlschmidt, G., & Heim, C. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.007 · Cited by 210 · see citing works
Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells
Szeto, A., Nation, D. A., Mendez, A. J., Domínguez‐Bendala, J., Brooks, L., Schneiderman, N., & McCabe, P. M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90718.2008 · Cited by 207 · see citing works
Social isolation disrupts autonomic regulation of the heart and influences negative affective behaviors
Grippo, A. J., Lamb, D. G., Carter, C. S., & Porges, S. W. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.011 · Cited by 188 · see citing works
Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men
Clodi, M., Vila, G., Geyeregger, R., Riedl, M., Stulnig, T. M., Struck, J., Luger, T. A., & Luger, A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90263.2008 · Cited by 178 · see citing works
The influence of the paraventriculo-spinal pathway, and oxytocin and vasopressin on sympathetic preganglionic neurones
Gilbey, M. P., Coote, J. H., Fleetwood-Walker, S. M., & PETERSON, D. F. (1982) · Brain Research · doi:10.1016/0006-8993(82)90745-4 · Cited by 167 · see citing works
Baroreflex control of heart rate by oxytocin in the solitary-vagal complex
Higa, K. T., Mori, E., Viana, F. F., Morris, M., & Michelini, L. C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00806.2000 · Cited by 157 · see citing works
Oxytocin Receptors in the Central Nervous System: Distribution, Development, and Species Differencesa
TRIBOLLET, E., DUBOIS‐DAUPHIN, M., DREIFUSS, J. J., BARBERIS, C., & JARD, S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34343.x · Cited by 156 · see citing works
Organization of the sympathetic postganglionic innervation of the rat heart
Pardini, B. J., Lund, D. D., & Schmid, P. G. (1989) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(89)90146-x · Cited by 138 · see citing works
Respiratory sinus arrhythmia and diseases of aging: Obesity, diabetes mellitus, and hypertension
Masi, C. M., Hawkley, L. C., Rickett, E. M., & Cacioppo, J. T. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.07.006 · Cited by 136 · see citing works
Self-citation
Does oxytocin influence the early detection of angry and happy faces?
Guastella, A. J., Carson, D. S., Dadds, M. R., Mitchell, P. B., & Cox, R. E. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.09.001 · Cited by 114 · see citing works
Selective influences of oxytocin on the evaluative processing of social stimuli
Norman, G. J., Cacioppo, J. T., Morris, J. S., Karelina, K., Malarkey, W. B., DeVries, A. C., & Berntson, G. G. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110367452 · Cited by 92 · cited 3× · see citing works
“…acute OT administration on baseline serum inflammatory measures in healthy people; OT has potent inhibitory effects on pro-inflammatory cytokine responses in humans (Clodi et al., 2008), and in experimental models of neuropathic pain (Norman et al., 2010b), and atherosclerosis (Szeto et al., 2008).”
Self-citation
Social interaction prevents the development of depressive-like behavior post nerve injury in mice: a potential role for oxytocin
Norman, G. J., Karelina, K., Morris, J. S., Zhang, N., Cochran, M., & Courtney DeVries, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181de8678 · Cited by 88 · see citing works
Self-citation
Effects of stress and the sympathetic nervous system on coronary artery atherosclerosis in the cynomolgus macaque
Manuck, S. B., Kaplan, J. R., Adams, M. R., & Clarkson, T. B. (1988) · American Heart Journal · doi:10.1016/0002-8703(88)90110-x · Cited by 75 · see citing works
Autonomic mechanisms and sudden death after abrupt coronary occlusion
Airaksinen, J. K. E. (1999) · Annals of Medicine · doi:10.3109/07853899908995886 · Cited by 60 · see citing works
Social isolation potentiates cell death and inflammatory responses after global ischemia
Weil, Z. M., Norman, G. J., Barker, J. M., Su, A. J., Nelson, R. J., & DeVries, A. C. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.70 · Cited by 41 · see citing works
Self-citation
Cardiac vagal activity during psychological stress varies with social functioning in older women
Egizio, V. B., Jennings, J. R., Christie, I. C., Sheu, L. K., Matthews, K. A., & Gianaros, P. J. (2008) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00698.x · Cited by 39 · see citing works
Social interaction prevents the development of depressive-like behavior following nerve injury: A potential role for IL-1β and oxytocin
DeVries, A. C., Norman, G. J., Karelina, K., Morris, J., Zhang, N., & Cochran, M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.07.118 · Cited by 7 · see citing works
Self-citation

Flagged first, then by citations

1 of the 59 references couldn’t be matched to a known paper.

