Error-related negativity in individuals with obsessive–compulsive symptoms: Toward an understanding of hoarding behaviors
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The error-related negativity (ERN), an event-related potential component elicited by error responses in cognitive tasks, has been shown to be abnormal in most, but not all, studies of obsessive-compulsive disorder or obsessive-compulsive symptoms (OCD/S); these inconsistencies may be due to task selection, symptom subtype, or both. We used meta-analysis to further characterize the ERN in OCD/S, and pooled data across studies to examine the ERN in OCD/S with hoarding. We found an enhanced ERN in OCD/S relative to controls, as well as heterogeneity across tasks. When stratified, OCD/S showed a significantly enhanced ERN only in response conflict tasks. However, OCD/S+hoarding showed a marginally larger ERN than OCD/S-hoarding, but only for probabilistic learning tasks. These results suggest that abnormal ERN in OCD/S is task-dependent, and that OCD/S+hoarding show different ERN activity from OCD/S-hoarding perhaps suggesting different pathophysiological mechanisms of error monitoring.
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OCD patients show abnormal error responses in a variety of response conflict and error monitoring tasks using EEG, suggesting overactivity of the performance monitoring system involving the anterior cingulate cortex.
“abnormal error responses in a variety of response conflict and error monitoring tasks using EEG (Gillan et al. 2017; Mathews et al. 2012), suggesting overactivity of the performance monitoring system involving the anterior cingulate cortex (Hammer et al. 2009).”
From Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder (2019) · cites this paper as Mathews et al. 2012
Patients with obsessive-compulsive disorder show exaggerated error responses and prediction error learning signals in a variety of EEG and fMRI tasks, with data converging on the anterior cingulate cortex as a key locus of dysfunction.
“Patients with obsessive-compulsive disorder (OCD) have been found to show exaggerated error responses and prediction error learning signals in a variety of EEG and fMRI tasks, with data converging on the anterior cingulate cortex as a key locus of dysfunction.”
From Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder (2019) · cites this paper as Mathews et al. 2012
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- Authors
- Mathews, C. A., Perez, V. B., Delucchi, K. L., & Mathalon, D. H.
- Affiliations
- University of California, San Francisco (US)
- San Francisco VA Medical Center (US)
- Corresponding author
- Mathews, Carol A.
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 89
- Issue
- 2
- Pages
- 487-494
- ISSN
- 0301-0511 (ISSN-L)
- PMC
- PMC3292435
- OpenAlex
- W2015723694
- Cited by
- 78
- References
- 70
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 9 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 6
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01mh058262-17)
- National Institute of Mental Health (R01MH-058262, T32MH089920)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- error-related negativity, obsessive-compulsive symptoms, hoarding behavior, obsessive-compulsive disorder, error monitoring, response conflict, probabilistic learning, event-related potentials
- MeSH terms
- Hoarding Disorder, Brain Mapping, Cerebral Cortex, Electroencephalography, Evoked Potentials, Humans
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