Purification and bioactivity of a sulphated polysaccharide conjugate from viscera of abalone Haliotis discus hannai Ino
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A sulphated polysaccharide conjugate ACP I was purified from the viscera of abalone Haliotis discus hannai Ino, and its immunostimulatory and anti-tumour activities were studied in vivo. Effect of ACP I on immune function was investigated in normal and cyclophosphamide-induced immunosuppressive mice. The anti-tumour effect was investigated by growth inhibition of tumour. Dose-dependent increase in spleen and thymus relative weight, lymphocyte proliferation, phagocytosis of macrophage, natural killer cell activity and antibody production was observed in all the tested mice administered with 10, 20 and 40 mg kg−1 body weight of ACP I. Significant increase of the above function was observed especially in immunosuppressive mice at dose of 40 mg kg−1. A significant inhibition of tumour growth was observed in 10, 20 and 40 mg kg−1 ACP I groups, with inhibitory rates of 40.24, 41.91 and 46.43%, respectively. Results suggested that ACP I might have immunomodulating and anti-tumour potential deserving application in functional food industry.
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The sulfated polysaccharide conjugate from viscera of abalone Heliotis discus hannai, administered at doses of 1-40 mg/kg to mice, inhibited tumor growth and increased lymphocyte proliferation, natural killer cell activity and antibody production.
“The sulfated polysaccharide conjugate from viscera of abalone Heliotis discus hannai, administered at doses of 1–40 mg/kg to mice inhibited tumor growth and increased lymphocyte proliferation, as well as natural killer cell activity and antibody production.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [142]
A significant increase of immune function was observed in cyclophosphamide-induced immunosuppressive mice on administration of 40 mg/kg dose.
“A significant increase of immune function was observed in cyclophosphamide-induced immunosuppressive mice on administration of 40 mg/kg dose [142].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [142]
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Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
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- Authors
- Sun, L., Zhu, B., Li, D., Wang, L., Dong, X., Murata, Y., Xing, R., & Dong, Y.
- Affiliations
- Dalian Polytechnic University (CN)
- Okayama University (JP)
- Dalian Medical University (CN)
- Jiangsu University (CN)
- Corresponding author
- Zhu, Beiwei
- Venue
- Food and Agricultural Immunology
- Publisher
- Informa UK Limited
- Published
- 2010-03
- Volume
- 21
- Issue
- 1
- Pages
- 15-26
- ISSN
- 0954-0105 (ISSN-L)
- 1465-3443
- OpenAlex
- W2093068057
- Cited by
- 42
- References
- 23
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Food and Agricultural Immunology (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- sulfated polysaccharides, Haliotis discus hannai, immune enhancement, antitumour activity, cyclophosphamide-induced immunosuppression, lymphocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity, antibody production, spleen and thymus weight, functional foods
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