Sorted by citations

Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · see citing works
Loneliness: clinical import and interventions
Cacioppo, S., Grippo, A. J., London, S., Goossens, L., & Cacioppo, J. T. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615570616 · Cited by 1,206 · see citing works
Self-citation
Oxytocin pathways and the evolution of human behavior
Carter, C. S. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115110 · Cited by 714 · see citing works
The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620 · see citing works
Loneliness, Social Isolation, and Cardiovascular Health
Xia, N., & Li, H. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7312 · Cited by 508 · see citing works
Understanding loneliness in the twenty-first century: an update on correlates, risk factors, and potential solutions
Lim, M. H., Eres, R., & Vasan, S. (2020) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-020-01889-7 · Cited by 438 · see citing works
Heart rate variability is associated with emotion recognition: Direct evidence for a relationship between the autonomic nervous system and social cognition
Quintana, D. S., Guastella, A. J., Outhred, T., Hickie, I. B., & Kemp, A. H. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.08.012 · Cited by 367 · see citing works
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326 · see citing works
“supports the concept that the gastrointestinal microbiota composition and richness may be responsible, together with other factors, for the host eating behaviour and appetite (Alcock et al., 2014; Fetissov, 2017; Goyal et al., 2015; Norris et al., 2013).”
Background
In the Eye of the Beholder: Individual Differences in Perceived Social Isolation Predict Regional Brain Activation to Social Stimuli
Cacioppo, J. T., Norris, C. J., Decety, J., Monteleone, G., & Nusbaum, H. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21007 · Cited by 322 · see citing works
Self-citation
A Systematic Review of Loneliness and Common Chronic Physical Conditions in Adults
Petitte, T. M., Mallow, J. A., Barnes, E. R., Petrone, A. B., Barr, T. L., & Theeke, L. A. (2015) · The Open Psychology Journal · doi:10.2174/1874350101508010113 · Cited by 297 · see citing works
The Role of Oxytocin in Human Affect: A Novel Hypothesis
Kemp, A. H., & Guastella, A. J. (2011) · Current Directions in Psychological Science · doi:10.1177/0963721411417547 · Cited by 228 · see citing works
Why empathy has a beneficial impact on others in medicine: unifying theories
Jean Decety, A., & Fotopoulou, A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00457 · Cited by 240 · see citing works
Brain oxytocin: how puzzle stones from animal studies translate into psychiatry
Grinevich, V., & Neumann, I. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0802-9 · Cited by 189 · see citing works
Loneliness and acute stress reactivity: A systematic review of psychophysiological studies
Brown, E. G., Gallagher, S., & Creaven, A. (2018) · Psychophysiology · doi:10.1111/psyp.13031 · Cited by 262 · see citing works
Intranasal administration of oxytocin: behavioral and clinical effects, a review
Veening, J. G., & Olivier, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.012 · Cited by 169 · see citing works
A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health
Cardoso, C., Kingdon, D., & Ellenbogen, M. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.014 · Cited by 171 · see citing works
The neuroscience of empathy and compassion in pro-social behavior
Stevens, F. L., & Taber, K. H. (2021) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2021.107925 · Cited by 178 · see citing works
Oxytocin increases heart rate variability in humans at rest: implications for social approach-related motivation and capacity for social engagement
Kemp, A. H., Quintana, D. S., Kuhnert, R.-L., Griffiths, K., Hickie, I. B., & Guastella, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044014 · Cited by 158 · see citing works
The Oxytocin–Vasopressin Pathway in the Context of Love and Fear
Carter, C. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00356 · Cited by 162 · see citing works
The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness
Li, H., & Xia, N. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101585 · Cited by 159 · see citing works
Roles of Oxytocin in Stress Responses, Allostasis and Resilience
Takayanagi, Y., & Onaka, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010150 · Cited by 164 · see citing works
Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions
Leknes, S., Wessberg, J., Ellingsen, D.-M., Chelnokova, O., Olausson, H., & Laeng, B. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss062 · Cited by 151 · see citing works
Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms
Miller, M., Bales, K. L., Taylor, S. L., Yoon, J., Hostetler, C. M., Carter, C. S., & Solomon, M. (2013) · Autism Research · doi:10.1002/aur.1270 · Cited by 151 · see citing works
Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model
Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149 · see citing works
A heartfelt response: oxytocin effects on response to social stress in men and women
Kubzansky, L. D., Mendes, W. B., Appleton, A. A., Block, J., & Adler, G. K. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.02.010 · Cited by 142 · see citing works
Social functions of individual vasopressin–oxytocin cell groups in vertebrates: What do we really know?
