Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation
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Positive social interactions and social support may protect against various forms of mental and physical illness, although the mechanisms for these effects are not well identified. The socially monogamous prairie vole, which--like humans--forms social bonds and displays high levels of parasympathetic activity, has provided a useful model for investigating neurobiological systems that mediate the consequences of sociality. In the present study, adult female prairie voles were exposed to social isolation or continued pairing with a female sibling (control conditions) for 4 weeks. During weeks 3 and 4 of this period, animals were administered oxytocin (20 microg/50 microl, s.c.) or saline vehicle (50 microl, s.c.) daily for a total of 14 days. In Experiment 1, autonomic parameters were recorded during and following isolation or pairing. Isolation (vs. pairing) significantly increased basal heart rate (HR) and reduced HR variability and vagal regulation of the heart; these changes in isolated animals were prevented with oxytocin administration. In Experiment 2, behaviors relevant to depression [sucrose intake and swimming in the forced swim test (FST)] were measured as a function of isolation. Isolation reduced sucrose intake and increased immobility in the FST; these behaviors also were prevented by oxytocin. Administration of oxytocin did not significantly alter cardiac, autonomic or behavioral responses of paired animals. These findings support the hypothesis that oxytocinergic mechanisms can protect against behavioral and cardiac dysfunction in response to chronic social stressors, and can provide insight into social influences on behavior and autonomic function in humans.
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In female prairie voles, peripheral OT administration reduced heart rate responses to social isolation and to social stress.
“In female prairie voles, peripheral OT administration reduced HR responses to social isolation (Grippo et al., 2009) and to social stress (resident intruder test) (Grippo et al., 2012).”
From Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict (2013) · cites this paper as Grippo et al., 2009
In women, the findings are concurrent with animal data on OT application and reduced ANS activation in female prairie voles.
“In women, our findings are concurrent with animal data on OT application and reduced ANS activation in female prairie voles (Grippo et al., 2009(Grippo et al., , 2012)).”
From Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict (2013) · cites this paper as Grippo et al., 2009
Administration of OT during periods of social isolation can alleviate elevated basal heart rate in prairie voles.
“Administration of OT during periods of social isolation can alleviate some of the behaviors relevant to depression including the elevated basal heart rate [43].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [43]
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Cites
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451 · see citing works
Porges, S. W. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2006.06.009 · Cited by 3,415 · see citing works
Self-citationMarriage and health: His and hers
Kiecolt-Glaser, J. K., & Newton, T. L. (2001) · Psychological Bulletin · doi:10.1037//0033-2909.127.4.472 · Cited by 2,460 · see citing works
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works
The polyvagal theory: phylogenetic substrates of a social nervous system.
Porges, S. W. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00162-3 · Cited by 1,582 · see citing works
Self-citationThe neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · cited 2× · see citing works
“…system regions and in the circulation during positive social experiences, and has been suggested to facilitate positive social interactions including social memory, pair bonding, and parental behavior (Carter, 1998; Cho et al., 1999; Ferguson et al., 2000; 2001; Carter, 2003; Young and Wang, 2004).”
BackgroundNeuroendocrine perspectives on social attachment and love
Sue Carter, C. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00055-9 · Cited by 1,425 · see citing works
The validity of animal models of depression
Willner, P. (1984) · Psychopharmacology · doi:10.1007/bf00427414 · Cited by 1,415 · see citing works
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · cited 1× · see citing works
“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript predictive validity of this test in rodents (Willner et al., 1987; 1992; Willner, 2005), and the prior application of this test as an index of behavioral changes as a result of negative social environmental…”
BackgroundLoneliness and health: potential mechanisms
Cacioppo, J. T., Hawkley, L. C., Crawford, L. E., Ernst, J. M., Burleson, M. H., Kowalewski, R. B., Malarkey, W. B., Van Cauter, E., & Berntson, G. G. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200205000-00005 · Cited by 1,149 · see citing works
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · see citing works
Cryan, J. F., Valentino, R. J., & Lucki, I. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.008 · Cited by 1,115 · see citing works
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
Uvnäs-Moberg, K. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00056-0 · Cited by 966 · see citing works
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505312102 · Cited by 806 · see citing works
Steptoe, A., Owen, N., Kunz-Ebrecht, S. R., & Brydon, L. (2004) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00086-6 · Cited by 620 · cited 1× · see citing works
“For instance, in humans perceived loneliness is associated with symptoms of depression and increased cardiovascular reactivity during exposure to a mental stressor (Steptoe et al., 2004).”
