Cited by 211Heart Rate Variability and Autonomic ControlNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

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Oxytocin increases autonomic cardiac control: Moderation by loneliness

Norman, Greg J., Cacioppo, John T., Morris, John S., Malarkey, William B., Berntson, Gary G., DeVries, A. Courtney·2011·Biological Psychology

DOI 10.1016/j.biopsycho.2010.11.006

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Abstract

The current study examined the role of perceived social isolation in moderating the effects of oxytocin on cardiac autonomic control in humans. Intranasal administration of 20 IU oxytocin resulted in a significant increase in autonomic (parasympathetic and sympathetic) cardiac control. Specifically, oxytocin increased high frequency heart rate variability, a relatively pure measure of parasympathetic cardiac control, and decreased pre-ejection period, a well-validated marker of enhanced sympathetic cardiac control. Derived metrics of autonomic co-activity and reciprocity revealed that oxytocin significantly increased overall autonomic cardiac control. Furthermore, the effects of oxytocin on cardiac autonomic control were significantly associated with loneliness ratings. Higher levels of loneliness were associated with diminished parasympathetic cardiac reactivity to intranasal oxytocin. The effects of OT on autonomic cardiac control were independent of any effects on circulating pro-inflammatory cytokine or stress hormone levels. Thus, lonely individuals may be less responsive to the salubrious effects of oxytocin on cardiovascular responsivity.

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Self-citation
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Authors: Norman, G. J., Cacioppo, J. T., Morris, J. S., Malarkey, W. B., Berntson, G. G., & DeVries, A. C.
Affiliations: University of Chicago (US)
The Ohio State University (US)
Corresponding author: Norman, Greg J.
ORCID: Norman, Greg J.
Cacioppo, John T.
Malarkey, William B.
Berntson, Gary G.
DeVries, A. Courtney
Venue: Biological Psychology
Publisher: Elsevier BV
Published: 2011-03
Volume: 86
Issue: 3
Pages: 174-180
ISSN: 0301-0511 (ISSN-L)
DOI: 10.1016/j.biopsycho.2010.11.006
OpenAlex: W2100442727
Semantic Scholar: 3cf9c7cd259a356839f42ecf143af3a8f6ef8b54
Cited by: 211
References: 59
Citations by year: 2026: 7 · 2025: 13 · 2024: 9 · 2023: 10 · 2022: 11 · 2021: 22 · 2020: 21 · 2019: 6 · 2018: 14 · 2017: 22 · 2016: 11 · 2015: 13 · 2014: 14 · 2013: 15 · 2012: 9
FWCI: 7.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychology (publishedVersion)
PubMed (publishedVersion)
Funders: Templeton Foundation
Clinical Research Center at The Ohio State University
National Center of Research Resources of the NIH (WM) (UL1-RR025755)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, loneliness, social isolation, cardiac autonomic control, heart rate variability, pre-ejection period, intranasal administration, inflammatory cytokines, stress hormones
MeSH terms: Adult, Autonomic Nervous System, Blood Pressure, Catecholamines, Electrocardiography, Female, Heart Rate, Humans, Hydrocortisone, Loneliness, Male, Models, Biological, Oxytocics, Oxytocin, Predictive Value of Tests, Time Factors, Cytokines, Young Adult

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Oxytocin increases autonomic cardiac control: Moderation by loneliness

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