Cited by 2,286Algal biology and biofuel productionMicrobial Metabolic Engineering and BioproductionAquaculture Nutrition and Growth

Recovery of microalgal biomass and metabolites: Process options and economics

Molina Grima, E, Belarbi, E.-H, Acién Fernández, F.G, Robles Medina, A, Chisti, Yusuf·2003·Biotechnology Advances

Abstract

Commercial production of intracellular microalgal metabolites requires the following: (1) large-scale monoseptic production of the appropriate microalgal biomass; (2) recovery of the biomass from a relatively dilute broth; (3) extraction of the metabolite from the biomass; and (4) purification of the crude extract. This review examines the options available for recovery of the biomass and the intracellular metabolites from the biomass. Economics of monoseptic production of microalgae in photobioreactors and the downstream recovery of metabolites are discussed using eicosapentaenoic acid (EPA) recovery as a representative case study.

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Crossref · 10.1016/s0734-9750(02)00050-2

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Authors
Molina Grima, E., Belarbi, E.-H., Acién Fernández, F. G., Robles Medina, A., & Chisti, Y.
Affiliations
University of Almería (ES)
Venue
Biotechnology Advances
Publisher
Elsevier BV
Published
2003-01
Volume
20
Issue
7-8
Pages
491-515
ISSN
0734-9750 (ISSN-L)
OpenAlex
W2080024205
Cited by
2,286
References
75
Citations by year
2026: 56 · 2025: 49 · 2024: 78 · 2023: 94 · 2022: 136 · 2021: 146 · 2020: 156 · 2019: 157 · 2018: 143 · 2017: 154 · 2016: 170 · 2015: 183 · 2014: 173 · 2013: 158 · 2012: 146
FWCI
4.87
Type
journal article
Language
en
Open access
closed
Locations
  • Biotechnology Advances (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords
downstream processing, eicosapentaenoic acid, photobioreactors, metabolite purification

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