BackgroundPhysiological substrates of mammalian monogamy: The prairie vole model
Sue Carter, C., Courtney Devries, A., & Getz, L. L. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00070-h · Cited by 615 · see citing works
Cho, M. M., DeVries, A. C., Williams, J. R., & Carter, C. S. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.1071 · Cited by 529 · see citing works
Self-citationNeuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
HEINRICHS, M., & DOMES, G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00428-7 · Cited by 479 · see citing works
Social Engagement and Attachment: A Phylogenetic Perspective
PORGES, S. W. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1301.004 · Cited by 472 · see citing works
Self-citationKrantz, D. S., & McCeney, M. K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135208 · Cited by 469 · see citing works
Neumann, I. D. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39014-9 · Cited by 387 · see citing works
Developmental consequences of oxytocin
Carter, C. S. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00151-3 · Cited by 367 · see citing works
Self-citationLove: An emergent property of the mammalian autonomic nervous system
W. Porges, S. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00057-2 · Cited by 354 · see citing works
De Vries, G. J., & Panzica, G. C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.050 · Cited by 346 · see citing works
Grippo, A. J., Gerena, D., Huang, J., Kumar, N., Shah, M., Ughreja, R., & Sue Carter, C. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.07.004 · Cited by 336 · see citing works
Self-citationCentral Nervous System Effects of the Neurohypophyseal Hormones and Related Peptides
de Wied, D., Diamant, M., & Fodor, M. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1009 · Cited by 327 · see citing works
Perspectives in cardiovascular psychophysiology
(1984) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(84)90190-1 · Cited by 294 · see citing works
Neumann, I. D., Krömer, S. A., Toschi, N., & Ebner, K. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00197-x · Cited by 285 · see citing works
Taylor, S. E., Gonzaga, G. C., Klein, L. C., Hu, P., Greendale, G. A., & Seeman, T. E. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000203242.95990.74 · Cited by 275 · see citing works
Results of the DSM-IV mood disorders field trial
Keller, M. B., Klein, D. N., Hirschfeld, R. M. A., Kocsis, J. H., McCullough, J. P., Miller, I. W., First, M. B., Holzer, C., Keitner, G. I., & Marin, D. B. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.6.843 · Cited by 249 · see citing works
Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress
Gibbs, D. M. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90241-8 · Cited by 233 · cited 1× · see citing works
“However, increased levels of oxytocin both in the central and peripheral nervous system also have been associated with stressful events in humans and rodents (Gibbs, 1984; Nishioka et al., 1998; Taylor et al., 2006; Grippo et al., 2007b).”
BackgroundBerkman, L. F. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh020 · Cited by 231 · see citing works
Oxytocin causes a long-term decrease of blood pressure in female and male rats
PETERSSON, M., ALSTER, P., LUNDEBERG, T., & UVNÄS-MOBERG, K. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00261-2 · Cited by 229 · see citing works
Bosch, O. J., Nair, H. P., Ahern, T. H., Neumann, I. D., & Young, L. J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.154 · Cited by 216 · see citing works
Cardiovascular alterations and autonomic imbalance in an experimental model of depression
Grippo, A. J., Moffitt, J. A., & Johnson, A. K. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00614.2001 · Cited by 215 · see citing works
Self-citationStress increases oxytocin release within the hypothalamic paraventricular nucleus
Nishioka, T., Anselmo-Franci, J. A., Li, P., Callahan, M. F., & Morris, M. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01159-1 · Cited by 214 · see citing works
Willner, P., Moreau, J.-L., Kurre Nielsen, C., Papp, M., & Sluzewska, A. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02256-2 · Cited by 205 · see citing works
Oxytocin acts as an antidepressant in two animal models of depression
Arletti, R., & Bertolini, A. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90600-x · Cited by 203 · see citing works
Konkle, A. T. M., Baker, S. L., Kentner, A. C., Barbagallo, L. S.-M., Merali, Z., & Bielajew, C. H. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.047 · Cited by 199 · see citing works
Grippo, A. J., Cushing, B. S., & Carter, C. S. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31802f054b · Cited by 196 · see citing works
Self-citationGrippo, A. J., Lamb, D. G., Carter, C. S., & Porges, S. W. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.011 · Cited by 188 · see citing works
Self-citationBlood—Brain Barrier and Peptides
Ermisch, A., Rühle, H., Landgraf, R., & Hess, J. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.49 · Cited by 187 · see citing works
Social isolation and cardiovascular disease: an atherosclerotic pathway?