Kelly, A. M., & Goodson, J. L. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.005 · Cited by 141 · see citing works
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.020 · Cited by 143 · see citing works
Effects of MDMA and intranasal oxytocin on social and emotional processing
Kirkpatrick, M. G., Lee, R., Wardle, M. C., Jacob, S., & de Wit, H. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.12 · Cited by 143 · see citing works
A registered replication study on oxytocin and trust
Declerck, C. H., Boone, C., Pauwels, L., Vogt, B., & Fehr, E. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-0878-x · Cited by 137 · see citing works
Brain-body interactions underlying the association of loneliness with mental and physical health
Quadt, L., Esposito, G., Critchley, H., & Garfinkel, S. N. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.015 · Cited by 141 · see citing works
The role of oxytocin in cardiovascular regulation
Gutkowska, J., Jankowski, M., & Antunes-Rodrigues, J. (2014) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20133309 · Cited by 131 · see citing works
The Neurobiology of Social Affiliation and Pair Bonding
Carter, C. S., & Keverne, E. B. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00004-8 · Cited by 128 · see citing works
From psychological moments to mortality: a multidisciplinary synthesis on heart rate variability spanning the continuum of time
Kemp, A. H., Koenig, J., & Thayer, J. F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.006 · Cited by 114 · see citing works
Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict
Ditzen, B., Nater, U. M., Schaer, M., La Marca, R., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss083 · Cited by 111 · see citing works
“Moreover, intranasal OT increased both sympathetic activity (assessed by PEP) and parasympathetic activity (assessed by high-frequency HR variability) (Norman et al., 2011).”
Background
Nonsocial Functions of Hypothalamic Oxytocin
Yang, H.-P., Wang, L., Han, L., & Wang, S. C. (2013) · ISRN Neuroscience · doi:10.1155/2013/179272 · Cited by 111 · see citing works
Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives
Vitale, E. M., & Smith, A. S. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.846315 · Cited by 112 · see citing works
A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows
Cerritelli, F., Frasch, M. G., Antonelli, M. C., Viglione, C., Vecchi, S., Chiera, M., & Manzotti, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.721605 · Cited by 108 · see citing works
A comparison of methods to measure central and peripheral oxytocin concentrations in human and non-human primates
Lefevre, A., Mottolese, R., Dirheimer, M., Mottolese, C., Duhamel, J.-R., & Sirigu, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17674-7 · Cited by 105 · see citing works
The Role of Oxytocin and Vasopressin in Attachment
Carter, C. S. (2017) · Psychodynamic Psychiatry · doi:10.1521/pdps.2017.45.4.499 · Cited by 105 · see citing works
Decreased heart rate variability during emotion regulation in subjects at risk for psychopathology
Simplicio, M. C. D., Costoloni, G., Western, D., Hanson, B. M., Taggart, P. I., & Harmer, C. J. (2011) · Psychological Medicine · doi:10.1017/s0033291711002479 · Cited by 87 · see citing works
MDMA decreases the effects of simulated social rejection
Frye, C. G., Wardle, M. C., Norman, G. J., & de Wit, H. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.030 · Cited by 85 · see citing works
Self-citation
Improving social perception in schizophrenia: The role of oxytocin
Fischer-Shofty, M., Brüne, M., Ebert, A., Shefet, D., Levkovitz, Y., & Shamay‐Tsoory, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.006 · Cited by 83 · see citing works
Psychophysiological Markers of Fear and Anxiety
Hyde, J., Ryan, K. M., & Waters, A. M. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1036-x · Cited by 83 · see citing works
The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces
Ellenbogen, M. A., Linnen, A., Grumet, R., Cardoso, C., & Joober, R. (2012) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01278.x · Cited by 82 · see citing works
“Social Ties, Health and Wellbeing: A Literature Review and Model”,
Kemp, A. H., Arias, J. A., & Fisher, Z. (2017) · Neuroscience and Social Science · doi:10.1007/978-3-319-68421-5_17 · Cited by 79 · see citing works
Loneliness: An Immunometabolic Syndrome
