Production, extraction and stabilization of lutein from microalga Chlorella sorokiniana MB-1
Abstract
The efficiencies of extraction and preservation of lutein from microalgae are critical for the success of its commercialization. In this study, lutein was produced by Chlorella sorokiniana MB-1 via semi-batch mixotrophic cultivation. The microalgal biomass with a lutein content of 5.21mg/g was pretreated by bead-beating and high pressure cell disruption methods, and the lutein content was harvested by a reduced pressure extraction method. The effect of pretreatment, pressure, solvent type, extraction time and temperature on lutein recovery was investigated. Using high pressure pretreatment followed by extraction with tetrahydrofuran (THF) as solvent resulted in high lutein recovery efficiencies of 87.0% (20min) and 99.5% (40min) at 850mbar and 25°C. In contrast, using ethanol as the solvent, 86.2% lutein recovery was achieved under 450mbar, 35°C and 40min extraction. The extracted lutein was stabilized in olive oil or sunflower oil with half-lives of 53.1 and 63.8days, respectively.
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Chen et al. (2016a, b) reported that the use of high pressure followed by extraction with tetrahydrofuran could result in 99.5% lutein recovery from C. sorokiniana.
“For instance, Chen et al. (2016a, b) reported that the use of high pressure followed by extraction with tetrahydrofuran could result in 99.5% lutein recovery from C. sorokiniana (Chen et al. 2016a, b).”
From Production of microalgae with high lipid content and their potential as sources of nutraceuticals (2023) · cites this paper as Chen et al. 2016a, b
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- Authors
- Chen, C.-Y., Jesisca, Hsieh, C., Lee, D.-J., Chang, C.-H., & Chang, J.-S.
- Affiliations
- National Cheng Kung University (TW)
- National Kaohsiung Normal University (TW)
- National Taiwan University (TW)
- Corresponding author
- Chang, Jo-Shu
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 200
- Pages
- 500-505
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W2192216707
- Cited by
- 116
- References
- 27
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 12 · 2023: 10 · 2022: 17 · 2021: 14 · 2020: 13 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 5
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education
- Ministry of Science and Technology, Taiwan (103-2221-E-006-190-MY3, MOST104-3113-E-006-003)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
- Keywords
- lutein, Chlorella sorokiniana, microalgae, mixotrophic cultivation, bead beating, lutein extraction, tetrahydrofuran, ethanol extraction, olive oil, sunflower oil, carotenoid recovery
- MeSH terms
- Olive Oil, Sunflower Oil, Chlorella, Furans, Plant Oils, Pressure, Solvents, Temperature, Lutein, Biomass, Microalgae
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