Knox, S. S., & Uvnäs-Moberg, K. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00061-4 · Cited by 186 · see citing works
Central administration of oxytocin modulates the infant rats response to social isolation
Insel, T. R., & Winslow, J. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90806-2 · Cited by 185 · see citing works
Progression of heart failure after myocardial infarction in the rat
Francis, J., Weiss, R. M., Wei, S., Johnson, A. K., & Felder, R. B. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.5.r1734 · Cited by 178 · see citing works
Guzzetti, S., Rovere, M. T. L., Pinna, G. D., Maestri, R., Borroni, E., Porta, A., Mortara, A., & Malliani, A. (2004) · European Heart Journal · doi:10.1093/eurheartj/ehi067 · Cited by 172 · see citing works
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170 · see citing works
Grippo, A. J., Beltz, T. G., Weiss, R. M., & Johnson, A. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.010 · Cited by 167 · see citing works
Self-citationBaroreflex control of heart rate by oxytocin in the solitary-vagal complex
Higa, K. T., Mori, E., Viana, F. F., Morris, M., & Michelini, L. C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00806.2000 · Cited by 157 · see citing works
Jones, P. M., & Robinson, I. C. A. F. (2008) · Neuroendocrinology · doi:10.1159/000123316 · Cited by 148 · see citing works
Effects of stress and glucocorticoids on CNS oxytocin receptor binding
Liberzon, I., & Young, E. A. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00045-0 · Cited by 147 · see citing works
Sgoifo, A., Stilli, D., Medici, D., Gallo, P., Aimi, B., & Musso, E. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00228-4 · Cited by 139 · see citing works
Grippo, A. J., Wu, K. D., Hassan, I., & Carter, C. S. (2007) · Depression and Anxiety · doi:10.1002/da.20375 · Cited by 138 · see citing works
Self-citationPeripheral Pulses of Oxytocin Increase Partner Preferences in Female, but Not Male, Prairie Voles
Cushing, B. S., & Carter, C. S. (2000) · Hormones and Behavior · doi:10.1006/hbeh.1999.1558 · Cited by 136 · see citing works
Self-citationCARTER, C. (1987) · Hormones and Behavior · doi:10.1016/0018-506x(87)90032-8 · Cited by 130 · see citing works
Self-citationThe Neurobiology of Social Affiliation and Pair Bonding
Carter, C. S., & Keverne, E. B. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00004-8 · Cited by 128 · see citing works
Self-citationPorges, C. C., & Getz, L. (1996) · American Scientist · Cited by 122 · see citing works
Jankowski, M., Danalache, B. A., Wang, D., Bhat, P. V., Hajjar, F., Marcinkiewicz, M. M., Paquin, J., McCann, S. M., & Gutkowska, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405324101 · Cited by 120 · see citing works
The Neurobiology of Social Affiliation and Pair Bonding
Carter, C. S., & Keverne, E. B. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50006-8 · Cited by 109 · see citing works
Self-citationPitzalis, M. V., Iacoviello, M., Todarello, O., Fioretti, A. M., Guida, P., Massari, F., Mastropasqua, F., Russo, G. D., & RIZZON, P. (2001) · American Heart Journal · doi:10.1067/mhj.2001.114806 · Cited by 89 · see citing works
Motivational Properties of Oxytocin in the Conditioned Place Preference Paradigm
Liberzon, I. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00070-5 · Cited by 82 · see citing works
Yongue, B. G., McCabe, P. M., Porges, S. W., Rivera, M., Kelley, S. L., & Ackles, P. K. (1982) · Psychophysiology · doi:10.1111/j.1469-8986.1982.tb02499.x · Cited by 74 · see citing works
Self-citationIshii, K., Kuwahara, M., Tsubone, H., et al. (1996) · Laboratory Animals · doi:10.1258/002367796780739880 · Cited by 72 · see citing works
Oxytocin increases locus coeruleus alpha 2-adrenoreceptor responsiveness in rats
Petersson, M., Uvnäs-Moberg, K., Erhardt, S., & Engberg, G. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00729-0 · Cited by 71 · see citing works
Mantella, R. C., Vollmer, R. R., Rinaman, L., Li, X., & Amico, J. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00387.2004 · Cited by 71 · see citing works
Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice
Michelini, L. C., Marcelo, M. C., Amico, J. A., & Morris, M. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00774.2002 · Cited by 69 · see citing works
Oxytocin Involvement in Male and Female Sexual Behavior
Arletti, R., Benelli, A., & Bertolini, A. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34354.x · Cited by 66 · see citing works
Cardiac regulation in the socially monogamous prairie vole
Grippo, A. J., Lamb, D. G., Carter, C. S., & Porges, S. W. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.09.037 · Cited by 62 · see citing works
Self-citationPrigerson, H. G., Reynolds, C. F., Frank, E., Kupfer, D. J., George, C. J., & Houck, P. R. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90045-0 · Cited by 52 · see citing works
