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Ferritin for the clinician

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Knovich, Mary Ann, Storey, Jonathan A., Coffman, Lan G., Torti, Suzy V., Torti, Frank M.·2009·Blood Reviews
DOI 10.1016/j.blre.2008.08.001
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Abstract

Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes. In clinical medicine, ferritin is predominantly utilized as a serum marker of total body iron stores. In cases of iron deficiency and overload, serum ferritin serves a critical role in both diagnosis and management. Elevated serum and tissue ferritin are linked to coronary artery disease, malignancy, and poor outcomes following stem cell transplantation. Ferritin is directly implicated in less common but potentially devastating human diseases including sideroblastic anemias, neurodegenerative disorders, and hemophagocytic syndrome. Additionally, recent research describes novel functions of ferritin independent of iron storage.

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Metadata

Authors
Knovich, M. A., Storey, J. A., Coffman, L. G., Torti, S. V., & Torti, F. M.
Venue
Blood Reviews
Publisher
Elsevier BV
Published
2009-05
Volume
23
Issue
3
Pages
95-104
ISSN
0268-960X (ISSN-L)
DOI
10.1016/j.blre.2008.08.001
OpenAlex
W2157296374
Cited by
627
References
8
FWCI
8.20
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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