Recovery of microalgal biomass and metabolites: Process options and economics
Abstract
Commercial production of intracellular microalgal metabolites requires the following: (1) large-scale monoseptic production of the appropriate microalgal biomass; (2) recovery of the biomass from a relatively dilute broth; (3) extraction of the metabolite from the biomass; and (4) purification of the crude extract. This review examines the options available for recovery of the biomass and the intracellular metabolites from the biomass. Economics of monoseptic production of microalgae in photobioreactors and the downstream recovery of metabolites are discussed using eicosapentaenoic acid (EPA) recovery as a representative case study.
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Harvesting represents 20% to 30% of the production costs of biomass.
“Harvesting represents 20% to 30% of the production costs of biomass [64,65].”
From The Perspective of Large-Scale Production of Algae Biodiesel (2020) · cites this paper as [65]
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- Authors
- Molina Grima, E., Belarbi, E.-H., Acién Fernández, F. G., Robles Medina, A., & Chisti, Y.
- Affiliations
- University of Almería (ES)
- ORCID
- Belarbi, E.-H
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 20
- Issue
- 7-8
- Pages
- 491-515
- ISSN
- 0734-9750 (ISSN-L)
- OpenAlex
- W2080024205
- Cited by
- 2,286
- References
- 75
- Citations by year
- 2026: 56 · 2025: 49 · 2024: 78 · 2023: 94 · 2022: 136 · 2021: 146 · 2020: 156 · 2019: 157 · 2018: 143 · 2017: 154 · 2016: 170 · 2015: 183 · 2014: 173 · 2013: 158 · 2012: 146
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- downstream processing, eicosapentaenoic acid, photobioreactors, metabolite purification
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