Cited by 346Algal biology and biofuel productionMicrobial Metabolic Engineering and BioproductionLipid metabolism and biosynthesis

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Manipulating environmental stresses and stress tolerance of microalgae for enhanced production of lipids and value-added products–A review

Chen, Bailing, Wan, Chun, Mehmood, Muhammad Aamer, Chang, Jo-Shu, Bai, Fengwu, Zhao, Xinqing·2017·Bioresource Technology

DOI 10.1016/j.biortech.2017.05.170

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Abstract

Microalgae have promising potential to produce lipids and a variety of high-value chemicals. Suitable stress conditions such as nitrogen starvation and high salinity could stimulate synthesis and accumulation of lipids and high-value products by microalgae, therefore, various stress-modification strategies were developed to manipulate and optimize cultivation processes to enhance bioproduction efficiency. On the other hand, advancements in omics-based technologies have boosted the research to globally understand microalgal gene regulation under stress conditions, which enable further improvement of production efficiency via genetic engineering. Moreover, integration of multi-omics data, synthetic biology design, and genetic engineering manipulations exhibits a tremendous potential in the betterment of microalgal biorefinery. This review discusses the process manipulation strategies and omics studies on understanding the regulation of metabolite biosynthesis under various stressful conditions, and proposes genetic engineering of microalgae to improve bioproduction via manipulating stress tolerance.

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RETRACTED ARTICLE: Soybean processing wastewater supported the removal of propyzamide and biochemical accumulation from wastewater by Rhodopseudomonas capsulata
Wu, P., Han, Z., Mo, W., Wu, X., Chen, Z., Zhang, Y., Wang, Y., Cui, Y., Dong, Y., Sun, H., et al. (2019) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-019-02137-2
Retracted
RETRACTED: Clothianidin wastewater treatment and the accumulation of high-value biochemical by Rhodopseudomonas spheroides
Wu, P., Zhang, Q., Wang, Y., Zhang, Y., Chen, Z., Cao, B., Wu, Y., Zhu, F., & Li, N. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122073
Retracted
An Integrated Biorefinery for Anaerobic Digestion of Thin Stillage and Microalgae Cultivation for Nutrient Recycling, Bioenergy and Bioproduct Production
Sayedin, F. (2019) · DalSpace (Dalhousie University)
Microalgae growing in stressed environments and their antioxidant potential from production of secondary metabolites
Gauthier, M. R. (2020) · Lu Zone Ul (Laurentian University)

Authors: Chen, B., Wan, C., Mehmood, M. A., Chang, J.-S., Bai, F., & Zhao, X.
Affiliations: Shanghai Jiao Tong University (CN)
Dalian University of Technology (CN)
National Cheng Kung University (TW)
Corresponding author: Zhao, Xinqing
ORCID: Chen, Bailing
Wan, Chun
Mehmood, Muhammad Aamer
Chang, Jo-Shu
Zhao, Xinqing
Venue: Bioresource Technology
Publisher: Elsevier BV
Published: 2017-11
Volume: 244
Issue: Pt 2
Pages: 1198-1206
ISSN: 0960-8524 (ISSN-L)
DOI: 10.1016/j.biortech.2017.05.170
OpenAlex: W2620135990
Cited by: 346
References: 100
Citations by year: 2026: 21 · 2025: 36 · 2024: 27 · 2023: 37 · 2022: 48 · 2021: 58 · 2020: 50 · 2019: 50 · 2018: 15 · 2017: 3
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Bioresource Technology (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (21536006)
Topics: Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: microalgae, lipid production, stress tolerance, nitrogen starvation, high salinity, microalgae biorefinery, genetic engineering of microalgae, multi-omics, synthetic biology, value-added products, metabolite synthesis
MeSH terms: Biotechnology, Lipids, Stress, Physiological, Biofuels, Microalgae

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