Pourriyahi, H., Yazdanpanah, N., Saghazadeh, A., & Rezaei, N. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182212162 · Cited by 82 · see citing works
Peripheral oxytocin administration buffers autonomic but not behavioral responses to environmental stressors in isolated prairie voles
Grippo, A. J., Pournajafi-Nazarloo, H., Sanzenbacher, L., Trahanas, D. M., McNeal, N., Clarke, D. A., Porges, S. W., & Sue Carter, C. (2012) · Stress · doi:10.3109/10253890.2011.605486 · Cited by 74 · see citing works
Social neuroscience: The social brain, oxytocin, and health
Norman, G. J., Hawkley, L. C., Cole, S. W., Berntson, G. G., & Cacioppo, J. T. (2011) · Social Neuroscience · doi:10.1080/17470919.2011.568702 · Cited by 72 · see citing works
Self-citation
Variation in the oxytocin receptor gene influences neurocardiac reactivity to social stress and HPA function: A population based study
Norman, G. J., Hawkley, L. C., Luhmann, M., Ball, A. B., Cole, S. W., Berntson, G. G., & Cacioppo, J. T. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.006 · Cited by 67 · see citing works
Self-citation
Coming Full Circle: Contributions of Central and Peripheral Oxytocin Actions to Energy Balance
Ho, J. M., & Blevins, J. E. (2012) · Endocrinology · doi:10.1210/en.2012-1751 · Cited by 67 · see citing works
Visualization of Oxytocin Release that Mediates Paired Pulse Facilitation in Hypothalamic Pathways to Brainstem Autonomic Neurons
Piñol, R. A., Jameson, H. S., Popratiloff, A. S., Lee, N. H., & Mendelowitz, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112138 · Cited by 67 · see citing works
Helping from the heart: Voluntary upregulation of heart rate variability predicts altruistic behavior
Bornemann, B., Kok, B. E., Böckler, A., & Singer, T. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2016.07.004 · Cited by 62 · see citing works
The Physiological Function of Oxytocin in Humans and Its Acute Response to Human-Dog Interactions: A Review of the Literature
Powell, L., Guastella, A. J., McGreevy, P., Bauman, A., Edwards, K. M., & Stamatakis, E. (2019) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2018.10.008 · Cited by 63 · see citing works
Improving the precision of intranasal oxytocin research
Winterton, A., Westlye, L. T., Steen, N. E., Andreassen, O. A., & Quintana, D. S. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-00996-4 · Cited by 62 · see citing works
Effects of a 10-day oxytocin trial in older adults on health and well-being
Barraza, J. A., Grewal, N. S., Ropacki, S., Perez, P., Gonzalez, A., & Zak, P. J. (2013) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0031581 · Cited by 61 · see citing works
Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity
Menuet, C., Ben‐Tal, A., Linossier, A., Allen, A. M., Machado, B. H., Moraes, D. J. A., Farmer, D., Paterson, D. J., Mendelowitz, D., Lakatta, E. G., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01160-z · Cited by 66 · see citing works
A role for autonomic cardiac control in the effects of oxytocin on social behavior and psychiatric illness
Quintana, D. S., Kemp, A. H., Alvares, G. A., & Guastella, A. J. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00048 · Cited by 61 · see citing works
Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial
Frijling, J. L., van Zuiden, M., Koch, S. B., Nawijn, L., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Bakker, F. C., Denys, D., et al. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-92 · Cited by 59 · see citing works
Intranasal oxytocin reduces provoked symptoms in female patients with posttraumatic stress disorder despite exerting sympathomimetic and positive chronotropic effects in a randomized controlled trial
Sack, M., Spieler, D., Wizelman, L., Epple, G., Stich, J., Zaba, M., & Schmidt, U. (2017) · BMC Medicine · doi:10.1186/s12916-017-0801-0 · Cited by 57 · see citing works
Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms
Ellenbogen, M. A., Linnen, A.-M., Cardoso, C., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.06.016 · Cited by 53 · see citing works
A novel role of oxytocin: Oxytocin-induced well-being in humans
Ito, E., Shima, R., & Yoshioka, T. (2019) · Biophysics and Physicobiology · doi:10.2142/biophysico.16.0_132 · Cited by 55 · see citing works
Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action
Yao, S., & Kendrick, K. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020323 · Cited by 52 · see citing works
