The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Graphene-based fully integrated portable nanosensing system for on-line detection of cytokine biomarkers in saliva
Abstract
Saliva has been reported to contain various cytokine biomarkers which are associated with some severe diseases such as cancers. Non-invasive saliva diagnosis using wearable or portable devices may pave a new avenue for monitoring conditions of the high risk population. Here, a graphene-based fully integrated portable nanosensing system, the entire size of which is smaller than a smart-phone and can be handheld, is presented for on-line detection of cytokine biomarkers in saliva. This miniaturized system employs an aptameric graphene-based field effect transistor (GFET) using a buried-gate geometry with HfO2 as the dielectric layer and on-line signal processing circuits to realize the transduction and processing of signals which reflect cytokine concentrations. The signal can be wirelessly transmitted to a smart-phone or cloud sever through the Wi-Fi connection for visualizing the trend of the cytokine concentration change. Interleukin-6 (IL-6) is used as a representative to examine the sensing capability of the system. Experimental results demonstrate that the nanosensing system responds to the change of IL-6 concentration within 400s in saliva with a detection limit down to 12 pM. Therefore, this portable system offers the practicality to be potentially used for non-invasive saliva diagnosis of diseases at early stage.
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Metadata
- Authors
- Hao, Z., Pan, Y., Shao, W., Lin, Q., & Zhao, X.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 134
- Pages
- 16-23
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2932501924
- Cited by
- 169
- References
- 9
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hao, Z., Pan, Y., Shao, W., Lin, Q., & Zhao, X. (2019). Graphene-based fully integrated portable nanosensing system for on-line detection of cytokine biomarkers in saliva. Biosensors and Bioelectronics. https://doi.org/10.1016/j.bios.2019.03.053
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