The research domain criteria framework: The case for anterior cingulate cortex

Holroyd, Clay B.; Umemoto, Akina

doi:10.1016/j.neubiorev.2016.09.021

Cited by 187Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorNeural dynamics and brain function

The research domain criteria framework: The case for anterior cingulate cortex

Holroyd, Clay B., Umemoto, Akina·2016·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2016.09.021

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Abstract

The United States National Institute of Mental Health has recently promoted the Research Domain Criteria framework, which emphasizes the study of neurocognitive constructs that cut across different disorders. These constructs are said to express dimensionally across the population, giving rise to psychopathologies only in the extreme cases where that expression is maladaptive. Inspired by the RDoC framework, we propose that recent insights into the function of anterior cingulate cortex (ACC), a brain area said to be responsible for selecting and motivating extended behaviors, may elucidate the etiology of a diverse array of mental disorders. We argue that ACC function contributes to individual differences in personality traits related to reward sensitivity and persistence, and propose that the maladaptive expression of these traits contributes to multiple mental and neurological disorders. Our discussion is organized around a computational framework that relates the reward processing and control functions of ACC, as revealed by two electrophysiological phenomena called the reward positivity and frontal midline theta oscillations, to a distributed neural system underlying cognitive control.

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“have consistently observed aMCC dysfunction in depressed individuals (Holroyd & Umemoto, 2016; Vogt, 2016).”
From Motivation in the Service of Allostasis: The Role of Anterior Mid-Cingulate Cortex (2019) · cites this paper as Holroyd & Umemoto, 2016

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Authors: Holroyd, C. B., & Umemoto, A.
Affiliations: University of Victoria (CA)
Corresponding author: Holroyd, Clay B.
ORCID: Holroyd, Clay B.
Umemoto, Akina
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2016-12
Volume: 71
Pages: 418-443
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2016.09.021
OpenAlex: W2523836484
Cited by: 187
References: 73
Citations by year: 2026: 14 · 2025: 10 · 2024: 15 · 2023: 21 · 2022: 21 · 2021: 14 · 2020: 21 · 2019: 26 · 2018: 23 · 2017: 20 · 2016: 2
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: Canada Research Chairs
Canadian Institutes of Health Research
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: Research Domain Criteria, anterior cingulate cortex, reward processing, cognitive control, reward positivity, individual differences, personality traits, reward sensitivity, persistence, etiology of mental disorders, computational framework, dimensional models of psychopathology
MeSH terms: Gyrus Cinguli, Humans, Individuality, Reward

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The research domain criteria framework: The case for anterior cingulate cortex

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