Legros, J., Chiodera, P., Geenen, V. G., & von Frenckell, R. (1987) · European Journal of Endocrinology · doi:10.1530/acta.0.1140345 · Cited by 48 · see citing works
Prognostic benefits of heart rate reduction in cardiovascular disease
Ferrari, R. (2003) · European Heart Journal Supplements · doi:10.1016/s1520-765x(03)90002-2 · Cited by 43 · see citing works
Petersson, M., Dı́az-Cabiale, Z., Narváez, J. Á., Fuxé, K., & Uvnäs‐Moberg, K. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.034 · Cited by 32 · see citing works
Analogies Between Oxytocin Systems of the Uterus and Brain
Caldwell, J., Walker, C. H., O’Rourke, S. T., Faggin, B. M., Morris, M., & Mason, G. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979131 · Cited by 24 · see citing works
Flagged first, then by citations
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Sorted by citations
Loneliness: clinical import and interventions
Cacioppo, S., Grippo, A. J., London, S., Goossens, L., & Cacioppo, J. T. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615570616 · Cited by 1,206 · see citing works
Self-citationThe oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954 · see citing works
Oxytocin pathways and the evolution of human behavior
Carter, C. S. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115110 · Cited by 714 · see citing works
Self-citationIncreased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511 · see citing works
Is oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394 · see citing works
Self-citationImmune and neuroendocrine mechanisms of stress vulnerability and resilience
Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374 · see citing works
Harshaw, C. (2015) · Psychological Bulletin · doi:10.1037/a0038101 · Cited by 302 · see citing works
Social vocalizations can release oxytocin in humans
Seltzer, L. J., Ziegler, T. E., & Pollak, S. D. (2010) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2010.0567 · Cited by 298 · see citing works
The prairie vole: An emerging model organism for understanding the social brain
McGraw, L. A., & Young, L. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.006 · Cited by 276 · see citing works
Marital behavior, oxytocin, vasopressin, and wound healing
Gouin, J.-P., Carter, C. S., Pournajafi-Nazarloo, H., Glaser, R., Malarkey, W. B., Loving, T. J., Stowell, J., & Kiecolt-Glaser, J. K. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.01.009 · Cited by 227 · see citing works
Self-citationOxytocin increases autonomic cardiac control: Moderation by loneliness
Norman, G. J., Cacioppo, J. T., Morris, J. S., Malarkey, W. B., Berntson, G. G., & DeVries, A. C. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2010.11.006 · Cited by 211 · see citing works
Ooishi, Y., Mukai, H., Watanabe, K., Kawato, S., & Kashino, M. (2017) · PLOS ONE · doi:10.1371/journal.pone.0189075 · Cited by 167 · see citing works
Kemp, A. H., Quintana, D. S., Kuhnert, R.-L., Griffiths, K., Hickie, I. B., & Guastella, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044014 · Cited by 158 · see citing works
Oxytocin and Social Relationships: From Attachment to Bond Disruption
Bosch, O. J., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_10 · Cited by 162 · see citing works
Miller, M., Bales, K. L., Taylor, S. L., Yoon, J., Hostetler, C. M., Carter, C. S., & Solomon, M. (2013) · Autism Research · doi:10.1002/aur.1270 · Cited by 151 · see citing works
Self-citationQuintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149 · see citing works
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Bowen, M. T., Carson, D. S., Spiro, A., Arnold, J. C., & McGregor, I. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027237 · Cited by 143 · see citing works
Sun, P., Smith, A. S., Lei, K., Liu, Y., & Wang, Z. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.016 · Cited by 141 · see citing works
Oxytocin Mediates Social Neuroprotection After Cerebral Ischemia
Karelina, K., Stuller, K. A., Jarrett, B., Zhang, N., Wells, J., Norman, G. J., & DeVries, A. C. (2011) · Stroke · doi:10.1161/strokeaha.111.628008 · Cited by 138 · see citing works
Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.125 · Cited by 128 · see citing works
Roles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
Onaka, T., Takayanagi, Y., & Yoshida, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02300.x · Cited by 123 · see citing works
Ditzen, B., Nater, U. M., Schaer, M., La Marca, R., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss083 · Cited by 111 · see citing works
“In female prairie voles, peripheral OT administration reduced HR responses to social isolation (Grippo et al., 2009) and to social stress (resident intruder test) (Grippo et al., 2012).”
