Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea
Abstract
Twenty-two algal species were evaluated for their potential anticoagulant activities. Hot water extracts from selected species, Codium fragile and Sargassum horneri showed high activated partial thromboplastin time (APTT). Ultraflo extract of C. fragile and S. horneri exhibited the most potent anticoagulant activity. Furthermore, in both algal species, active compounds were mainly concentrated in >30kDa faction. The crude polysaccharide fraction (>30kDa; CpoF) of C. fragile composed of approximately 80% carbohydrate and approximately 19% of protein; the crude polysaccharide fraction (>30kDa; CpoF) of S. horneri was composed of 97% of carbohydrate and approximately 2% of protein. Therefore, most probably the active compound, or compounds of the algal species were related to high molecular weight polysaccharide, or a complex form with carbohydrate and protein (proteoglycan).
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Phlorotannins and sulfated polysaccharides such as fucoidans in brown algae, carrageenans in red algae, and ulvans in green algae have been recognized as potential anticoagulant agents.
“Phlorotannins and sulfated polysaccharides such as fucoidans in brown algae, carrageenans in red algae, and ulvans in green algae have been recognized as potential anticoagulant agents [61,62,63,64].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [64]
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- Authors
- ATHUKORALA, Y., LEE, K., KIM, S., & JEON, Y.
- Affiliations
- Jeju National University (KR)
- Pukyong National University (KR)
- Corresponding author
- JEON, Y
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 98
- Issue
- 9
- Pages
- 1711-1716
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W2073980938
- Cited by
- 253
- References
- 22
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 12 · 2023: 11 · 2022: 16 · 2021: 9 · 2020: 18 · 2019: 12 · 2018: 15 · 2017: 5 · 2016: 10 · 2015: 23 · 2014: 22 · 2013: 19 · 2012: 21
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- anticoagulant activity, marine algae, green algae, brown algae, Codium fragile, Sargassum horneri, activated partial thromboplastin time, algal polysaccharides, proteoglycans, high molecular weight polysaccharides, Jeju Island
- MeSH terms
- Phaeophyceae, Chlorophyta, Anticoagulants, Blood Coagulation, Geography, Humans, Korea, Molecular Weight, Prothrombin Time
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