Neurobiology and Treatment of Compulsive Hoarding

Saxena, Sanjaya

doi:10.1017/s1092852900026912

Cited by 73Obsessive-Compulsive Spectrum DisordersPerfectionism, Procrastination, Anxiety StudiesPersonal Information Management and User Behavior

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Neurobiology and Treatment of Compulsive Hoarding

Saxena, Sanjaya·2008·CNS Spectrums

DOI 10.1017/s1092852900026912

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Abstract

Compulsive hoarding is a common and often disabling neuropsychiatric disorder. This article reviews the phenomenology, etiology, neurobiology, and treatment of compulsive hoarding. Compulsive hoarding is part of a discrete clinical syndrome that includes difficulty discarding, urges to save, clutter, excessive acquisition, indecisiveness, perfectionism, procrastination, disorganization, and avoidance. Epidemiological and taxometric studies indicate that compulsive hoarding is a separate but related obsessive-compulsive spectrum disorder that is frequently comorbid with obsessive-compulsive disorder (OCD). Compulsive hoarding is a genetically discrete, strongly heritable phenotype. Neuroimaging and neuropsychological studies indicate that compulsive hoarding is neurobiologically distinct from OCD and implicate dysfunction of the anterior cingulate cortex and other ventral and medial prefrontal cortical areas that mediate decision-making, attention, and emotional regulation. Effective treatments for compulsive hoarding include pharmacotherapy and cognitive-behavioral therapy. More research will be required to determine the etiology and pathophysiology of compulsive hoarding, and to develop better treatments for this disorder.

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Abnormalities specific to hoarding have been suggested in prefrontal areas such as the dorsal anterior cingulate and ventromedial prefrontal cortex over and above the fronto-striatal abnormalities typically found in OCD.
“Abnormalities specific to hoarding have been suggested in prefrontal areas such as the dorsal anterior cingulate and ventromedial prefrontal cortex over and above the fronto-striatal abnormalities typically found in OCD (Saxena, 2008; Mataix-Cols et al., 2011), suggesting that executive functions may be specifically informative in characterizing hoarders with and without OCD.”
From The profile of executive function in OCD hoarders and hoarding disorder (2014) · cites this paper as Saxena, 2008

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Research works printed but not linked: 4

Saxena, 2007, Anterior cingulate cortex dysfunction in compulsive hoarding
Pertusa, 2008, Am J Psychiatry
Olatunji, 2007, Depress Anxiety
An, 2008, Mol Psychiatry

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Authors: Saxena, S.
Affiliations: University of California San Diego (US)
Corresponding author: Saxena, Sanjaya
Venue: CNS Spectrums
Publisher: Cambridge University Press (CUP)
Published: 2008
Volume: 13
Issue: S14
Pages: 29-36
ISSN: 1092-8529 (ISSN-L)
2165-6509
DOI: 10.1017/s1092852900026912
OpenAlex: W154596448
Cited by: 73
References: 79
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 8
FWCI: 8.16
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 2502 d)
Locations: CNS Spectrums (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01MH069433)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Social Sciences › Psychology › Clinical Psychology › Perfectionism, Procrastination, Anxiety Studies
Social Sciences › Decision Sciences › Information Systems and Management › Personal Information Management and User Behavior
Keywords: hoarding disorder, obsessive-compulsive spectrum disorders, obsessive-compulsive disorder comorbidity, heritability, anterior cingulate cortex, prefrontal cortex dysfunction, decision-making, emotion regulation, clutter, pharmacotherapy, cognitive behavioral therapy, taxometric analysis
MeSH terms: Combined Modality Therapy, Compulsive Behavior, Decision Making, Gyrus Cinguli, Humans, Motivation, Obsessive-Compulsive Disorder, Phenotype, Stereotyped Behavior, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors, Prefrontal Cortex, Positron-Emission Tomography

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Neurobiology and Treatment of Compulsive Hoarding

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