Benefits of oxytocin administration in obstructive sleep apnea
Jain, V., Marbach, J., Kimbro, S., Andrade, D. C., Jain, A., Capozzi, E., Mele, K., Río, R. D., Kay, M. W., & Mendelowitz, D. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00206.2017 · Cited by 54 · see citing works
Intranasal oxytocin administration promotes emotional contagion and reduces aggression in a mouse model of callousness
Zoratto, F., Sbriccoli, M., Martinelli, A., Glennon, J. C., Macrı̀, S., & Giovanni Laviola, A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.010 · Cited by 51 · see citing works
Mathematical detection of aortic valve opening (B point) in impedance cardiography: A comparison of three popular algorithms
Árbol, J. R., Perakakis, P., Garrido, A., Mata, J. L., Fernández‐Santaella, M. C., & Vila, J. (2016) · Psychophysiology · doi:10.1111/psyp.12799 · Cited by 50 · see citing works
A unifying conceptual framework of factors associated to cardiac vagal control
Laborde, S., Mosley, E., & Mertgen, A. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e01002 · Cited by 47 · see citing works
Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system
Gryksa, K., & Neumann, I. D. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105601 · Cited by 49 · see citing works
Autonomic and prefrontal events during moral elevation
Piper, W. T., Saslow, L. R., & Saturn, S. R. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.03.004 · Cited by 45 · see citing works
CD 38 expression, attachment style and habituation of arousal in relation to trust-related oxytocin release
Kiss, I., Levy‐Gigi, E., & Kéri, S. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.08.005 · Cited by 45 · see citing works
Exposure to chronic isolation modulates receptors mRNAs for oxytocin and vasopressin in the hypothalamus and heart
Pournajafi‐Nazarloo, H., Kenkel, W. M., Mohsenpour, S. R., Sanzenbacher, L., Saadat, H., Partoo, L., Yee, J. R., Azizi, F., & Carter, C. S. (2013) · Peptides · doi:10.1016/j.peptides.2013.02.007 · Cited by 44 · see citing works
Nesfatin‐1 activates cardiac vagal neurons of nucleus ambiguus and elicits bradycardia in conscious rats
Brailoiu, G. C., Deliu, E., Tica, A. A., Rabinowitz, J. E., Tilley, D. G., Benamar, K., Koch, W. J., & Brailoiu, E. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12355 · Cited by 41 · see citing works
Race and Resting-State Heart Rate Variability in Brazilian Civil Servants and the Mediating Effects of Discrimination: An ELSA-Brasil Cohort Study
Kemp, A. H., Koenig, J., Thayer, J. F., Bittencourt, M. S., Pereira, A. C., Santos, I. S., Dantas, E. M., Mill, J. G., Chor, D., Ribeiro, A. L. P., et al. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000359 · Cited by 41 · see citing works
Effects of Human–Dog Interactions on Salivary Oxytocin Concentrations and Heart Rate Variability: A Four-Condition Cross-Over Trial
Powell, L., Edwards, K. M., Michael, S., McGreevy, P., Bauman, A., Guastella, A. J., Drayton, B., & Stamatakis, E. (2020) · Anthrozoös · doi:10.1080/08927936.2020.1694310 · Cited by 39 · see citing works
Oxytocin promotes functional coupling between paraventricular nucleus and both sympathetic and parasympathetic cardioregulatory nuclei
Yee, J. R., Kenkel, W. M., Frijling, J. L., Dodhia, S., Onishi, K. G., Tovar, S., Saber, M. J., Lewis, G. F., Liu, W., Porges, S. W., et al. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.01.010 · Cited by 39 · see citing works
Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction
Goh, K. K., Chen, C. Y.-A., Wu, T., Chen, C.-H., & Lu, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137092 · Cited by 37 · see citing works
Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure
Dyavanapalli, J., Rodriguez, J., dos Santos, C. R., Escobar, J. B., Dwyer, M. K. R., Schloen, J., Lee, K.-M., Wolaver, W., Wang, X., Dergacheva, O., et al. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2020.03.007 · Cited by 36 · see citing works
Positive Social Interactions in a Lifespan Perspective with a Focus on Opioidergic and Oxytocinergic Systems: Implications for Neuroprotection
Colonnello, V., Petrocchi, N., Farinelli, M., & Ottaviani, C. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160816120209 · Cited by 35 · see citing works
Influences of oxytocin and respiratory sinus arrhythmia on emotions and social behavior in daily life.