BackgroundResultDonovan, M., Mackey, C. S., Platt, G. N., Rounds, J., Brown, A. N., Trickey, D. J., Liu, Y., Jones, K. M., & Wang, Z. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100278 · Cited by 85 · see citing works
Holt-Lunstad, J., Birmingham, W., & Light, K. C. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.007 · Cited by 103 · see citing works
Salubrious effects of oxytocin on social stress-induced deficits
Smith, A. S., & Wang, Z. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.010 · Cited by 88 · see citing works
Hydration State Controls Stress Responsiveness and Social Behavior
Krause, E. G., de Kloet, A. D., Flak, J. N., Smeltzer, M. D., Solomon, M. B., Evanson, N. K., Woods, S. C., Sakai, R. R., & Herman, J. P. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6078-10.2011 · Cited by 85 · see citing works
Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C. W., Kassiou, M., Hunt, G. E., & McGregor, I. S. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02311.x · Cited by 73 · see citing works
Hicks, C., Ramos, L., Reekie, T., Misagh, G. H., Narlawar, R., Kassiou, M., & McGregor, I. S. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12613 · Cited by 76 · see citing works
Grippo, A. J., Pournajafi-Nazarloo, H., Sanzenbacher, L., Trahanas, D. M., McNeal, N., Clarke, D. A., Porges, S. W., & Sue Carter, C. (2012) · Stress · doi:10.3109/10253890.2011.605486 · Cited by 74 · see citing works
Self-citationIs oxytocin a maternal-foetal signalling molecule at birth? Implications for development
Kenkel, W. M., Yee, J. R., & Carter, C. S. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12186 · Cited by 70 · see citing works
Self-citationOxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys
Cavanaugh, J., Carp, S. B., Rock, C. M., & French, J. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.12.027 · Cited by 64 · see citing works
Gemmer, A., Mirkes, K., Anneser, L., Eilers, T., Kibat, C., Mathuru, A., Ryu, S., & Schuman, E. (2022) · Scientific Reports · doi:10.1038/s41598-022-07990-y · Cited by 56 · see citing works
Robinson, K. J., Hazon, N., Lonergan, M., & Pomeroy, P. P. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.01.019 · Cited by 52 · see citing works
Long-term impact of social isolation and molecular underpinnings
Arzate-Mejía, R. G., Lottenbach, Z., Schindler, V., Jawaid, A., & Mansuy, I. M. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.589621 · Cited by 51 · see citing works
Suraev, A. S., Bowen, M. T., Ali, S. O., Hicks, C., Ramos, L., & McGregor, I. S. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.002 · Cited by 35 · see citing works
Oxytocin administration modulates rats’ helping behavior depending on social context
Yamagishi, A., Okada, M., Masuda, M., & Sato, N. (2020) · Neuroscience Research · doi:10.1016/j.neures.2019.04.001 · Cited by 33 · see citing works
Pfundmair, M., Aydin, N., Frey, D., & Echterhoff, G. (2014) · Journal of Experimental Social Psychology · doi:10.1016/j.jesp.2014.07.016 · Cited by 31 · see citing works
Anxiolytic drug discovery: What are the novel approaches and how can we improve them?
Stewart, A. M., & Kalueff, A. V. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.857309 · Cited by 22 · see citing works
Babb, P. L., Fernandez-Duque, E., & Schurr, T. G. (2015) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2015.05.006 · Cited by 16 · see citing works
The organizational effects of oxytocin and vasopressin: Behavioral implications
Cushing, B. S. (2013) · Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior · doi:10.1017/cbo9781139017855.006 · Cited by 9 · see citing works
- Authors
- Grippo, A. J., Trahanas, D. M., Zimmerman, R. R., Porges, S. W., & Carter, C. S.
- Affiliations
- Northern Illinois University (US)
- University of Illinois Chicago (US)
- Corresponding author
- Grippo, Angela J.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 34
- Issue
- 10
- Pages
- 1542-1553
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC2841348
- OpenAlex
- W2046327192
- Cited by
- 240
- References
- 79
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 12 · 2022: 8 · 2021: 14 · 2020: 10 · 2019: 12 · 2018: 13 · 2017: 15 · 2016: 17 · 2015: 16 · 2014: 28 · 2013: 21 · 2012: 18
- FWCI
- 21.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH77581, R21MH077581, MH 67446, MH 73233, F32MH073233, MH72935, R21MH067446, R01MH072935)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, social isolation, Microtus ochrogaster, social stress, autonomic function, heart rate variability, vagal regulation, depression-like behavior, sucrose intake, forced swim test, social bonding, parasympathetic activity
- MeSH terms
- Animals, Autonomic Nervous System, Behavior, Animal, Body Weight, Arvicolinae, Female, Heart, Heart Rate, Helplessness, Learned, Organ Size, Oxytocin, Social Isolation, Time Factors
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