Structural Characteristics and Biological Activity of Fucoidans from the Brown Algae Alaria sp. and Saccharina japonica of Different Reproductive Status
Abstract
Structural characteristics and the antitumor activity of fucoidans isolated from vegetative and reproductive tissue of the brown algae Alaria sp. and Saccharina japonica were studied. The reproductive status of the brown algae affected the yield of fucoidans and their structural characteristics. The fucoidan yield was 5.7% (w/w on the basis of the dried algae weight) for fertile and 3.8% for sterile Alaria sp. and 1.42 and 0.71% for fertile and sterile S. japonica, respectively. The fucoidans from fertile Alaria sp. and S. japonica had a slightly higher degree of sulfation and a somewhat more homogeneous monosaccharide composition, with predominate amounts of fucose and galactose, than those isolated from sterile algae tissue. The fucoidans from both the sterile and fertile brown algae tissue tested possessed selective cytotoxicity towards human breast cancer (T-47D) and melanoma (RPMI-7951) cell lines, but not to normal mouse epidermal cells (JB6 Cl41), and effectively inhibited the proliferation and colony formation of the breast cancer and melanoma cell lines. The fucoidans from reproductive tissue of brown algae possessed higher antitumor activity than those from vegetative plants.
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Inhibition of cell transformation provided evidence of anti-tumorigenic potential of fucoidans from A. nodosum, S. japonica, U. pinnatifida, Alaria sp., and F. evanescens.
“The inhibition of cell transformation provided evidence on the anti-tumorigenic potential of fucoidans from A. nodosum [57], S. japonica, U. pinnatifida, Alaria sp., and F. evanescens [29,45,58].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [58]
Cancer preventive properties of fucoidans have been shown in many experiments.
“Cancer preventive properties of fucoidans have been shown in many experiments.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [58]
Content and structure of fucoidans depends on seaweed species, parts of the plant, harvest season, and mainly stage of development of the algae.
“Furthermore it is known that the content and structure of fucoidans depends on the seaweed species, the parts of the plant, the harvest season and mainly on the stage of development of the algae [58,80,81].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [58]
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Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
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- Authors
- Vishchuk, O. S., Tarbeeva, D. V., Ermakova, S. P., & Zvyagintseva, T. N.
- Affiliations
- Far Eastern Federal University (RU)
- Russian Academy of Sciences (RU)
- Venue
- Chemistry & Biodiversity
- Publisher
- Wiley
- Published
- 2012-04
- Volume
- 9
- Issue
- 4
- Pages
- 817-828
- ISSN
- 1612-1872 (ISSN-L)
- 1612-1880
- OpenAlex
- W1986485320
- Cited by
- 56
- References
- 41
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 3 · 2014: 1 · 2013: 6
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemistry & Biodiversity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- fucoidan, brown algae, Alaria, Laminaria japonica, reproductive status, anticancer activity, degree of sulfation, fucose, galactose, breast cancer, melanoma, selective cytotoxicity, cell proliferation inhibition, colony formation, marine polysaccharides
- MeSH terms
- Phaeophyceae, Animals, Antineoplastic Agents, Cell Line, Cell Survival, Humans, Neoplasms, Polysaccharides, Cell Line, Tumor, Mice
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