Isgett, S. F., Kok, B. E., Bączkowski, B. M., Algoe, S. B., Grewen, K., & Fredrickson, B. L. (2017) · Emotion · doi:10.1037/emo0000301 · Cited by 35 · see citing works
Oxytocin release increases with age and is associated with life satisfaction and prosocial behaviors
Zak, P. J., Curry, B., Owen, T., & Barraza, J. A. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.846234 · Cited by 35 · see citing works
Effects of Intranasal Oxytocin on Aggressive Responding in Antisocial Personality Disorder
Alcorn, J. L., Rathnayaka, N. S., Swann, A. C., Moeller, F. G., & Lane, S. D. (2015) · The Psychological Record · doi:10.1007/s40732-015-0139-y · Cited by 35 · see citing works
Potential Psychosocial Explanations for the Impact of Pet Ownership on Human Well-Being: Evaluating and Expanding Current Hypotheses
Barcelos, A. M., Kargas, N., Maltby, J., & Mills, D. S. (2023) · Human-Animal Interactions · doi:10.1079/hai.2023.0008 · Cited by 36 · see citing works
Loneliness and Social Isolation: Determinants of Cardiovascular Outcomes
Sharma, T., Padala, P. R., & Mehta, J. L. (2021) · Current Cardiology Reviews · doi:10.2174/1573403x17666210129101845 · Cited by 36 · see citing works
Autonomic Substrates of the Response to Pups in Male Prairie Voles
Kenkel, W. M., Paredes, J., Lewis, G. F., Yee, J. R., Pournajafi‐Nazarloo, H., Grippo, A. J., Porges, S. W., & Carter, C. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069965 · Cited by 33 · see citing works
Oxytocin and Facial Emotion Recognition
Ellenbogen, M. A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_20 · Cited by 33 · see citing works
Love alters autonomic reactivity to emotions.
Schneiderman, I., Zilberstein-Kra, Y., Leckman, J. F., & Feldman, R. (2011) · Emotion · doi:10.1037/a0024090 · Cited by 33 · see citing works
Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training
Bornemann, B., Kovacs, P., & Singer, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-44201-7 · Cited by 30 · see citing works
Novel approaches to restore parasympathetic activity to the heart in cardiorespiratory diseases
Dyavanapalli, J. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00398.2020 · Cited by 27 · see citing works
Intranasal Oxytocin Treatment Increases Eye-Gaze Behavior toward the Owner in Ancient Japanese Dog Breeds
Nagasawa, M., Ogawa, M., Mogi, K., & Kikusui, T. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01624 · Cited by 29 · see citing works
A comparison of heart rate variability in women at the third trimester of pregnancy and during low-risk labour
Lagos, J. J. R., Echeverría, J. C., Peña‐Castillo, M. Á., García-González, M. T., Ortíz-Pedroza, M. D. R., Pacheco‐López, G., Vargas-García, C., Camal-Ugarte, S., & González-Camarena, R. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.041 · Cited by 29 · see citing works
Sensory impairment and cognitive decline among older adults: An analysis of mediation and moderation effects of loneliness
Ge, S., Pan, W., Wu, B., Plassman, B. L., Dong, X., & McConnell, E. S. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1092297 · Cited by 28 · see citing works
Early involvement in friendships predicts later plasma concentrations of oxytocin and vasopressin in juvenile rhesus macaques (Macaca mulatta)
Weinstein, T. A. R., Bales, K. L., Maninger, N., Hostetler, C. M., & Capitanio, J. P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00295 · Cited by 26 · see citing works
Oxytocin Responses After Dog and Cat Interactions Depend on Pet Ownership and May Affect Interpersonal Trust
Curry, B. A., Donaldson, B., Vercoe, M., Filippo, M., & Zak, P. J. (2015) · Human-animal interaction bulletin · doi:10.1079/hai.2015.0008 · Cited by 25 · see citing works
Oxytocin and Human Evolution
Carter, C. S. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_18 · Cited by 25 · see citing works
The role of oxytocin and vasopressin in the pathophysiology of heart failure in pregnancy and in fetal and neonatal life
Szczepanska‐Sadowska, E. K., Cudnoch‐Jędrzejewska, A., & Wsół, A. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00484.2019 · Cited by 24 · see citing works
