Cited by 56Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

Structural Characteristics and Biological Activity of Fucoidans from the Brown Algae Alaria sp. and Saccharina japonica of Different Reproductive Status

Vishchuk, Olesya S., Tarbeeva, Dariya V., Ermakova, Svetlana P., Zvyagintseva, Tatyana N.·2012·Chemistry & Biodiversity

Abstract

Structural characteristics and the antitumor activity of fucoidans isolated from vegetative and reproductive tissue of the brown algae Alaria sp. and Saccharina japonica were studied. The reproductive status of the brown algae affected the yield of fucoidans and their structural characteristics. The fucoidan yield was 5.7% (w/w on the basis of the dried algae weight) for fertile and 3.8% for sterile Alaria sp. and 1.42 and 0.71% for fertile and sterile S. japonica, respectively. The fucoidans from fertile Alaria sp. and S. japonica had a slightly higher degree of sulfation and a somewhat more homogeneous monosaccharide composition, with predominate amounts of fucose and galactose, than those isolated from sterile algae tissue. The fucoidans from both the sterile and fertile brown algae tissue tested possessed selective cytotoxicity towards human breast cancer (T-47D) and melanoma (RPMI-7951) cell lines, but not to normal mouse epidermal cells (JB6 Cl41), and effectively inhibited the proliferation and colony formation of the breast cancer and melanoma cell lines. The fucoidans from reproductive tissue of brown algae possessed higher antitumor activity than those from vegetative plants.

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Crossref · 10.1002/cbdv.201100266

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Authors
Vishchuk, O. S., Tarbeeva, D. V., Ermakova, S. P., & Zvyagintseva, T. N.
Affiliations
  • Far Eastern Federal University (RU)
  • Russian Academy of Sciences (RU)
Venue
Chemistry & Biodiversity
Publisher
Wiley
Published
2012-04
Volume
9
Issue
4
Pages
817-828
ISSN
  • 1612-1872 (ISSN-L)
  • 1612-1880
OpenAlex
W1986485320
Cited by
56
References
41
Citations by year
2026: 4 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 3 · 2014: 1 · 2013: 6
FWCI
3.28
Type
journal article
Language
en
Open access
closed
Locations
  • Chemistry & Biodiversity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords
fucoidan, brown algae, Alaria, Laminaria japonica, reproductive status, anticancer activity, degree of sulfation, fucose, galactose, breast cancer, melanoma, selective cytotoxicity, cell proliferation inhibition, colony formation, marine polysaccharides
MeSH terms
Phaeophyceae, Animals, Antineoplastic Agents, Cell Line, Cell Survival, Humans, Neoplasms, Polysaccharides, Cell Line, Tumor, Mice

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