The role of oxytocin in regulating loneliness in old age
Elheja, R. A., Palgi, Y., Feldman, R., Zagoory‐Sharon, O., Keisari, S., & Shamay‐Tsoory, S. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105413 · Cited by 24 · see citing works
From Social Stress and Isolation to Autonomic Nervous System Dysregulation in Suicidal Behavior
Alacreu‐Crespo, A., Sebti, E., Moret, R. M., & Courtet, P. (2024) · Current Psychiatry Reports · doi:10.1007/s11920-024-01503-6 · Cited by 23 · see citing works
Social support and stress, depression, and cardiovascular disease
Uchino, B. N., Cronan, S. B., Scott, E. E., Landvatter, J., & Papadakis, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815015-3.00009-x · Cited by 26 · see citing works
DNA methylation ofOXTRis associated with parasympathetic nervous system activity and amygdala morphology
Lancaster, K., Goldbeck, L., Puglia, M. H., Morris, J. P., & Connelly, J. J. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy086 · Cited by 23 · see citing works
Self-citation
Intranasal oxytocin attenuates the human acoustic startle response independent of emotional modulation
Ellenbogen, M. A., Linnen, A., Cardoso, C., & Joober, R. (2014) · Psychophysiology · doi:10.1111/psyp.12263 · Cited by 22 · see citing works

A role for autonomic cardiac control in the effects of oxytocin on social behavior and psychiatric illness
Quintana, D. S., Kemp, A. H., Alvares, G. A., & Guastella, A. J. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00048 · Cited by 61 · see citing works
Chronic oxytocin treatment mediates heart rate responses following social isolation
Grippo, A. J., Carter, C. S., & Porges, S. W. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.5.a475-d
Oxytocin modulates the expression of norepinephrine transporter, β3-adrenoceptors and muscarinic M2 receptors in the hearts of socially isolated rats
Jovanović, P., Spasojević, N., Puškaš, N., Stefanović, B., & Dronjak, S. (2018) · Peptides · doi:10.1016/j.peptides.2018.06.008 · Cited by 12 · see citing works
sydney.edu.au;
Quintana, D. S., Kemp, A. H., Alvares, G. A., Guastella, A. J., Kok, B. E., Planck, M., Kemp, A. H., & Guastella, A. J. (2013)
Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation
Grippo, A. J., Trahanas, D. M., Zimmerman, R. R., Porges, S. W., & Carter, C. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.017 · Cited by 240 · see citing works

Authors: Norman, G. J., Cacioppo, J. T., Morris, J. S., Malarkey, W. B., Berntson, G. G., & DeVries, A. C.
Affiliations: University of Chicago (US)
The Ohio State University (US)
Corresponding author: Norman, Greg J.
ORCID: Norman, Greg J.
Cacioppo, John T.
Malarkey, William B.
Berntson, Gary G.
DeVries, A. Courtney
Venue: Biological Psychology
Publisher: Elsevier BV
Published: 2011-03
Volume: 86
Issue: 3
Pages: 174-180
ISSN: 0301-0511 (ISSN-L)
DOI: 10.1016/j.biopsycho.2010.11.006
OpenAlex: W2100442727
Semantic Scholar: 3cf9c7cd259a356839f42ecf143af3a8f6ef8b54
Cited by: 211
References: 59
Citations by year: 2026: 7 · 2025: 13 · 2024: 9 · 2023: 10 · 2022: 11 · 2021: 22 · 2020: 21 · 2019: 6 · 2018: 14 · 2017: 22 · 2016: 11 · 2015: 13 · 2014: 14 · 2013: 15 · 2012: 9
FWCI: 7.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychology (publishedVersion)
PubMed (publishedVersion)
Funders: Templeton Foundation
Clinical Research Center at The Ohio State University
National Center of Research Resources of the NIH (WM) (UL1-RR025755)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, loneliness, social isolation, cardiac autonomic control, heart rate variability, pre-ejection period, intranasal administration, inflammatory cytokines, stress hormones
MeSH terms: Adult, Autonomic Nervous System, Blood Pressure, Catecholamines, Electrocardiography, Female, Heart Rate, Humans, Hydrocortisone, Loneliness, Male, Models, Biological, Oxytocics, Oxytocin, Predictive Value of Tests, Time Factors, Cytokines, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxytocin increases autonomic cardiac control: Moderation by loneliness

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks